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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López Juan B.Ortiz-Delgado Eva Vallejos-Vidal Lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo miguel A.Moriñigo Carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition Low fish meal diet Microbiota Transcriptomics Yeast probiotic

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Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta Muñoz-Islas Edgar David Santiago-SanMartin Eduardo Mendoza-Sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-Quintanilla Christopher Michael Peters Juan miguel Jiménez-Andrade Unidad Académica Multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

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Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen Rodrigo miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

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海外大型露天矿山智能化建设体系与应用实践——以拉斯邦巴斯铜矿为例

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金属矿山 2024年

作者：吴立活 miguel Canz Hermes Guevara 李国清侯杰张永芳北京科技大学土木与资源工程学院拉斯邦巴斯铜矿 2. 五矿资源有限公司

拉斯邦巴斯铜矿运用现代化信息技术构建覆盖“地质资源—计划管理—过程控制—安全保障—智能决策”全方位智能化建设框架，通过关键应用场景设计与应用，实现矿山生产运营的高效协同与智能管理。针对矿体赋存条件复杂、开采规模庞大、... 详细信息

拉斯邦巴斯铜矿运用现代化信息技术构建覆盖“地质资源—计划管理—过程控制—安全保障—智能决策”全方位智能化建设框架，通过关键应用场景设计与应用，实现矿山生产运营的高效协同与智能管理。针对矿体赋存条件复杂、开采规模庞大、作业地点分散等问题，应用矿床地质建模、三维可视化及无人机技术，实现矿山全生命周期的地质资源精细化管控，在此基础上优化开采工艺，应用精准定位及智能卡调技术，实现大规模高陡边坡的精准穿孔、控制爆破以及矿岩运输。构建了以超前预防为目标，全面覆盖人、机、环、管，与生产过程深度融合的矿山安全监测预警体系，显著提升了矿山的安全作业水平。通过云平台和数据湖技术实现多源异构数据融合，应用机器学习算法构建数据分析与决策模型，为矿山管理者科学决策提供有力支持。拉斯邦巴斯铜矿智能化建设成果对国内大型露天矿山智能化建设具有一定示范作用。

关键词：海外矿产资源大型露天矿拉斯邦巴斯铜矿智能矿山应用场景

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The Effectiveness of the Havriliak-Negami Model in Predicting the Master Curves of the Asphalt Blends with SBS Triblock Copolymer and Organic-Montmorillonite at Different Temperatures and Frequencies

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Journal of Materials Science and Chemical Engineering 2024年第7期12卷 23-39页

作者： María Ángeles Vargas-Hernández miguel Ángel Vargas Pedro R. García-Morán Humberto Vázquez-Torres Divisin de Ingeniera Qumica y Bioqumica TecNMTecnolgico de Estudios Superiores de Ecatepec Edo. de Mxico Mxico Facultad de Qumica Universidad Nacional Autonma de Mxico Cd. de Mxico Mxico Facultad de Ciencias Bsicas Ingeniera y Tecnologa Universidad Autnoma de Tlaxcala Tlaxcala Mxico Departamento de Fsica Universidad Autnoma Metropolitana-Iztapalapa Cd. de Mxico Mxico

The dynamic viscoelastic properties of asphalt AC-20 and its composites with Organic-Montmorillonite clay (OMMt) and SBS were modeled using the empirical Havriliak-Negami (HN) model, based on linear viscoelastic theory (LVE). The HN parameters, α, β, G0, G∞and τHN were determined by solving the HN equation across various temperatures and frequencies. The HN model successfully predicted the rheological behavior of the asphalt and its blends within the temperature range of 25˚C - 40˚C. However, deviations occurred between 40˚C - 75˚C, where the glass transition temperature Tg of the asphalt components and the SBS polymer are located, rendering the HN model ineffective for predicting the dynamic viscoelastic properties of composites containing OMMt under these conditions. Yet, the prediction error of the HN model dropped to 2.28% - 2.81% for asphalt and its mixtures at 100˚C, a temperature exceeding the Tg values of both polymer and asphalt, where the mixtures exhibited a liquid-like behavior. The exponent α and the relaxation time increased with temperature across all systems. Incorporating OMMt clay into the asphalt blends significantly enhanced the relaxation dynamics of the resulting composites.

关键词： Asphalt Blends Master Curve Linear Viscoelasticity Havriliak-Negami Model

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当代中国人群牙齿可观测特征的多样性研究

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基因组学与应用生物学 2024年第1期43卷 150-171页

作者：罗浩陈颖洁杨光睿 Kaustubh Adhikari 夏斌 Andrés Ruiz-Linares miguel Delgado 复旦大学生命科学学院现代人类学教育部重点实验室人类遗传学与人类学系上海200438 开放大学科学技术工程和数学学院数学与统计学院英国伦敦MK76AA 北京大学口腔医学院北京100086 拉普拉塔国立大学自然科学及博物馆学院人类学科阿根廷拉普拉塔1900

本研究基于当代中国人群3D牙齿模型数据,参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America,CANDELA)所使用的牙齿特征点标记方法,使用牙齿特征点间的欧几里得线性距离... 详细信息

本研究基于当代中国人群3D牙齿模型数据,参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America,CANDELA)所使用的牙齿特征点标记方法,使用牙齿特征点间的欧几里得线性距离(Euclidean linear distances,ELD)表示的牙齿表型作为牙齿可观测特征的度量,探究个体因素(年龄、性别)和群体因素(民族)对当代中国人群牙齿可观测特征多样性的影响。通过对牙齿标记特征点的典型变量分析(canonical variate analysis,CVA)、交叉验证(cross validation,CV)、主成分分析(principal component analysis,PCA)以及对牙齿表型的Pearson相关性分析和差异分析,本研究发现进化上相近的群体牙齿可观测特征往往更接近。具体来说,汉族的上颌牙齿可观测特征和壮族、苗族较为接近而不同于蒙古族的,而藏族的上、下颌牙齿可观测特征不同于维吾尔族的;南北中汉族牙齿表型的差异具有明确的方向性,下颌牙齿差异比上颌更明显;从性别角度看,男女牙齿表型差异主要体现在尖牙上,男性尖牙平均宽度和高度显著大于女性的;对不同年龄群体的差异分析表明,遗传外因素对牙齿可观测特征的影响主要体现在尖牙、上颌第一磨牙、下颌第一前磨牙上。

关键词：当代中国人群牙齿可观测特征表型差异

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Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

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Neural Regeneration Research 2022年第1期17卷 59-64页

作者： M.Ángeles García-Pallero Diana Cardona Lola Rueda-Ruzafa miguel rodriguez-Arrastia Pablo Roman Hospital Universitario Central de Asturias AsturiasSpain Department of Nursing Science Physiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health Sciences Faculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health Sciences Pre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYS Faculty of Health SciencesJaume I UniversityCastello de la PlanaSpain

Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDLINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.

关键词： central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review

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漫长的岁月卡斯凯什乡村博物馆

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室内设计与装修 2024年第4期 64-67页

作者： [葡萄牙]miguel Marcelino 西竹(编译) miguel Marcelino

位于葡萄牙奥泰罗·德·波利马(Outeiro de Polima)的Casal Saloio可谓是一座承载着丰富历史与文化底蕴的古老建筑。这座古老而朴素的乡村房屋,经过漫长岁月的沉淀和变迁,如今已被改造成一个富有历史韵味的博物馆。最初的Casal Saloio... 详细信息

位于葡萄牙奥泰罗·德·波利马(Outeiro de Polima)的Casal Saloio可谓是一座承载着丰富历史与文化底蕴的古老建筑。这座古老而朴素的乡村房屋,经过漫长岁月的沉淀和变迁,如今已被改造成一个富有历史韵味的博物馆。最初的Casal Saloio只是一个单间,仅能满足基本的居住需求。随着时间的推移,居民陆续对房屋进行了改造和扩建。

关键词：居住需求博物馆葡萄牙

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Effectiveness of statins *** on reducing postprandial hypertriglyceridemia in dyslipidemic population:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2022年第5期11卷 567-577页

作者： Laura Alvarez-Jimenez Alfonso Moreno-Cabanas miguel Ramirez-Jimenez Felix Morales-Palomo Juan FOrtega Ricardo Mora-rodriguez Exercise Physiology Lab at Toledo Sports Science DepartmentUniversity of Castilla-La ManchaToledo 45004Spain

Background:Individuals at risk of suffering cardiovascular disease(CVD) present with larger increases in blood trigyceride(TG) concentration after a high-fat meal than do healthy *** postprandial hypertriglyceride levels are an independent risk factor for *** of statins and a bout of prolonged exercise are both effective in lowering postprandial hypertriglyceride *** aimed to evaluate the comparative effectiveness of statins vs.a bout of aerobic exercise in reducing fasting and postprandial TG(PPTG) concentrations in indiv、duals at high nsk of developing ***:Thirty-seven sltudies from a systematic literature search of the PubMed,EMBASE,and Cochrane databases were included in this *** selected studies conducted trials involving statin therapy(n=20) or a bout of aerobic exercise(n=19) and measured their impact on PPTG levels as the *** studies analyzed both treatments and were included in *** meta-analysis was constructed using a random-effects model to calculate the mean difference(MD).The Student t test was used to compare the data sets for statins ***:Overall,statin and exercise interventions showed similar reductions in PPTG levels,with an MD of-0.65 mmol/L for statins(95% confidence interval(95%CI):-0.54 to-0.77;p <0.001) and-0.46 mmol/L for exercise(95%CI:-0.21 to-0.71;p <0.01).However,statins lowered fasting TG levels more than exercise(MD=-1.54 mmol/L,95%CI:-2.25 to-0.83;p=0.009).Conclusion:Although aerobic exercise is effective in lowering blood TG levels,statins seem to be more efficient,especially in the fasted state.A combination of exercise and statins might reveal a valuable approach to the treatment and prevention of *** studies are required to determine the underlying mechanisms and the possible additive effects of these interventions.

关键词： Aerobic exercise Cardiovascular disease Hydroxymethylglutaryl-CoA reductase inhibitor Meta-analysis Metabolic syndrome

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Camalote Grass (Paspalum fasciculatum Willd) as a Sustainable Raw Material for the Production of Lignocellulosic Ethanol

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Journal of Sustainable Bioenergy Systems 2024年第2期14卷 23-33页

作者： María Luz May-Reyes Cintya Valerio-Cárdenas Gloria Ivette Bolio-López Manuel Mateo Hernández-Villegas miguel Ángel Velázquez-Carmona Patricia De la Cruz-Burelo Research and Postgraduate Coordination Universidad Popular de la Chontalpa Crdenas Tabasco Mexico

The current trend of replacing a percentage of gasoline with ethanol has promoted the development of new processes for its production from lignocellulosic biomass. This work reports the production of ethanol from the Camalote grass (Paspalum fasciculatum Willd). The lignocellulosic biomass was subjected to acid hydrolysis at 125C and 15 psi with H2SO4 concentrations at 5%, 10%, and 20%, obtaining an average of reducing sugars (pentoses and hexoses) from the hydrolyzed juice with 12.3%, 10%, and 17% Brix, respectively. The sugars were fermented using yeast of the Saccharomyces cerevisiae at 30C for 48 hours. Finally, the ethanol was distilled at 78C, and the average yields were obtained through analysis of variance with a 95% confidence level. The values indicate that there is a significant difference (p > 0.05), the Tukey study shows that all the % v/v averages are different from each other. For H2SO4 concentration at 5% (10.33 ± 2), H2SO4 at 10% (9.33 ± 1.8), and H2SO4 at 20% (6.33 ± 2). The acidity analysis for the ethanol obtained from each treatment gave a value of 1.8 mg/L of acetic acid in all cases.

关键词： Lignocellulosic Ethanol Lignocellulosic Biomass Camalote Grass Acid Hydrolysis Energy Crops

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