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Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie Yu-long Ma ming-tai Gui Lei Yao Jian-hua Li ming-zhu Wang Xun-jie Zhou yi-fan Wang ming-yi Zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (P<0.001) in clinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

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Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites

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Rare Metals 2024年第10期43卷 5202-5215页

作者： Zhong-Hua Li Liang Liu Xin You Jian-Hong yi Rui Bao ming-yi Zhu Song Lu Jun-Jun Pai Faculty of Materials Science and Engineering Kunming University of Science and Technology Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Strengthening interface bonding between boron nitride nanosheets(BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites(CMCs) with high strength and wear resistance. Herein, BNNS/Cu composites were fabricated by the powder metallurgy route, matrix-alloying(adding 1.0 wt% Ti) strategy was adopted to improve the interfacial wettability and strengthen interface adhesion. A typical "sandwich"-like multiply interface structure involving TiN transition layers, BNNS and Cu matrix had been well constructed through the rational heat treatment(900℃for 120 min). Additionally, nano-sized TiB whisker was in situ formed in the vicinity of the interface, it had linked the BNNS-Cu-TiN multiply interface, which played a role of "threading the needle" and significantly strengthened the multi-interfaces bonding. This specific interface structure was finely characterized, and the formation mechanism of solid-state interfacial reaction feature was proposed. The results demonstrated that the ultimate tensile strength(UTS) of BNNS/Cu-(Ti)-900℃ increased from 248 to 530 MPa(increased by 114%), and the coefficient of friction(COF) decreased from 0.51 to 0.28 than pure Cu. This work highlights the importance of interface configuration design, which contributes to the development of CMCs with prominent comprehensive properties.

关键词： Boron nitride nanosheets Copper matrix composites Interface structure Mechanical and frictional properties

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Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors

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Nuclear Science and Techniques 2024年第4期35卷 200-207页

作者： Lan-Kun Li ming-yi Dong Ze Gao Liang-Cheng-Long Jin Shu-Jun Zhao School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Particle Detection and Electronics(Institute of High Energy Physics CAS)Beijing 100049China University of Chinese Academy of Science Beijing 100049China University of South China Hengyang 421001China

In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance *** the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and *** study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam *** were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope *** simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be *** with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.

关键词： Silicon Pixel Detectors Beam Telescope Multiple Coulomb Scattering Spatial Resolution

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Incidence of surgical site infection in minimally invasive colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1121-1129页

作者： Lu-Ting Ni Ru Zhao yi-Ru Ye yi-ming Ouyang Xin Chen Department of Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Surgical site infection(SSI)is a common complication of colorectal *** invasive surgery notably reduces the incidence of *** study aimed to compare the incidences of SSI after robot-assisted colorectal surgery(RACS)vs that after laparoscopic assisted colorectal surgery(LACS)and to analyze associated risk factors for SSI in minimally invasive colorectal *** To compare the incidences of SSI after RACS and LACS,and to analyze the risk factors associated with SSI after minimally invasive colorectal *** Clinical data derived from patients who underwent minimally invasive colorectal surgery between October 2020 and October 2022 at the First Affiliated Hospital of Soochow University were *** in clinical characteristics and surgeryrelated information associated with RACS and LACS were compared,and possible risk factors for SSI were *** A total of 246 patients(112 LACS and 134 RACS)were included in the ***(17.5%)developed *** proportions of patients who developed SSI were similar in the two groups(17.9%vs 17.2%,P=0.887).Diabetes mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for *** additional risk factors included neoadjuvant therapy,lesion site,and operation *** There was no difference in SSI incidence in the RACS and LACS *** mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for postoperative SSI.

关键词： Colorectal surgery Minimally invasive surgery Surgical site infection

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PAHs removal by soil washing with thiacalix[4]arene tetrasulfonate

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Environmental Science and Ecotechnology 2024年第5期21卷 256-267页

作者： Le-Yao Xing Guan-Han Meng Ji-Xian Yang ming-Han Xu yi-ming Xu Hai-Xiao Xie Ai-Jie Wang yi-Lu Sun State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Hangzhou Yanqu Information Technology Co. Ltd.Y2Hangzhou310003China

Remediating soil contaminated with polycyclic aromatic hydrocarbons(PAHs)presents a significant environmental challenge due to their toxic and carcinogenic *** PAHs remediation methodsdchemical,thermal,and bioremediationdalong with conventional soil-washing agents like surfactants and cyclodextrins face challenges of cost,ecological harm,and *** we show an effective and environmentally friendly calixarene derivative for PAHs removal through soil ***[4]arene tetrasulfonate(TCAS)has a unique molecular structure of a sulfonate group and a sulfur atom,which enhances its solubility and facilitates selective binding with *** forms host-guest complexes with PAHs through p-p stacking,OH-p interactions,hydrogen bonding,van der Waals forces,and electrostatic *** interactions enable partial encapsulation of PAH molecules,aiding their desorption from the soil *** results show that a 0.7%solution of TCAS can extract approximately 50%of PAHs from contaminated soil while preserving soil nutrients and minimizing adverse environmental *** research unveils the pioneering application of TCAS in removing PAHs from contaminated soil,marking a transformative advancement in resource-efficient and sustainable soil remediation strategies.

关键词： Calixarenes Soil-washing Host-guest interaction PAHs

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L-Type Calcium Channel Modulates Low-Intensity Pulsed Ultrasound-Induced Excitation in Cultured Hippocampal Neurons

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Neuroscience Bulletin 2024年第7期40卷 921-936页

作者： Wen-Yong Fan yi-ming Chen yi-Fan Wang Yu-Qi Wang Jia-Qi Hu Wen-Xu Tang yi Feng Qian Cheng Lei Xue State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Department of Physiology and Neurobiology School of Life SciencesFudan UniversityShanghai 200438China Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji UniversityShanghai 200070China Center for Rehabilitation Medicine Department of Pain ManagementZhejiang Provincial People's HospitalAffliated People's HospitalHangzhou Medical CollegeHangzhou 310014China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 201210China Research Institute of Intelligent Complex Systems Fudan UniversityShanghai 200433China

As a noninvasive technique,ultrasound stimulation is known to modulate neuronal activity both in vitro and in *** latest explanation of this phenomenon is that the acoustic wave can activate the ion channels and further impact the electrophysiological properties of targeted ***,the underlying mechanism of low-intensity pulsed ultrasound(LIPUS)-induced neuro-modulation effects is still ***,we characterize the excitatory effects of LIPUS on spontaneous activity and the intracellular Ca^(2+)homeostasis in cultured hippocampal *** whole-cell patch clamp recording,we found that 15 min of 1-MHz LIPUS boosts the frequency of both spontaneous action potentials and spontaneous excitatory synaptic currents(sEPSCs)and also increases the amplitude of sEPSCs in hippocampal *** phenomenon lasts for>10 min after LIPUS *** with Ca^(2+)imaging,we clarified that LIPUS increases the[Ca^(2+)]cyto level by facilitating L-type Ca^(2+)channels(LTCCs).In addition,due to the[Ca^(2+)]cyto elevation by LIPUS exposure,the Ca^(2+)-dependent CaMKII-CREB pathway can be activated within 30 min to further regulate the gene transcription and protein *** work suggests that LIPUS regulates neuronal activity in a Ca^(2+)-dependent manner via *** may also explain the multi-activation effects of LIPUS beyond *** stimulation potentiates spontaneous neuronal activity by increasing Ca^(2+)influx.

关键词： Low-intensity pulsed ultrasound Neuromodulation L-type calcium channel Hippocampal neuron

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Plasmon-enhanced ultra-high photoresponse of single-wall carbon nanotube/copper/silicon near-infrared photodetectors

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Nano Research 2024年第7期17卷 5930-5936页

作者： yi-ming Zhao Xian-Gang Hu Chao Chen Zuo-Hua Wang An-Ping Wu Hong-Wang Zhang Peng-Xiang Hou Chang Liu Hui-ming Cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling College of Mechanical EngineeringYanshan UniversityQinhuangdao 066004China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Single wall carbon nanotube(SWCNT)/Si heterojunction photodetectors have the advantages of high photoresponse ability and simple structure,however,their detection wavelength range are usually lower than 1100 nm,which limits their application in the infrared *** report a SWCNT/Cu/Si photodetector with both a high photoresponse and a detection range up to the infrared band by depositing a Cu nanoparticles(NPs)layer between a SWCNT film and a n-Si *** was found that the Cu NPs produce strong surface plasmon resonance(SPR)under laser irradiation,which breaks through the limitation of Si band gap and greatly improves the photoresponse of the SWCNT/Cu/Si photodetector in the near infrared *** responsivity(R)of the photodetector in the wavelength range of 1850–1200 nm reached 2.2–14.15 mA/W,which is the highest value in the reported plasmon enhanced n-Si based photodetectors,and about 20,000 times higher than that of a SWCNT/Si *** R value for 1550 nm wavelength used in optical communications reached~8.2 mA/W,which is 64%higher than the previously reported values of commonly used *** attribute the significant increase to the strong SPR and low Schottky barrier of Cu with n-Si,which facilitates the generation and transfer of the carriers.

关键词： single wall carbon nanotube photodetector silicon surface plasmon resonance copper

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Reactive oxygen species:Multidimensional regulators of plant adaptation to abiotic stress and development

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Journal of Integrative Plant Biology 2024年第3期66卷 330-367页

作者： Pengtao Wang Wen-Cheng Liu Chao Han Situ Wang ming-yi Bai Chun-Peng Song State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Faculty of Science McGill UniversityMontreal H3B1X8Canada

Reactive oxygen species(ROS)are produced as undesirable by-products of metabolism in various cellular compartments,especially in response to unfavorable environmental conditions,throughout the life cycle of *** ROS production disrupts normal cellular function and leads to oxidative *** cope with excessive ROS,plants are equipped with a sophisticated antioxidative defense system consisting of enzymatic and non-enzymatic components that scavenge ROS or inhibit their harmful effects on ***,when maintained at relatively low levels,ROS act as signaling molecules that regulate plant growth,development,and adaptation to adverse ***,we provide an overview of current approaches for detecting *** also discuss recent advances in understanding ROS signaling,ROS metabolism,and the roles of ROS in plant growth and responses to various abiotic stresses.

关键词： abiotic stress growth and development plant reactive oxygen species

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Targeting cytokine and chemokine signaling pathways for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3381-3428页

作者： ming yi Tianye Li Mengke Niu Haoxiang Zhang Yuze Wu Kongming Wu Zhijun Dai Department of Breast Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000People's Republic of China Department of Gynecology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000People's Republic of China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People's Republic of China Department of Hepatopancreatobiliary Surgery Fujian Provincial HospitalFuzhou 350001People's Republic of China

Cytokines are critical in regulating immune responses and cellular behavior,playing dual roles in both normal physiology and the pathology of diseases such as *** molecules,including interleukins,interferons,tumor necrosis factors,chemokines,and growth factors like TGF-β,VEGF,and EGF,can promote or inhibit tumor growth,influence the tumor microenvironment,and impact the efficacy of cancer *** advances in targeting these pathways have shown promising therapeutic potential,offering new strategies to modulate the immune system,inhibit tumor progression,and overcome resistance to conventional *** this review,we summarized the current understanding and therapeutic implications of targeting cytokine and chemokine signaling pathways in *** exploring the roles of these molecules in tumor biology and the immune response,we highlighted the development of novel therapeutic agents aimed at modulating these pathways to combat *** review elaborated on the dual nature of cytokines as both promoters and suppressors of tumorigenesis,depending on the context,and discussed the challenges and opportunities this presents for therapeutic *** also examined the latest advancements in targeted therapies,including monoclonal antibodies,bispecific antibodies,receptor inhibitors,fusion proteins,engineered cytokine variants,and their impact on tumor growth,metastasis,and the tumor ***,we evaluated the potential of combining these targeted therapies with other treatment modalities to overcome resistance and improve patient ***,we also focused on the ongoing research and clinical trials that are pivotal in advancing our understanding and application of cytokine-and chemokine-targeted therapies for cancer patients.

关键词： cytokine chemokine overcome

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Modeling the dynamic impacts of maritime network blockage on global supply chains

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The Innovation 2024年第4期5卷 103-109,102页

作者： Shen Qu Yunlei She Qi Zhou Jasper Verschuur Lu-Tao Zhao Huan Liu ming Xu yi-ming Wei Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management Beijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Energy Economics and Environmental Management Beijing 100081China Oxford Programme for Sustainable Infrastructure Systems(OPSIS) Environmental Change InstituteUniversity of OxfordOX12JD OxfordUK State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China School of Environment Tsinghua UniversityBeijing 100084China

Recent phenomena such as pandemics,geopolitical tensions,and climate change-induced extreme weather events have caused transportation network interruptions,revealing vulnerabilities in the global supply chain.A salient example is the March 2021 Suez Canal blockage,which delayed 432 vessels carrying cargo valued at$92.7 billion,triggering widespread supply chain *** ability to model the spatiotemporal ramifications of such incidents remains *** fill this gap,we develop an agent-based complex network model integrated with frequently updated maritime *** Suez Canal blockage is taken as a case *** results indicate that the effects of such blockages go beyond the directly affected countries and *** Suez Canal blockage led to global losses of about$136.9($127.5–$147.3)billion,with India suffering 75%of these *** losses show a nonlinear relationship with the duration of blockage and exhibit intricate trends post *** proposed model can be applied to diverse blockage scenarios,potentially acting as an earlyalert system for the ensuing supply chain ***,high-resolution daily data post blockage offer valuable insights that can help nations and industries enhance their resilience against similar future events.

关键词： chains valued extreme

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