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Hydrological Structure, Circulation and Water Mass Transport in the Gulf of Cadiz

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International Journal of Geosciences 2011年第4期2卷 432-456页

作者： Jose miguel rodrigues Alves Xavier Carton Isabel Ambar 不详

Hydrological and LADCP data from four experiments at sea (Semane 1999, 2000/1 2000/3, 2001) are used to describe the structure and circulation of Mediterranean Water in the Gulf of Cadiz. These data were gathered on meridional sections along 8?20′W and 6?15′W and between these longitudes on a zonal section along 35?50′N. The mesoscale and the submesoscale structures (Mediterranean Water Undercurrents, meddies, cyclones) observed along these sections are characterized in terms of thermohaline properties and of velocity. The transports of mass and salt in each class of density (North Atlantic Central Water, Mediterranean Water, North Atlantic Deep Water) are computed with an inverse model. The model indicates a general eastward flux in the Central Water layer, and a westward flux in the Mediterranean Water layer, but there is also a horizontal recirculation and entrainment in these two layers, as well as strong transports associated with the meddy and cyclone found during Semane 1999.

关键词： Mediterranean Water Gulf of Cadiz Hydrology Water Masses Regional Scale Circulation Inverse Model Transport

Transformation of leather waste into microwave-activated and N-doped carbon for Li-S batteries

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新型炭材料(中英文) 2025年

作者： Carolina Pano-Azucena Roberto Rosas-Rangel miguel Olvera-Sosa David Salvador González-González Rene Rangel-Mendez Luis Felipe Chazaro-Ruiz miguel Avalos-Borja Javier Antonio Arcibar-Orozco CIATEC.Center for Applied Innovation in Competitive Technologies Tecnologico de Monterrey School of Engineering and Sciences Instituto Potosino de Investigación Científica y Tecnológica Universidad Autónoma de Coahuila Facultad de SistemasCiudad Universitaria

The use of carbon from waste biomass has the potential to buffer the drawbacks of Li-S batteries and improve their overall performance. Chrome-Tanned-LeatherShavings(CTLS) are undesirable wastes, highly available for transformation into porous carbon. Microwave activation is an efficient state-of-the-art procedure to obtain unique porous structures and nitrogen incorporation can improve the performance of porous carbons. This study proposes the transformation of CTLS into a microwave activated porous carbon, and then was modified to introduce nitrogen. A microporous activated carbon with a specific surface area of 556 m2g-1 with honeycomb-like structure was obtained. Both urea thermal decomposition and ethanolamine impregnation improves the nitrogen and amine presence of surface groups. However,the results indicated that only urea treatment was effective in improving the initial capacity of the cell(1363 mAhg-1), which is probably linked with the sorption of long-chain polysulfides. This investigation confirms that it is possible to obtain carbon materials from CTLS, for use as sulfur-host cathodes in Li-S batteries, and improve their performance with urea thermal decomposition. Furthermore, a Radial basis function neural network was fitted to provide statistical support to the experimental results. The trained model corroborated the importance of nitrogen content of the carbons in the discharge capacity of the cells.

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可持续农业机器人:有效控制害虫和杂草

工业设计 2021年第10期 24-24页

作者： miguel rodrigues

NEW HOLLAND LEG农业机器人是一个经过优化的农业设备,负责使用有效和专门的处理方法来控制害虫和有害杂草。仅在受影响的区域使用少量农药,可防止植物,土壤和有益昆虫中毒。

关键词：农业机器人有益昆虫可持续农业 LAN 有害杂草

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农业机器人——有效控制害虫和杂草

工业设计 2022年第6期 14-14页

作者： miguel rodrigues 不详

NEW HOLLAND LEG农业机器人和2030年的可持续农业LEG是一种经过优化的农业设备,其使用有效和专门的处理方法来控制害虫和有害杂草。仅在受影响的区域使用少量农药,即可防止植物、土壤和有益昆虫中毒。

关键词：有益昆虫可持续农业有害杂草农业机器人控制害虫中毒

Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity

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Journal of Environmental Sciences 2020年第10期32卷 163-170页

作者： Elsa T rodrigues Susana F Nascimento Maria Joao Moreno Paulo J Oliveira miguel A Pardal University of Coimbra Centre for Functional EcologyDepartment of Life SciencesCalcada Martim de FreitasCoimbra 3000-456Portugal University of Coimbra Coimbra Chemistry CenterDepartment of ChemistryCoimbra 3004-535Portugal Centre for Neuroscience and Cell Biology Uniuersity of CoimbraUC BiotechBiocant ParkCantanhede 3060-197Portugal

The treatment of wastewaters is crucial to maintain the ecological status of receiving waters,and thereby guarantee the protection of aquatic life and human *** quality evaluation is conventionally based on physicochemical parameters,but increasing attention has been paid to integrate physicochemical and biological ***,the regulatory use of fish in biological testing methods has been subject to various ethical and cost concerns,and in vitro cell-based assays have thus become an important topic of ***,the present study intends:(a) to evaluate the efficiency of two different sample pre-concentration techniques (lyophilisation and solid phase extraction) to assess the toxicity of municipal effluents on rat cardiomyoblast H9c2(2-1) cells,and (b) maximizing the use of the effluent sample collected,to estimate the environmental condition of the receiving *** gathered results demonstrate that the H9c2(2-1) sulforhodamine B-based assay is an appropriate in vitro method to assess biological effluent toxicity,and the best results were attained by lyophilising the sample as *** to its response,the H9c2(2-1) cell line might be a possible alternative in vitro model for fish lethal testing to assess the toxicity of municipal *** physicochemical status of the sample suggests a high potential for eutrophication,and iron exceeded the permissible level for wastewater discharge,possibly due to the addition of ferric chloride for wastewater *** general,the levels of carbamazepine and sulfamethoxazole are higher than those reported for other countries,and both surpassed the aquatic protective values for long-term exposure.

关键词： Municipal wastewater treatment plant effluent Lyophilisation Solid phase extraction Cell-based assays H9c2(2-1)cell line SRB assay

Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

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Regenerative Biomaterials 2021年第1期8卷 73-82页

作者： Isabel Pereira Jose Eduardo Pereira Luis Maltez Alexandra rodrigues Catarina rodrigues Manuela Oliveira Dina MSilva Ana Rita Caseiro Justina Prada Ana Colette Mauricio Jose Domingos Santos miguel Gama CEB Centre of Biological EngineeingUniversity of MinhoCampus de GualtarBraga 4710-057Portugal CECAV Animal and Veterinary Research CentreUniversity of Trias-os-Montes e Alto DouroVila Real 5001-801Portugal Department of Veterinary Sciences University of Tras-os-Montes e Alto DouroVila Real 5001-801Portugal Bios ckin Molecular and Cell Therapies S.A.Laboratorio CriovidaTecMaiaRua Engenheiro Frederico Ulrich 2650Moreira da Maia 4470-605Portugal Departamento de Clinicas Veterinarias Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreiran°228Porto 4050-313Portugal Centro de Estudos de Ciencia Animal(CECA) Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IApartado 55142Porto 4051-401 Portugal Centro de Investigaqao Vasco da Gama(CIVG)/Escola Universitaria Vasco da Gama(EUVG) Avenida Jose R.Sousa Femandesn°197 LordemaoCoimbra 3020-210Portugal REQUIMTE/LAQV Departamento de Engenharia Metalurgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRua Dr Roberto FriasPorto 4200-495Portugal

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular *** this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established ***,in situ forming hydrogels have arisen as a new IBS *** in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive *** this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and *** results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation *** multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the *** bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.

关键词： polysaccharide injec table hydrogel granular ceramics Bonelike' bone regen eration calvarial defect

Toxic effect of plasma and ultrasound activated cashew apple juice in Artemia salina nauplii

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Food Bioscience 2023年第3期53卷 1396-1404页

作者： Thaiz Batista Azevedo Rangel miguel Luiza Michelly Gonçalves Lima Sergimar Kennedy de Paiva Pinheiro Emilio de Castro miguel Fabiano AndréNarciso Fernandes Sueli rodrigues Laboratório de Biotecnologia Departamento de Engenharia de AlimentosUniversidade Federal do CearáCampus do PiciFortalezaCearáCEP60455-900Brazil Laboratório de Biomateriais Departamento de Engenharia Metalúrgica e de Materiais(DEMM)Universidade Federal do CearáFortalezaCearáCEP60020-181Brazil Departamento de Engenharia Química Universidade Federal do CearáFortalezaCearáCEP60455-760Brazil

Cashew is a tropical economically important *** apple can be processed to improve its shelf-life and desirable characteristics by traditional methods,however,non-thermal technologies are emerging as viable methods due the preservation of organoleptic proprieties,freshness and minimizing nutritional and sensory *** these technologies are emerging as an alternative for the food industry,little is known about the effect of this processing on the food ***,this work aimed to evaluate the toxic and protective effect of unprocessed and cold plasma and ultrasound-processed cashew apple juice against oxidative stress in Artemia salina *** this purpose,nauplii were exposed to cashew apple juice processed by plasma and ultrasound to test the toxicity and the protective effect of the juice against hydrogen *** were also analyzed under light and scanning electron *** cold plasma treated at 1000 Hz juice provoked deaths and structural changes in ***,also presented a protective effect,mainly at 1000μ***^(-1).The sonicated juice did not cause deaths although nauplii morphology was *** results suggest that cold plasma treatment might form toxic substances in cashew apple juice,while the ultrasonic treatment is less harmful,considering the *** model.

关键词： Artemia salina Cashew apple juice Protective effect Non-thermal processing Toxicity

Functionalization of AuMSS nanorods towards more effective cancer therapies

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Nano Research 2019年第4期12卷 719-732页

作者： Carolina F. rodrigues Telma A. Jacinto Andre F. Moreira Elisabete C. Costa Sonia P. miguel Ilidio J. Correia CICS-UBI -Centro de Investigagao em Ciencias da Saude Universidade da Beira Interior Covilhd 6200-506 Portugal CIEPQF - Departamento de Engenharia Quimica Universidade de Coimbra Rua 13 Silvio Lima Coimbra 3030-790 Portugal

The applicatio n of nano particles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among the different nanostructures, gold-core mesoporous silica shell (AuMSS) nanorods have been one of the most explored due to their unique physical and chemical properties. The mesoporous silica biocompatibility, high surface area that can be easily functionalized, tubular pores that can store the drugs, conjugated with the intrinsic capacity of gold nanorod to absorb near-infrared radiation, allows the combination of hyperthermia (i.e., photothermal effect) with drug delivery, making them a nanoplatforms with a huge potential for cancer therapy. Nevertheless, the successful applicati on of AuMSS nanoparticles as an effective can cer nano medicine is hindered by the uncon trolled release of the therapeutic payloads, limited blood circulation time and unfavorable pharmacokinetics. In this review, an overview of the modificati ons performed to improve the AuMSS nano rods applicati on in nanom edicine is provided, highlighting the practical approaches that enhaneed the AuMSS nanorods targeting, responsiveness to different stimuli, and blood circulation time. Further, the basics of AuMSS nano rods syn thesis procedures, gen eral properties, and its applicati on in can cer therapy are also described.

关键词： gold nano rods silica surface modifications targeting cancer

Regulation of ABCB1 activity by microRNA-200c and microRNA-203a in breast cancer cells: the quest for microRNAs’ involvement in cancer drug resistance

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Cancer Drug Resistance 2019年第3期2卷 897-911页

作者： Ana Armada Bruno Costa Gomes miguel Viveiros Jose Rueff António Sebastião rodrigues Global Health and Tropical Medicine Instituto de Higiene e Medicina TropicalUniversidade NOVA de LisboaRua da Junqueira 100Lisbon 1349-008Portugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyNOVA Medical School/Faculdade de Ciências MédicasUniversidade Nova de LisboaRua Câmara Pestana 6LisbonLisbon 1150-008Portugal.

Aim:ABCB1 is a major player in cancer drug *** purpose of this study was to functionally assess the regulation of ABCB1 activity in a doxorubicin-resistant breast cancer cell line by miR-200c and ***:Human breast carcinoma cell lines MCF-7(Doxorubicin-sensitive and not expressing ABCB1)and KCR(Doxorubicin-resistant and expressing ABCB1)were used to evaluate the expression levels of miR-200c and miR-203 by Real-time quantitative PCR(RT-qPCR).The effects of transient ectopic expression of miRNA-200c and miR-203 on the expression of ABCB1 in KCR and MCF-7 cells was verified by RT-qPCR and Western *** extrusion activity of the ABCB1 pump was analyzed by fluorescence microscopy and flow cytometry through fluorescence substrate retention assays(DiOC2)in the presence and absence of the ABCB1 inhibitor ***:RT-qPCR results indicated a 100,000-fold increase in ABCB1 mRNA expression levels in KCR cells compared to MCF-7 cells,and is inversely correlated with the expression of miR-203 and *** insertion of miR-200c and miR-203 led to a higher retention of DiOC2 within KCR cells,and slightly reduced the protein levels of ABCB1 in KCR cells,although the high initial expression of ABCB1 masked the reduction in protein *** increased intracellular accumulation of the fluorescent due DiOC2 in the presence of the ABCB1 inhibitor verapamil correlated with the inhibition caused by miR-203 and miR-200c in transfected ***: The present study demonstrates that miR-200c and miR-203 exert a negative modulating effect on the activity of ABCB1 associated with doxorubicin resistance.

关键词： ABCB1 drug resistance drug extrusion breast cancer miR2003 miR203