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Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

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World Journal of Clinical Cases 2024年第5期12卷 931-941页

作者： Hongsik Kim Song-Yi Choi Tae-young Heo Kyeong-Rok Kim Jisun Lee min young yoo Taek-Gu Lee Joung-Ho Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungnam National University College of MedicineDaejeon 35015South Korea Information and Statistics Chungbuk National UniversityCheongju 28644South Korea Department of Radiology College of MedicineChungbuk National UniversityChungbuk National University HospitalCheongju-si 28644South Korea Department of Nuclear Medicine School of MedicineInha UniversityIncheon 22332South Korea Department of Surgery Chungbuk National UniversityCollege of MedicineCheongju-si 28644South Korea Department of Internal Medicen Chungbuk National UniversityCollege of medicineCheongju-si 28644South Korea

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal ***-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/*** This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May *** tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical *** analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/*** GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 ***-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy ***3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph *** GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph *** should consider GLUT-1 expression in preoperative endoscop

关键词： 18F-FDG-PET-CT Biomarker Colorectal neoplasms Glucose transporter type 1 Lymph node

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Properties of ZnO Thin Films Grown on Si (100) Substrates by Pulsed Laser Deposition

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Journal of Materials Science & Technology 2010年第11期26卷 973-976页

作者： young Rae Jang Keon-Ho yoo Seung min Park Department of Physics Kyung Hee University Department of Chemistry Kyung Hee University

ZnO thin films were grown on Si （100） substrates by pulsed laser deposition using a ZnO *** substrate temperature was varied in the range of room temperature to 800 ℃,and the oxygen partial pressure of 0.1333 Pa （1 m Torr） to 1333 Pa （10 Torr）.The properties of the resulting films were investigated by photoluminescence （PL）,grazing incidence X-ray diffraction （GIXRD）,X-ray photoelectron spectroscopy （XPS）,and field emission scanning electron microscopy （FESEM）.Based on the ultraviolet （UV,～380 nm） to visible emission ratio in the PL spectrum,the optimum growth conditions were determined to be 600 ℃ and 133.3 Pa （1 Torr）,*** oxygen 1s peak in the XPS spectrum was decomposed into two *** peak at lower binding energy increased in intensity with the oxygen partial pressure from 0.1333 Pa （1 m Torr） to 133.3 Pa （1 Torr） while the other peak *** GIXRD curve at the optimum condition showed strong two peaks （002） and （103）.A strong correlation between the （103） peak intensity and the UV emission intensity was found.

关键词： ZnO Pulsed laser deposition Photoluminescence

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Self-Assembled Wire Arrays and ITO Contacts for Silicon Nanowire Solar Cell Applications

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Chinese Physics Letters 2011年第3期28卷 132-135页

作者： YANG Cheng ZHANG Gang LEE Dae-young LI Hua-min LIM young-Dae yoo Won Jong PARK young-Jun KIM Jong-min Sungkyunkwan University SKKU Advanced Institute of Nano Technology300 Cheoncheon-dongJangan-guSuwon 440-746Korea Samsung Electronics Co.Ltd. San 14-1 Nongseo-dongGiheung-guYongin 446-712Korea

Self-assembly of silicon nanowire(SiNW)arrays is studied using SF_(6)/0_(2)plasma *** self-assembly method can be applied to single-and poly-crystalline Si *** conditions can control the length and diameter of the SiNW *** reflectance of the wire arrays over the wavelength range 200-1100nm is *** conducting transparent indium-tin-oxide(ITO)electrode can be fully coated on the self-assembled SiNW arrays by *** ITO-coated SiNW solar cells show the same low surface light reflectance and a higher carrier collection efficiency than SiNW solar cells without ITO *** efficiency enhancement of around 3 times for ITO coated SiNW solar cells is demonstrated via experiments.

关键词： reflectance Solar transparent

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Functional photonic structures for external interaction with flexible/ wearable devices

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Nano Research 2021年第9期14卷 2904-2918页

作者： young Jin yoo Se-Yeon Heo Yeong Jae Kim Joo Hwan Ko Zafrin Ferdous Mira young min Song School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-roBukguGwangju 61005Republic of Korea Korea Institute of Ceramic Engineering&Technology Ceramics Test-Bed Center3321 Gyeongchung-daeroSindun-myeonIcheon-si Gyeonggi-do 17303Republic of Korea Anti-Viral Research Center Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-roBukguGwangju 61005Republic of Korea AI Graduate School Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-roBukguGwangju 61005Republic of Korea

In addition to vital functions,more subsidiary functions are being expected from wearable *** wearable technology thus far has achieved the ability to maintain homeostasis by continuously monitoring physiological *** quality of life improves if,through further developments of wearable devices to detect,announce,and even control unperceptive or noxious signals from the *** materials based on photonic engineering can fulfil the abovementioned *** to the flexibility and zero-power operation of such materials,they can be applied to conventional wearables without affecting existing *** achievements to freely tailoring a broad range of electromagnetic waves have encouraged the development of wearable systems for independent recognition/manipulation of light,pollution,chemicals,viruses and ***,the role that photonic engineering on a flexible platform plays in detecting or reacting to environmental changes is reviewed in terms of material selection,structural design,and regulation mechanisms from the ultraviolet to infrared spectral ***,issues emerging with the evolution of the wearable technology,such as Joule heating,battery durability,and user privacy,and the potential solution strategies are *** article provides a systematic review of current progress in wearable devices based on photonic structures as well as an overview of possible ubiquitous advances and their applications,providing diachronic perspectives and future outlook on the rapidly growing research field of wearable technology.

关键词： photonic structure wearable device health care device colorimetric sensor radiative cooling infrared camouflage

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Dipole-assisted carrier transport in bis(trifluoromethane) sulfonamide-treated O-ReS_(2) field-effect transistor

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Nano Research 2021年第7期14卷 2207-2214页

作者： Jae young Park SangHyuk yoo Byeongho Park Taekyeong Kim young Tea Chun Jong min Kim Keonwook Kang Soo Hyun Lee Seong Chan Jun Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Center for Biomicrosystem Brain Science InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Sensor System Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Physics Hankuk University of Foreign StudiesYongin 17035Republic of Korea Division of Electronics and Electrical Information Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Electrical Engineering Division Engineering Department University of CambridgeCambridgeCB3 OFAUK

We demonstrate the dipole-assisted carrier transport properties of bis(trifluoromethane)sulfonamide(TFSI)-treated O-ReS_(2) field-effect *** ReS_(2) was compared with defect-mediated ReS_(2) to confirm whether the presence of defects on the interface enhances the interaction between O-ReS_(2) and TFSI *** to the experiment,density functional theory(DFT)calculation was performed,and the result indicated that the charge transfer between TFSI and O-ReS_(2) is more sensitive to external electric fields than that between TFSI and pristine ReS_(2).After TFSI treatment,the drain current of O-ReS_(2) FET was significantly increased up to 1,113.4 times except in the range of−0.32–0.76 V owing to Schottky barrier modulation from dipole polarization of TFSI molecules,contrary to a significant degradation in device performance in pristine ReS_(2) ***,in the treated O-ReS_(2) device,the dipole direction was highly influenced by the voltage sweep direction,generating a significant area of hysteresis in I–V and transfer characteristics,which was further verified by the surface potential ***,the dipole state was enhanced according to the wavelength of the light source and *** results indicate that TFSI-treated ReS_(2) FET has large potential for use as next-generation memristor,memory,and photodetector.

关键词： Two-dimensional material ReS_(2) field-effect transistor TFSI superacid dipole

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Companion diagnostics for the targeted therapy of gastric cancer

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World Journal of Gastroenterology 2015年第39期21卷 10948-10955页

作者： Changhoon yoo young Soo Park Departments of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine

Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer.

关键词： Companion diagnostics gastric cancer human epiderm

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Purtscher-like retinopathy with macular ischemia as the initial presentation of Behcet's disease

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 520-522页

作者： min Ho Shin Woong Sun yoo Ji Sung Jung In young Chung Department of Ophthalmology Chosun University HospitalGwangju 61453Republic of Korea Department of Ophthalmology Gyeongsang National University HospitalJinju 52727Republic of Korea

Dear Editor,We would like to present a case report of Purtscher-like retinopathy (PLR) with macular ischemia as the initial presentation of Behcet’s disease (BD).

关键词： ischemia Behcet macular

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Label-Free White Blood Cell Classification Using Refractive Index Tomography and Deep Learning

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Biomedical Engineering Frontiers 2021年第1期2卷 18-26页

作者： DongHun Ryu Jinho Kim Daejin Lim Hyun-Seok min In young yoo Duck Cho YongKeun Park Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Department of Health Sciences and Technology Samsung Advanced Institute For Health Sciences and TechnologySungkyunkwan UniversitySeoul 06355Republic of Korea Department of Health and Safety Convergence Science Korea UniversitySeoul 02841Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Tomocube Inc.Daejeon 34051Republic of Korea Department of Laboratory Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Stem Cell&Regenerative Medicine Institute Samsung Medical CenterSeoul 06531Republic of Korea

Objective and Impact *** propose a rapid and accurate blood cell identification method exploiting deep learning and label-free refractive index(RI)*** computational approach that fully utilizes tomographic information of bone marrow(BM)white blood cell(WBC)enables us to not only classify the blood cells with deep learning but also quantitatively study their morphological and biochemical properties for hematology *** methods for examining blood cells,such as blood smear analysis by medical professionals and fluorescence-activated cell sorting,require significant time,costs,and domain knowledge that could affect test *** label-free imaging techniques that use a specimen’s intrinsic contrast(e.g.,multiphoton and Raman microscopy)have been used to characterize blood cells,their imaging procedures and instrumentations are relatively time-consuming and *** RI tomograms of the BM WBCs are acquired via Mach-Zehnder interferometer-based tomographic microscope and classified by a 3D convolutional neural *** test our deep learning classifier for the four types of bone marrow WBC collected from healthy donors(n=10):monocyte,myelocyte,B lymphocyte,and T *** quantitative parameters of WBC are directly obtained from the *** results show>99%accuracy for the binary classification of myeloids and lymphoids and>96%accuracy for the four-type classification of B and T lymphocytes,monocyte,and *** feature learning capability of our approach is visualized via an unsupervised dimension reduction *** envision that the proposed cell classification framework can be easily integrated into existing blood cell investigation workflows,providing cost-effective and rapid diagnosis for hematologic malignancy.

关键词： Blood diagnosis utilize

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Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第12期21卷 3671-3678页

作者： Namo Kim young-Chul yoo Sang Kil Lee Hyunzu Kim Hyang Mi Ju Kyeong Tae min Department of Anesthesiology and Pain Medicine Severance Hospital Yonsei University College of Medicine Department of Internal Medicine Yonsei University College of Medicine Department of Anesthesiology and Pain Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine

AIM: To compare the efficacy and safety of sedation protocols for endoscopic submucosal dissection(ESD) between dexmedetomidine-remifentanil and ***: Fifty-nine patients scheduled for ESD were randomly allocated into a dexmedetomidineremifentanil(DR) group or a propofol-remifentanil(PR) group. To control patient anxiety, dexmedetomidine or propofol was infused to maintain a score of 4-5 on the Modified Observer's Assessment of Alertness/Sedation scale. Remifentanil was infused continuously at a rate of 6 μg/kg per hour in both groups. The ease of advancing the scope into the throat, gastric motility grading, and satisfaction of the endoscopist and patient were assessed. Hemodynamic variables and hypoxemic events were compared to evaluate patient ***: Demographic data were comparable between the groups. The hemodynamic variables and pulse oximetry values were stable during the procedure in both groups despite a lower heart rate in the DR group. No oxygen desaturation events occurred in either group. Although advancing the scope into the throat was easier in the PR group("very easy" 24.1% vs 56.7%, P = 0.010), gastric motility was moresuppressed in the DR group("no + mild" 96.6% vs 73.3%, P = 0.013). The endoscopists felt that the procedure was more favorable in the DR group("very good + good" 100% vs 86.7%, P = 0.042), whereas patient satisfaction scores were comparable between the groups. En bloc resection was performed 100% of the time in both groups, and the complete resection rate was 94.4% in the DR group and 100% in the PR group(P = 0.477). CONCLUSION: The efficacy and safety of dexmedetomidine and remifentanil were comparable to propofol and remifentanil during ESD. However, the endoscopists favored dexmedetomidine perhaps due to lower gastric motility.

关键词： Dexmedetomidine Efficacy Peristalsis Safety Endosc

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Entacapone promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2021年第6期16卷 1005-1010页

作者： Dae young yoo Hyo young Jung Woosuk Kim Kyu Ri Hahn Hyun Jung Kwon Sung min Nam Jin young Chung Yeo Sung yoon Dae Won Kim In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of MedicineSoonchunhyang UniversityCheonanSouth Korea Department of Biomedical Sciences and Research Institute for Bioscience and BiotechnologyHallym UniversityChuncheonSouth Korea Department of Biochemistry and Molecular Biology Research Institute of Oral SciencesCollege of DentistryGangneung-Wonju National UniversityGangneungSouth Korea Department of Anatomy College of Veterinary MedicineKonkuk UniversitySeoulSouth Korea Department of Veterinary Internal Medicine and Geriatrics College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea

Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s ***,few studies are reported on whether entacapone can affect hippocampal neurogenesis in *** investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg *** results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object *** staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly *** blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor *** results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB *** study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval ***-130730-1)on February 24,2014.

关键词： brain-derived neurotrophic factor entacapone hippocampus neurogenesis neurotrophic factor phosphorylated cAMP response element-binding protein tyrosine kinase receptor B receptor

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