METTL1 promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1/S phase arrest

作     者：Houxiang Jiang Ying Liu Huibin Song Jinquan Xia Ying Tian Luolin Wang Mingwei Li Zhenyu Xu Zhenglei Xu Chang Zou Houxiang Jiang;Ying Liu;Huibin Song;Jinquan Xia;Ying Tian;Luolin Wang;Mingwei Li;Zhenyu Xu;Zhenglei Xu;Chang Zou

作者机构：Department of Gastrointestinal SurgeryThe First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China Anhui Province Clinical Research Center for Critical Respiratory MedicineWuhuAnhui 241001China Department of Clinical Medical Research CenterThe Second Clinical Medical College (Shenzhen People's Hospital) of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdong 518020China Integrated Chinese and Western Medicine Postdoctoral Research StationJinan UniversityGuangzhouGuangdong 510632China School of PharmacySouthwest Medical UniversityLuzhouSichuan 646000China Department of GastroenterologyShenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Precision Medicine CenterThe First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China School of MedicineLife and Health SciencesThe Chinese University of Hong KongShenzhenGuangdong 518172China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第2期

页      面：579-581页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Science and Technology Foundation of Shenzhen,Guangdong,China(No.JCYJ20210324115800001) the Natural Science Foundation of Guangdong Province,China(No.2018A0303130278) the Basic and Applied Basic Research of Guangdong Province,China(No.2021A1515110253) the Shenzhen Key Medical Discipline Construction Fund(China)(No.SZXK053) 

主　　题：cancer colorectal globally 

摘      要：Colorectal carcinoma(CRC),the third most commonly diagnosed cancer,accounts for 9.7%of all newly diagnosed cancer cases and 9.4%of cancer-related deaths globally.1 Recent studies have demonstrated that post-transcriptional RNA modifications,such as N^(6)-methyladenosine,N^(5)-methylcytosine,and N^(7)-methylguanosine,play critical roles in the regulation of mRNA stability and translation,primary microRNA processing,and lncRNA-protein complex that contributes to the progression of human cancer.