检索结果-南通市图书馆

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen Rodrigo miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

维普期刊数据库

Dysregulation of the PD-1/PD-L1 pathway contributes to the pathogenesis of celiac disease

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第9期16卷 777-779页

作者： Candelaria Ponce de Leon miguel Angel Lopez-casado Pedro Lorite Teresa Palomeque Maria Isabel Torres Department of Experimental Biology University of JaenJaenSpain Department of Pediatrics Gastroenterology Hospital Virgen de las NievesGranadaSpain

In this study,we focus on the alteration of the programmed cell death 1(PD-1)/PD-L1 pathway in celiac *** discuss the diverse roles of the PD-1 pathway in regulating immune responses and how this knowledge can improve celiac disease(CD)*** PD-1 and PD-L1 levels in the serum and in intestinal biopsies of CD patients may be relevant to the determination of a possible correlation between markers of the autoimmune response,inflammation,and disease activity.

关键词： celiac pathogenesis inflammation

The Effectiveness of the Havriliak-Negami Model in Predicting the Master Curves of the Asphalt Blends with SBS Triblock Copolymer and Organic-Montmorillonite at Different Temperatures and Frequencies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2024年第7期12卷 23-39页

作者： María Ángeles Vargas-Hernández miguel Ángel Vargas Pedro R. García-Morán Humberto Vázquez-Torres Divisin de Ingeniera Qumica y Bioqumica TecNMTecnolgico de Estudios Superiores de Ecatepec Edo. de Mxico Mxico Facultad de Qumica Universidad Nacional Autonma de Mxico Cd. de Mxico Mxico Facultad de Ciencias Bsicas Ingeniera y Tecnologa Universidad Autnoma de Tlaxcala Tlaxcala Mxico Departamento de Fsica Universidad Autnoma Metropolitana-Iztapalapa Cd. de Mxico Mxico

The dynamic viscoelastic properties of asphalt AC-20 and its composites with Organic-Montmorillonite clay (OMMt) and SBS were modeled using the empirical Havriliak-Negami (HN) model, based on linear viscoelastic theory (LVE). The HN parameters, α, β, G0, G∞and τHN were determined by solving the HN equation across various temperatures and frequencies. The HN model successfully predicted the rheological behavior of the asphalt and its blends within the temperature range of 25˚C - 40˚C. However, deviations occurred between 40˚C - 75˚C, where the glass transition temperature Tg of the asphalt components and the SBS polymer are located, rendering the HN model ineffective for predicting the dynamic viscoelastic properties of composites containing OMMt under these conditions. Yet, the prediction error of the HN model dropped to 2.28% - 2.81% for asphalt and its mixtures at 100˚C, a temperature exceeding the Tg values of both polymer and asphalt, where the mixtures exhibited a liquid-like behavior. The exponent α and the relaxation time increased with temperature across all systems. Incorporating OMMt clay into the asphalt blends significantly enhanced the relaxation dynamics of the resulting composites.

关键词： Asphalt Blends Master Curve Linear Viscoelasticity Havriliak-Negami Model

Mesoporous fibrous silicon nitride by catalytic nitridation of silicon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2019年第2期29卷 190-197页

作者： Tatevik Minasyan Le Liu Marina Aghayan miguel A.rodriguez Sofiya Aydinyan Irina Hussainova Tallinn University of Technology Functional Advanced Composite Technology Industries 3. Instituto de Cerámica y Vidrio ICV-CSIC ITMO University Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign

The catalytic effect of metal oxide/alumina whiskers（CeO;, Mn;O;, NiO, Co;O;, Fe;O;, Cr;O;/AW） was evaluated on their ability to drive the nitridation of silicon and to generate mesoporous fibrous silicon *** powder with different particles size along with the catalyst was nitridized at 1300 °C for 5 h in nitrogen and nitrogen diluted with 10 vol% ammonia atmospheres. Nitridation degree of silicon up to 99% was recorded using 1.5 wt% CeO;and Fe;O;catalysts in nitrogen-ammonia atmosphere. The catalyzed samples contain submicronic silicon nitride fibres with a diameter of 400–500 nm and a length of up to few micrometers. The compressive strength of 46 ± 1 MPa was measured for silicon samples catalyzed with nickel oxide/alumina whiskers and nitridized in N;/10 vol%NH;atmosphere. Porous silicon nitride networks were produced with 45–52% porosity, pore sizes in the range of 370–1200 nm and median pore in the range of 495–1655 nm.

关键词： Mesoporous substrate Silicon nitride Nanofibers Wet-combustion Catalytic nitridation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

当代中国人群牙齿可观测特征的多样性研究

基因组学与应用生物学 2024年第1期43卷 150-171页

作者：罗浩陈颖洁杨光睿 Kaustubh Adhikari 夏斌 Andrés Ruiz-Linares miguel Delgado 复旦大学生命科学学院现代人类学教育部重点实验室人类遗传学与人类学系开放大学科学技术工程和数学学院数学与统计学院北京大学口腔医学院拉普拉塔国立大学自然科学及博物馆学院人类学科

本研究基于当代中国人群3D牙齿模型数据，参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America, CANDELA)所使用的牙齿特征点标记方法，使用牙齿特征点间的欧几里得线性... 详细信息

本研究基于当代中国人群3D牙齿模型数据，参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America, CANDELA)所使用的牙齿特征点标记方法，使用牙齿特征点间的欧几里得线性距离(Euclidean linear distances, ELD)表示的牙齿表型作为牙齿可观测特征的度量，探究个体因素(年龄、性别)和群体因素(民族)对当代中国人群牙齿可观测特征多样性的影响。通过对牙齿标记特征点的典型变量分析(canonical variate analysis, CVA)、交叉验证(cross validation, CV)、主成分分析(principal component analysis, PCA)以及对牙齿表型的Pearson相关性分析和差异分析，本研究发现进化上相近的群体牙齿可观测特征往往更接近。具体来说，汉族的上颌牙齿可观测特征和壮族、苗族较为接近而不同于蒙古族的，而藏族的上、下颌牙齿可观测特征不同于维吾尔族的；南北中汉族牙齿表型的差异具有明确的方向性，下颌牙齿差异比上颌更明显；从性别角度看，男女牙齿表型差异主要体现在尖牙上，男性尖牙平均宽度和高度显著大于女性的；对不同年龄群体的差异分析表明，遗传外因素对牙齿可观测特征的影响主要体现在尖牙、上颌第一磨牙、下颌第一前磨牙上。

关键词：当代中国人群牙齿可观测特征表型差异

Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2017年第6期10卷 791-804页

作者： Carlos Perea-Resa miguel A. rodriguez-Milla Elisa Iniesto Vicente Rubio Julio Salinas Departamento de Biologia Medioambiental Centro de Investigaciones Biologicas CSIC 28040 Madrid Spain Departamento de Genetica Molecular de Plantas Centro Nacional de Biotecnologia CSIC 28049 Madrid Spain present address: Department of Molecular Biology Massachusetts General Hospital Boston MA 02214 USA Present address: Unidad de Biotecnologia Celular Instituto de Salud Garlos Ⅲ 28222 Madrid Spain

The process of cold acclimation is an important adaptive response whereby many plants from temperate regions increase their freezing tolerance after being exposed to low non-freezing temperatures. The correct development of this response relies on proper accumulation of a number of transcription factors that regulate expression patterns of cold-responsive genes. Multiple studies have revealed a variety of molecular mechanisms involved in promoting the accumulation of these transcription factors. Interestingly, however, the mechanisms implicated in controlling such accumulation to ensure their adequate levels remain largely unknown. In this work, we demonstrate that prefoldins （PFDs） control the levels of HY5, an Arabidopsis transcription factor with a key role in cold acclimation by activating anthocyanin biosynthesis, in response to low temperature. Our results show that, under cold conditions, PFDs accumulate into the nucleus through a DELLA-dependent mechanism, where they interact with HY5, triggering its ubiquitination and subsequent degradation. The degradation of HY5 would result, in turn, in anthocyanin biosynthesis attenuation, ensuring the accurate development of cold acclimation. These findings uncover an unanticipated nuclear function for PFDs in plant responses to abiotic stresses.

关键词： prefoldins cold acclimation Arabidopsis HY5 anthocyanin DELLAs

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik Diaz miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 59-64页

作者： M.Ángeles García-Pallero Diana Cardona Lola Rueda-Ruzafa miguel rodriguez-Arrastia Pablo Roman Hospital Universitario Central de Asturias AsturiasSpain Department of Nursing Science Physiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health Sciences Faculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health Sciences Pre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYS Faculty of Health SciencesJaume I UniversityCastello de la PlanaSpain

Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDLINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.

关键词： central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

漫长的岁月卡斯凯什乡村博物馆

室内设计与装修 2024年第4期 64-67页

作者： [葡萄牙]miguel Marcelino 西竹(编译) miguel Marcelino

位于葡萄牙奥泰罗·德·波利马(Outeiro de Polima)的Casal Saloio可谓是一座承载着丰富历史与文化底蕴的古老建筑。这座古老而朴素的乡村房屋,经过漫长岁月的沉淀和变迁,如今已被改造成一个富有历史韵味的博物馆。最初的Casal Saloio... 详细信息

位于葡萄牙奥泰罗·德·波利马(Outeiro de Polima)的Casal Saloio可谓是一座承载着丰富历史与文化底蕴的古老建筑。这座古老而朴素的乡村房屋,经过漫长岁月的沉淀和变迁,如今已被改造成一个富有历史韵味的博物馆。最初的Casal Saloio只是一个单间,仅能满足基本的居住需求。随着时间的推移,居民陆续对房屋进行了改造和扩建。

关键词：居住需求博物馆葡萄牙

维普期刊数据库