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Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters

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Journal of Environmental Sciences 2015年第7期27卷 254-260页

作者： M.Martínez-Sales F.García-Ximénez F.J.espinós Aquaculture and Environmental Research Group (ACUMA) Polytechnic University of Valencia

Organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of30 embryos with the chorion intact were cultured in drinking waters from different sources,throughout their full life-cycle up to 5 months, in 20 L tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations（F0 and F1） were studied and the following parameters were tested： in the F0 generation, survival and abnormality rates evaluated at 5 dpf（days post-fertilization） and at 5 mpf（months post-fertilization）,the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring（F1）, survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work.

关键词： Organic pollutants Bioindicator Development and reproduction parameters Drinking water Zebrafish

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 330-339页

作者： Ana Mora-Boza Francisco J.Aparicio Maria Alcaire Carmen López-Santos Juan P.espinós Daniel Torres-Lagares Ana Borrás Angel Barranco Consejo Superior de Investigaciones Cientificas. Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla) c/Americo Vespucio 49 41092 SevillaSpain Facultad de Odontologia Universidad de Sevilla (USE) c/Avicena41009 SevillaSpain

Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against Escherichia coli K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

关键词： plasma polymers conformal plasma deposition chlorhexidine bactericide PDMS biocompatibility

Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin

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World Journal of Gastroenterology 2013年第26期19卷 4166-4171页

作者： Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C espinós Josep M Viver Antonio Salas Fernando Fernández-Baares Departments of Gastroenterology Hospital Universitari Mútua Terrassa Centro de Investigación Biomédica en Red de Enfer-medades Hepáticas y Digestivas (CIBERehd) Departments of Pathology Hospital Universitari Mútua Terrassa

AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients.

关键词： Helicobacter pylori Iron-deficiency anaemia Iron refractoriness Gluten-sensitive enteropathy Menopause

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通过胚珠拯救向日葵属杂种胚

国外农学（油料作物） 1992年第2期 25-29页

作者： espin.,A 韩福光

Cytogenetic and Molecular Characterization of Hematological Neoplasm in an Ecuadorian Population

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Open Journal of Blood Diseases 2013年第4期3卷 108-115页

作者： Cesar Paz-y-Mino Maria Eugenia Sanchez Santiago Araujo Ligia Ocampo Victor Hugo espin Paola ELeone Instituto de Investigaciones Biomedicas Universidad de las AmericasQuitoEcuador Laboratorio de Genetica Sociedad de Lucha contra el Cancer(SOLCA)QuitoEcuador Laboratorio de Genetica Hospital Carlos Andrade MarinQuitoEcuador.

Cancer is one of the major causes of mortality in Ecuador and annually, hematological malignancies are within the top ten most common cancers. In this multicentric study, we analyzed a series of patients diagnosed with different hematological disorders between the years 1984 and 2012. Chromosome abnormalities were detected in 1886 (45.9%) patients. FISH and RT-PCR techniques were used in order to determine the presence of genetic rearrangements and complement conventional cytogenetics results. Using FISH and RT-PCR, positive cases were increased by 1.8% and 6.9% respec- tively. We analyzed fusion genes resulting from t(8;21), t(15;17), inv(16), t(9;22), 11q23 rearrangements, t(4;11) and t(1;19). The frequency of transcripts of some of these fusion genes was of particular interest as our results differ from studies on other populations. Specifically, the fusion gene BCR-ABL was present in the form of the b2/a2 transcript in 95% of CML patients and in the form of b3/a2 transcript in the remaining 5%. The PML-RARA fusion gene also showed a distinct pattern of transcript expression. This fusion gene exhibited the bcr2 (36%) and bcr3 (64%) transcripts, how- ever the bcr1 transcript was absent from our sample population. All cases carrying the CBFB-MYH11 fusion gene ex- hibited the F transcript. This was also of interest due to the rarity of this particular transcript worldwide. Finally all cases carrying the MLL-AF4 fusion gene displayed the e7-e8 transcript. The frequency of the subtypes of some fusion genes differ from those reported in other populations, possibly due to the particular genetic make-up of the Ecuadorian population, mostly mestizo, as well as environmental factors.

关键词： Hematological Diseases Chromosomal Aberration BCR-ABL PML-RARA CBFB-MYH11 MLL-AF4 Geographical Heterogeneity

New frontiers in focal therapy for prostate cancer:Prostate-specific membrane antigen positron emission tomography/magnetic resonance imaging

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World Journal of Clinical Oncology 2021年第2期12卷 61-68页

作者： Celeste Manfredi Esau Fernandez-Pascual Estefanía Linares-espinós Felipe Couñago Juan Ignacio Martínez-Salamanca Department of Woman Child and General and Specialized SurgeryUrology UnitUniversity of Campania“Luigi Vanvitelli”Naples 81110Italy Department of Urology Hospital Universitario La PazMadrid 28046Spain LYX Institute of Urology Facultad de MedicinaUniversidad Francisco de VitoriaPozuelo de Alarcón 28223MadridSpain Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Urology Hospital Universitario Puerta Hierro-MajadahondaMajadahonda 28222MadridSpain

Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of *** papers reported the potential advantages of PSMA PET/MRI in different clinical *** evidence on PSMA PET/MRI is available in the setting of *** PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary *** PET/MRI also shows high performance for restaging and detecting tumor *** higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed *** PET/MRI could represent a turning point in the management of patients with PCa in the context of *** studies are needed to confirm its applications in this specific clinical setting.

关键词： Prostate-specific membrane antigen Positron emission tomography/magnetic resonance imaging Prostate cancer Focal therapy High-intensity focused ultrasound Cryotherapy

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对外汉语口语教学中面临的问题及思考

河北广播电视大学学报 2014年第5期19卷 81-84页

作者：孔凡洁 Mari Carmen espin-卡门河北师范大学国际文化交流学院河北石家庄050024

分析当前对外汉语口语课所肩负的任务,以及其中所存在的问题。某些口语课依然存在以讲授语言点为重点,而不是侧重语言技能的训练。教学进度与练习时间冲突。在语言环境不够真实的情况下,教学方法又太过传统。在教学实践中,各任课教师集... 详细信息

分析当前对外汉语口语课所肩负的任务,以及其中所存在的问题。某些口语课依然存在以讲授语言点为重点,而不是侧重语言技能的训练。教学进度与练习时间冲突。在语言环境不够真实的情况下,教学方法又太过传统。在教学实践中,各任课教师集体备课,协调词汇语法教学任务。以及走出课堂,充分利用学校和社会语言环境等方法对提高口语课的实效都很有帮助。

关键词：对外汉语口语教学法口语表达能力语言技能训练

A Simple Two-Phase System Involving the Commercial Organophosphorous Extractant Cyanex 471x for the Preparation of Silver Sulphide Nanoparticles

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Materials Sciences and Applications 2012年第12期3卷 843-850页

作者： Rosa Lina Tovar-Tovar Octavio Domínguez-espinós Adriana Gaona-Couto Azdrubal Lobo-Guerrero Salvador Palomares-Sánchez María Guadalupe Sánchez-Loredo Instituto de Metalurgia San Luis PotosíMéxico Facultad de Ciencias San Luis PotosíMéxico Facultad de Ingeniería Univer-sidad Autónoma de San Luis PotosíSan Luis PotosíMéxico

The facile chemical synthesis of silver sulphide nanocrystals from metal-loaded organic media, containing a silver-selective organophosphorous ligand as extractant, is reported. The method involves the phase-transfer of silver species from aqueous nitrate media to organic solution using the commercial extractant Cyanex? 471x (tri-isobutylphosphine sulphide, Cytec Co.) as extractant, followed by precipitation stripping using ammonium sulphide as strip reagent. The nanoparticles were structurally characterized, and some aspects of the synthetical process, are briefly discussed. Under the conditions studied, the extractant Cyanex? 471x was able to act as stabilizer adsorbing on the particles surface, maintaining the size of the particles nanometrical.

关键词： Silver Sulphide Solvent Extraction Precipitation Stripping Cyanex 471x Tri-Isobutylphosphine Sulphide

低位直肠癌Turnbull-Cutait分期拖出式结肠肛管吻合术:一项随机临床试验

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结直肠肛门外科 2020年第4期26卷 490-491页

作者：黄胜辉(评论) BIONDO S TRENTI L espin E 福建医科大学附属协和医院结直肠外科福建福州350001 不详

意义与目的:与标准的手工结肠肛管吻合+转流性回肠造口+后续回肠造口还纳术相比,低位直肠癌Turnbull-Cutait分期拖出式手工结肠肛管吻合术在术后并发症发生率方面似乎可提供获益。本文拟比较直肠癌行超低位直肠前切除后Turn-bull-Cutai... 详细信息

意义与目的:与标准的手工结肠肛管吻合+转流性回肠造口+后续回肠造口还纳术相比,低位直肠癌Turnbull-Cutait分期拖出式手工结肠肛管吻合术在术后并发症发生率方面似乎可提供获益。本文拟比较直肠癌行超低位直肠前切除后Turn-bull-Cutait拖出式手工结肠肛管吻合术与标准的手工结肠肛管吻合+转流性回肠造口术的术后30天和术后1年随访结果。

关键词：低位直肠癌结肠肛管吻合术随机临床试验回肠造口术拖出式随访结果 Cut