Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation

作     者：Mo Zhang Philippa Malko Lin-Hua Jiang Mo Zhang;Philippa Malko;Lin-Hua Jiang

作者机构：Department of Physiology and Pathophysiologyand Sino-UK Joint Laboratory of Brain Function and Injury of Henan ProvinceXinxiang Medical UniversityXinxiangHenan ProvinceChina School of Biomedical SciencesFaculty of Biological SciencesUniversity of LeedsLeedsUK A4245-TransplantationImmunology and InflammationFaculty of MedicineUniversity of ToursToursFrance 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第11期

页      面：2385-2386页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：A PhD Studentship from University of Leeds (to PM) Start-Up Fund from Xinxiang Medical University (to LHJ) 

主　　题：inflammation diseases function 

摘      要：Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and play a crucial role in CNS health and disease (Paolicelli et al.,2022).Under the homeostatic conditions,microglial cells assume diverse and dynamic states,depending upon interactions with neighboring cells and structures in local contextual settings,continuously patrol brain parenchyma utilizing their highly mobile fine processes,phagocytize protein aggregates,unwanted synapses and cells to maintain CNS health,and secrete neurotrophic factors to support neuronal function (Colonna and Butovsky,2017;Paolicelli et al.,2022).