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Retrospective chart review of skin cancer presence in the wide excisions

World Journal of Clinical Cases 2014年第3期2卷 52-56页

作者： Ye Yuan michelle l duff Dawn l Sammons Shiyong Wu Edison Biotechnology Institute and Department of Chemistry and Biochemistry Ohio University Athens OH 45701 United States Department of Specialty Medicine Heritage College of Osteopathic Medicine Ohio University Athens OH 45701 United States

AIM: To investigate cancer cell absence or presence in wide excision after biopsy of squamous cell carcinoma(SCC) and basal cell carcinoma(BCC) ***: 200 patients(100 BCC and 100 SCC) from the same dermatology clinic, who had positive margin upon biopsy, were selected from a computer generated randomized report. All selected patients had wide excision following biopsy. To determine the correlation of gender, age distribution and cancer absence, BCC and SCC cases were separated based on excision-cancer absent or present after wide excision. χ2 tests, Fisher's exact tests were used to analyze the ratio of male to female between excision-cancer absent and excision-cancer present patients, while Mann-Whitney U test were used to compare the age distribution in the two groups. Statistical analyses were performed using SPSS version 16.0 for ***: Our retrospective chart review of the patients showed that cancer cells were absent in 49% of BCC patients(n = 100) and 64% of SCC patients(n = 100) who had previously had positive margins upon biopsy. Gender analysis showed the ratio of male to female(M/F) in the BCC arm was significantly higher compared with the SCC arm in those with excision-cancer absent(2.06 vs 0.66; P = 0.004; χ2 test). But M/F of excision-cancer absent and excision-cancer present in neither BCC nor SCC patients was statistically significant. Age adjustment showed no significant difference between excision-cancer absent and excision-cancer present in BCC and SCC patients. Nevertheless, in excision-cancer absent cases, the age distribution showed that the BCC patients were younger than SCC patients(average age 67 vs 74; P lso indicated that in the patient group of 71-80 years old, there were more SCC patients who showed excision-cancer absence(67.6% vs 39.4%; P = 0.02; χ2 test).CONClUSION: Our study indicates that approximately 50% or more of BCC and SCC patients with positive margin

关键词： Biopsy Histology Positive margin Skin cancer Wide excision

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Fortification of pork loins with docosahexaenoic acid(DHA) and its effect on flavour

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Journal of Animal Science and Biotechnology 2014年第1期5卷 106-113页

作者： William J Meadus Tyler D Turner Michael ER Dugan Jennifer l Aalhus Pascale duff David Rolland Bethany Uttaro lorna l Gibson Agriculture and Agri-Food Canada Lacombe Research Centre 6000 C&E TrailLacombe T4L 1 W1AB Canada

Pork is traditionally low in docosahexanoic acid （DHA, C22：6n-3） and deficient in omega-3 fats for a balanced human diet. DHA as triglycerides was commercially prepared from the microalgae Schizochytfium and injected into fresh pork loins. Treatments of a mixed brine control （CON）, 3.1% sunflower oil in mixed brine （SF） and a 3.1% DHA oil in mixed brine （DHA） were injected into pork loins at 10 ml/100 g and grilled at 205℃. After cooking, the CON and SF pork loins contained 0.03 to 0.05 mg DHA/g of pork and the DHA injected loins contained approximately 1.46 mg DHA/g. This also changed the fatty acid profile of omega-6：omega-3 from, 5 to 1 in the CON pork, to a ratio of 1.7 to 1 in DHA pork. The appearance, odor, oxidation rates and sensory taste, as judged by a trained panel, determined the DHA injected meat to be, ＇slightly desirable＇ and gave lower ＇off flavour＇ scores, relative to the CON and SF injected pork. Pork can be fortified with DHA oil to 146 mg/100 g serving, which would meet half the recommended daily omega 3 fatty acid requirements for adult humans and would be desirable in taste.

关键词： Docosahexaenoic acid Injection marinade Pork Sensory characteristics

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Pigs fed camelina meal increase hepatic gene expression of cytochrome 8b1, aldehyde dehydrogenase, and thiosulfate transferase

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Journal of Animal Science and Biotechnology 2014年第2期5卷 215-221页

作者： William Jon Meadus Pascale duff Tanya McDonald William R Caine AAFC-lacombe 6000 C&E TrailLacombeABCanada T4L 1 W1 School of Innovation Olds College4500-50th St.OldsABCanada T4H 1R6 Caine Research Consultinq Box #1124NiskuABCanada T9E 8A8

Comelina sotivo is an oil seed crop which can be grown on marginal lands. Camelina seed oil is rich in omega-3 fatty acids （〉35%） and y-tocopherol but is also high in erucic acid and glucosinolates. Camelina meal, is the by-product after the oil has been extracted. Camelina meal was fed to 28 d old weaned pigs at 3.7% and 7.4% unt age 56 d. The camelina meal supplements in the soy based diets, improved feed efficiency but also significantly increased the liver weights. Gene expression analyses of the livers, using intra-species microarrays, identified increased expression of phase 1 and phase 2 drug metabolism enzymes. The porcine versions of the enzymes were confirmed by real time PCR. Cytochrome 8b1 （CYPSB1）, aldehyde dehydrogenase 2 （Aldh2）, and thiosulfate transferase （TST） were all significantly stimulated. Collectively, these genes implicate the camelina glucosinolate metabolite, methyl-sulfinyldecyl isothiocyanate, as the main xeniobiotic, causing increased hepatic metabolism and increased liver weight.

关键词： Camelina meal Gene expression Glucosinolates Pig liver

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Heterologous expression of lamA gene encoded endo-β-1,3- glucanase and CO2 fixation by bioengineered Synechococcus sp. PCC 7002

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 115-122页

作者： Di li Swati Yewalkar Xiaotao Bi Sheldon duff Dusko Posarac Heli Wang layne A. Woodfin Jan-Hendrik Hehemann Sheila C. Potter Francis E. Nano School of Water Resources and Environment China University of Geosciences Beijing 100083 China Department of Chemical and Biological Engineering University of British Columbia Vancouve V6T 1Z3 Canada Department of Biochemistry and Microbiology University of Victoria Victoria V5Z 4H4 Canada

The gene for the catalytic domain of thermostable endo-β-1,3-glucanase （laminarinase） lamA was cloned from Thermotoga maritima MSB8 and heterologously expressed in a bioengineered Synechococcus sp. PCC 7002. The mutant strain was cultured in a photobioreactor to assess biomass yield, recombinant laminarinase activity, and CO2 uptake. The maximum enzyme activity was observed at a oH of 8.0 and a temoerature of 70℃. At a CO2 concentration of 5%, we obtained a maximum specific growth rate of 0.083 h^-1 a biomass productivity of 0.42 g· l^-1·d^-1 a blomass concentration of 3.697 g.l^-1 , and a specific enzyme activity of the mutant strain of 4.325 ***^- 1 dry mass. All parameters decreased as CO2 concentration increased from 5% to 10% and further to 15% CO2, except enzyme activity, which increased from 5% to 10% CO2. However, the mutant culture still 1 1 grew at 15% CO2 concentration, as reflected by the blomass productwlty （0.26 g.l .d ）, biomass concentration （2.416 g.l^- 1）, and specific enzyme activity （3.247 ***^-1 dry mass）.

关键词： Synechococcus sp. PCC 7002Thermotoga maritimalamA geneEndo-β-1 3-glucanaseCO2 fixation

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Currently Clinical Views on Genetics of Wilson＇s Disease

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Chinese Medical Journal 2015年第13期128卷 1826-1830页

作者： Chen Chen Bo Shen Jia-Jia Xiao Rong Wu Sarah Jane duff Canning Xiao-Ping Wang Department of Neurology Shanghai General Hospital Shanghai Jiao-'rong University Shanghai 200080 China

Objective： Tile objective of this study was to review the research on clinical genetics of Wilson＇s disease （WD）. Data Sources： We searched docunlents from PubMed and Wanfang databases both in English and Chinese up to 2014 using the keywords WD in combination with genetic,ATP7B gene, gene mntation, genotype, phenotype. Study Selection： Publications about the ATP7B gene and protein timction associated with clinical features were selected. Results： Wilson＇s disease, also named hepatolenticular degeneration, is an autosomal recessive genetic disorder characterized by abnormal copper metabolism caused by mutations to the copper-transporting gene A TP7B. Decreased biliary copper excretion and redtlced incorporation of copper into apoeeruloplasmin caused by defunctionalization of ATP7B protein lead to acct, mulation of copper in many tissues and organs, including liver; brain, and cornea, finally restllting in liver disease and extrapyramidal symptoms. It is the most common genetic neurological disorder in the onset of adolescents, second to muscular dystrophy in China. Early diagnosis and medical therapy are of great significance tbr improving the prognosis of WD patients. However, diagnosis of this disease is usually *** because of its complicated phenotypes. In the last l0 years, an increasing number of clinical studies have used molecular genetics techniques. Improved diagnosis and prediction ol＇the progression of this disease at the molecular level will aid in the development of more individualized and effective intervcntions, which is a key to transition from molecular genetic research to the clinical study. Conclusions： Clinical genetics studies are necessary to understand the mechanism underlying WD at the molecular level from the genotype to the phenotype. Clinical genetics research benefits newly emerging medical treatments including stem cell transplantation and gone therapy for WD patients.

关键词： A TP7B Gene Clinic Gene Mutation Genetic Hepatolenticular Degeneration Phenotype Wilson's Disease

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冰上奔跑者

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汽车与运动 2014年第6期 20-21页

作者： Mike duff 韩啸

这是我们第一次接触第七代高尔夫R:除了四轮驱动和218kW的输出功率,还有更多……在瑞典一个结冰的湖面上驾驶完最新一代的高尔夫R之后,我们可以告诉你,大众汽车正为"R"系列子品牌的迅速扩张做准备。第一辆高尔夫R推出至今仅有12年,它极... 详细信息

这是我们第一次接触第七代高尔夫R:除了四轮驱动和218kW的输出功率,还有更多……在瑞典一个结冰的湖面上驾驶完最新一代的高尔夫R之后,我们可以告诉你,大众汽车正为"R"系列子品牌的迅速扩张做准备。第一辆高尔夫R推出至今仅有12年,它极为疯狂,搭载174kW的3.2l V6发动机,四轮驱动的第四代R32是整个演变过程中的经典的一笔;其次是第五代R32,不过仅比两轮驱动的"同胞妹妹"GTI快上一点可算是它的"终生遗憾";第六代出现在2010年,车身上仅标记了一个"R"。它保留了四轮驱动,但是动力系统转而选择了4缸涡轮增压发动机;第七代紧跟其脚步。

关键词：四轮驱动涡轮增压发动机两轮驱动终生遗憾奔跑者输出功率子品牌动力系统梅赛德斯稳定控制

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奥迪性能车的未来

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汽车与运动 2014年第6期 18-19页

作者： Mike duff 韩啸

输出功率为305kW的2.0l发动机和R8电动量产版呼之欲出,一场风暴正在德国英戈尔施塔特酝酿……在去日内瓦车展之前,我们并没有期待在奥迪展台找到什么惊喜。我们知道有新TT,一辆"循规蹈矩"的出现在我们Radar版块的车。但是,在众多性能机... 详细信息

输出功率为305kW的2.0l发动机和R8电动量产版呼之欲出,一场风暴正在德国英戈尔施塔特酝酿……在去日内瓦车展之前,我们并没有期待在奥迪展台找到什么惊喜。我们知道有新TT,一辆"循规蹈矩"的出现在我们Radar版块的车。但是,在众多性能机器的包围夹击下,这辆充满魅感力的奥迪第三代Coupe似乎抢不到太多风头。事实也的确如此。真正出彩的是它的"同桌"——TT quattro运动概念车。其输出功率为305kW的2.0l发动机炫耀着奥迪发动机的实力,同时,TT quattro运动概念车本身也展现了奥迪轻量化技术的新重点。

关键词：输出功率轻量化技术碳纤维结构日内瓦车展兰博基尼第三代扭矩输出塔特量产车悬架结构

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M3压境,AMG坚守V8信仰

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汽车与运动 2014年第6期 16-17页

作者： Mike duff 韩啸

继M3减缸之后,新C级AMG版也加入到了这场高性能车发动机的"瘦身革命"中。只是,它选择了降低排量,采用4.0l双涡轮增压发动机,但是依旧坚持V8信仰到目前为止,梅赛德斯·奔驰C级AMG版一直在试图击败不可一世的对手M3。随着多了两个气缸,动... 详细信息

继M3减缸之后,新C级AMG版也加入到了这场高性能车发动机的"瘦身革命"中。只是,它选择了降低排量,采用4.0l双涡轮增压发动机,但是依旧坚持V8信仰到目前为止,梅赛德斯·奔驰C级AMG版一直在试图击败不可一世的对手M3。随着多了两个气缸,动力优势更明显的新C级AMG版出现,那个不可一世的"宿敌"终于有苦头吃了。

关键词：涡轮增压发动机梅赛德斯 AMG M3 V8 车将轮圈输出功率自然吸气发动机声音

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Wildland fires and moist deciduous forests of Chhattisgarh, India: divergent component assessment

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Journal of Forestry Research 2014年第4期25卷 857-866页

作者： B.H.Kittur S.l.Swamy S.S.Bargali Manoj Kumar Jhariya Department of Silviculture & Agroforestry College of Forestry Kerala Agriculture University Vellanikara Thrissure Kerala India Department of Forestry College of Agriculture Indira Gandhi Krishi Vishwavidyalaya Raipur (C.G.) 492006 India Department of Botany DSB Campus Kumaun University Nainital–263001 (Uttarakhand) India

We studied moist deciduous forests of Chhattisgarh, India （1） to assess the effect of four levels of historic wildland fire frequency （high, medium, low, and no-fire） on regeneration of seedlings in fire affected areas during pre and post-fire seasons, （2） to evaluate vegetation struc- ture and diversity by layer in the four fire frequency zones, （3） to evalu- ate the impact of fire frequency on the structure of economically impor- tant tree species of the region, and （4） to quantify fuel loads by fire fre- quency level. We classified fire-affected areas into high, medium, low, and no-fire frequency classes based on government records. Tree species were unevenly distributed across fire frequency categories. Shrub density was maximum in zones of high fire frequency and minimum in low- frequency and no-fire zones. lower tree density after fires indicated that regeneration of seedlings was reduced by fire. The population structure in the high-frequency zone was comprised of seedlings of size class （A） and saplings of size class （B）, represented by Diospyros melanoxylon, Dalbergia sissoo, Shorea robusta and Tectona grandis. Younger and older trees were more abundant for Tectona grandis and Dalbargia sis- soo after fire, whereas intermediate-aged trees were more abundant pre- fire, indicating that the latter age-class was thinned by the catastrophic effect of fire. The major contributing components of fuel load included duff litter and small woody branches and twigs on the forest floor. Total fuel load on the forest floor ranged from 2.2 to 3.38 Mg/ha. The netchange in fuel load was positive in high- and medium-frequency fire zones and negative under low- and no-fire zones. Repeated fires, how- ever, slowly reduced stand stability. An ecological approach is needed for fire management to restore the no-fire spatial and temporal structure of moist deciduous forests, their species composition and fuel loads. The management approach should incorporate participatory forest ma

关键词： forest fire diversity fuel load vegetation structure

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A database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning

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npj Computational Materials 2023年第1期9卷 2265-2278页

作者： Cameron J.Hargreaves Michael W.Gaultois luke M.Daniels Emma J.Watts Vitaliy A.Kurlin Michael Moran Yun Dang Rhun Morris Alexandra Morscher Kate Thompson Matthew A.Wright Beluvalli-Eshwarappa Prasad Frédéric Blanc Chris M.Collins Catriona A.Crawford Benjamin B.duff Jae Evans Jacinthe Gamon Guopeng Han Bernhard T.leube Hongjun Niu Arnaud J.Perez Aris Robinson Oliver Rogan Paul M.Sharp Elvis Shoko Manel Sonni William J.Thomas Andrij Vasylenko lu Wang Matthew J.Rosseinsky Matthew S.Dyer Department of Chemistry University of LiverpoolLiverpool L697ZDUK leverhulme Research Centre for Functional Materials Design Materials Innovation FactoryUniversity of LiverpoolLiverpool L73NYUK Department of Computer Science University of LiverpoolLiverpool L693BXUK Stephenson Institute for Renewable Energy University of LiverpoolLiverpool L697ZFUK

The application of machine learning models to predict material properties is determined by the availability of high-quality *** present an expert-curated dataset of lithium ion conductors and associated lithium ion conductivities measured by *** *** dataset has 820 entries collected from 214 sources;entries contain a chemical composition,an expert-assigned structural label,and ionic conductivity at a specific temperature(from 5 to 873°C).There are 403 unique chemical compositions with an associated ionic conductivity near room temperature(15–35°C).The materials contained in this dataset are placed in the context of compounds reported in the Inorganic Crystal Structure Database with unsupervised machine learning and the Element Movers *** dataset is used to train a CrabNet-based classifier to estimate whether a chemical composition has high or low ionic *** classifier is a practical tool to aid experimentalists in prioritizing candidates for further investigation as lithium ion conductors.

关键词： spectroscopy lithium classifier

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