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iTRAQ proteomics reveals the regulatory response to Xanthomonas campestris *** in resistant *** pepper genotypes

Horticultural Plant Journal 2022年第6期8卷 747-756页

作者： Fei Wang Shenghua Gao Juntawong Niran Ning Li Yanxu Yin Chuying Yu Chunhai Jiao minghua yao Hubei Academy of Agricultural Sciences Hubei Key Laboratory of Vegetable Germplasm Enhancement and Genetic ImprovementCash Crops Research InstituteHubei Academy of Agricultural SciencesWuhanHubei 430070China Kasetsart University Bangkok 10900Thailand

Bacterial spot(BS)is a severe bacterial disease induced by Xanthomonas campestris ***(Xcv),a pathogen that causes serious damage to pepper growth and *** is therefore important to study the mechanisms of pepper resistance to Xcv and to breed and promote Xcvresistant pepper ***,studies of the responses to Xcv infection in peppers at the protein level are ***,we examined Xcv-induced proteomic changes in leaves of the BS susceptible bell pepper ECW and the resistant bell pepper VI037601 using the isobaric tags for relative and absolute quantitation(iTRAQ)-based protein labeling technology.A total of 6,120 distinct proteins were identified,and there were 1,289 significantly differentially accumulated proteins(DAPs)in ECW and VI037601 leaves after Xcv *** these,339(250up-and 89 down-regulated)and 479(300 up-and 179 down-regulated)DAPs were specifically identified in ECW and VI037601,respectively,with 459(364 up-and 95 down-regulated)similarly expressed DAPs being shared by ECW and *** on bioinformatics analysis,many defense-associated proteins were identified as up-regulated in ECW and VI037601,especially the proteins involved in plant-pathogen interaction,phenylpropanoid biosynthesis,protein processing in the endoplasmic reticulum,and MAPK signaling ***,we evaluated transcript levels of six differentially expressed genes from the iTRAQ results by q *** analysis revealed transcriptional changes that were consistent with the changes at the protein *** study will provide a valuable resource for understanding the molecular basis of pepper resistance to Xcv infection and for improving the disease resistance of pepper cultivars.

关键词： Pepper Proteomics analysis Bacterial spot Xanthomonas campestris pv.vesicatoria

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Regulation of the macrophage-related inflammatory microenvironment for atherosclerosis treatment and angiogenesis via anti-cytokine agents

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Nano Research 2022年第8期15卷 7342-7354页

作者： Hongji Pu minghua yao Zhaoyu Wu Zhijue Xu Chaoyi Cui Renhua Huang Muhammad Shafiq Weimin Li Xinwu Lu Bo Li Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Ultrasound Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200040China Department of Radiation Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu University744 MotookaNishi-kuFukuoka 819-0395Japan

Macrophages-mediated atherosclerosis(AS)is an inflammatory disease and the most common cause of *** the progress of basic and clinical research,anti-cytokine therapy has garnered considerable attention of the research community for the regulation of the inflammatory microenvironment for AS *** of their promising potential,primary clinical trials have revealed that anti-cytokine drugs exhibit poor selectivity and thus affect other parts of the immune system,especially during long-term *** circumvent these limitations,herein we exploited mesoporous silica nanoparticles(MSNs)with a pore size of 15.5 nm as carriers for the anti-interleukin-1β(anti-IL-1β)delivery to be the anti-cytokine *** vitro mechanistic studies indicated that the MSNs@anti-IL-1βcan regulate the macrophage-related inflammatory microenvironment,promote the viability of vascular endothelial cells(vECs),and reduce proliferation and phenotypic switching of vascular smooth muscle cells(vSMCs).In vivo evaluation further revealed that the MSNs@anti-IL-1βwere preferentially accumulated in macrophages,impeding the AS progress by maintaining the endothelium integrity and inhibiting the vSMCs ***,MSNs@antiIL-1βinduced neovascularization and improved hindlimb ischemia *** together,these MSNs affording the sustained release of anti-cytokine agents may have broad implications for the clinical management of the AS,including the reduction of the AS progression and alleviation of the ischemia.

关键词： atherosclerosis inflammatory response nanocarriers macrophage endothelial cells

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Diagnostic Value of Virtual Touch Tissue Quantification to the Different Sizes of Breast Lesions

Diagnostic Value of Virtual Touch Tissue Quantification to t...

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中华医学会第十三次全国超声医学学术会议

作者： minghua yao Department of Ultrasound in Medicine Shanghai tenth People’s HospitalTongji University School of Medicine

Objectives Breast cancer was one of the major diseases that threaten women’s *** ultrasound could give a general diagnosis of the breast lesion,but there was still a lot of overlap between the benign and *** Touch Tissue Quantification(VTQ) was a non-invasive elastosonography which could provide information about tissue *** value of VTQ in the diagnosis of breast lesions,especially in dif-

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Current Situation of Introduction and Use of African Crop Germplasm Resources and Recommendations

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Asian Agricultural Research 2015年第4期7卷 65-68页

作者： Zili DING minghua yao Chunhai JIAO Hubei Academy of Agricultural Sciences

Africa is the origin center of many crops. It is rich in original ecological resources,especially special resources which are excellent materials for breeding research. With acceleration of commercial seeds in agriculture of African countries,some original ecological resources are disappearing. Through experience of introduction of African varieties in recent years,it analyzed current situation of introduction and use of African crop germplasm resources. Finally,it came up with recommendations for rescuing and taking full advantage of excellent African resources,solving difficult problem restricting crop breeding,enriching China's crop germplasm bank,and improving China's and African crop breeding level and innovation ability.

关键词： Africa Crop germplasm Introduction Recommendations

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Survey and Analysis of Vegetable Germplasm Resources in Hubei Province

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Asian Agricultural Research 2018年第8期10卷 75-80页

作者： Yanxu YIN minghua yao Fei WANG Ning LI Chunhai JIAO Institute of Economic Crops Hubei Academy of Agricultural SciencesWuhan 430064China Hubei Academy of Agricultural Sciences Wuhan 430064China

Based on the general survey of crop germplasm resources in Hubei Province,the third survey and collection of crop germplasm resources was conducted in 199 villages of 19 counties( cities/districts) of Hubei Province during 2015-2017. A total of 1 072 accessions of vegetables were collected. The taxonomy,distribution,agronomic traits and preservation of the vegetable germplasm resources,as well as the main vegetable resources and characteristic resources in the 19 counties( cities/districts) were analyzed. The results showed that the local vegetable landraces cover 26 families. Hong'an County,Zhongxiang City,Gucheng County,Nanzhang County and Yuan'an County have more vegetable landraces than other counties( cities/districts). The local landraces are characterized by good quality,strong resistance and tolerance to barrenness,but most of them are distributed in remote areas with low purity,low yield and serious threat of degradation. The local vegetable landraces are mostly preserved by some well-educated elder farmers. The vegetable cultivars of Cruciferae,Solanaceae,Cucurbitaceae,Liliaceae and Leguminosae account for 71. 46% of the total vegetable resources. The characteristic vegetable resources such as pearl flower( Staghylea bumalda DC.),scallion( Allium paepalanthoides) and elephant-foot yam( Amorphophallus spp.) are scattered in the mountainous areas of Hubei Province. This study can provide reference for the protection and utilization of local resources of vegetables in Hubei Province.

关键词：农作物种质资源农业发展现状

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老年性肺炎患者经阿奇霉素联合头孢哌酮钠舒巴坦钠治疗的临床效果观察

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中国社区医师 2016年第31期32卷 46-46,48页

作者：姚鸣华江苏省溧阳市人民医院呼吸内科 213300

目的:分析不同方式治疗老年性肺炎患者的临床效果。方法:收治老年性肺炎患者84例,随机分为研究组和对照组各42例。研究组给予阿奇霉素联合头孢哌酮钠舒巴坦钠治疗,对照组给予美罗培南联合左氧氟沙星治疗,比较两组的临床效果。结果:研究... 详细信息

目的:分析不同方式治疗老年性肺炎患者的临床效果。方法:收治老年性肺炎患者84例,随机分为研究组和对照组各42例。研究组给予阿奇霉素联合头孢哌酮钠舒巴坦钠治疗,对照组给予美罗培南联合左氧氟沙星治疗,比较两组的临床效果。结果:研究组的总有效率明显高于对照组(P<0.05)。结论:阿奇霉素联合头孢哌酮钠舒巴坦钠治疗老年性肺炎患者具有更佳的疗效。

关键词：老年性肺炎阿奇霉素头孢哌酮钠舒巴坦钠

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辣椒抗马铃薯Y病毒(PVY)研究进展

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分子植物育种 2018年第3期16卷 813-820页

作者：李宁姚明华王飞尹延旭湖北省农业科学院经济作物研究所武汉430064

马铃薯Y病毒(Potato virus Y,PVY)是限制辣椒生产的主要病毒病害之一,该病毒是马铃薯Y病毒组(Potyvirus)的典型代表,能够侵染辣椒等茄科作物,造成重大的经济损失。应用抗病资源、选育抗病品种是克服PVY对辣椒危害最为经济有效的方法。... 详细信息

马铃薯Y病毒(Potato virus Y,PVY)是限制辣椒生产的主要病毒病害之一,该病毒是马铃薯Y病毒组(Potyvirus)的典型代表,能够侵染辣椒等茄科作物,造成重大的经济损失。应用抗病资源、选育抗病品种是克服PVY对辣椒危害最为经济有效的方法。文中综述了辣椒PVY病毒的发现、流行和检测与分类,并针对辣椒抗PVY育种工作描述了抗性鉴定方法、抗原筛选、抗性遗传、分子定位和标记开发的研究进展,介绍了PVY抗性基因与病毒的互作机理,并就辣椒抗PVY育种中存在的问题及未来研究方向进行了讨论。

关键词：辣椒 PVY 分子标记

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中小学课程开发与创新精神培养

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教育研究 2014年第9期35卷 139-144页

作者：王桂亮韩志亮姚明华潍坊市教育科学研究院山东潍坊261041 潍坊第五中学校山东潍坊261041 潍坊市奎文区教研室山东潍坊261041

培养学生的创新精神和实践能力是实施素质教育的重点。在中小学课程实施过程中强化对学生创新精神和实践能力的培养,一是要围绕"创新精神和实践能力核心目标"开发课程,包括中小学课程"创新精神和实践能力核心目标"内涵开发,创建中小学课... 详细信息

培养学生的创新精神和实践能力是实施素质教育的重点。在中小学课程实施过程中强化对学生创新精神和实践能力的培养,一是要围绕"创新精神和实践能力核心目标"开发课程,包括中小学课程"创新精神和实践能力核心目标"内涵开发,创建中小学课程"一核三维"目标,开发学科课程、综合实践活动课程和专门课程;二是要围绕"创新精神和实践能力核心目标"实施课程,包括创设激励创新的教育环境,采用激励创新的教与学方式,形成激发创新精神的教学过程,建立激励创新的评价机制。

关键词：中小学课程开发创新精神实践能力核心目标课程实施

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肌筋膜触发点疼痛的实验动物模型研究

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中国运动医学杂志 2009年第4期28卷 415-418页

作者：姚明华黄强民上海体育学院运动医学康复中心临床运动医学教研室上海200438

目的:根据肌筋膜触发点疼痛的形成机制建立实验动物模型。方法:36只雄性SD大鼠,随机分成3组,分别采用打击、离心运动和打击结合离心运动的方法进行肌筋膜触发点疼痛造模,以打击组非打击侧作为正常对照。造模组每周进行1次造模实验,连续... 详细信息

目的:根据肌筋膜触发点疼痛的形成机制建立实验动物模型。方法:36只雄性SD大鼠,随机分成3组,分别采用打击、离心运动和打击结合离心运动的方法进行肌筋膜触发点疼痛造模,以打击组非打击侧作为正常对照。造模组每周进行1次造模实验,连续4周。最后一次造模结束1周后,在局部解剖直视下观察局部紧张带,肌电自发电位和局部抽搐反应。结果:(1)可触及紧张带检查显示,正常对照组均为阴性。打击结合离心运动组的紧张带阳性率最高,为100%,显著高于正常对照组(P0.05)。各造模组组间比较,打击结合离心运动组阳性率最高(P<0.05)。结论:打击与打击结合离心运动的方法均可建立肌筋膜触发点疼痛的实验动物模型,但从临床特点上看,打击结合离心运动的方法更稳定可靠。重复同样强度的离心运动并不能有效激活触发点。

关键词：肌筋膜触发点打击离心运动紧张带肌电图抽搐反应

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Experimental Study of Four Wave Mixing in Semiconductor Laser Amplifier and its Application to Dispersion Compensation in Mid Span Spectral Inversion System

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Chinese Journal of Lasers 2000年第1期 72-75页

作者： CHEN minghua yao Minyu ZHENG Haocheng ZHANG Jianfeng XU Lei XIE Shizhong GAO Yizhi (Department of Electronics Engineering, Tsinghua University, Beijing 100084, China)

1　Ｉｎｔｒｏｄｕｃｔｉｏｎ　　Ｔｈｅｍｉｄｓｐａｎｓｐｅｃｔｒａｌｉｎｖｅｒｓｉｏｎｅｍｐｌｏｙｉｎｇｆｏｕｒｗａｖｅｍｉｘｉｎｇｉｎａｓｅｍｉｃｏｎｄｕｃｔｏｒｌａｓｅｒａｍｐｌｉｆｉｅｒ（ＳＬＡ）ｉｓｏｎｅｏｆ... 详细信息

1　Ｉｎｔｒｏｄｕｃｔｉｏｎ　　Ｔｈｅｍｉｄｓｐａｎｓｐｅｃｔｒａｌｉｎｖｅｒｓｉｏｎｅｍｐｌｏｙｉｎｇｆｏｕｒｗａｖｅｍｉｘｉｎｇｉｎａｓｅｍｉｃｏｎｄｕｃｔｏｒｌａｓｅｒａｍｐｌｉｆｉｅｒ（ＳＬＡ）ｉｓｏｎｅｏｆｔｈｅｐｏｔｅｎｔｉａｌｃｈｒｏｍ?..

关键词： Experimental Study of Four Span Spectral Inversion System in Mid Application to Dispersion Compensation Semiconductor Laser Amplifier and its Wave Mixing in

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