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Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation

World Journal of Biological Chemistry 2022年第4期13卷 72-82页

作者： Malwina Rybicka-Ramos mirosław markiewicz Aleksandra Suszka-Świtek Ryszard Wiaderkiewicz Sylwia Mizia Monika Dzierżak-Mietła Krzysztof Białas Department of Hematology Specialist Hospital No.1 in BytomBytom 41-902Poland Department of Hematology University of RzeszowCollege of Medical SciencesInstitute of Medical SciencesRzeszów 35-315Poland Department of Histology and Embryology School of Medicine in KatowiceMedical University of SilesiaKatowice 40-752Poland Department of Population Health Division of Epidemiology and Health EducationWroclaw Medical UniversityWrocław 51-618Poland Department of Bone Marrow Transplantation and Hematooncology Maria Sklodowska-Curie National Research Institute of OncologyGliwice 44-102Poland Department of Hematology and Bone Marrow Transplantation SPSK-M HospitalKatowice 40-027Poland

BACKGROUND Allogeneic hematopoietic stem cell transplantation(allo-HSCT)may be related to the occurrence of complications,including graft-versus-host disease(GvHD)and *** pathogenesis of acute GvHD is connected with T lymphocytes,which identify alloantigens on host's antigen-presenting cells,activate production of interferon-gamma(IFN-gamma)and interleukin-2(IL-2),and act on the immune effector cells and damage tissues and *** The aim of the study was to investigate and distinguish serum concentration profiles of IFN-gamma and IL-2 within a 30-d period after *** We enrolled 62 patients,i.e.,30(48%)male and 32(52%)female subjects[median age 49.5(19-68)years],after allo-HSCT from siblings(n=12)or unrelated donors(n=50)due to acute myeloid leukemia with myeloablative conditioning(n=26;42%)and with non-myeloablative conditioning(n=36;58%).All patients were given standard immunosuppressive therapy with cyclosporin-A and methotrexate and pre-transplant antithymocyte globulin in the unrelated *** samples were collected pre-transplant before and after(on day-1)the conditioning therapy and on days+2,+4,+6,+10,+20,and+30 after *** levels of IL-2 and IFNgamma were determined using *** Patients were divided into four groups depending on the presence of acute GvHD and clinical manifestations of *** I included patients with neither acute GvHD nor infections[n=15(24%)],group II consisted of patients with infections without acute GvHD[n=17(27%)],group III was comprised of patients with acute GvHD without infections[n=9(15%)],and group IV included patients with both acute GvHD and infections[n=21(34%)].IFN-gamma concentrations were higher in Group II than in other groups on days+20(P=0.014)and+30(P=0.008).Post-hoc tests showed lower concentrations of IFN-gamma on day+30 in groups I(P=0.039)and IV(P=0.017)compared to group *** levels of IL-2 were mostly *** Serum levels of IFN-gamma fol

关键词： Interleukin-2 Interferon-gamma Cytokine profiles Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation Acute graft-versus-host disease

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Self-assembly as a route to one-dimensional lanthanum(Ⅲ) salicylaldimine coordination polymer

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Journal of Rare Earths 2010年第S1期28卷 51-55页

作者： Wanda Radecka-Paryzek Izabela Pospieszna-markiewicz Maciej Kubicki Faculty of Chemistry Adam Mickiewicz University

The self-assembled formation of a one-dimensional lanthanum salicylald imine coordination polymer was proved by the X-ray diffraction analysis of new l anthanum(Ⅲ) nitrate complex containing N,N’-bis(salicylidene)-1,5-pentanediami ne ligand(H2L) . It was obtained in situ in a one-step,metal-templated condensa tion of salicylaldehyde with 1,5-pentanediamine(cadaverine,biogenic polyamine) and characterized by microanalysis and spectroscopic(IR,ESI-MS,UV-Vis,and 1 H NMR) data. The [La(NO3) 3(μ-H2L) 2]∞ complex displayed 10-coordinate distorted bicapped dodecahedron geometry with unusual coordination pattern of undeprotonat ed salicylaldimines which acted as μ-bridging ditopic ligands using exclusivel y the oxygens as donor atoms with the nitrogen atoms not being involved in the c oordination environment.

关键词： self assembly lanthanum salicylaldimine crystal structure coordina tion polymer rare earths

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Tightening up the structure, lighting up the pathway:application of molecular constraints and light to manipulate protein folding, self-assembly and function

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Science China Chemistry 2014年第12期57卷 1615-1624页

作者： markiewicz Beatrice N. CULIK Robert M. GAI Feng Department of Chemistry University of Pennsylvania Department of Biochemistry and Biophysics University of Pennsylvania

Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and ***,other types of molecular constraints,especially photoresponsive linkers and functional groups,have also found increased use in a wide variety of ***,we provide a concise review of using various forms of molecular strategies to constrain proteins,thereby stabilizing their native states,gaining insight into their folding mechanisms,and/or providing a handle to trigger a conformational process of interest with *** applications discussed here cover a wide range of topics,ranging from delineating the details of the protein folding energy landscape to controlling protein assembly and function.

关键词： protein folding aggregation self-assembly cross-linker phototrigger light-activation

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Labile and stabile soil organic carbon fractions in surface horizons of mountain soils–relationships with vegetation and altitude

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Journal of Mountain Science 2017年第12期14卷 2391-2405页

作者： bojko oskar kabala cezary mendyk Lukasz markiewicz maciej pagacz-kostrzewa magdalena glina bartlomiej institute of soil science and environmental protection wroclaw university of environmental and life sciencesGrunwaldzka 5350-357W roctawPoland department of soil science and landscape management nicolaus copernicus university in toruńLwowska187-100 Torn fiPoland Department of Soil Science and Land Protecion Poznan University of Life ScienceSzydlowska5060-656 PoznafiPoland

Global and local climate changes could disturb carbon sequestration and carbon stocks in forest soils. Thus, it is important to characterize the stability of soil organic matter and the dynamics of soil organic carbon(SOC) fractions in forest ecosystems. This study had two aims:(1) to evaluate the effects of altitude and vegetation on the content of labile and stabile forms of organic carbon in the mountain soils; and(2) to assess the impact of the properties of soil organic matter on the SOC pools under changing environmental conditions. The studies were conducted in the Karkonosze Mountains(SW Poland, Central Europe). The content of the most labile fraction of carbon(dissolved organic carbon,DOC) decreases with altitude, but the content of fulvic acids(FA), clearly increases in the zone above 1000 m asl, while the stabile fraction(humins, nonhydrolyzing carbon) significantly decreases. A higher contribution of stabile forms was found in soils under coniferous forests(Norway spruce), while a smaller-under deciduous forests(European beech) and on grasslands. The expected climate change and the ongoing land use transformations in the zone above1000 m asl may lead to a substantial increase in the stable humus fraction(mainly of a non-hydrolyzing carbon) and an increase in the SOC pools, even if humus acids are characterized by a lower maturity and greater mobility favorable to soil *** the lower zone(below 1000 m asl), a decrease in the most stable humus forms can be expected,accompanied by an increase of DOC contribution,which will result in a reduction in SOC pools. Overall,the expected prevailing(spatial) effect is a decreasing contribution of the most stable humus fractions,which will be associated with a reduction in the SOC pools in medium-high mountains of temperate zone of Central Europe.

关键词： Soil organic matter Humus fractions Dissolved organic carbon Organic carbon pools Vegetation Climate Mountain soils

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The intensity of supplementary feeding in an urban environment impacts overwintering Mallards(Anas platyrhynchos)as wintering conditions get harsher

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Avian Research 2024年第4期15卷 438-444页

作者： Marta Witkowska Wojciech Wesołowski Martyna markiewicz Jonasz Pakizer Julia Neumann Agnieszka O˙zarowska Włodzimierz Meissner Ornithology Unit Department of Vertebrate Ecology and ZoologyFaculty of BiologyUniversity of GdanskWita Stwosza 5980-308GdanskPoland Student’s Scientific Club KOS Department of Vertebrate Ecology and ZoologyFaculty of BiologyUniversity of GdanskWita Stwosza 5980-308GdanskPoland Department of Molecular Biology Faculty of BiologyUniversity of GdanskWita Stwosza 5980-308GdanskPoland Regional Directorate for Environmental Protection Chmielna 54/5780-748GdanskPoland

Although urbanization poses various threats to avifauna,some bird species,including Mallards(Anas platyrhynchos),choose towns and cities as their wintering habitats,possibly due to favourable temperatures and abundant anthropogenic *** this study,we investigated how population dynamics changed in relation to winter harshness and intensity of supplementary bird feeding in Mallard,a dabbing duck species well adapted to an urban *** surveyed 15 city ponds for five consecutive years,counting overwintering individuals and incidents of bird feeding conducted by the citizens of Gda′*** of Mallards observed in the studied area fluctuated both annually and within seasons,with on average 327(±SD=108.5)individuals and a malebiased sex ratio *** observed a gradient of feeding intensity on the surveyed ponds,with number of feeding incidents ranging from 0 to 30 in a *** results indicated that the number of Mallards increased with the bird feeding intensity,independently of the size of the studied ponds,and both males and females were similarly attracted by food *** severe wintering conditions,expressed by the percentage of the ice cover of studied ponds resulted in more birds wintering in the urban *** effect was more pronounced in females compared to males,possibly due to females having a lower ability to withstand severe wintering conditions,forcing them to relocate towards urban *** results confirm that urbanized areas may serve as wintering grounds for birds,due to additional food resources available there and milder wintering conditions compared to surrounding rural areas.

关键词： Anthropogenic food Duck Ecology of cities Human impact Urban ecology Waterbird

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Flood Risk for Embanked Rivers

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Journal of Geoscience and Environment Protection 2014年第3期2卷 135-143页

作者： Ewa Bogdanowicz Witold G.Strupczewski Krzysztof Kochanek Iwona markiewicz Institute of Meteorology and Water Management Podlesna 6101-673 WarsawPoland Institute of Geophysics Polish Academy of SciencesKsiecia Janusza 6401-452 WarsawPoland

Flood frequency analysis (FFA) concentrates on peak flows of flood hydrographs. However, floods that last years devastated large parts of Poland lead us to revision of the views on the assessment of flood risk in Poland. It turned out that it is the prolonged exposure to high water on levees that causes floods, not only the water overflowing the levee crest. This is because, the levees are weakened by water and their disruption occurs when it seems that the danger is over, i.e. after passing culmination. Two main causes of inundation of embanked rivers, namely over-crest flow and wash out of the levees, are combined to assess the total risk of inundation. Therefore the risk of inundation is the total of risk of exceeding embankment crest by flood peak and risk of washout of levees. Hence, while modeling the flood events in addition to the maximum flow one should consider also the duration of high water in a river channel, Analysis of the frequency of annual peak flows based on annual maxima and peaks over threshold is the subject of countless publications. Therefore we will here mainly modeling the duration of high water levels. In the paper the two-component model of flood hydrograph shape i.e. “duration of flooding-discharge- probability of nonexceedance” (DqF), with the methodology of its parameters estimation for stationary case was developed as a completion to the classical FFA with possible extension to non stationary flood regime. The model combined with the technical evaluation of probability of levees breach due to the d-days duration of flow above alarm stage gives the annual probability of inundation caused by the embankment breaking. The results of theoretical research were supplemented by a practical example of the model application to the series for daily flow in the Vistula River in Szczucin. Regardless promising results, this method is still in its infancy despite its great cognitive potential and practical importance. Therefore, we would like to poi

关键词： Flood Frequency Analysis Levee Break Flood Duration Maximum Likelihood Nonstationarity

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British Journal of General Practice论文摘要汇编——患者从医院安全转到全科诊所的危险因素：一项在伦敦西北部全科诊所进行的共识研究

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中国全科医学 2020年第9期23卷 1126-1126页

作者： markiewicz O LAVELLE M LORENCATTO F 本刊编辑部(整理) National Institute for Health Research (NIHR) Imperial Patient Safety Translational Research Centre Department of Surgery and Cancer Imperial College London London. University College London (UCL) Centre for Behaviour Change UCL London.

背景医疗环境转换对患者来说可能是影响病情的危险因素。目的调查与患者从医院转到全科诊所相关的危险因素。设计与场所对英国伦敦西北部39个全科诊所的临床和非临床人员进行三轮在线德尔菲法调查。方法在第1轮调查中,研究对象自由表达... 详细信息

背景医疗环境转换对患者来说可能是影响病情的危险因素。目的调查与患者从医院转到全科诊所相关的危险因素。设计与场所对英国伦敦西北部39个全科诊所的临床和非临床人员进行三轮在线德尔菲法调查。方法在第1轮调查中,研究对象自由表达想法回答问卷。在第2轮和第3轮调查中,研究对象逐渐达成共识。鼓励全科诊所以小组会议形式完成问卷。对每项与患者从医院转到全科诊所相关的危险因素的重要性评分进行累计:1~3分:“不重要”;4~6分:“有点重要”;7~9分:“非常重要”。计算研究对象对每类患者或药物治疗患者组的投票百分比。≥75%的调查对象同意该评估结果为达成一致。

关键词：全科诊所危险因素德尔菲法调查对象环境转换药物治疗自由表达非临床

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在长材轧制中采用激光光切法测量系统以获得高尺寸精度产品

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国际冶金设备和技术 2010年第1期 32-32,34页

作者： Erwin Knittelfelder Peter markiewicz Boehler Edelstahl GmbH

在Boehler Edelstahl GmbH＆ CoKG公司的Kapfenberg钢厂初轧机上安装了一套LAP公司的Profile Check系统。新系统可以线上测量轧件整个横截面的形状，并能够线上控制尺寸，并即时调节偏差。通过安装该系统，Boehler公司进一步优化生产过... 详细信息

在Boehler Edelstahl GmbH＆ CoKG公司的Kapfenberg钢厂初轧机上安装了一套LAP公司的Profile Check系统。新系统可以线上测量轧件整个横截面的形状，并能够线上控制尺寸，并即时调节偏差。通过安装该系统，Boehler公司进一步优化生产过程，目前能提供更高尺寸精度的产品。

关键词：测量系统尺寸精度长材轧制产品光切法激光 GmbH 生产过程

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纽约现代艺术博物馆改建

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现代装饰 2020年第2期 68-75页

作者： ChrisKupski Daniel markiewicz Jess Austin Mario Bastianell Iwan Baan(摄影) Brett Beyer(摄影) Geordie Wood(摄影) 刘印梅(编译) 无不详 Diller Scofidio+Renfro&Gensler

在Diller Scofidio+Renfro与Gensler的合作下,纽约现代艺术博物馆(MoMA)于近期完成了翻新和扩建。展厅面积在原来的基础上增加了百分之三十,为顾客带来了更加友好和舒适的观展体验,同时也使得MoMA与曼哈顿中心区的城市肌理连接得更加紧... 详细信息

在Diller Scofidio+Renfro与Gensler的合作下,纽约现代艺术博物馆(MoMA)于近期完成了翻新和扩建。展厅面积在原来的基础上增加了百分之三十,为顾客带来了更加友好和舒适的观展体验,同时也使得MoMA与曼哈顿中心区的城市肌理连接得更加紧密。扩建之后,展厅总面积达到了约15329平方米,使得博物馆能够以新颖的跨学科的方式展示更多数量的艺术作品。设计对于空间的流通性和展示技术上进行了优化,博物馆的主要展示空间被扩充和打开,成为了一个光线充足层且高达两层的空间,无缝连接了第53街道和第54街道,同时创造了更多的流通动线和更加宽敞的空间,来访者可以在此驻足和思考。

关键词：纽约现代艺术博物馆光线充足展厅面积无缝连接展示空间城市肌理艺术作品流通性

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红外光谱的检测灵敏度和选择性的提升及其应用

红外光谱的检测灵敏度和选择性的提升及其应用

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中国化学会第30届学术年会-第四十四分会：化学动力学

作者：张文凯 Beatrice N.markiewicz Jeffrey M.Rodgers 陈建新盖锋北京师范大学高等量子研究中心物理学系 Department of Chemistry University of Pennsylvania

红外光谱已被广泛应用于各种多肽和蛋白质的结构和动力学的研究中。但在推广到生物大分子体系的研究时却面临着很多困难,主要原因是红外光谱的选择性不够好、灵敏度不够高。因此人们无法通过生物分子自带的振动模式来获得位点选择的蛋... 详细信息

红外光谱已被广泛应用于各种多肽和蛋白质的结构和动力学的研究中。但在推广到生物大分子体系的研究时却面临着很多困难,主要原因是红外光谱的选择性不够好、灵敏度不够高。因此人们无法通过生物分子自带的振动模式来获得位点选择的蛋白质结构和动力学信息。为了克服这些困难,我们发展了非天然氨基酸红外光谱探针、提高了二维红外光谱的检测灵敏度。在此基础上,我们对一些蛋白质体系展开了研究工作。例如,我们研究了甲型流感病毒中的离子通道M2,它是由低pH激活的质子选择性离子通道,其质子传导是病毒复制的关键步骤,同时也是抗病毒药物的主要目标对象。研究表明通道中的Trp41氨基酸残基是负责通道开启和关闭的阀门,过去的研究认为M2离子通道内的质子传导的调控是依赖于通道中的水的结构变化。我们利用TrpCN红外探针研究了不同pH值情况下通道中的水的结构和动力学变化。研究结果表明,Trp41氨基酸残基附近的水的结构在通道开启和关闭的情况下没有显著的变化。

关键词：红外光谱红外探针氨基酸 M2离子通道

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