Retrospective chart review of skin cancer presence in the wide excisions

作     者：Ye Yuan Michelle L Duff Dawn L Sammons Shiyong Wu 

作者机构：Edison Biotechnology Institute and Department of Chemistry and Biochemistry Ohio University Athens OH 45701 United States Department of Specialty Medicine Heritage College of Osteopathic Medicine Ohio University Athens OH 45701 United States 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2014年第2卷第3期

页      面：52-56页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by NIH RO1CA086928 to Wu S Graduate assistantship to Yuan Y from the Department of Chemistry and Biochemistry,Ohio University 

主　　题：Biopsy Histology Positive margin Skin cancer Wide excision 

摘      要：AIM: To investigate cancer cell absence or presence in wide excision after biopsy of squamous cell carcinoma(SCC) and basal cell carcinoma(BCC) ***: 200 patients(100 BCC and 100 SCC) from the same dermatology clinic, who had positive margin upon biopsy, were selected from a computer generated randomized report. All selected patients had wide excision following biopsy. To determine the correlation of gender, age distribution and cancer absence, BCC and SCC cases were separated based on excision-cancer absent or present after wide excision. χ2 tests, Fisher s exact tests were used to analyze the ratio of male to female between excision-cancer absent and excision-cancer present patients, while Mann-Whitney U test were used to compare the age distribution in the two groups. Statistical analyses were performed using SPSS version 16.0 for ***: Our retrospective chart review of the patients showed that cancer cells were absent in 49% of BCC patients(n = 100) and 64% of SCC patients(n = 100) who had previously had positive margins upon biopsy. Gender analysis showed the ratio of male to female(M/F) in the BCC arm was significantly higher compared with the SCC arm in those with excision-cancer absent(2.06 vs 0.66; P = 0.004; χ2 test). But M/F of excision-cancer absent and excision-cancer present in neither BCC nor SCC patients was statistically significant. Age adjustment showed no significant difference between excision-cancer absent and excision-cancer present in BCC and SCC patients. Nevertheless, in excision-cancer absent cases, the age distribution showed that the BCC patients were younger than SCC patients(average age 67 vs 74; P 0.001; Mann-Whitney U test). In addition, our data also indicated that in the patient group of 71-80 years old, there were more SCC patients who showed excision-cancer absence(67.6% vs 39.4%; P = 0.02; χ2 test).CONCLUSION: Our study indicates that approximately 50% or more of BCC and SCC patients with positive margin