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Report of the first international workshop on onchocerciasis-associated epilepsy

Infectious Diseases of Poverty 2018年第1期7卷 238-242页

作者： Robert Colebunders michel Mandro Alfred K.Nj.mnshi michel Boussinesq An Hotterbeekx j.seph Kamgno Sarah O’Neill Adrian Hopkins Patrick Suykerbuyk Maria-Gloria Basanez Rory j.Post Belen Pedrique Pierre-Marie Preux Wilma A.Stolk Thomas B.Nutman Richard Idro Global Health Institute University of AntwerpAntwerpBelgium Provincial Health Division of Ituri BuniaDemocratic Republic of the Congo Department of Neurology Yaounde Central Hospital/University of Yaounde 1Brain Research Africa Initiative(BRAIN)YaoundeCameroon Institut de Recherche pour le Developpement(IRD) MontpellierFrance Centre for Research on Filariasis and other Tropical Diseases(CRFilMT) and Faculty of Medicine and Biomedical SciencesUniversity of Yaounde 1YaoundeCameroon Department of Public Health Institute of Tropical MedicineAntwerpBelgium Neglected and Disabling Diseases of Poverty Consultant KentUK London Centre for Neglected Tropical Disease Research Imperial College LondonLondonUK London School of Hygiene&Tropical Medicine and Liverpool j.hn Moores University LondonUK Drugs for Neglected Diseases initiative GenevaSwitzerland Preux Pierre-Marie INSERMUniversity LimogesCHU LimogesUMR_S 1094Tropical NeuroepidemiologyInstitute of Neuroepidemiology and Tropical NeurologyCNRS FR 3503 GEIST87000 LimogesFrance Department of Public Health Erasmus MCUniversity Medical Centre RotterdamRotterdamThe Netherlands Laboratory of Parasitic Diseases National Institutes of HealthBethesdaMarylandUSA Makerere University College of Health SciencesKampalaUganda

Background:Recently,several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy(OAE)may constitute an important but neglected public health problem in many countries where onchocerciasis is still *** text:On October 12-14th 2017,the first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,*** workshop was attended by 79 participants from 20 different *** research findings strongly suggest that *** is an important contributor to epilepsy,particularly in meso-and hyperendemic areas for *** with *** is associated with a spectrum of epileptic seizures,mainly generalised tonic-clonic seizures but also atonic neck seizures(nodding),and stunted *** is characterised by an onset of seizures between the ages of 3-18 *** working groups discussed topics such as how to 1)strengthen the evidence for an association between onchocerciasis and epilepsy,2)determine the burden of disease caused by OAE,3)prevent OAE,4)improve the treatment/care for persons with OAE and affected families,5)identify the pathophysiological mechanism of OAE,and 6)deal with misconceptions,stigma,discrimination and gender violence associated with *** OAE Alliance was created to increase awareness about OAE and its public health importance,stimulate research and disseminate research findings,and create partnerships between OAE researchers,communities,advocacy groups,ministries of health,non-governmental organisations,the pharmaceutical industry and funding ***:Although the exact pathophysiological mechanism underlying OAE remains unknown,there is increasing evidence that by controlling and eliminating onchocerciasis,OAE will also ***,OAE constitutes an additional argument for strengthening onchocerciasis elimination *** the high numbers of people with epilepsy

关键词： Onchocerciasis Epilepsy Nodding syndrome Nakalanga syndrome Prevalence Burden of disease Africa

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Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis(Baker)***

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Natural Products and Bioprospecting 2016年第5期6卷 261-265页

作者： Vincent E.Rasamison Peggy j.Brodie Emilio F.Merino Maria B.Cassera michel A.Ratsimbason Stephan Rakotonandrasana Andriamalala Rakotondrafara Elie Rafidinarivo David G.I.Kingston Harinantenaina L.Rakotondraibe Centre National d’Application de Recherches Pharmaceutiques B.P.702101 AntananarivoMadagascar Department of Chemistry and the Virginia Tech Center for Drug Discovery M/C 0212Virginia TechBlacksburgVA 24061USA Department of Biochemistry and the Virginia Tech Center for Drug Discovery M/C 0308Virginia TechBlacksburgVA 24061USA Institut Superieur de Technologie B.P.8122101 AntananarivoMadagascar Division of Medicinal Chemistry and Pharmacognosy College of PharmacyThe Ohio State UniversityColumbusOH 43210USA

Melicope madagascariensis(Rutaceae)is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia j.R.&***(Rutaceae)under the scientific name Euodia madagascariensis *** on morphological characteristics,Thomas Gordon Hartley taxonomically revised *** Baker to be ***(Baker)*** studies have long been used to help the identification and confirmation of taxonomical classification of plant species and *** to find more evidences to support the taxonomical revision performed on ***,we carried out phytochemical investigation of two samples of the *** of the ethanol extracts prepared from two stem bark samples of ***(Baker)*** led to the isolation of seven known furoquinoline alkaloids 1–7 and two known methoxyflavones 8 and *** presence of furoquinoline alkaloids and methoxyflavones in the title species is in agreement with its taxonomic transfer from Euodia to *** evaluation of the isolated compounds showed that 6-methoxy-7-hydroxydictamnine(heliparvifoline,3)showed weak antimalarial activity(IC_(50)=35μM)against the chloroquine-resistant strain Dd2 of Plasmodium ***(4)displayed moderate cytotoxicity with IC_(50)value of 1.5 lM against HT-29 colon cancer cell line whereas 3,5-dihydroxy-30,40,7-trimethoxyflavone(9)was weakly active in the same assay(IC_(50)=13.9μM).

关键词： Chemotaxonomy Furoquinoline alkaloids Methoxyflavones Antimalarial activity Cytotoxicity Melicope madagascariensis(Rutaceae)

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最小可销售专利实施单元的起源、沿革及走向

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竞争政策研究 2017年第2期 87-98页

作者： David j.Kappos Paul R.michel Cravath Swaine&Moor律师事务所美国联邦巡回上诉法院

一、引言专利侵权损害赔偿额的估算问题,已经成为一项棘手而颇富争议的工作。在这个规则体系的演进过程中,一个争议很大的概念是最小可售专利实施单元（The Smallest Salable Patent Practicing Unit,以下简称＂最小可售单元＂或SSPPU... 详细信息

一、引言专利侵权损害赔偿额的估算问题,已经成为一项棘手而颇富争议的工作。在这个规则体系的演进过程中,一个争议很大的概念是最小可售专利实施单元（The Smallest Salable Patent Practicing Unit,以下简称＂最小可售单元＂或SSPPU）。目前较为流行的观点是：最小可销售单元是确定适当许可费计费基数的一种（不区分目的或场合的）普适性、实体标准。

关键词：专利侵权损害赔偿专利权人概念思维形式巡回上诉法院合理许可费专利实施专利发明国家结构陪审团

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Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

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Cellular & Molecular Immunology 2019年第10期16卷 810-819页

作者： Mohamad Omar Ashi Nivine Srour j.an-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac j.rome Sauliere j.rome Moreaux michel Cogne Laurent Delpy Unite Mixte de Recherche Centre National de la Recherche Scientifique 7276 INSERM U1262-Controle de la Reponse Immune B et LymphoproliferationsUniversitede LimogesLimogesFrance Institute of Human Genetics CNRS-UM UMR9002Department of Biological HaematologyCHU MontpellierUniversity of MontpellierUFR MedecineMontpellierFrance Institut Universitaire de France Universitede LimogesLimogesFrance Present address:Lady Davis Institute for Medical Research McGill University3755 Cote Ste-Catherine RoadMontrealQC H3T 1E2Canada

The error-prone V(D)j.recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)*** recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)***,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)*** questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell *** address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced *** found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC *** analysis further revealed that the skipped V exon turned into a ***,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.

关键词： Immunoglobulin Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing

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Triggering star formation:Experimental compression of a foam ball induced by Taylor–Sedov blast waves

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Matter and Radiation at Extremes 2022年第3期7卷 31-39页

作者： B.Albertazzi P.Mabey Th.michel G.Rigon, j.R.Marques S.Pikuz S.Ryazantsev E.Falize L.Van Box Som j.Meinecke N.Ozaki G.Gregori M.Koenig LULI-CNRS CEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau cedexFrance Department of Physics Freie Universitat Berlin14195 BerlinGermany j.HT-RAS 13-2 Izhorskaya st.Moscow 125412Russia National Research Nuclear University“MEPhI ”Moscow 115409Russia CEA-DAM-DIF F-91297 ArpajonFrance Clarendon Laboratory University of OxfordParks RoadOxford OX13PUUnited Kingdom Graduate School of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan

The interaction between a molecular cloud and an external agent(e.g.,a supernova remnant,plasma j.t,radiation,or another cloud)is a common phenomenon throughout the Universe and can significantly change the star formation rate within a *** process leads to fragmentation of the cloud and to its subsequent compression and can,eventually,initiate the gravitational collapse of a stable molecular *** is,however,difficult to study such systems in detail using conventional techniques(numerical simulations and astronomical observations),since complex interactions of flows *** this paper,we experimentally investigate the compression of a foam ball by Taylor–Sedov blast waves,as an analog of supernova remnants interacting with a molecular *** formation of a compression wave is observed in the foam ball,indicating the importance of such experiments for understanding how star formation is triggered by external agents.

关键词： cloud galaxy supernova

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新母鸡日粮中的葵花籽饼粉

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国外畜牧学(猪与禽) 1986年第6期 16-17页

作者： j.Norberto michel 李凯年美国威斯康星大学家禽科学系

美国是世界上向日葵生产第二大国。由于向日葵种子加工的数量较大,给畜牧业提供的葵花籽饼粉(SM)和籽壳也随之增加。在配制含SM的母鸡日粮时,如果不用其它蛋白质或合成氨基酸进行调整,可能发生两种氨基酸缺乏症。赖氨酸是第一限制性氨... 详细信息

美国是世界上向日葵生产第二大国。由于向日葵种子加工的数量较大,给畜牧业提供的葵花籽饼粉(SM)和籽壳也随之增加。在配制含SM的母鸡日粮时,如果不用其它蛋白质或合成氨基酸进行调整,可能发生两种氨基酸缺乏症。赖氨酸是第一限制性氨基酸。在含有至少5％SM和高水平玉米的产蛋鸡日粮中,必须使用合成赖氨酸以满足母鸡的需要量。苏氨酸似乎是肉用

关键词：母鸡 SM 赖氨酸二氨基己酸日粮笼养鸡葵花籽饼粉

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Efficacy of a Novel Antibody TLR3 Modulator in the Self-Treatment of Common Cold: The ESTUAR Trial

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Advances in Infectious Diseases 2015年第4期5卷 204-217页

作者： Andrey Martyushev-Poklad j.cques Bruhwyler Stéphane Heij.ans michel Thiry CONTRAFLU PTE LTD. Singapore City Singapore ECSOR Blanmont Belgium ResearchLink Linkebeek Belgium Theranor Trooz Belgium

Context: Since the discovery of toll-like receptor 3 (TLR3), no specific tools have been developed to modulate its activity in upper respiratory tract viral infections (URTIs). ContafluTM (antibodies to TLR3 cytoplasmic fragment) is the first specific TLR3 modulator that showed efficacy in a mouse model of influenza. Obj.ctive: To evaluate the efficacy of Contaflu in URTI. Methods: A double-blind randomized placebo-controlled trial in adults with self-reported URTI (the ESTUAR trial) was conducted in 2012/2013 in Belgium. Adult outpatients started a 7-day treatment course with oral tablets of Contaflu or placebo within 36 h after onset of at least one of 4 typical symptoms of URTI. Patients were examined twice by their general practitioners, on days 2-3 and 10-14 after start of treatment. The primary endpoint was the overall severity of URTI calculated as the sum of Wisconsin Upper Respiratory Symptom Survey (WURSS-21) scores over the follow-up. Independent Student’s t test was used to compare the disease severity between groups. Results: A total of 243 patients were enrolled by 32 investigators (121 Contaflu, 122 placebo);92% of cases matched ICD codes j.0 or j.6. Most patients had very mild (41.8%) or mild (18.2%) URTI symptoms. In the ITT cohort, neither primary nor secondary outcome measures (duration of URTI, day-to-day and overall functional impairments) showed statistically significant differences between groups. The rate of adverse events was similar in both groups. In patients with moderate to severe URTI symptoms, Contaflu tended to reduce the overall disease severity, daily symptoms, and to improve the functional state. Due to the small size of the corresponding subgroups, Contaflu efficacy on daily scores was statistically significant (p < 0.05) only 1, 2, and 5 days after start of treatment. Conclusion: Contaflu was ineffective in mild URTI and showed efficacy in moderate to severe URTI cases.

关键词： Common Cold Treatment Toll-Like Receptor 3 TLR3 Modulation Randomized Clinical Trial

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<i>In Vitro</i>Antiprotozoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of <i>Brucea sumatrana</i>Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo

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Chinese Medicine 2012年第1期3卷 65-71页

作者： michel Tshodi Ehata Adelard Mbenza Phuati Stanislas Nsaka Lumpu Cyprien Kikweta Munduki Donatien Bakana Phongi Gaston Tona Lutete Oscar Kambu Kabangu Richard Cimanga Kanyanga Ann Matheeussen Paul Cos Sandra Apers Luc Pieters Louis Maes Arnold j. Vlietinck Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa XI Democratic Republic of Congo Laboratory of Microbiology Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium Laboratory of Microbiology Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium Laboratory of Pharmacognosy and Pharmaceutical Analysis Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium

The in vitro antiprotozoal and cytotoxic activity of the aqueous extract, the 80% methanol extract, and its different soluble fractions and subfractions from Brucea sumatrana seeds were assessed against two Trypanosoma (T. cruzi and T. brucei brucei), Leishmania infantum and chloroquine and pyrimethanine-resistant K1strain of P. falciparum and against MRC-5 cell-lines respectively. Results indicated that the 80% methanol extract showed a cytotoxic effect against MRC-5 cell lines with CC50 value of 0.54 μg/ml. It however exhibited pronounced and non selective activity against T. cruzi (IC50 = 1.52 μg/ml, SI = 0.03) and L. infantum (IC50 = 2.41 μg/ml, SI = 0.22). It however displayed pronounced and selective effect against T. brucei brucei (IC50 2.16) and chloroquine and pyrimethamine-resistant K1 strain of P. falciparum (IC50 2.16). All soluble fractions and subfractions from the partition of the 80% methanol extract were found to exhibit an antiprotozoal activity with IC50 values ranging from T .cruzi, T. b. brucei, L. infantum and chloroquine and pyrimethamine-resistant K1 strain of P. falciparum with IC50 values of 0.33, 81, 81 and >81 respectively. The chloroform soluble fraction rich in alkaloid was cytotoxic against MRC-5 cell lines (CC50 = 27.09 μg/ml) and showed good activity against T. b. brucei (IC50 = 8.36 and SI = 3.24) and moderate activity against T. cruzi, L. infantum and chloroquine-pyrimethane-resistant K1 strain of P. falciparum (20 50 50 = 1.55 and 0.43 μg/ml respectively), they however displayed pronounced antiprotozoal activity against T. cruzi, T. b. brucei and chloroquine and pyrimethamine-resistant K1 strain of P. falciparum with IC50 values ranging from P. falciparum (SI = >6.2 and >1.72 respectively). These extracts however showed good and low activity respectively against L. infantum (IC50 = 24.05 and 6.82 μg/ml respectively).

关键词： Brucea sumatrana Simaroubaceae Seeds Antiprotozoal Activity Cytotoxicity

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Label-free imaging of red blood cells and oxygenation with color third-order sum-frequency generation microscopy

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Light(Science & Applications) 2023年第2期12卷 168-182页

作者： j.lia Ferrer Ortas Pierre Mahou Sophie Escoto Chiara Stringari Nicolas BDavid Laure Bally-Cuif Nicolas Dray michel Negrerie Willy Supatto Emmanuel Beaurepaire Laboratory for Optics and Biosciences CNRSINSERMEcole polytechniqueIP Paris91128 PalaiseauFrance Zebrafish Neurogenetics Unit team supported by Ligue Nationale contre le CancerInstitut PasteurCNRS75015 ParisFrance

Mapping red blood cells(RBCs)flow and oxygenation is of key importance for analyzing brain and tissue *** microscopy methods are limited either in sensitivity or in spatio-temporal *** this work,we introduce a novel approach based on label-free third-order sum-frequency generation(TSFG)and third-harmonic generation(THG)***,we propose a novel experimental scheme for color TSFG microscopy,which provides simultaneous measurements at several wavelengths encompassing the Soret absorption band of *** show that there is a strong three-photon(3P)resonance related to the Soret band of hemoglobin in THG and TSFG signals from zebrafish and human RBCs,and that this resonance is sensitive to RBC oxygenation *** demonstrate that our color TSFG implementation enables specific detection of flowing RBCs in zebrafish embryos and is sensitive to RBC oxygenation dynamics with single-cell resolution and microsecond pixel ***,it can be implemented on a 3P microscope and provides label-free RBC-specific contrast at depths exceeding 600μm in live adult zebrafish *** results establish a new multiphoton contrast extending the palette of deep-tissue microscopy.

关键词： zebra exceeding free

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连续线性系统在IBM5100机上的分析

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国外自动化 1981年第2期 42-50页

作者： C.R.Merer j.M.michel 朱复明

本文叙述一组由于分析、综合、测辨连续线性系统参数的计算机程序。这些程序是用APL语言写的,所选择的算法在IBM5100便携式小计算机上能迅速选择求解。目程序设计容易。在叙述程序的编制后,我们详细地讨论算法并列举它的使用例子。

关键词：函数 IBM5100 矩阵模型数学模型线性系统

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