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Health 2014年第20期6卷 2765-2774页

作者： Carina Wennerholm michaela Jern Marja-Liisa Honkasalo Tomas Faresjö Department of Medicine and Health Sciences Community Medicine/General Practice Link&ouml ping University Link&ouml ping Sweden Center for the Study of Culture and Health University of Turku Turku Finland

The health burden of myocardial infarction is rising for middle-aged women and they are underrepresented in research of cardiovascular diseases. The aim of this qualitative study was to explore how life had been for middle-aged women before they suffered a myocardial infarction (MI). Through a health care register, we identified all women (n = 46) under 65 years of age in a defined region in southeast Sweden who had suffered an MI the past 2 years and a strategic selection of n = 16 women from these was made. These selected women were interviewed and their narratives were interpreted by qualitative content analysis. The qualitative interviews generated five general themes: “Serious life events”, “Negative affectivity”, “Loneliness”, “Being a good girl” and “Lack of control”. The interviews revealed that many of these women had been exposed to extreme and repeated traumatic life events in their lives. Many had a cynical attitude towards others, felt lonely and experienced a lack of social support. Many of these women endeavored to “be a good girl”, which was a special psychosocial phenomenon found. This study uncovered that these women before they suffered an MI were affected by a variety of psychosocial factors. The study stresses the importance of psychosocial risk factors in the assessment of middle-aged women’s risk profile for MI. A general conclusion for clinical practice is that in the assessment of the individual risk for myocardial infarction for middle-aged women, potential psychosocial factors might also be considered.

关键词： Myocardial Infarction Women Risk Factors Psychosocial Factors Qualitative Research

RADIOFREQUENCY　CURRENT　CATHETER　ABLATION　OF　THE　LEFT　ATRIOVENTRICULAR　ACCESSORY　PATHWAYS　WITH　PAROXYSMAL　SUPRAVENTRICULAR　TAC

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Chinese Medical Sciences Journal 1994年第2期9卷 132-134页

作者：王静毅郭继鸿吴益明朱继红王伟民赵红刘喜荣 michaela.Lee CardiologyDivision PcopiersHospitalBcijingMedicalUniversityBcijing100044

ＲＡＤＩＯＦＲＥＱＵＥＮＣＹＣＵＲＲＥＮＴＣＡＴＨＥＴＥＲＡＢＬＡＴＩＯＮＯＦＴＨＥＬＥＦＴＡＴＲＩＯＶＥＮＴＲＩＣＵＬＡＲＡＣＣＥＳＳＯＲＹＰＡＴＨＷＡＹＳＷＩＴＨＰＡＲＯＸＹＳＭＡＬＳＵＰＲＡＶＥＮＴＲＩＣＵＬＡ... 详细信息

ＲＡＤＩＯＦＲＥＱＵＥＮＣＹＣＵＲＲＥＮＴＣＡＴＨＥＴＥＲＡＢＬＡＴＩＯＮＯＦＴＨＥＬＥＦＴＡＴＲＩＯＶＥＮＴＲＩＣＵＬＡＲＡＣＣＥＳＳＯＲＹＰＡＴＨＷＡＹＳＷＩＴＨＰＡＲＯＸＹＳＭＡＬＳＵＰＲＡＶＥＮＴＲＩＣＵＬＡＲＴＡＣＨＹＣＡＲＤＩＡ￥Ｗａｎｇ...

关键词：心动过速导管射频消融 PSVT 左室旁径路

Proteomic and metabolic prediction of response to therapy in gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13648-13657页

作者： michaela Aichler Birgit Luber Florian Lordick Axel Walch Research Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum MünchenInstitute of Pathology Technische Universit t MünchenUniversity Cancer Center Leipzig University of LeipzigResearch Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum München German Research Centre for Environmental Health

Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced ***,these new therapeutic strategies do not uniformly benefit all *** whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment *** imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant *** and validating tissue-based biomarkers are ongoing *** this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.

关键词： Gastric cancer Therapy Response predic-tion Positr

Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool

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Cellular & Molecular Immunology 2021年第2期18卷 398-414页

作者： Marc Permanyer Berislav Bošnjak Silke Glage michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster Institute of Immunology Hannover Medical SchoolHannoverGermany Institute for Laboratory Animal Science Hannover Medical SchoolHannoverGermany Department Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625HannoverGermany

Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and ***,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory ***,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R *** noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune *** contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory ***,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell ***,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool.

关键词： Regulatory T cells IL-2R signaling scRNA sequencing Treg heterogeneity

Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination

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Cellular & Molecular Immunology 2021年第10期18卷 2455-2456页

作者： Swantje I.Hammerschmidt Berislav Bosnjak Günter Bernhardt michaela Friedrichsen Inga Ravens Alexandra Dopfer-Jablonka Markus Hoffmann Stefan Pöhlmann Georg M.N.Behrens Reinhold Förster Institute of Immunology Hannover Medical SchoolHannoverGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany Infection Biology Unit German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany German Center for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany German Center for Lung Research(DZL) HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

Since the beginning of the COVID-19 pandemic,divergent variants of concern(VoCs)of SARS-CoV-2 have evolved and become the most prevalent SARS-CoV-2 variants in distinct locations at different ***,the Delta variant(B.1.617.2)dominates infection events in large parts of the *** campaigns,however,still use SARS-CoV-2 vaccines based on the spike(S)protein of the original Wuhan virus.

关键词： Delta homologous campaign

低能电子与N_2分子碰撞的振动共振激发微分散射截面

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中国科学（A辑） 1999年第7期29卷 637-642页

作者：孙卫国 michaela.Morrison 四川大学原子分子物理研究所和化学工程学院成都610065 DepartmentofPhysics&Astronomy

用经作者改进后的振动密耦合散射方法和基于量子力学从头计算的静电、交换、与极化散射作用势研究了低能电子与N2 分子的振动激发共振微分散射截面 .由于充分考虑了高角动量和分子高对称性对散射过程的贡献 ,所得到的 ( 0→ 2 ,0→ 3,0... 详细信息

用经作者改进后的振动密耦合散射方法和基于量子力学从头计算的静电、交换、与极化散射作用势研究了低能电子与N2 分子的振动激发共振微分散射截面 .由于充分考虑了高角动量和分子高对称性对散射过程的贡献 ,所得到的 ( 0→ 2 ,0→ 3,0→ 4)振动激发微分散射截面与实验结果符合得很好。

关键词：分子碰撞振动激发散射截面氮气分子低能电子

Tanning capacityof Tessmannia burttii extracts:thepotentialeco-friendlytanning agents fortheleatherindustry

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Journal of Leather Science and Engineering 2021年第1期3卷 149-157页

作者： Cecilia R.China Stephen S.Nyandoro Joan J.E.Munissi Mihayo M.Maguta Michael Meyer michaela Schroepfer Division of Textile and Leather Technologies Tanzania Industrial Research and Development OrganizationP.O.Box 2355Dar es SalaamTanzania Chemistry Department College of Natural and Applied SciencesUniversity of Dar es SalamP.O.Box 35061Dar es SalaamTanzania Department of Environmental Planning Institute of Rural Development Planning(IRDP)P.O.Box 138DodomaTanzania FILK-Research Institute of Leather and Plastic Sheeting Meißner Ring 1-509599 FreibergGermany

In the present study,the tannins from stem and root barks of Tessmannia burttii Harms(Caesalpiniaceae),a plant species abundantly growing in Tanzania and other parts of Africa,were investigated for their suitability in hides *** powder was extracted at selected temperatures(30,50 and 80°C)and the influence of each temperature on the crosslinking capacity was *** interaction mechanism between hide powder collagen and the tannins was studied by Differential Scanning Calorimetry(DSC),trinitrobenzensulfonic(TNBS)acid assay and amino acid hydrolysis *** temperatures showed low influence on crosslinking capacity of the ***,extract obtained at 50°C exhibited best performance in terms of gap size between T onset and T *** stem bark extract yield was higher than that from the root bark,but both were within the recommended *** tannin content(61%)of *** stem bark extract was above recommended value(10%),whereas its total phenolic content and total flavonoic content were found to be above that of commercial Acacia mearnsii *** study of cross-linking parameters as a function of pH showed cross-linking to occur via a covalent mechanism at the basic amino ***,the bonds were not resistant to acid *** observed interaction mechanism indicated that tannins from stem and root barks of *** belong to the condensed tannin,similar to ***(black wattle),a commercial tannin source that was used in this study as a *** from this study depict that *** extracts are auspicious eco-friendly alternative source of vegetable tannins to overcome the use of chromium salts in the leather industry.

关键词： Tessmannia burttii Caesalpiniaceae Leather industry Vegetable tanning Tanning capacity

Influencing the Crystallization of Glass-Ceramics by Ultrashort Pulsed Laser Irradiation after Nucleation

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New Journal of Glass and Ceramics 2018年第1期8卷 1-11页

作者： Florian Senn Ronald Holtz Sonja-michaela Gross-Barsnick Uwe Reisgen Institute of Product and Production Engineering—IPPE FHNW Technik Windisch Switzerland Central Institute of Engineering Electronics and Analytics—ZEA Forschungszentrum Jülich GmbH Jülich Germany Welding and Joining Institute—ISF RWTH Aachen University Aachen Germany

An ultra-fast laser with central wavelength at 1064?nm and 10?ps pulse duration?was used to tightly focus laser radiation?with a microscope objective inside the volume of nucleated Lithium Aluminosilicate (LAS) glass-ceramic. The nonlinear absorption?of the LAS glass-ceramic was measured?for different laser parameters and a thermal simulation was performed to determine the temperature field inside the laser-modified area. After laser processing,?the samples were crystallized in a furnace and the effect of the laser-induced modifications on the microstructure was analyzed with SEM. The SEM analysis shows an increase in the length and size of whisker-shaped?β-spodumene crystals in the laser-modified area. By increasing the dimension of these whisker-shaped crystals, the flexural strength of LAS can be improved locally.?First?four-point bending flexural tests were performed to examine the influence on the mechanical properties.

关键词： Glass-Ceramics Microstructure Nonlinear Absorption Picosecond Laser

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