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A scorpion venom peptide Ev37 restricts viral late entry by ...

A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles

作     者:Fangfang Li Yange Lang Zhenglin Ji Zhiqiang Xia Yuewen Han Yuting Cheng Gaomin Liu Fang Sun Yonghui Zhao Minjun Gao Zongyun Chen Yingliang Wu Wenxin Li Zhijian Cao 

会议名称:《第十四届生物毒素毒理学术大会暨第一届生物毒素——从生存适应到转化医学专题学术会议》

会议日期:2019年

学科分类:1007[医学-药学(可授医学、理学学位)] 10[医学] 

关 键 词:scorpion venom peptide antiviral peptide antiviral mechanism dengue virus(DENV) hepatitis C virus(HCV) Zika virus(ZIKV) herpes simplex virus(HSV) viral entry membrane fusion endosome 

摘      要:Viral infection still threatens human health all over the world,and many people die from viral diseases every ***,there are no effective vaccines or drugs for preventing or managing most viral ***,the discovery and development of broad-spectrum antiviral agents remain ***,we expressed and purified a scorpion venom peptide,Ev37,from the scorpion Euscorpiops validus in a prokaryotic *** found that rEv37 can inhibit dengue virus type 2(DENV-2),hepatitis C virus(HCV),Zika virus(ZIKV) and herpes simplex virus type 1(HSV-1)infections in a dose-dependent manner at noncytotoxic concentrations,but that it has no effect on Sendai virus(SeV) and Adenovirus(AdV) infections in ***,rEv37 alkalized acidic organelles to prevent low pH-dependent fusion of the viral membrane-endosomal membrane,which mainly blocks the release of the viral genome from the endosome to the cytoplasm and then restricts viral late *** together,our results indicate that the scorpion venom peptide Ev37 is a broadspectrum antiviral agent with a specific molecular mechanism against viruses undergoing low pHdependent fusion activation during entry into host *** conclude that Ev37 is a potential candidate for development as an antiviral drug.

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