Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute
作者机构:CEBCentre of Biological EngineeingUniversity of MinhoCampus de GualtarBraga 4710-057Portugal CECAVAnimal and Veterinary Research CentreUniversity of Trias-os-Montes e Alto DouroVila Real 5001-801Portugal Department of Veterinary SciencesUniversity of Tras-os-Montes e Alto DouroVila Real 5001-801Portugal Bios ckinMolecular and Cell Therapies S.A.Laboratorio CriovidaTecMaiaRua Engenheiro Frederico Ulrich 2650Moreira da Maia 4470-605Portugal Departamento de Clinicas VeterinariasInstituto de Ciencias Biomedicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreiran°228Porto 4050-313Portugal Centro de Estudos de Ciencia Animal(CECA)Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IApartado 55142Porto 4051-401 Portugal Centro de Investigaqao Vasco da Gama(CIVG)/Escola Universitaria Vasco da Gama(EUVG)Avenida Jose R.Sousa Femandesn°197 LordemaoCoimbra 3020-210Portugal REQUIMTE/LAQVDepartamento de Engenharia Metalurgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRua Dr Roberto FriasPorto 4200-495Portugal
出 版 物:《Regenerative Biomaterials》 (再生生物材料(英文版))
年 卷 期:2021年第8卷第1期
页 面:73-82页
核心收录:
学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 08[工学] 0805[工学-材料科学与工程(可授工学、理学学位)] 0836[工学-生物工程]
基 金:This work was funded by the project‘DEXGELERATION-Advanced solu-tions for bone regeneration based on dextrin hydrogels’(Norte-07-0202-FEDER-038853).It was also funded by FCT under the scope of the strategic funding of UID/BIO/04469/2013 and UID/BIM/04293/2013 units and COMPETE 2020(POCI-01-0145-FEDER-006684) BioTecNorte operation(NORTE-01-0145-FEDER-000004)and NORTE-01-0145-FEDER-000012 funded by FEDER under the scope of Norte2020-Programa Operacional Regional do Norte.Isabel Pereira and Ana Rita Caseiro were supported by the grants SFRH/BD90066/2012 and SFRH/BD/101174/2014 respectively from FCT Portugal
主 题:polysaccharide injec table hydrogel granular ceramics Bonelike' bone regen eration calvarial defect
摘 要:The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular *** this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established ***,in situ forming hydrogels have arisen as a new IBS *** in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive *** this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and *** results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation *** multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the *** bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.