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Science China Earth Sciences 2024年第6期67卷 1932-1951页

作者： Yu LI Zhansen ZHANG Xueru ZHOU minjun gao Junjie DUAN Yaxin XUE Hao SHANG Shiyu LIU Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

The northern Tibetan Plateau is a climatically sensitive zone influenced by monsoon and westerly *** summer,water vapor transport can reach Qinghai Lake and the eastern section of the Qilian Mountains;in winter,westerly winds mainly control the *** article compares the wet/dry changes in the region during the mid-Holocene(MH)warm period,the medieval climate anomaly(MCA),the current warm period(CWP),and the future warm period from the perspective of *** found that the MH warm period was mainly affected by the orbit-controlled East Asian summer monsoon,and the region showed warm and humid climate *** MCA was mainly controlled by solar radiation,and there was a warm and dry *** CWP and the future warm period are mainly controlled by the rise in temperature caused by the increase in greenhouse gases,and the climate is becoming more *** wet/dry patterns in the CWP and the future warm period in the next century on the northern Tibetan Plateau are similar to those in the *** warming will lead to the expansion of the westerly belt and a gradually humid *** future wet/dry changes will be more similar to the MH warm period.

关键词： Northern Tibetan Plateau Wet/dry change Warm period similarity Driving mechanism Future assessment

The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response

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Virologica Sinica 2018年第6期33卷 545-556页

作者： Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo minjun gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao State Key Laboratory of Virology Modern Virology Research Center College of Life Sciences Wuhan University Bio-drug Research Center Wuhan University International Centre for Chemical and Biological Sciences (ICCBS) HEJ Research Institute of Chemistry University of Karachi Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals Wuhan University

Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is ***, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral *** mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators.

关键词： Dengue virus(DENV) Zika virus(ZIKV) Scorpion venom peptide Smp76 Antiviral mechanism Type-Ⅰ interferon response

Application Strategies of Pipe Jacking Technology in Municipal Rainwater Pipeline Engineering

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Journal of Architectural Research and Development 2024年第6期8卷 5-10页

作者： Yao Tong Xiaoqing Hu Yuwenhui Guo minjun gao Chongqing Institute of Engineering Chongqing 400056China

Traditional construction techniques have a significant impact on the environment and are associated with long construction durations in the construction of municipal rainwater *** jacking technology,a new type of pipeline construction method,enables non-excavation construction and can address the shortcomings of traditional pipeline *** article analyzes the concept and application advantages of pipe jacking *** engineering examples,it explores the application strategies of pipe jacking technology in the construction process of municipal rainwater pipelines for reference.

关键词： Municipal engineering Rainwater pipeline Pipe jacking construction

磺胺二甲嘧啶分子印迹二维光子晶体水凝胶传感器的研究

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高等学校化学学报 2018年第2期39卷 212-218页

作者：陈小娟刘根起任宸锐高敏君范晓东西北工业大学理学院应用化学系陕西省高分子科学与技术重点实验室西安710129

以聚苯乙烯二维光子晶体为模板,磺胺二甲嘧啶为印迹分子,甲醇为溶剂,甲基丙烯酸为功能单体,二甲基丙烯酸乙二醇酯为交联剂,2,2-二乙氧基苯乙酮为引发剂,经紫外光引发低温聚合反应,用甲醇/乙酸(体积比9∶1)混合液洗脱除去印迹分子,制备... 详细信息

以聚苯乙烯二维光子晶体为模板,磺胺二甲嘧啶为印迹分子,甲醇为溶剂,甲基丙烯酸为功能单体,二甲基丙烯酸乙二醇酯为交联剂,2,2-二乙氧基苯乙酮为引发剂,经紫外光引发低温聚合反应,用甲醇/乙酸(体积比9∶1)混合液洗脱除去印迹分子,制备得到能够特异性识别磺胺二甲嘧啶的分子印迹二维光子晶体水凝胶(MIPH).通过测试该水凝胶传感器在不同浓度的磺胺二甲嘧啶溶液中德拜环直径的变化,考察了其响应性能.实验结果表明,当磺胺二甲嘧啶的浓度从0增加到1×10^(-6)mol/L时,德拜环直径增加0.9 cm,相应的晶格间距减小46 nm.研究发现,当MIPH的交联度为10%,印迹分子与功能单体摩尔比为1∶75时,德拜环直径变化量最大.此外,该水凝胶传感器在浓度为10-6mol/L的磺胺二甲嘧啶类似物磺胺嘧啶(SDZ)、磺胺异噁唑(SIZ)及其它抗生素四环素(TE)、罗红霉素(RM)溶液中,德拜环直径变化量分别为0.4,0.3,0.25和0.2 cm,可见该传感器具有良好的特异性识别功能.将该传感器用于模拟水样及兽用药片中磺胺二甲嘧啶的测定,均具有良好的响应性.

关键词：磺胺二甲嘧啶分子印迹二维光子晶体水凝胶传感器

A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles

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A scorpion venom peptide Ev37 restricts viral late entry by ...

第十四届生物毒素毒理学术大会暨第一届生物毒素——从生存适应到转化医学专题学术会议

作者： Fangfang Li Yange Lang Zhenglin Ji Zhiqiang Xia Yuewen Han Yuting Cheng gaomin Liu Fang Sun Yonghui Zhao minjun gao Zongyun Chen Yingliang Wu Wenxin Li Zhijian Cao

Viral infection still threatens human health all over the world,and many people die from viral diseases every ***,there are no effective vaccines or drugs for preventing or managing most viral ***,the discovery and development of broad-spectrum antiviral agents remain ***,we expressed and purified a scorpion venom peptide,Ev37,from the scorpion Euscorpiops validus in a prokaryotic *** found that rEv37 can inhibit dengue virus type 2(DENV-2),hepatitis C virus(HCV),Zika virus(ZIKV) and herpes simplex virus type 1(HSV-1)infections in a dose-dependent manner at noncytotoxic concentrations,but that it has no effect on Sendai virus(SeV) and Adenovirus(AdV) infections in ***,rEv37 alkalized acidic organelles to prevent low pH-dependent fusion of the viral membrane-endosomal membrane,which mainly blocks the release of the viral genome from the endosome to the cytoplasm and then restricts viral late *** together,our results indicate that the scorpion venom peptide Ev37 is a broadspectrum antiviral agent with a specific molecular mechanism against viruses undergoing low pHdependent fusion activation during entry into host *** conclude that Ev37 is a potential candidate for development as an antiviral drug.

关键词： scorpion venom peptide antiviral peptide antiviral mechanism dengue virus(DENV) hepatitis C virus(HCV) Zika virus(ZIKV) herpes simplex virus(HSV) viral entry membrane fusion endosome

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防空反导领域关键技术发展与需求分析

战术导弹技术 2023年第6期 148-154页

作者：李航宇徐培高敏畯李信淦朱永皓上海机电工程研究所上海201109

随着前沿颠覆性技术和“黑科技”在军事攻防领域不断涌现,针对未来防御体系的发展形势与需求,深入开展战略研究与剖析,归纳出体系级、平台级、武器级、技术级四类典型威胁目标特征,并通过对防空反导领域关键技术现状与发展趋势进行梳理... 详细信息

随着前沿颠覆性技术和“黑科技”在军事攻防领域不断涌现,针对未来防御体系的发展形势与需求,深入开展战略研究与剖析,归纳出体系级、平台级、武器级、技术级四类典型威胁目标特征,并通过对防空反导领域关键技术现状与发展趋势进行梳理,分析了常规防空反导技术及人工智能、量子信息等新型前沿技术的应用形式。遵循技术发展影响武器装备变革的原则,对该领域装备和技术提出相关启示与建议,为后续防御体系建设提供参考。

关键词：防空反导作战体系装备体系人工智能量子信息智能隐身制导控制

Ultraviolet-attenuated cercariae ofSchistosoma japonicum fail to effectively induce a Th1 response in spite of up-regulating expression of cytotoxicity-related genes in C57BL/6 mice

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The Journal of Biomedical Research 2010年第4期24卷 277-284页

作者： Meijuan Zhang Fang Tian Yanan gao minjun Ji Guanling Wu Department of Pathogen Biology and Immunology Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Clinical Laboratory the first Affiated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Jiangsu Province Key Laboratory of Modern Pathogen Biology Nanjing 210029 Jiangsu Province China

Objective： To better understand the reason that Schistosoma japonicurn （S. japonicum） ultraviolet （UV）- radiated cercariae could not induce high level of protection in C57BL/6 mice. Methods： Microarray technology was performed to investigate the gene transcription profile in skin draining lymph nodes （sdLNs） at 1 w after exposure to attenuated cercariae （AC） or normal cercariae （NC） of S. japonicum in C57BL/6 mice. The expressions of some representative genes were further confirmed by real-time PCR. Subsequently, the expressions of Th1/Th2 cytokine genes, cytotoxicity-related genes, as well as co-stimulator genes in spleens from AC-vaccinated and NC- infected mice were analyzed by real-time PCR at w 3 and 6 post-exposure. Results： The gene expressions of Th1 cytokines, including interferon-y （IFN-γ）, interleukin （IL）-12 and tumor necrosis factor-α （TNF-α） in the sdLNs were significantly lower in AC-vaccinated mice than in NC-infected mice. Furthermore, the gene expressions of Th1- and Th2- cytokines, including IFN-γ, IL-12, TNF-α, IL-4 and IL-10, in the spleens from AC-vaccinated mice showed little changes at w 3 and 6 post-vaccination. In addition, cytotoxicity-related molecules including granzyme A, granzyme B, granzyme K, perforin 1 and Fas L were up-regulated from the early stage of vaccination, and peaked at the 3rd w after vaccination with UV-AC. Conclusion： UV-AC of S. japonicum could not ef- fectively induce a Thl response in C57BL/6 mice, which may be an explanation for the low protection against parasite challenge, and the role played by up-regulated expression of cytotoxicity-related genes in mice needs to be further investigated.

关键词： Schistosoma japonicum ultraviolet-attenuated cercariae Thl response cytotoxicity-related genes,C57BL/6 mice

Wearable and stretchable conductive polymer composites for strain sensors:How to design a superior one?

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Nano Materials Science 2023年第4期5卷 392-403页

作者： Liwei Lin Sumin Park Yuri Kim minjun Bae Jeongyeon Lee Wang Zhang Jiefeng gao Sun Ha Paek Yuanzhe Piao Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul08826South Korea Department of Neurosurgery Movement Disorder CenterSeoul National University HospitalHypoxia/Ischemia Disease InstituteCancer Research InstituteSeoul National University College of MedicineSeoul03080South Korea School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsu225002China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHung HomHong Kong SAR999077China Advanced Institutes of Convergence Technology 145 Gwanggyo-roYeongtong-guSuwon-siGyeonggi-do443-270South Korea

Wearable and stretchable strain sensors have potential values in the fields of human motion and health monitoring,flexible electronics,and soft robotic *** wearable and stretchable strain sensors can be directly attached to human skin,providing visualized detection for human motions and personal *** polymer composites(CPC)composed of conductive fillers and flexible polymers have the advantages of high stretchability,good flexibility,superior durability,which can be used to prepare flexible strain sensors with large working strain and outstanding *** review has put forward a comprehensive summary on the fabrication methods,advanced mechanisms and strain sensing abilities of CPC strain sensors reported in recent years,especially the sensors with superior ***,the structural design,bionic function,integration technology and further application of CPC strain sensors are prospected.

关键词： Wearable strain sensors Conductive polymer composites Mechanism Sensing performance

Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming

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Acta Pharmaceutica Sinica B 2023年第2期13卷 834-851页

作者： Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling gao Hongzhuan Chen Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China

Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative ***,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains ***,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded *** ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model *** findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases.

关键词： Microglia Metabolism Misfolded proteins Phagocytosis Degradation Polyphenol Nanoparticles Neurodegenerative diseases

食品中氟喹诺酮类药物残留的快速检测研究进展

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食品科学 2022年第5期43卷 383-391页

作者：孙敏君高雪徐阳鑫刘秀英励建荣渤海大学食品科学与工程学院辽宁省食品安全重点实验室生鲜农产品贮藏加工及安全控制技术国家地方联合工程研究中心辽宁锦州121013

氟喹诺酮药物是一类高效抗菌药物,被广泛应用于畜牧业和水产养殖业中动物疾病的预防和治疗。但由于不规范用药问题的发生,导致食品中兽药残留问题日益凸显,因此针对氟喹诺酮类药物残留,建立快速、便捷、高效的检测方法对于保障食品安全... 详细信息

氟喹诺酮药物是一类高效抗菌药物,被广泛应用于畜牧业和水产养殖业中动物疾病的预防和治疗。但由于不规范用药问题的发生,导致食品中兽药残留问题日益凸显,因此针对氟喹诺酮类药物残留,建立快速、便捷、高效的检测方法对于保障食品安全具有非常重要的意义。本文综述了荧光分析法在食品中氟喹诺酮类药物残留检测的应用情况,凸显出荧光分析法优异的检测性能,同时本文对氟喹诺酮类药物荧光分析方法进行探讨和展望,以期为食品中氟喹诺酮类药物残留检测提供参考。

关键词：氟喹诺酮类残留限量荧光分析法食品安全快速检测