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Acta Pharmaceutica Sinica B 2024年第2期14卷 893-896页

作者： mingwei Fu Min Ge Wanxiang Yang Chunchen Hu Xiaowei Li Yuanjiang Wang Shaohua Gou Pharmaceutical Research Center and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast UniversityNanjing 211189China Zenji Research Laboratories Nanjing 211189China

To the Editor:Kinase cell division cycle 7(CDC7),a cell division cycle protein,takes a vital role in mediating DNA ***7 complexes in the nucleus can phosphorylate the minichromosome maintenance complex(MCM)family members that bind to *** addition,CDC7 kinase,as a molecular switch regulating DNA replication,can mediate DNA damage signaling pathways to stimulate cell cycle termination as well as DNA *** have shown that CDC7 is overexpressed in many types of cancer cells,and its overexpression was related to poor patient survival,tumor grade,genetic instability,aneuploidy and so ***,CDC7 is a promising target for antitumor therapy.

关键词： Cell division cycle 7 DNA replication CDC7 inhibitor Anti-tumor

Growth,leaf anatomy,and photosynthesis of cotton(Gossypium hirsutum L.)seedlings in response to four light-emitting diodes and high pressure sodium lamp

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Journal of Cotton Research 2024年第1期7卷 79-89页

作者： ZhanG Yichi LIAO Baopeng LI Fangjun ENEJI AEgrinya DU mingwei TIAN Xiaoli Engineering Research Center of Plant Growth Regulator Ministry of EducationCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Department of Soil Science Faculty of AgricultureForestryand Wildlife Resources ManagementUniversity of CalabarCalabarNigeria

Background Light is a critical factor in plant growth and development,particularly in controlled ***-emitting diodes(LEDs)have become a reliable alternative to conventional high pressure sodium(HSP)lamps because they are more efficient and versatile in light *** contrast to well-known specialized LED light spectra for vegetables,the appropriate LED lights for crops such as cotton remain *** In this growth chamber study,we selected and compared four LED lights with varying percentages(26.44%–68.68%)of red light(R,600–700 nm),combined with other lights,for their effects on growth,leaf anatomy,and photosynthesis of cotton seedlings,using HSP lamp as a *** total photosynthetic photon flux density(PPFD)was(215±2)μmol·m-2·s-1 for all LEDs and HSP *** results showed significant differences in all tested parameters among lights,and the percentage of far red(FR,701–780 nm)within the range of 3.03%–11.86%was positively correlated with plant growth(characterized by leaf number and area,plant height,stem diameter,and total biomass),palisade layer thickness,photosynthesis rate(Pn),and stomatal conductance(Gs).The ratio of R/FR(4.445–11.497)negatively influenced the growth of cotton seedlings,and blue light(B)suppressed stem elongation but increased palisade cell length,chlorophyll content,and *** The LED 2 was superior to other LED lights and HSP *** had the highest ratio of FR within the total PPFD(11.86%)and the lowest ratio of R/FR(4.445).LED 2 may therefore be used to replace HPS lamp under controlled environments for the study of cotton at the seedling stage.

关键词： Cotton seedling Light-emitting diodes Biomass Palisade cell Photosynthesis

Microwave-Assisted Efficient and Green Synthesis of Acyclic Nucleoside Analogues

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Microwave-Assisted Efficient and Green Synthesis of Acyclic ...

Identification of 3-ketocapnine reductase activity within the human microbiota

第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： Qu Guirong Zhang Zhiguang Geng mingwei han Suhui and Yang Xining College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007

In modern antiviral therapy, an important role is played by acyclic nucleosides and their analogues, in which the alkylation at the 1-position of a pyrimidine or 9-position of a purine nucleosides, such as Acyclovir, Ganciclovir, PMEA and so on. In our experiment, using H2O as the solvent and Et3N as the base, we realized a rapid and green synthesis of acyclic nucleosides from pyrimidine derivatives and Ethyl acrylate by Michael addition under microwave irradiation in moderate to high yields.

关键词： Michael Microwave-Assisted Efficient and Green Synthesis of Acyclic Nucleoside Analogues

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mLife 2024年第2期3卷 307-316页

作者： Xiaotong Wu Lukuan Hou Haili Zhang Yi Ma Jufang Wang mingwei Cai Xiaoyu Tang School of Biology and Biological Engineering South China University of TechnologyGuangzhouChina Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhenChina College of Chemistry and Pharmacy Northwest A&F UniversityYanglingChina

The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing ***,the enzymes responsible for their biosynthesis remain largely *** this study,we identified and verified the role of 3-ketocapnine reductase,the third-step enzyme,in the four-step conversion of L-phosphoserine into sulfobacin B both in vivo and in *** finding builds upon our previous research into sulfonolipid biosynthesis,which focused on the vaginal bacterium Chryseobacterium gleum DSM 16776 and the gut bacterium Alistipes finegoldii DSM *** comprehensive gene mapping,we demonstrate the widespread presence of potential sulfonolipid biosynthetic genes across diverse bacterial species inhabiting various regions of the human *** findings shed light on the prevalence of sulfonolipid-like metabolites within the human microbiota,suggesting a potential role for these lipid molecules in influencing the intricate biointeractions within the complex microbial ecosystem of the human body.

关键词： 3-ketocapnine reductase capnines human microbiota sulfonolipids

Microwave-prompted Rapid and Efficient Synthesis of N6- （2-hydroxyethyl） adenosine and Its Analogues Using Water as Solvent

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Microwave-prompted Rapid and Efficient Synthesis of N6- （2-...

METTL1 promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1/S phase arrest

第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： Qu Guirong Geng mingwei han Suhui Zhang Zhiguang Xue feng (College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007)

N6- (2-hydroxyethyl) adenosine, which behaves as a Ca2+ antogonists and an inotropic agent, was isolated from the extracts of Cordyceps and Isaria species by Furuya etal. in 1983. An efficient protocol for the synthesis of N6- (2-hydroxyethyl) adenosine and its analogues through nucleophilic substitution was developed. All the reactions were complished in 10 minutes using microwave irradiation. And it's easy to handle and eco-friendly using water as solvent.

关键词： Microwave-prompted Rapid and Efficient Synthesis of N6 adenosine and Its Analogues Using Water as Solvent hydroxyethyl

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Genes & Diseases 2024年第2期11卷 579-581页

作者： Houxiang Jiang Ying Liu Huibin Song Jinquan Xia Ying Tian Luolin Wang mingwei Li Zhenyu Xu Zhenglei Xu Chang Zou Department of Gastrointestinal Surgery The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China Anhui Province Clinical Research Center for Critical Respiratory Medicine WuhuAnhui 241001China Department of Clinical Medical Research Center The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdong 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdong 510632China School of Pharmacy Southwest Medical UniversityLuzhouSichuan 646000China Department of Gastroenterology Shenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Precision Medicine Center The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China School of Medicine Life and Health SciencesThe Chinese University of Hong KongShenzhenGuangdong 518172China

Colorectal carcinoma(CRC),the third most commonly diagnosed cancer,accounts for 9.7%of all newly diagnosed cancer cases and 9.4%of cancer-related deaths globally.1 Recent studies have demonstrated that post-transcriptional RNA modifications,such as N^(6)-methyladenosine,N^(5)-methylcytosine,and N^(7)-methylguanosine,play critical roles in the regulation of mRNA stability and translation,primary microRNA processing,and lncRNA-protein complex that contributes to the progression of human cancer.

关键词： cancer colorectal globally

Effects of prebiotics on the fermentation of traditional suancai of Northeast China

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Food Science and Human Wellness 2024年第3期13卷 1358-1367页

作者： mingwei Zhao Xinying Cao Yuzheng Wu Sibo Zou Zhigao Li Xinping Lin Chaofan Ji Liang Dong Sufang Zhang Chenxu Yu Huipeng Liang National Engineering Research Center of Seafood Collaborative Innovation Center of Provincial and Ministerial Co-construction for Deep ProcessingCollaborative Innovation Center of Seafood Deep ProcessingSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Department of Agricultural and Biosystems Engineering Iowa State UniversityIA 50011USA

Suancai is a traditional fermented vegetable widely consumed in Northeast *** this study,different prebiotics were used to improve the quality of *** prebiotics(inulin(INU),xylooligosaccharide(XO S),galactooligosaccharide(GOS),and stachyose(STA))were shown to reduce the pH value and increase the content of total titratable acidity(TTA)in suancai,while the contents of most organic acids were also *** addition of prebiotics had significant effects on the bacterial microbiota during the suancai fermentation *** prebiotics were shown to contribute to the growth of *** suancai sample with fructooligosaccharides(FOS)had the highest relative abundance of ***,INU and XOS could increase the abundance of *** evaluate the quality of suancai fermented with prebiotics,profiles of volatile flavor compounds(VOCs)and free amino acids(FAA)were *** prebiotics affected the VOCs and FAA profiles via transforming the bacterial *** addition,the addition of prebiotics also changed the taste profiles of the suancai *** study is among the first attempts to reveal the effects of different prebiotics on suancai fermentation,and the findings provide a foundation to develop new ways for improving the quality of suancai.

关键词： Bacterial microbiota Lactic acid bacteria Flavor Amino acid Taste

基于 MPEG-4的视频编解码系统研究与实现

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无线电工程 2005年第12期35卷 60-62页

作者：韩明伟西安电子科技大学西安710071

采用了专用 MPEG-4芯片(vw2010) 方案来实现 MPEG-4音视频编解码功能。首先介绍了 VW2010的特点以及其工作原理，然后详细地阐述了以此芯片为核心的电路模块的设计，主要包括编解码系统电路原理设计、接口设计、编解码工作原理及编解... 详细信息

采用了专用 MPEG-4芯片(vw2010) 方案来实现 MPEG-4音视频编解码功能。首先介绍了 VW2010的特点以及其工作原理，然后详细地阐述了以此芯片为核心的电路模块的设计，主要包括编解码系统电路原理设计、接口设计、编解码工作原理及编解码流程等。最后就实现的编解码功能给予分析与展望。

关键词： MPEG-4 编解码视频 VW2010

免疫调节分子Rho GTP酶活化蛋白11A(ARHGAP11A)在肺腺癌高表达且与预后差正相关

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细胞与分子免疫学杂志 2021年第7期37卷 596-601页

作者：闫柄文韩明伟刘蓉蓉空军军医大学西京医院整形外科陕西西安710032 空军军医大学基础医学院学员队陕西西安710032 空军军医大学基础医学院微生物与病原生物学教研室陕西西安710032

目的研究Rho GTP酶活化蛋白11A(ARHGAP11A)在肺腺癌中的表达及临床意义。方法通过检索Oncomine等多个在线数据库,获取和分析ARHGAP11A在肺腺癌和正常组织中的表达,并对肺癌患者相关的临床病理参数和生存数据进行生物信息学分析,采用Prog... 详细信息

目的研究Rho GTP酶活化蛋白11A(ARHGAP11A)在肺腺癌中的表达及临床意义。方法通过检索Oncomine等多个在线数据库,获取和分析ARHGAP11A在肺腺癌和正常组织中的表达,并对肺癌患者相关的临床病理参数和生存数据进行生物信息学分析,采用PrognoScan预后分析数据库分析ARHGAP11A基因表达和肺腺癌预后的关系,利用检索相互作用基因/蛋白质的搜索工具(STRING)数据库构建ARHGAP11A及其功能相关基因网络。结果与正常组织相比,ARHGAP11A在肺腺癌的癌组织高表达,且临床分期越晚癌组织分化越差,ARHGAP11A表达越高,临床预后也越差。结论ARHGAP11A在肺腺癌组织高表达且与肺腺癌预后差相关。

关键词： Rho GTP酶活化蛋白11A(ARHGAP11A) 肺腺癌预后

ARGA-Unet:Advanced U-net segmentation model using residual grouped convolution and attention mechanism for brain tumor MRI image segmentation

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 203-216页

作者： Siyi XUN Yan ZhanG Sixu DUAN mingwei WANG Jiangang CHEN Tong TONG Qinquan GAO Chantong LAM Menghan HU Tao TAN Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Jinan Branch of China Telecom Co.Ltd. Jinan 250000China School of Physics and Electronics Shandong Normal UniversityJinan 250000China Department of Dardiovascular Medicine Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000China Clinical School of Medicine Hangzhou Normal UniversityHangzhou 310000China hangzhou Institute of Cardiovascular Diseases Hangzhou 310000China Shanghai Key Laboratory of Multidimensional Information Processing Shanghai 200000China School of Communication&Electronic Engineering East China Normal UniversityShanghai 200000China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghai 200000China College of Physics and Information Engineering Fuzhou UniversityFuzhou 350000China

Background Magnetic resonance imaging(MRI)has played an important role in the rapid growth of medical imaging diagnostic technology,especially in the diagnosis and treatment of brain tumors owing to its non invasive characteristics and superior soft tissue ***,brain tumors are characterized by high non uniformity and non-obvious boundaries in MRI images because of their invasive and highly heterogeneous *** addition,the labeling of tumor areas is time-consuming and *** To address these issues,this study uses a residual grouped convolution module,convolutional block attention module,and bilinear interpolation upsampling method to improve the classical segmentation network *** influence of network normalization,loss function,and network depth on segmentation performance is further *** In the experiments,the Dice score of the proposed segmentation model reached 97.581%,which is 12.438%higher than that of traditional U-net,demonstrating the effective segmentation of MRI brain tumor *** In conclusion,we use the improved U-net network to achieve a good segmentation effect of brain tumor MRI images.

关键词： Brain tumor MRI U-net Segmentation Attention mechanism Deep learning