检索结果-南通市图书馆

Animal Diseases 2024年第3期4卷 207-216页

作者： Qiuhua Li Yanyan Qu Li Yao Ning Ma mingxing ding Yi ding College of Veterinary Medicine Huazhong Agricultural UniversityWuhanChina

Canine atopic dermatitis(CAD)is a prevalent genetically susceptible infammatory and pruritic allergic skin condition afecting not only the health of dogs but also the quality of life of their ***-31(IL-31)and interleukin-31 receptor alpha(IL-31RA)are essential for the development of pruritus in primates and ***,it is expected that inhibiting IL-31RA will be an efective approach to alleviate *** purpose of the study was to produce anti-canine IL-31RA polyclonal antibodies(anti-IL-31RA pAbs)and evaluate their efcacy in inhibiting house dust mite(HDM)-evoked pruritic *** were immunized with antigens formed by IL-31RA recombinant short peptides coupled to BSA to produce anti-IL-31RA *** CAD model was developed by using HDM allergen stimulation,and the efects of IL-31RA pAbs on the reduction of pruritus in CAD model dogs were *** Canine Atopic Dermatitis Extent and Severity Index(CADESI)-4 and pruritus Visual Analog Scale(pVAS)were utilized to evaluate pruritic responses,and skin tissue samples were collected from the inguinal area for pathological assessment of skin infammatory cell *** results showed that anti-IL-31RA pAbs with high titers(1:128,000)and specifcity were efectively *** the CAD model group,the severity of skin damage,pruritus score,infammatory cell infltration and level of infammatory factors were considerably ***-IL-31RA pAbs relieved pruritic behavior and dermatitis in dogs compared to placebo-treated *** conclusion,anti-IL-31RA pAbs efectively suppressed CAD in vivo and are anticipated to be an efective novel treatment for pruritic skin disorders such as CAD.

关键词： IL-31RA Atopic dermatitis Polyclonal antibody Canine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智能病案编码模型的构建及应用研究

中国数字医学 2024年第10期19卷 56-64页

作者：应华永宋莹莹熊尚华杨旋丁明星张怡浙江金华广福肿瘤医院浙江金华321000

目的:构建融合深度学习和知识图谱技术的智能病案编码模型,解决传统人工编码方式质量不高、效率低下等问题。方法:首先利用自然语言处理技术(NLP)构建电子病历信息抽取模型,提取电子病历中和编码相关的文本特征向量,并识别临床诊断实体... 详细信息

目的:构建融合深度学习和知识图谱技术的智能病案编码模型,解决传统人工编码方式质量不高、效率低下等问题。方法:首先利用自然语言处理技术(NLP)构建电子病历信息抽取模型,提取电子病历中和编码相关的文本特征向量,并识别临床诊断实体;其次构建文本多标签分类模型,对临床诊断实体进行分类编码并得到ICD粗编码;然后构建基于知识图谱的核心词匹配模型,对粗编码结果进行进一步甄选;最后,比较智能病案编码模型与卷积神经网络模型(CNN)等方法及传统人工编码的性能。结果:本研究构建的智能病案编码模型编码性能优于CNN模型、BiLSTM+注意力机制模型以及本研究不带数据简单扰动增强的智能病案编码模型;智能病案编码模型对恶性肿瘤病种主要诊断和主要手术编码的正确率分别为96.63%和98.94%,显著高于传统人工编码的正确率85.25%和89.36%(P<0.05)。结论:智能病案编码模型可以提升病案编码质量,同时提高编码效率,可为后续开展DRG/DIP预分组和精细化运营管理提供更高质量的数据支撑。

关键词：病案编码深度学习知识图谱 DRG/DIP

Ultrafast dynamics and dissociative ionization of CS_2 molecules studied via the femtosecond pump-probe method

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2011年第9期56卷 855-861页

作者： ZHANG DongDong FAN Zhen SUN ErPing ZHANG JunFeng LIU Hang XU HaiFeng JIN mingxing ding DaJun Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China

The ultrafast dynamics and dissociative ionization of CS2 were studied using the pump-probe method with time-of-flight mass spectroscopy. The transient behavior of both parent ion (CS2+) and fragment ions (S+ and CS+) was observed. It was found that all the ionic signals decay exponentially with lifetimes that were different for delay times, t>0 and t<0, which can be attributed to the evolution of different Rydberg states pumped by 267-nm and 400-nm laser pulses. The lifetimes of two Rydberg states were obtained simultaneously from one fitting of the transients. The fragment ions were produced by the dissociation of CS2+, and it is suggested that the final ionic state is the C2Σg+ state of CS2+ based on the measured S+/CS+ branching ratio. The S+/CS+ ratio is dependent on the delay time of the two lasers, indicating that the dissociation process of CS2+ is related to the evolution of the intermediate Rydberg state.

关键词：泵浦探测法超快动力学解离电离分子离解 Cs2 飞秒碎片离子二硫化碳

Effect of Ca^(2+) complexation on oxygen partial pressure in the urinary bladder meridian of goats

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2009年第1期3卷 96-99页

作者： Qi WANG Hongzhi JIANG Shengli CHEN Mingmin ZHANG mingxing ding Esheng KONG Guangying HUANG Institute of Traditional Chinese&Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmaceutical Analysis Tongji School of PharmacyHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese&Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China College of Animal Breeding and Veterinary Huazhong Agricultural UniversityWuhan 430070China Institute of Environmental Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The aim of this paper was to explore the relationship between energy metabolism and the meridian *** manner of change of oxygen partial pressure in acupoints and no-acupoints of the urinary bladder meridian of goats was observed with a needle-type tissue oxygen tension sensor after the acupuncture effect was blocked by Ca^(2+) complexation with ethylenediamine tetraacetic acid(EDTA)-*** results showed that:(1)the concentration of calcium ion in urinary bladder meridian acupoints was higher than that in no-acupoints(P<0.01 or P<0.05);(2)the tissue oxygen tension in urinary bladder meridian acupoints was higher than that in no-acupoints(P<0.01);(3)the oxygen partial pressure in acupoints decreased signiﬁcantly after injection with EDTA-Na2,compared with injection of either normal sodium or nothing(P<0.01);(4)the oxygen partial pressure in acupoints was higher than that in no-acupoints after EDTA-Na2 injection(P<0.01).Acupuncture could reduce oxygen partial pressure in acupoints by regulating microcirculation and increasing metabolic levels.

关键词： oxygen partial pressure biosensor calcium channels acupoint

Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

动物模型与实验医学(英文) 2023年第4期6卷 306-316页

作者： Shuaiyang Liu Yun Chen Xiaoming Wang Shuang Wang Lan Bai Xu Cheng Juan Wan Yufeng Hu Yi ding Xin Zhang mingxing ding Hongliang Li Manli Hu School of Basic Medical Science Wuhan UniversityWuhanChina Institute of Model Animal Wuhan UniversityWuhanChina Clinical Trial Centers Huanggang Central HospitalHuanggangChina College of Veterinary Medicine Huazhong Agricultural UniversityWuhanChina Key Laboratory of Cardiovascular Disease Prevention and Control Ministry of EducationSchool of Basic Medical ScienceGannan Medical UniversityGanzhouChina Gannan Innovation and Translational Medicine Research Institute Gannan Medical UniversityGanzhouChina

Background:The purpose of our study was to study the composition and content of the feline plasma metabolome revealing the critical metabolites and metabolic pathways associated with age during growth and ***:Blood samples were collected from juvenile and adult groups for blood routine tests and serum biochemistry ***-targeted metabolomics analyses of plasma were also performed to investigate changes in metabolites and metabolic ***:In this study,we found that the red blood cell counts,liver function indexes(albumin and gamma-glutamyl transpeptidase),and the concentration of triglyceride and glucose changed significant with growth and *** metabolomics results revealed that 1427 metabolites were identified in the plasma of young and adult *** of these metabolites belong to major classes of lipids and lipid-like *** most obvious age-related metabolites include reduced levels of chenodeoxycholate,taurocholate,cholate,and taurochenodeoxycholate but increased levels of L-cysteine and taurocyamine in the adult cat's *** metabolites are mainly involved in the primary bile acid biosynthesis pathway,the bile secretion pathway,and the taurine and hypotaurine metabolism ***:This study revealed many age-related metabolite alterations in the feline *** age-varying metabolites,especially in the bile acid biosynthesis and secretion metabolism pathways,indicate that the regulation of these pathways is involved in the growth and development of *** study promotes our understanding of the mechanism of feline growth and provides new insights into nutrition and medicine for cats of different ages.

关键词： bile acids cat growth metabolomics plasma

Evaluation of spinal cord injury animal models

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第22期9卷 2008-2012页

作者： Ning Zhang Marong Fang Haohao Chen Fangming Gou mingxing ding Department of Medical Sciences Jinhua Polytechnic Institute of Neuroscience Zhejiang University School of Medicine

Because there is no curative treatment for spinal cord injury, establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries. In this article, we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.

关键词： nerve regeneration spinal cord injury animal model establishment evaluation reviews neural regeneration

Essential role of CRIM1 on endometrial receptivity in goat

在线全文

学校读者我要写书评

暂无评论

Essential role of CRIM1 on endometrial receptivity in goat

Mifepristone Treatment in Pregnant Murine Model Induced Mammary Gland Dysplasia and Postpartum Hypogalactia

中国畜牧兽医学会兽医外科学分会第十届二次理事会暨第25次学术研讨会

作者： Diqi Yang Hongmei Zhu Jianguo Chen Li Han mingxing ding Yi ding College of Veterinary Medicine Huazhong Agricultural University

In domestic ruminants,endometrial receptivity is related to successful pregnancy and economic *** several molecules reported in the past regarding endometrial receptivity regulation,much about the mechanism of endometrial receptivity regulation remains unknown due to the complex nature of the ***,we demonstrated that the cysteine rich transmembrane bone morphogenetic protein(BMP) regulator 1(CRIM1)served a novel regulator in the regulation of goat endometrial receptivity in *** results showed that hormones and IFN-τ increased the expression of CRIM1 in goat endometrial epithelial cells(EECs).Knockdown of CRIM1 via specific shRNA hindered cell proliferation,cell adhesion and the prostaglandins(PGs) secretion and thus derailed normal endometrial *** further confirmed that receptivity defect phenotypes due to CRIM1 interference was restored by ATG7 overexpression in EECs,while loss of ATG7 further impaired receptivity ***,our results showed that changing the expression of ATG7 affected the reactive oxygen species(ROS) ***,mR-143-5 p is a potential upstream factor of CRIM1-regulated endometrial receptivity in ***,these results suggested that CRIM1,as the downstream target of miR-143-5 p,effects on ATG7-dependent autophagy,regulating cell proliferation,cell adhesion and the PGs secretion,and provided a new target for the diagnosis and treatment of early pregnancy failure,and improving the success rates for artificial reproduction.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Mifepristone Treatment in Pregnant Murine Model Induced Mamm...

中国畜牧兽医学会兽医产科学分会第八届会员代表大会暨第十五次学术研讨会

作者： ZHU Hongmei JIA Qianqian ZHANG Yanyan CHEN Jianguo HAN Li ding mingxing College of Veterinary Medicine Huazhong Agricultural University

Objective:Mammary gland dysplasia and postpartum hypogalactia often occur in humans and in the livestock breeding *** study aimed to explore the mechanisms of mammary gland dysplasia and postpartum hypogalactia by establishing a pregnant murine model with mifepristone treatment [1-2].Methods:Mice were administered 1.20 mg mifepristone/kg body weight(BW) on pregnancy day 4(Pd4),this strategy caused significant reduction in milk yields on lactation day 1(Ldl),Ld2,and Ld3,as assessed using a weigh-suckle-weigh *** P-casein expression,milk yields,litter growth rates,gland structure,and serum concentrations of estrogen(E),P,prolactin(PRL),growth hormone(GH),corticosterone(CORT) and oxytocin(OT) as well as the receptors of these hormones were determined during pregnancy or lactation after mifepristone treatment on ***:The results demonstrated that mifepristone administration during early pregnancy decreasedβ-casein expression,milk yields and litter growth rates,induced fewer alveoli,enlarged alveolar lumina,and altered the levels of E,P,PRL,GH,CORT,and OT as well as the mRNA expression of these hormonal receptors during pregnancy or early ***:The defects in mammary gland development and hypogalactia after mifepristone treatment may be a comprehensive regulation of E,P,PRL,GH,CORT,OT,hormone receptors,and hormone-related signaling *** present study on pregnant mice treated with mifepristone offers an innovative murine model to study the mechanism underlying mammary gland dysplasia and postpartum hypogalactia.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

铅原子非共振多光子电离过程的研究

光学学报 1989年第5期9卷 407-411页

作者：金明星丁大军刘航潘守甫吉林大学原子与分子物理研究所

在激光波长为1064nm、532nm和355nm下,研究了铅原子的非共振多光子过程.通过改变激光脉冲的线宽研究了铅原子非共振7-光子电离速率和激光统计性的依赖关系.

关键词：多光子电离铅原子相干性

Experimental and theoretical study excited state dynamics of the dye in solvents

在线全文

学校读者我要写书评

暂无评论

Experimental and theoretical study excited state dynamics of...