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Continuous preparation of strong and tough PVA nanocomposite fibers by mechanical stretching-assisted salting-out treatment

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Nano Research 2024年第4期17卷 3156-3163页

作者： Hang Chen Guangze Yang Yingzhi sun Yichao Xu mingjie Liu Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China Research Institute for Frontier Science Beihang UniversityBeijing 100191China International Research Institute for Multidisciplinary Science Beihang UniversityBeijing 100191China

Polymer composite fibers with superior properties such as excellent combined strength and toughness and biocompatibility can be used in high-tech applications of braided protective devices and smart wearable,however the research of high-performance polymer composite fiber remains in the infant *** we present a strategy to produce strong and tough anisotropic polymer nanocomposite fibers with orientedly aligned salt rods using mechanical stretching-assisted salting-out *** prepared nanocomposite fibers have a tensile strength of up to 786±2.7 MPa and an elongation at break of 81%,and the anisotropic fibers exhibit good transmission of mechanical vibration in the longitudinal direction with high *** the fabrication process,the salt builds up into oriented rods during the directional salting process,and the polymer is confined to the 150 nm domain between the rods after the solvent is completely evaporated,giving the nanocomposite fibers superior mechanical *** presented strategy can be applied to the continuous mass production of nanocomposite fibers and is also generalizable to other polymer nanocomposites,which could extend the applicability of nanocomposite fibers to conditions involving more demanding mechanical loading and mechanical vibration transmission.

关键词： poly(vinyl alcohol)(PVA)nanofibers oriented structure ultrastrong and stiff mechanical vibration transmission salting out continuous production

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Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats

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Journal of Traditional Chinese Medicine 2019年第4期39卷 492-501页

作者： Huang Ying Kong Liting Wang Yanping sun mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of ***: Thoracic aortas were isolated from Wistar rats, and were suspended in tissue organ chambers for vascular tension measurement. The effect of cumulative osthole(10-9, 10-8, 10-7, 10-6, and 10-5 mol/L) on endothelium-intact and endothelium-denuded thoracic aortic rings pre-contracted with phenylephrine(PE, 10-6 mol/L) or KCl(6 × 10-2 mol/L) was recorded. Histomorphological changes of thoracic aorta were analyzed by hematoxylin-eosin. The effects of different osthole concentrations on endothelium-intact aortic rings, which were pre-inhibited with the non-selective nitric oxide synthase inhibitor L-Arg(NO2)-OMe·HCl(3 × 10-4 mol/L), endothelium-derived nitric oxide synthase inhibitor Nω-nitro-L-arginine(3 × 10-4 mol/L), guanylate cyclase inhibitor 1 H-[1,2,4] oxadiazolo [4,3-α]quinoxaline-1-one(10-5 mol/L), cyclooxygenase inhibitor indometacin(10-5 mol/L), and the Ca2+-activated potassium channel inhibitor tetraethylammonium nitrate(10-5 mol/L), and then contracted with PE, were examined. Aortic rings incubated with osthole(10-5 mol/L), phentolamine(10-5 mol/L), or verapamil(10-5 mol/L) in Ca2+-free Krebs-Henseleit solution(KHS) were stimulated with PE or ***: There was a dose-dependent increase in vasorelaxation of isolated thoracic aortic rings(both with and without endothelium) with increasing osthole concentration. Hematoxylin-eosin staining showed that osthole significantly improved thoracic aorta ring morphology. Compared with the control group, there were also significant differences after incubation with L-Arg(NO2)-OMe ω-nitro-L-arginine, and 1 H-[1,2,4] oxadiazo·lo HCl,N [4,3-α] quinoxaline-1-one(P < 0.05 for all). The relaxation rate of the rings in the osthole group incubated with indometacin and tetraethylammonium nitrate were similar to controls. In Ca2+-free KHS, the PE-induced contraction was similar between

关键词： Aorta,thoracic Osthole Phentolamine Verapamil Vasorelaxation Calcium Nitric oxide

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Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer

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Cellular & Molecular Immunology 2008年第6期5卷 439-445页

作者： Jing Li Qingli Kong Zhe Lv Yuanzhi Guan Yong Qiu Chen Li mingjie sun Zhenlong Liu Yunqing An Department of Immunology Capital Medical University Beijing 100069China Laboratory Department Capital Institute of Pediatrics Beijing 100020China Department of Microbiology Institute of Basic Medical Sciences ChineseAcademy of Medical Sciences ＆ Peking Union Medical College Beijing100005 China Laboratory Department Beijing Shijitan Hospital Beijing 100038 China China Rehabilitation Center Institute of Medical Sciences Beijing 100077China

In previous research, chimerical BPI23-Fcy1 gene which consisted of human bactericidal/permeability increasing protein （BPI） gene of encoding the functional N terminus （amino acid residues 1 to 199） of human BPI and Fcy1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed within a recombinant adeno-associated virus serotype 2 （rAAV2） vector as rAAV2-BPI23-Fcy1. Here, to evaluate the potentiality of applying gene therapy to gram negative bacterial （GNB） infection in high-risk patients, we investigated protection of immuno-compromised mice and immunocompetent mice from challenge with minimal lethal dose （MLD） Klebsiella pneumonia infection after rAAV2-BPI23-Fcy1 gene transferred. The results showed that the survival rate of rAAV2-BPI23-Fcy1 transferred immunocompetent mice as well as immuno-compromised mice （40.0% and 44.4%, respectively） were significant higher than that of corresponding control mice （6.7% and 4.4%, respectively）; the bacteria counting, level of endotoxin and proinflammatory cytokines in the rAAV2-BP123-Fcy1 transferred immuno-compromised mice were markedly lower than that of rAAV2-EGFP and rAAV2-Null transferred immuno- compromised mice. Our data suggest that rAAV2-BPI23-Fcy1 gene transferring offered immuno-compromised mice with resistance against GNB infection, so it is quite potential in preventing GNB infection of clinical high-risk patients. Cellular ＆ Molecular Immunology. 2008;5（6）：439-445.

关键词： rAAV2 BPI immuno-compromised mouse Klebsiella pneumonia gene transfer

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Fast and deterministic optical phased array calibration via pointwise optimisation

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Light(Advanced Manufacturing) 2023年第2期4卷 39-47页

作者： Jingwen Shan Hanyi Zhang Lijing Li Weijie Deng mingjie sun Department of Opto-electronic Engineering Beihang UniversityBeijing 100191China Key Laboratory of Optical System Advanced Manufacturing Technology Chinese Academy of SciencesChangchun.*mingjie.sun@***

Owing to the structural errors in the optical phased array,an initial random phase reduces the quality of the deflection *** most commonly applied approach to phase calibration is based on adaptive ***,adaptive optimisation approaches have slow convergence and low diffraction *** proposed a pointwise optimisation approach to achieve fast and accurate beam *** approach conducts phase calibration,combining global traversal and local searches individually for each array *** built a phase-calibration optical system containing a one-dimensional optical waveguide phase array for further verification and designed the relevant *** simulation and experimental results demonstrate that the pointwise optimisation approach accelerates the calibration process and improves the diffraction efficiency.

关键词： Beam deflection Optical phase array Phase calibration

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智能机器人消毒与传统人工消毒在ICU终末消毒中的应用效果对比

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河南医学研究 2024年第6期33卷 1082-1085页

作者：赵敬裴永菊张红梅王曦孙明洁河南省人民医院呼吸与危重症医学科河南省护理医学重点实验室郑州大学人民医院河南郑州450000

目的对比智能机器人与传统人工消毒在ICU终末消毒中的应用效果。方法2022年3—9月,在河南省人民医院呼吸重症病区分别采用智能消毒机器人和传统人工消毒的方法进行终末消毒,比较两种消毒方式对物体表面和空气消毒的合格率、消毒后检出... 详细信息

目的对比智能机器人与传统人工消毒在ICU终末消毒中的应用效果。方法2022年3—9月,在河南省人民医院呼吸重症病区分别采用智能消毒机器人和传统人工消毒的方法进行终末消毒,比较两种消毒方式对物体表面和空气消毒的合格率、消毒后检出菌落数及终末消毒时间的影响。结果观察组物表消毒合格率高于对照组(P0.05)。结论智能消毒机器人能提高ICU物体表面的终末消毒效果,减轻护士的工作负担。

关键词：消毒机器人人工消毒重症监护病房终末消毒

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Effects of lead pollution on soil microbial community diversity and biomass and on invertase activity

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Soil Ecology Letters 2023年第1期5卷 118-127页

作者： Xin sun mingjie sun Ying Chao Xiaoyang Shang Hui Wang Hong Pan Quangang Yang Yanhong Lou Yuping Zhuge National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai’an 271018China Tai’an Hi-Tech Industrial Development Zone Tai’an 271000China Rizhao Municipal Bureau of Agricultural and Rural Affairs Rizhao 276800China Key Laboratory of Technologies and Models for Cyclic Utilization from Agricultural Resources Ministry of Agriculture and Rural AffairsBeiJing 100125China

Lead(Pb)pollution is one of the most widespread and harmful environmental problems *** of changes in soil properties and microbial functional diversity due to land use is needed to establish a basis for remediation of soil *** study aimed to investigate soils contaminated by Pb from different sources and to analyze the functional diversity and metabolism of soil microbial communities using Biolog *** pollution(>300 mg kg-1)significantly influenced the diversity and metabolic functions of soil microbial ***,Pb contamination significantly reduced soil microbial biomass carbon(C)and nitrogen(N)levels and catalase activity while increasing invertase ***,Biolog EcoPlate assays revealed that Pb pollution reduced the general activities of soil microorganisms,suppressing their ability to utilize C *** Pb-contaminated areas lacking vegetation cover,Shannon,Simpson,and McIntosh diversity indices of soil microorganisms were significantly *** microbial diversity and biomass C and N levels were affected by land use and soil properties,respectively,whereas soil enzyme activity was primarily affected by the interaction between land use and soil *** results provide a reference and a theoretical basis for developing soil quality evaluation and remediation strategies.

关键词： Lead pollution Biolog Microbial functional diversity Soil enzyme activities Environment toxicity

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Large-area ultrastrong and stiff aramid nanofiber based layered nanocomposite films

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Nano Research 2024年第2期17卷 829-835页

作者： Zhidong Nie Yingzhi sun Tianxu Zhou Shengwen Kong Linxing Liu Chuangqi Zhao mingjie Liu Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China University of Science and Technology of China Hefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China International Research Institute for Multidisciplinary Science Beihang UniversityBeijing 100191China

One-dimensional(1D)aramid nanofiber(ANF)based nanocomposite films have drawn increasing attentions in various applications due to their excellent mechanical properties and impressive chemical and thermal ***,the large-area fabrication of aramid nanocomposite films with ultrastrong mechanical properties under mild conditions remains a great *** we present a facile superspreading-assisted strategy to produce aramid nanofiber based oriented layered nanocomposites using phase inversion process that occurs at the fully swollen hydrogel *** nanocomposite films based on ANF,carboxylation carbon tube(CNT–COOH),poly(vinyl alcohol)(PVA),and MXene nanosheet exhibit a tensile strength of up to 870.8±85 MPa,a Young’s modulus of 21.8±2.2 GPa,and outstanding toughness(up to 43.2±4.6 MJ/m^(3)),which are much better than those conventional aramid nanofiber based *** conductivity of our nanocomposite films reaches the maximum of about 1100 S/*** fabulous mechanical properties combination and continuous production capability render our strategy representing a promising direction for the development of high-performance nanocomposites.

关键词： aramid nanofibers MXene nanosheets nanocomposites ultrastrong and stiff superspreading large-area production

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Flow characteristics and hot workability of a typical low-alloy high-strength steel during multi-pass deformation

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 323-336页

作者： mingjie Zhao Lihong Jiang Changmin Li Liang Huang Chaoyuan sun Jianjun Li Zhenghua Guo School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang 330063China Jiangxi Key Laboratory of Forming and Joining Technology for Aerospace Components Nanchang Hangkong UniversityNanchang 330063China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China China National Erzhong Group Deyang Wanhang Die Forging Co.LTD. Deyang 618000China Hubei Huangshi Mold Industrial Technology Research Institute Huangshi 435007China

Heavy components of low-alloy high-strength(LAHS) steels are generally formed by multi-pass forging. It is necessary to explore the flow characteristics and hot workability of LAHS steels during the multi-pass forging process, which is beneficial to the formulation of actual processing parameters. In the study, the multi-pass hot compression experiments of a typical LAHS steel are carried out at a wide range of deformation temperatures and strain rates. It is found that the work hardening rate of the experimental material depends on deformation parameters and deformation passes, which is ascribed to the impacts of static and dynamic softening behaviors. A new model is established to describe the flow characteristics at various deformation passes. Compared to the classical Arrhenius model and modified Zerilli and Armstrong model, the newly proposed model shows higher prediction accuracy with a confidence level of 0.98565. Furthermore, the connection between power dissipation efficiency(PDE) and deformation parameters is revealed by analyzing the microstructures. The PDE cannot be utilized to reflect the efficiency of energy dissipation for microstructure evolution during the entire deformation process, but only to assess the efficiency of energy dissipation for microstructure evolution in a specific deformation parameter *** a result, an integrated processing map is proposed to better study the hot workability of the LAHS steel, which considers the effects of instability factor(IF), PDE, and distribution and size of grains. The optimized processing parameters for the multi-pass deformation process are the deformation parameters of 1223–1318 K and 0.01–0.08 s^(-1). Complete dynamic recrystallization occurs within the optimized processing parameters with an average grain size of 18.36–42.3 μm. This study will guide the optimization of the forging process of heavy components.

关键词： low-alloy high-strength steel work hardening rate constitutive model hot workability multi-pass deformation

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Lotus seedpod-inspired internal vascularized 3D printed scaffold for bone tissue repair

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Bioactive Materials 2021年第6期6卷 1639-1652页

作者： Xiaoyu Han mingjie sun Bo Chen Qimanguli Saiding Junyue Zhang Hongliang Song Lianfu Deng Peng Wang Weiming Gong Wenguo Cui Department of Orthopedics Jinan Central HospitalShandong First Medical University&Shandong Academy of Medical Sciences105 Jiefang RoadLixia DistrictJinanShandong250013PR China Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

In the field of bone defect repair,3D printed scaffolds have the characteristics of personalized customization and accurate internal ***,how to construct a well-structured vascular network quickly and effectively inside the scaffold is essential for bone repair after ***,inspired by the unique biological structure of“lotus seedpod”,hydrogel microspheres encapsulating deferoxamine(DFO)liposomes were prepared through microfluidic technology as“lotus seeds”,and skillfully combined with a three-dimensional(3D)printed bioceramic scaffold with biomimetic“lotus”biological structure which can internally grow blood *** this composite scaffold system,DFO was effectively released by 36%in the first 6 h,which was conducive to promote the growth of blood vessels inside the scaffold *** the following 7 days,the release rate of DFO reached 69%,which was fundamental in the formation of blood vessels inside the scaffold as well as osteogenic differentiation of bone mesenchymal stem cells(BMSCs).It was confirmed that the composite scaffold could significantly promote the human umbilical vein endothelial cells(HUVECs)to form the vascular morphology within 6 h in *** vivo,the composite scaffold increased the expression of vascularization and osteogenic related proteins Hif1-α,CD31,OPN,and OCN in the rat femoral defect model,significantly cutting down the time of bone *** sum up,this“lotus seedpod”inspired porous bioceramic 3D printed scaffold with internal vascularization functionality has broad application prospects in the future.

关键词： 3D scaffolds Drug release Neovascularization Osteogenesis Regeneration

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温度对光纤准直器的角度偏移影响分析

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光子学报 2006年第10期35卷 1509-1513页

作者：孙鸣捷浙江大学现代光学仪器国家重点实验室国家光学仪器工程技术研究中心杭州310027

通过对光纤准直器准直失配,即离轴耦合、偏角耦合、间距耦合三种情况的耦合损耗进行分析,发现角度偏移对耦合效率影响最大.实验中随着温度周期性的变化,光斑位置也出现了有一定规律性的变化.实验通过确定光斑位置的变化量从而求出鞍型... 详细信息

通过对光纤准直器准直失配,即离轴耦合、偏角耦合、间距耦合三种情况的耦合损耗进行分析,发现角度偏移对耦合效率影响最大.实验中随着温度周期性的变化,光斑位置也出现了有一定规律性的变化.实验通过确定光斑位置的变化量从而求出鞍型和拱型支承架在温度循环时的角度偏移为519μrad和395μrad,并导致了0.944dB和0.718dB的耦合损耗;在温度冲击时的角度偏移为986μrad和138μrad,并导致了1.793dB和0.251dB的耦合损耗.实验结果表明拱型支承架在两种不同的温度变化情况下均优于鞍型支承架.

关键词：光纤准直器光纤支承架激光焊接角度偏移

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