Proteomic and metabolic prediction of response to therapy in gastric cancer
Proteomic and metabolic prediction of response to therapy in gastric cancer出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第38期
页 面：13648-13657页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Ministry of Education and Research of the Federal Republic of Germany,Grant No.0315508A and No.01IB10004E(to AW),SYS-Stomach to BL,FL and AW) the Deutsche Forschungsgemeinschaft,Grant No.HO 1258/3-1,No.SFB 824 TP Z02 and No.WA 1656/3-1(to AW)
主 题：Gastric cancer Therapy Response predic-tion Positr
摘 要：Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced ***,these new therapeutic strategies do not uniformly benefit all *** whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment *** imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant *** and validating tissue-based biomarkers are ongoing *** this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.
维普期刊数据库