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成年树鼩实验感染丁型肝炎病毒的初步研究

中华实验和临床病毒学杂志 1995年第2期9卷 138-141页

作者：丁明权李奇芬吴纯清毛青王洪袁良平重庆解放军第三军医大学西南医院 630038

在证实成年树可感染人乙型肝炎病毒（ＨＢＶ）的基础上，进行了丁型肝炎病毒－乙型肝炎病毒（ＨＤＶ／ＨＢＶ）实验感染的探索。ＨＤＶ／ＨＢＶ阳性人血清经同时和重叠感染方式接种于成年树后，定期留取感染树血清及肝组织，检测血清中... 详细信息

在证实成年树可感染人乙型肝炎病毒（ＨＢＶ）的基础上，进行了丁型肝炎病毒－乙型肝炎病毒（ＨＤＶ／ＨＢＶ）实验感染的探索。ＨＤＶ／ＨＢＶ阳性人血清经同时和重叠感染方式接种于成年树后，定期留取感染树血清及肝组织，检测血清中ＨＢｓＡｇ、ＨＤＡｇ、抗－ＨＤ、ＨＢＶＤＮＡ及ＨＤＶＲＮＡ，初步探讨成年树实验感染ＨＤＶ的可能性。研究发现：①成年树对人ＨＢＶ易感，ＨＢｓＡｇ阳性率为７５％，其血清学反应及肝组织病理改变与文献报道一致；②ＨＤＶ可通过同时和重叠两种方式感染成年树，感染树血清中可出现ＨＤＡｇ及抗－ＨＤ，经分子杂交证实其血清及肝内均有ＨＤＶＲＮＡ和ＨＢＶＤＮＡ存在，且可导致明显的肝细胞损伤。结果提示：成年树既可感染人ＨＢＶ也可感染ＨＤＶ，可作为研究ＨＤＶ人工感染的实验动物；成年树感染ＨＤＶ后的特点与人及黑猩猩感染时十分相似，能较好地反映人丁型肝炎的真实情况。

关键词：丁型肝炎病毒感染动物实验树Qu 病理学

陆海杂交种纤维品质和产量相关性状的鉴定与分析

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棉花学报 2020年第4期32卷 348-359页

作者：李腾宇许超李耀明苟成飞洪铸丁明全孙晨栋浙江农林大学农业与食品科学学院浙江临安311300 浙江省农作物品质改良技术研究重点实验室浙江临安311300 浙江农林大学林业与生物技术学院浙江临安311300

【目的】深入研究棉花陆海杂交种纤维品质和产量相关性状杂种优势遗传规律,为培育高产优质陆海杂交种奠定理论基础。【方法】使用12份陆地棉材料和5份海岛棉材料配制陆海杂交种,对海南三亚和浙江临安种植的亲本及F1进行纤维品质和产量... 详细信息

【目的】深入研究棉花陆海杂交种纤维品质和产量相关性状杂种优势遗传规律,为培育高产优质陆海杂交种奠定理论基础。【方法】使用12份陆地棉材料和5份海岛棉材料配制陆海杂交种,对海南三亚和浙江临安种植的亲本及F1进行纤维品质和产量性状测定。【结果】陆海杂交种纤维长度、纤维强度普遍具有显著的中亲优势,部分杂交组合具有较强的超亲优势,纤维长度性状在两地间变异系数较小,可以稳定遗传;在产量方面,部分陆海杂交种籽棉产量、皮棉产量和衣分等性状具有中亲优势,但仍显著低于陆地棉亲本。【结论】获得2个5A级优质长绒棉杂交组合T035和T044,筛选到1个海岛棉骨干亲本塔10-280,可为探讨陆海杂交种棉纤维品质杂种优势遗传规律提供有价值数据。

关键词：棉花陆海杂交种杂种优势纤维品质产量相关性状

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埋设管道在混凝土分缝处的应力计算与研究

水力发电 2022年第4期48卷 65-69页

作者：李胜兵方杰葛新峰丁铭泉中国电建集团华东勘测设计研究院有限公司浙江杭州311122 河海大学能源与电气学院江苏南京211100

在水电站的设计中,不可避免地会采用埋设管道,其中一些埋设管道会穿越混凝土建筑物分缝,需要进行“过缝保护处理”。一般情况下,参照已有的经验,套用过缝处理的经验数据进行设计;而在某些情况下,这样的套用可能存在风险,应根据应用环境... 详细信息

在水电站的设计中,不可避免地会采用埋设管道,其中一些埋设管道会穿越混凝土建筑物分缝,需要进行“过缝保护处理”。一般情况下,参照已有的经验,套用过缝处理的经验数据进行设计;而在某些情况下,这样的套用可能存在风险,应根据应用环境条件计算过缝管段最大组合应力,判断埋设管道在通过混凝土分缝处是否安全。为此,提出了基于经典应力分析理论的过缝管道应力计算方法,并通过工程实例与有限元计算方法进行比较,验证了该计算方法的可靠性。

关键词：水电站设计埋设管道过缝处理应力计算计算方法

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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秋茄KcRD22基因的克隆与功能分析

基因组学与应用生物学 2011年第4期30卷 273-280页

作者：黄旭新侯佩臣丁明全王美娟邓澍荣李妮亚周晓阳沈昕陈少良北京林业大学生物科学与技术学院教育部树木花卉遗传育种重点实验室北京100083 国家农业信息化工程技术研究中心北京100097

本文以用200mmol/LNaCl处理24h后的秋茄幼苗为材料提取秋茄叶片总RNA,利用RT-PCR方法克隆获得KcRD22基因的全长cDNA,通过构建pCAMBIA-2300-KcRD22过表达载体,利用农杆菌侵染的方式获得过表达KcRD22的烟草转基因株系,并对转基因株系的耐... 详细信息

本文以用200mmol/LNaCl处理24h后的秋茄幼苗为材料提取秋茄叶片总RNA,利用RT-PCR方法克隆获得KcRD22基因的全长cDNA,通过构建pCAMBIA-2300-KcRD22过表达载体,利用农杆菌侵染的方式获得过表达KcRD22的烟草转基因株系,并对转基因株系的耐盐性做出初步分析。实验结果显示:KcRD22基因的ORF长1131bp,编码1个等电点为9.07、分子量为39.8kD、由375个氨基酸组成的蛋白。PCR及RT-PCR鉴定结果表明,KcRD22基因已经分别整合到8株烟草的染色体中,并在两个株系中获得表达。对转基因烟草进行光合作用测定,结果显示100mmol/LNaCl处理显著降低了野生型烟草的净光合速率,而转基因植株叶片的光合作用受到的影响较小。盐浓度达到200mmol/L时,转基因植株及野生型烟草净光合速率都明显降低,但盐胁迫解除后,转基因烟草光合作用的恢复情况明显好于野生型烟草,说明KcRD22的过表达提高了烟草的抗盐性。本文初步确定了KcRD22基因对植物耐盐性的贡献,这为进一步深入研究该基因在耐盐机制中的功能奠定了良好基础。

关键词：秋茄 KcRD22 转基因烟草抗盐性

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian Liang Li Xu Changsheng ding Yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu ding ding Yu Song Ya-Feng Deng Cheng-Ming Zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

Evaporation Stage of Paleo-saline Lake in the Sichuan Basin, China: Insight from Fluid inclusions in Halite

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 801-808页

作者： ding Ting LIU Chenglin GUO Fusheng ZHAO Yanjun WANG mingquan CHEN Liuqin State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth Sciences East China University of TechnologyNanchang 330013China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China China University of Geosciences Beijing 10086China

Sichuan Basin is one of the most important marine–salt forming basins in China. The Simian and Triassic have a large number of evaporites. The Triassic strata have found a large amount of polyhalite and potassium-rich brine. However, no soluble potassium salt deposit were found. In this study, the halite in well Changping 3 which is located at the eastern part of the Sichuan basin was studied using the characteristics, hydrogen and oxygen isotopes of the fluid inclusion in halite to reconstruct the paleoenvironment. The salt rocks in well Changping 3 can be divided into two types: grey salt rock and orange salt rock. The result shows that the isotopic composition of the halite fluid inclusion is distinct from the global precipitation line reflecting that the salt formation process is under strong evaporation conditions and the climate is extremely dry. At the same time, compared with the hydrogen and oxygen isotopes of brine in the Sichuan Basin and the hydrous isotope composition of the inclusions in the salt inclusions of other areas in China, it is shown that the evaporation depth of the ancient seawater in the Sichuan Basin was high and reached the precipitation of potassium and magnesium stage.

关键词： hydrogen and oxygen isotopes fluid inclusions halite Triassic Sichuan Basin