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In vivo detection of mucosal healing-involved histiocytes by confocal laser endomicroscopy

World Journal of Gastroenterology 2012年第32期18卷 4447-4449页

作者： Gheorghe Hundorfean Abbas Agaimy mircea T chiriac Walter GeiBdrfer Jochen Wacker Markus F Neurath Jonas Mudter Medical ClinicⅠ University of ErlangenNuremberg91054 ErlangenGermany Institute of Pathology University of Erlangen-Nuremberg91054 ErlangenGermany Microbiology Institute-Clinical Microbiology Immunology and HygieneUniversity of Erlangen-Nuremberg91054 ErlangenGermany Medical Clinic Ⅲ University of Erlangen-Nuremberg91054 ErlangenGermany

Histiocytes have a pivotal role in wound repair and intestinal epithelial recovery-the most important goal to sustain gut ***,an in vivo description of colonic histiocytes by confocal laser endomicroscopy(CLE) is ***,we report the case of a 45-yearsold male patient who was referred to our clinic with weight loss and a history of two consecutive Clostridium difficile colitis episodes,the latter cured 3 wk before present *** microbiology was *** colonoscopy showed atrophy and a light mucosal oedema in the distal *** on-going endoscopy,we performed a fluorescein-aided CLE which revealed large polygonal(histiocytes-like) cells with copious cytoplasm and large nuclei in the lamina propria of the sigmoid colon as well as regenerative epithelial *** assessment of biopsies from the same areas confirmed the endomicroscopical findings:Periodic acid-Schiff-and CD68-positive foamy histiocytes in the colonic lamina propria and an advanced epithelial *** stool microbiology was repeatedly negative and polymerase chain reaction-analysis from colonic biopsies could not detect any mRNA for Thropheryma whippleii and common pathogens,we interpreted this particular setting as a mucosal healing process after consecutive Clostridium difficile *** conclusion,by describing these colonic histiocytes,we highlight the clinical usefulness of CLE in describing the entity of histiocytes in vivo and in real-time during the process of post-infectious mucosal healing in the colon.

关键词： Endomicroscopy Mucosal healing Advanced colonic imaging Colonic histiocytes

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The Relationship between the Systemic Stress Produced by the Neuropsychic Strain and the Sensorial Integrity in Young People

The Relationship between the Systemic Stress Produced by the...

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The 6th Pan-Pacific Conference on Occupational Ergonomics

作者： Ion Anghel Mihaela Anghel Gabriela Anghel Ioana Tatar mircea chiriac Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA

The stress, "disease of the 20th century", concernes today all the fields of human life. In spite of the efforts made to fight against it, the phenomenon presents a worrying tendency to expand. The neurosensorial strain is likely to have an increasing importance in the future, that is the reason why we decided to study in our paper the impact of some nervous activities upon the functional entity of the organism through the induced systemic distress. Our investigation has been performed on a group of Medicine students (15), a group of Conservatory students (string instruments 15) and a group of blind pupils(12). They were all examined both in conditions of relative

关键词： Stress Occupational overstrain Ergonomy

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The Role of Viral Infection in Inducing Variability in Virus-Free Progeny in Tomato

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Journal of Integrative Plant Biology 2009年第5期51卷 476-488页

作者： Liliana Marii Gheorghe chiriac Institute of Genetics and Plant Physiology Academy of Sciences of Moldova

The effect of virus-host interactions on subsequent generations is poorly understood. The evaluation of the effects of viral infection on inheritance of quantitative traits in the progeny of infected plants and elucidation of a possible relationship between chiasma frequency in the infected plants and variability of traits in the progeny were investigated. The current study involved genotypes of four intraspecific hybrids of tomato （Solanum lycopersicum L.）, their parental forms and two additional cultivars. Used as infection were the tobacco mosaic virus （TMV） and potato virus X （PVX）. The consequences of the effect of viral infection were evaluated based on chromosome pairing in diakinesis and/or by examining quantitative and qualitative traits in the progeny of the infected tomato plants. Tomato plants infected with TMV ＋ PVX were found to differ in chiasma frequency per pollen mother cell or per bivalent. Deviations have been observed for genotypes of both F1 hybrids and cultivars. At the same time, differences in mean values of the traits under study have only been found for progeny populations （F2-F4） derived from virus-infected F1 hybrids, but not in the case of progeny of the infected cultivars. The rate of recombinants combining traits of both parents increased significantly （2.22-8.24 times） in progeny populations of hybrids infected with TMV＋PVX. The above suggests that the observed effects could be the result of modification of recombination frequencies that can be manifested in heterozygous hybrids and make small contributions to variability in cases of ＇homozygous＇ tomato genotypes （i.e. cultivars）.

关键词： chiasma recombination Solanum lycopersicum traits variability viral infection.

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Update on adrenal insufficiency in patients with liver cirrhosis

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World Journal of Gastroenterology 2013年第4期19卷 445-456页

作者： Anca Trifan Stefan chiriac Carol Stanciu "Gr.T.Popa" University of Medicine and Pharmacy Institute of Gastroenterology and Hepatology"St.Spiridon" University Hospital

Liver cirrhosis is a major cause of mortality worldwide,often with severe sepsis as the terminal *** the last two decades,several studies have reported that in septic patients the adrenal glands respond inappropriately to stimulation,and that the treatment with corticosteroids decreases mortality in such *** cirrhosis and septic shock share many hemodynamic abnormalities such as hyperdynamic circulatory failure,decreased peripheral vascular resistance,increased cardiac output,hypo-responsiveness to vasopressors,increased levels of proinflammatory cytokines [interleukine(IL)-1,IL-6,tumor necrosis factor-alpha] and it has,consequently,been reported that adrenal insufficiency(AI) is common in critically ill cirrhotic *** may also be present in patients with stable cirrhosis without sepsis and in those undergoing liver *** term hepato-adrenal syndrome defines AI in patients with advanced liver disease with sepsis and/or other complications,and it suggests that it could be a feature of liver disease per se,with a dif-ferent pathogenesis from that of septic *** AI is the term given to inadequate cortisol response to *** recently,another term is used,namely "critical illness related corticosteroid insufficiency" to define "an inadequate cellular corticosteroid activity for the severity of the patient's illness".The mechanisms of AI in liver cirrhosis are not completely understood,although decreased levels of high-density lipoprotein cholesterol and high levels of proinflammatory cytokines and circulatory endotoxin have been *** prevalence of AI in cirrhotic patients varies widely according to the stage of the liver disease(compensated or decompensated,with or without sepsis),the diagnostic criteria defining AI and the methodology *** effects of corticosteroid therapy on cirrhotic patients with septic shock and AI are *** review aims to summarize the existing published information rega

关键词： Liver cirrhosis Adrenal insufficiency Septic shock Corticosteroid therapy

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A thermo-fluid analysis in magnetic hyperthermia

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Chinese Physics B 2014年第4期23卷 358-364页

作者： Iordana Astefanoae Ioan Dumitru Alexandru Stancu Horia chiriac Faculty of Physics Alexandru Ioan Cuza University National Institute of Research & Development for Technical Physics

In the last years, hyperthermia induced by the heating of magnetic nanoparticles （MNPs） in an alternating magnetic field received considerable attention in cancer therapy. The thermal effects could be automatically controlled by using MNPs with selective magnetic absorption properties. In this paper, we analyze the temperature field determined by the heating of MNPs, injected in a malignant tissue, subjected to an alternating magnetic field. The main parameters which have a strong influence on temperature field are analyzed. The temperature evolution within healthy and tumor tissues are analyzed by finite element method （FEM） simulations in a thermo-fluid model. The cooling effect produced by blood flow in blood vessels from the tumor is considered. A thermal analysis is conducted under different distributions of MNP injection sites. The interdependence between the optimum dose of the nanoparticles and various types of tumors is investigated in order to understand their thermal effect on hyperthermia therapy. The control of the temperature field in the tumor and healthy tissues is an important step in the healing treatment.

关键词： hyperthermia magnetic nanoparticles Bioheat equations

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Accumulation of dysprosium,samarium,terbium,lanthanum,neodymium and ytterbium by Arthrospira platensis and their effects on biomass biochemical composition

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Journal of Rare Earths 2021年第9期39卷 1133-1143页

作者： Inga Zinicovscaia Liliana Cepoi Ludmila Rudi Tatiana chiriac Dmitrii Grozdov Sergey Pavlov Svetlana Djur Joint Institute for Nuclear Research 6 Joliot-Curie Str.1419890DubnaRussia Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering 30 Reactorului Str.MG-6BucharestMagureleRomania Institute of Microbiology and Biotechnology 1 Academiei Str.202&ChisinauMoldova State University "Dimitrie Cantemir"3/2 Academiei Str.2028ChisinauMoldova

The growth of Arthrospira platensis and physiological changes in biomass under the effects of six rare earth elements Dy,Sm,Tb,La,Nd and Yb were *** were tested by three concentrations of 10,20 and 30 mg/*** to neutron activation analysis data ***’s accumulation capacity toward studied elements changes in the following order of La>Dy>Nd>Sm>Yb>*** results show that Dy and La ions stimulate biomass growth and Yb ions inhibit it,while Sm,Tb and Nd ions do not affect biomass *** contents of proteins and chlorophyll a are not affected by the presence of rare earth elements in the cultivation *** elements affect to different extents carbohydrates,phycobilins,β-carotene,lipids and MDA contents in spirulina *** in the antioxidant activity under applied metal loads reveal a moderate stress in exposed *** *** can be successfully used for bioremediation of natural water contaminated with REEs as well as REEs recovery from low polluted industrial effluents.

关键词： Rare earth elements Arthrospira platensis Biochemical composition Antioxidant activity Neutron activation analysis

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A Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor Cell

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Engineering 2021年第10期7卷 1434-1440页

作者： Annalisa Volpe Udith Krishnan Maria Serena chiriacò Elisabetta Primiceri Antonio Ancona Francesco Ferrara Department of Physics University of Bari“Aldo Moro”Bari 70126Italy Institute for Photonics and Nanotechnologies Bari 70126Italy Institute of Nanotechnology Lecce 73100Italy STMicroelectronics Lecce 73100Italy

Rapid prototyping methods for the design and fabrication of polymeric labs-on-a-chip are on the rise,as they allow high degrees of precision and *** example,a microfluidic platform may require an optimization phase in which it could be necessary to continuously modify the architecture and geometry;however,this is only possible if easy,controllable fabrication methods and low-cost materials are *** this paper,we describe the realization process of a microfluidic tool,from the computer-aided design(CAD)to the proof-of-concept application as a capture device for circulating tumor cells(CTCs).The entire platform was realized in polymethyl methacrylate(PMMA),combining femtosecond(fs)laser and micromilling fabrication *** multilayer device was assembled through a facile and low-cost solvent-assisted method.A serpentine microchannel was then directly biofunctionalized by immobilizing capture probes able to distinguish cancer from non-cancer cells without *** low material costs,customizable methods,and biological application of the realized platform make it a suitable model for industrial exploitation and applications at the point of care.

关键词： Lab-on-a-chip Fs laser Circulating tumor cells Point of care Thermal bonding Polymers

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Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms

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Cancer Biology & Medicine 2017年第2期14卷 162-175页

作者： Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni chiriacò Diego Serraino Carla Di Loreto Sabina Cauci Department of Medical Area School of MedicineUniversity of Udine Dermatology Clinic Udine University-HospitalUniversity of Udine Unit of Cancer Epidemiology CRO Aviano National Cancer Institute

Objective:Vitamin D receptor(VDR)mediates vitamin D *** examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)***:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI ***-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ *** expression was categorized as follows:100% positive vs.1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma ***:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma *** VDR expression in AATT carriers is a new finding that merits further *** expression possibly poses implications for vitamin D supplementation against *** expression and VDR genotype may become precise medicinal tools for melanoma in the future.

关键词： Vitamin D receptor VDR protein expression VDR polymorphism cutaneous melanoma metastatic melanoma skin cancer predictive biomarkers FokI polymorphism

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Carbon sequestration in a bamboo plantation:a case study in a Mediterranean area

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Journal of Forestry Research 2024年第3期35卷 231-238页

作者： Tommaso Chiti Emanuele Blasi Maria Vincenza chiriaco Department for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean Center on Climate Change(CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien species that can seriously alter plant and ani-mal biocoenosis,the area occupied by bamboo plantations continues to increase,especially for the purpose to seques-ter carbon(C).However,the C dynamics in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the C mitigation potential of the fast-growing Moso bamboo(Phyllostachys edulis)introduced in Italy for climate-change *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic C(SOC)at O-15-and 15-30-cm depths in a 4-year-old bamboo plantation in comparison with the former annual cropland on which the bamboo was *** have an idea of the maximum C stored at an ecosystem level,a natural forest adjacent the two sites was also *** the plantation,C accumulation as AGB was stimulated,with 14.8±3.1 Mg C ha^(-1) stored in 3 years;because thinning was done to remove culms from the first year,the mean sequestration rate was 4.9 Mg C ha^(-1) a^(-1).The sequestration rates were high but comparable to other fast-growing tree species in Italy(e.g.,Pinus nigra).SOC was significantly higher in the bamboo plantation than in the cropland only at the 0-15 cm depth,but SOC stock did not *** 4 years were not enough time for a clear increase in SOC,or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic matter formation by *** comparison,the natural forest had significantly higher C levels in all the *** C dynamics at an ecosystem level,the bamboo plantation on the former annual cropland led to substantial C removal from the atmosphere(about 12 Mg C ha^(-1) a^(-1)).However,despite the promising C sequestration rates by bamboo,its introduction should be carefully considered due to potential ecological problems caused by this species in overexploited environments such as the Med

关键词： Carbon sequestration Climate change mitigation Mediterranean area Moso bamboo Soil organic carbon

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Ulcerated intussuscepted jejunal lipoma-uncommon cause of obscure gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3765-3771页

作者： Tudor Cuciureanu Laura Huiban Stefan chiriac Ana-Maria Singeap Mihai Danciu Florin Mihai Carol Stanciu Anca Trifan Nutu Vlad Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Pathology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of General Surgery “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania

BACKGROUND Intestinal lipomas are rare benign gastrointestinal(GI)tumors,usually asymptomatic,but may become symptomatic as the result of some complications such as intussusception,intestinal obstruction,volvulus or *** can occur at any site along the entire GI tract,more frequent in colon and rarely in small *** patient reported here is a very rare case of jejunal lipoma,ulcerated and intussuscepted,diagnosed in an adult investigated for a chronic iron deficiency anemia(IDA),and successfully managed by segmental jejunal *** SUMMARY A 63-year-old male was referred to“***”Hospital,Institute of Gastroenterology and Hepatology,Iasi,to investigate an obscure GI bleeding with an *** upper GI endoscopy and colonoscopy were performed,excluding potentially bleeding lesions,videocapsule endoscopy was then carried out,revealing fresh blood and a protruding lesion in proximal jejunum,findings confirmed by a single-balloon *** biopsies were taken from the lesion,but histological results were ***,contrast-enhanced computed tomography was performed showing jejunal polypoid mass with homogenous fat density,suggestive for lipoma.A week later a laparotomy was performed revealing the intussuscepted jejunal segment which was resected enbloc,and sent for further histopathologic *** patient made an uneventful recovery and was discharged seven days later,and at six months follow-up he had no complains and his hemoglobin returned to normal *** Lipomas are very rarely located in the jejunum,usually asymptomatic,but they may lead to complications such as intussusception and *** resection remains the treatment of choice.

关键词： Lipoma Intussusception Computed tomography Video capsule endoscopy Gastrointestinal bleeding Case report

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