Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

作     者：M.Ángeles García-Pallero Diana Cardona Lola Rueda-Ruzafa Miguel Rodriguez-Arrastia Pablo Roman 

作者机构：Hospital Universitario Central de AsturiasAsturiasSpain Department of Nursing SciencePhysiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health SciencesFaculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health SciencesPre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYSFaculty of Health SciencesJaume I UniversityCastello de la PlanaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第1期

页      面：59-64页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review 

摘      要：Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDLINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.