Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis(Baker)***

作     者：Vincent E.Rasamison Peggy J.Brodie Emilio F.Merino Maria B.Cassera Michel A.Ratsimbason Stephan Rakotonandrasana Andriamalala Rakotondrafara Elie Rafidinarivo David G.I.Kingston Harinantenaina L.Rakotondraibe 

作者机构：Centre National d’Application de Recherches PharmaceutiquesB.P.702101 AntananarivoMadagascar Department of Chemistry and the Virginia Tech Center for Drug DiscoveryM/C 0212Virginia TechBlacksburgVA 24061USA Department of Biochemistry and the Virginia Tech Center for Drug DiscoveryM/C 0308Virginia TechBlacksburgVA 24061USA Institut Superieur de TechnologieB.P.8122101 AntananarivoMadagascar Division of Medicinal Chemistry and PharmacognosyCollege of PharmacyThe Ohio State UniversityColumbusOH 43210USA 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2016年第6卷第5期

页      面：261-265页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：The authors are thankful to the ICBG project(Grant No U01 TW000313)and the CNARP for financial support during the plant collections and the supply of chemicals critical to this study 

主　　题：Chemotaxonomy Furoquinoline alkaloids Methoxyflavones Antimalarial activity Cytotoxicity Melicope madagascariensis(Rutaceae) 

摘      要：Melicope madagascariensis(Rutaceae)is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia J.R.&***(Rutaceae)under the scientific name Euodia madagascariensis *** on morphological characteristics,Thomas Gordon Hartley taxonomically revised *** Baker to be ***(Baker)*** studies have long been used to help the identification and confirmation of taxonomical classification of plant species and *** to find more evidences to support the taxonomical revision performed on ***,we carried out phytochemical investigation of two samples of the *** of the ethanol extracts prepared from two stem bark samples of ***(Baker)*** led to the isolation of seven known furoquinoline alkaloids 1–7 and two known methoxyflavones 8 and *** presence of furoquinoline alkaloids and methoxyflavones in the title species is in agreement with its taxonomic transfer from Euodia to *** evaluation of the isolated compounds showed that 6-methoxy-7-hydroxydictamnine(heliparvifoline,3)showed weak antimalarial activity(IC_(50)=35μM)against the chloroquine-resistant strain Dd2 of Plasmodium ***(4)displayed moderate cytotoxicity with IC_(50)value of 1.5 lM against HT-29 colon cancer cell line whereas 3,5-dihydroxy-30,40,7-trimethoxyflavone(9)was weakly active in the same assay(IC_(50)=13.9μM).