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伴睑板腺炎的疱性角膜炎青年患者

世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 10-10页

作者： Suzuki T mitsuishi y Sano y 陈立军 Department of Ophthalmology Kyoto Prefectural University of Medicine Kajii-cho Kamigyo-ku Kyoto City 602- 0841 JapanDr

PURPOSE: To describe the unique clinical features of phlyctenular keratitis, including the association with meibomitis, in young patients. DESIGN: Observational case series. METHODS: The study population consisted of 23 Japanese patients aged under 35 years with phlyctenular keratitis. We examined their clinical history, signs and symptoms, human leukocyte antigen (HLA), bacterial cultures of meibum, and the efficacy of antibiotics. The minimal diagnostic criteria included corneal nodules consisting of cellular infiltrates and superficial neovascularization. RESULTS: Of the 23 patients, 20 (87% )- were women, and 13 (56.5% ) had a history of chalazia. In all cases, the lesions and the severity of corneal nodules and neovascularization corresponded well with the location and the severity of meibomitis. The frequency of HLA- A26 and HLA- B35 was significantly increased in our patients (P=.003 and .016, respectively). Propionibacterium acnes in bacterial cultures of pure meibum in 12 of the 20 patients (60% ) was statistically more highly positive than those in four of the 17 age-matched normal control subjects (23.5% ; P=.028). CONCLUSION: The characteristics of phlyctenular keratitis in our cases include significantly higher prevalence in female patients, severity variation of ocular surface manifestation corresponding to meibomitis, specific HLA association, and possible P. acnes involvement.

关键词：睑板腺炎小疱棒状杆菌霰粒肿人白细胞抗原研究人群严重度病例研究观察性

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A New Method of Photopatterning with LB Films Based on a Chemically Amplified Mechanism

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Chemical Research in Chinese Universities 2006年第4期22卷 543-546页

作者： LI Tie-sheng Masaya mitsuishi Tokuji Miyashta Department of Chemistry Zhengzhou University Zhengzhou 450052 P. R. China Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai 980-8577 Japan

A new approach to introducing a photoacid generator（PAG） into Langmuir-Blodgett （LB） films to draw photopatterns as a lithographic process is described here. The chemically amplified positive-tone resist system used here consists of two components ： a copolymer, poly （ dodecrylacrylamide-co-4-t-butyloxylvinyl-phenylcarbonate ） [ P （ DDA-t- BVPC53 ） ] and a PAG, tri （2,3-dibromopropyl） isocyanurate （ TDBPIC ）. In the two-component system, the acid generated by the PAG catalyzes the deprotection reaction of P（ DDA-t-BVPC53）, to remove the tert-butoxycarbonyl group（t-BOC） in the exposed region during the postexposure baking process, thus rendering the exposed region soluble to alkaline aqueous solvents to form a positive tone. Photolithographic properties of the LB films have been evaluated. The patterns can be resolved with a resolution of 1 μm line width by UV irradiation, followed by development with an alkaline solution. The LB films can be used to generate etched gold relief images on a glass substrate via an aqueous iodide, like ammonium iodide, in alcohol/water as the etchant. The etch resistance of such LB films is sufficiently good, allowing patterning of a gold film suitable for photomask fabrication.

关键词： LB film Copolymer Photopatterning Chemically amplified resist

The Effect of Brief, Low-Intensity Stretching Gymnastics on Autonomic Nervous System Activity and Cognitive Function

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Health 2022年第12期14卷 1274-1286页

作者： Hisashi mitsuishi Department of Health and Sports Science Kyoto University of Advanced Science Kameoka Japan

Purpose: Stretching exercise and gymnastics both have beneficial effects, such as improvement of autonomic nervous system activity and mood. Additionally, studies on the effects of exercise on cognitive function have been conducted covering a wide range of age groups and have attracted much attention. However, conventional studies have set up programs with implementation times of 20 to 30 minutes. Therefore, shorter stretching programs are needed in order to fit them more easily into one’s free time. We examined the effects of a short 7-minute stretching gymnastics regime on the autonomic nervous system activity and cognitive function in 21 healthy participants. Methods: In this study, the participants performed a 10-minute cognitive task, followed by either Stretch Well Gymnastics, Stretch Band Gymnastics, or Radio Gymnastics sessions on different days. The participants then performed the cognitive task again. Heart rate was measured continuously throughout the experiment and we analyzed the heart rate variability. The cognitive tasks completed by all of the participants were evaluated for inhibitory control and cognitive flexibility. Results: A significant increase was shown in the sympathetic nerve activity during the Stretch Well Gymnastics, compared to the Radio Gymnastics and Stretch Band Gymnastics. Parasympathetic nerve levels were significantly increased after the gymnastics, compared to during the gymnastics, although there were no significant differences between any of the tasks. Additionally, in both the Stroop task and the number-Letter task, reaction times were faster in all of the sessions. In particular, the Stroop task showed the highest values for the Radio Gymnastics sessions, with marginally significantly lower scores for the Stretch Well Gymnastics sessions. Conclusion: The results showed that these heart rate variability responses supported the effects of autonomic activity associated with conventional low-intensity exercise. Additionally, stre

关键词： Stretching Gymnastics Autonomic Nervous System Cognitive Function Stretch Well Gymnastics

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2019年第6期25卷 707-718页

作者： yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri Department of Endoscopy The Jikei University School of Medicine Department of Gastroenterology Dokkyo Medical University Department of Endoscopy The Jikei University Katsushika Medical Center Department of Pathology The Jikei University School of Medicine Department of Innovative Interventional Endoscopy Research The Jikei University School of Medicine

BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and *** adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized *** To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case *** This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after *** In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 *** pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR

关键词： Duodenal adenoma Duodenal cancer Endoscopic resection Endoscopic submucosal dissection Long-term outcome

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

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Microsystems & Nanoengineering 2022年第4期8卷 137-149页

作者： yuta Taniguchi Hirotaka Sugiura Toshiro yamanaka Shiro Watanabe Seiji Omata Kanako Harada Mamoru mitsuishi Tomoyasu Shiraya Koichiro Sugimoto Takashi Ueta Kiyohito Totsuka Fumiyuki Araki Muneyuki Takao Makoto Aihara Fumihito Arai Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Faculty of Advanced Science and Technology Kumamoto University2-39-1 KurokamiChuo-kuKumamoto-shiKumamoto 860-8555Japan Center for Disease Biology and Integrative Medicine The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8655Japan

To provide quantitative feedback on surgical progress to ophthalmologists practicing inner limiting membrane(ILM)peeling,we developed an artificial eye module comprising a quartz crystal resonator(QCR)force sensor and a strain body that serves as a uniform force transmitter beneath a retinal *** a sufficiently large initial force must be loaded onto the QCR force sensor assembly to achieve stable contact with the strain body,the highly sensitive and wide dynamic-range property of this sensor enables the eye module to detect the slight forceps contact force.A parallel-plate strain body is used to achieve a uniform force sensitivity over the 4-mm-diameter ILM peeling *** these two components allowed for a measurable force range of 0.22 mN to 29.6 N with a sensitivity error within−11.3 to 4.2%over the ILM peeling *** this eye module,we measured the applied force during a simulation involving artificial ILM peeling by an untrained individual and compensated for the long-term drift of the obtained force data using a newly developed *** compensated force data clearly captured the characteristics of several types of motion sequences observed from video recordings of the eye bottom using an ophthalmological *** a result,we succeeded in extracting feature values that can be potentially related to trainee skill level,such as the mean and standard deviation of the pushing and peeling forces,corresponding,in the case of an untrained operator,to 122.6±95.2 and 20.4±13.2 mN,respectively.

关键词： artificial quartz resonator

Molecular Dynamics Simulation of Behaviours of Non-Polar Droplets Merging and Interactions with Hydrophobic Surfaces

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Journal of Bionic Engineering 2008年第4期5卷 271-281页

作者： y.y. yan C.y. Ji School of the Built Environment University of Nottingham Nottingham NG7 2RD UK

This paper presents a molecular dynamics simulation of the behaviours of non-polar droplets merging and also the fluid molecules interacting with a hydrophobic surface. Such behaviours and transport phenomena are popular in general microchannel flow boiling and two-phase flow. The droplets are assumed to be composed of Lennards-Jones type molecules. Periodic boundary conditions are applied in three coordinate directions of a 3-D system, where there exist two liquid droplets and their vapour. The two droplets merge when they come within the prescribed small distance. The merging of two droplets apart from each other at different initial distances is tested and the possible larger （or critical） non-dimensional distance, in which droplets merging can occur, is discussed. The evolution of the merging process is simulated numerically by employing the Molecular Dynamics （MD） method. For interactions with hydrophobic solid wall, a system with fluid confined between two walls is used to study the wetting phenomena of fluid and solid wall. The results are compared with those of hydrophilic wall to show the unique characteristics of hydrophobic interactions by microscopic methods.

关键词： molecular dynamics simulation mist flow droplets merging hydrophobic wetting