Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat

作     者：Shuaiyang Liu Yun Chen Xiaoming Wang Shuang Wang Lan Bai Xu Cheng Juan Wan Yufeng Hu Yi Ding Xin Zhang Mingxing Ding Hongliang Li Manli Hu Shuaiyang Liu;Yun Chen;Xiaoming Wang;Shuang Wang;Lan Bai;Xu Cheng;Juan Wan;Yufeng Hu;Yi Ding;Xin Zhang;Mingxing Ding;Hongliang Li;Manli Hu

作者机构：School of Basic Medical ScienceWuhan UniversityWuhanChina Institute of Model AnimalWuhan UniversityWuhanChina Clinical Trial CentersHuanggang Central HospitalHuanggangChina College of Veterinary MedicineHuazhong Agricultural UniversityWuhanChina Key Laboratory of Cardiovascular Disease Prevention and ControlMinistry of EducationSchool of Basic Medical ScienceGannan Medical UniversityGanzhouChina Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhouChina 

出 版 物：《动物模型与实验医学(英文)》 (Animal Models and Experimental Medicine)

年 卷 期：2023年第6卷第4期

页      面：306-316页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071002[理学-动物学] 

基　　金：supported by grants from the National Science Foundation of China,grant numbers 82260121 and 82200327 Zhanggong Science and Technology Plan Project the Hubei Province Innovation Platform Construction Project grant number 20204201117303072238 Hubei Provincial Engineering Research Center of Model Animal 

主　　题：bile acids cat growth metabolomics plasma 

摘      要：Background:The purpose of our study was to study the composition and content of the feline plasma metabolome revealing the critical metabolites and metabolic pathways associated with age during growth and ***:Blood samples were collected from juvenile and adult groups for blood routine tests and serum biochemistry ***-targeted metabolomics analyses of plasma were also performed to investigate changes in metabolites and metabolic ***:In this study,we found that the red blood cell counts,liver function indexes(albumin and gamma-glutamyl transpeptidase),and the concentration of triglyceride and glucose changed significant with growth and *** metabolomics results revealed that 1427 metabolites were identified in the plasma of young and adult *** of these metabolites belong to major classes of lipids and lipid-like *** most obvious age-related metabolites include reduced levels of chenodeoxycholate,taurocholate,cholate,and taurochenodeoxycholate but increased levels of L-cysteine and taurocyamine in the adult cat s *** metabolites are mainly involved in the primary bile acid biosynthesis pathway,the bile secretion pathway,and the taurine and hypotaurine metabolism ***:This study revealed many age-related metabolite alterations in the feline *** age-varying metabolites,especially in the bile acid biosynthesis and secretion metabolism pathways,indicate that the regulation of these pathways is involved in the growth and development of *** study promotes our understanding of the mechanism of feline growth and provides new insights into nutrition and medicine for cats of different ages.