Essential role of CRIM1 on endometrial receptivity in goat
作者单位：College of Veterinary MedicineHuazhong Agricultural University
会议名称：《中国畜牧兽医学会兽医外科学分会第十届二次理事会暨第25次学术研讨会》
会议日期：2021年
摘 要：In domestic ruminants,endometrial receptivity is related to successful pregnancy and economic *** several molecules reported in the past regarding endometrial receptivity regulation,much about the mechanism of endometrial receptivity regulation remains unknown due to the complex nature of the ***,we demonstrated that the cysteine rich transmembrane bone morphogenetic protein(BMP) regulator 1(CRIM1)served a novel regulator in the regulation of goat endometrial receptivity in *** results showed that hormones and IFN-τ increased the expression of CRIM1 in goat endometrial epithelial cells(EECs).Knockdown of CRIM1 via specific shRNA hindered cell proliferation,cell adhesion and the prostaglandins(PGs) secretion and thus derailed normal endometrial *** further confirmed that receptivity defect phenotypes due to CRIM1 interference was restored by ATG7 overexpression in EECs,while loss of ATG7 further impaired receptivity ***,our results showed that changing the expression of ATG7 affected the reactive oxygen species(ROS) ***,mR-143-5 p is a potential upstream factor of CRIM1-regulated endometrial receptivity in ***,these results suggested that CRIM1,as the downstream target of miR-143-5 p,effects on ATG7-dependent autophagy,regulating cell proliferation,cell adhesion and the PGs secretion,and provided a new target for the diagnosis and treatment of early pregnancy failure,and improving the success rates for artificial reproduction.