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“危机”解除，数字广告引领乐观未来

国际品牌观察 2022年第4期 34-36页

作者： michaela Jefferson 骆佳

近几年以来，行业关于“投放广告的ROI越来越低”的言论不绝于耳，但新的数据显示，在过去的五年中，ROI一直在上升。计量经济学公司Magic Numbers的一份新报告显示，网络广告的发展是广告营销支出的投资回报率增长之背后驱动因素。在...

近几年以来，行业关于“投放广告的ROI越来越低”的言论不绝于耳，但新的数据显示，在过去的五年中，ROI一直在上升。计量经济学公司Magic Numbers的一份新报告显示，网络广告的发展是广告营销支出的投资回报率增长之背后驱动因素。在《神秘博士》《豪斯医生》或《24小时》这些周播剧集中，每一集都是一个小故事，但角色之间却串联起了整个情节。每周发生的事情形成了整体的起承转合：问题出现、结论推导和整个旅程。

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Dental and periodontal phenotype in sclerostin knockout mice

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International Journal of Oral Science 2014年第2期6卷 70-76页

作者： Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt michaela Kneissel Reinhard Gruber Department of Oral Surgery Medical University of Vienna Vienna Austria Austrian Cluster for Tissue Regeneration Vienna Austria Department of Oral Surgery and Stomatology School of Dental Medicine University of Berne Berne Switzerland Karl Donath Laboratory for Hard Tissue and Biomaterial Research University Clinic of Dentistry Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA Research Center Vienna Austria Robert K. Schenk Laboratory of Oral Histology School of Dental Medicine University of Berne Berne Switzerland Musculoskeletal Disease Area Novartis Institutes for BioMedical Research Basel Switzerland Laboratory of Oral Cell Biology School of Dental Medicine University of Berne Berne Switzerland

Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear. Here, we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography （μCT） imaging, μCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls, pCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice. No significant differences were observed for the tooth and pulp chamber volume. Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width. Taken together, these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin.

关键词： alveolar bone micro-computed tomography mouse periodontium sclerostin tooth

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广告,应以推动品牌长期增长为要义

国际品牌观察 2022年第8期 42-45页

作者： michaela Jafferson 骆佳(译) 不详

通过广告来拉近消费者与品牌的距离,建立亲近感,方能促进品牌获得长期业绩增长,这是System 1多年来的研究所揭示的结论,也是宝洁公司长期实践的结果,而创意作为推动品牌增长核心力量的地位再度被提及并被强化。

关键词：长期业绩宝洁公司亲近感核心力量品牌广告消费者研究所

Consumer Response to the Product Carbon Footprint （PCF）

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Journal of Physical Science and Application 2012年第4期2卷 95-102页

作者： michaela Schlich Home Economics and Nutritional Science University Koblenz-Landau Campus Koblenz 56070 Koblenz Germany

预退火处理对等通道转角挤压双辊铸轧AA3003铝合金显微组织演变的影响

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Transactions of Nonferrous Metals Society of China 2016年第3期26卷 627-633页

作者： michaela Slapákova POKOVA Mariia ZIMINA Miroslav CIESLAR Faculty of Mathematics and Physics Charles University in PragueKe Karlovu 5121 16 Prague 2Czech Republic

添加少量锆元素对双辊铸轧AA3003铝合金进行改性。在450℃对合金进行退火处理产生Al_3Zr析出相,同时出现富Mnα-Al(Mn,Fe)Si相。由等通道转角挤压引起的大塑性变形致使合金的晶粒细化且硬度增加。电子背散射衍射及透射电镜观察结果显示... 详细信息

添加少量锆元素对双辊铸轧AA3003铝合金进行改性。在450℃对合金进行退火处理产生Al_3Zr析出相,同时出现富Mnα-Al(Mn,Fe)Si相。由等通道转角挤压引起的大塑性变形致使合金的晶粒细化且硬度增加。电子背散射衍射及透射电镜观察结果显示在热处理变形后期预先退火处理对合金显微组织变化的影响。对于变形前未进行退火处理的合金,在450℃退火时,其位错回复和α-Al(Mn,Fe)Si相析出使再结晶提前发生。由于预变形退火使固溶体中Mn原子含量降低,因此,在变形过程中对合金进行预变形退火处理会使回复更容易发生。Al_3Zr析出相能促进再结晶过程的进行。

关键词：铝合金 Al_(3)Zr α-Al(Mn,Fe)Si 预退火回复再结晶组织演变

Is the schatzki ring a unique esophageal entity?

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World Journal of Gastroenterology 2011年第23期17卷 2838-2843页

作者： michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt Department of Gastroenterology German Clinic for Diagnostics Wiesbaden65191 WiesbadenGermany Department of General and Abdominal Surgery University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Medical Statistics Informatics and EpidemiologyUniversity of Cologne50924 CologneGermany Institute of Medical Biostatistics Epidemiology and InformaticsUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its ***:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and *** of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic *** and radiographic studies determined the presence of an SR and additional morphological ***:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were *** patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food *** experienced symptoms for a mean of 4.7±5.2 years before *** in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously *** presentation,the mean ring diameter was 13.9±4.97 *** hundred and sixty-two (97%) patients showed a sliding hiatal *** reflux esophagitis was found in 47 (28.1%) ***-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal *** (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility ***:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial *** typical symptoms,SRs might be overlooked.

关键词：食管实体临床症状平均年龄嗜酸性粒细胞 SRS 运动障碍非特异性

The effect of powder size on the mechanical and corrosion properties and the ignition temperature of WE43 alloy prepared by spark plasma sintering

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Journal of Magnesium and Alloys 2021年第4期9卷 1356-1369页

作者： Drahomír Dvorský JiríKubásek michaela Roudnická Filip Pruša David Necas Peter Minárik Jitka Stráská Dalibor Vojtech University of Chemistry and Technology Faculty of Chemical TechnologyDepartment of Metals and Corrosion EngineeringTechnická516628 Praha 6–DejvicePragueCzech Republic Institute of Physics Czech Academy of ScienceNa Slovance 1999/218221 Praha 8PragueCzech Republic Department of Physics of Materials Charles UniversityKe Karlovu 5Prague 12116Czech Republic

Powder metallurgy is a powerful method for the preparation of materials with superior *** work aimed to investigate the effect of powder size on the microstructure,mechanical,and corrosion properties of advanced WE43(Mg-4Y-3REE-Zr)alloy prepared by spark plasma sintering(SPS).At the same time,the effect of HF pre-treatment of the powder on the properties of final compacted products is *** powder particles yielded microstructure with more interfaces formed by Y_(2)O_(3),or MgF_(2) and YF_(3).These interfaces work as barriers against corrosion,which greatly improves corrosion *** suggested pre-treatment of powder in HF further reduced the corrosion rate of the compacted *** the contrary,fragile interfaces of YF_(3) decreased mechanical properties as the crack primarily propagates through these *** original powder containing the mixture of all powder fractions exerted the best combination of mechanical *** size has also shown to affect ignition *** highest ignition temperature was measured for the finest powder fraction.

关键词： Powder metallurgy Mechanical properties Corrosion Interface SPS

Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study

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World Journal of Gastroenterology 2017年第22期23卷 4102-4111页

作者： tomas koller martina galambosova simona filakovska michaela kubincova tibor hlavaty jozef toth anna krajcovicova juraj payer 5th Department of Internal Medicine Gastroenterology and Hepatology Comenius University in Bratislava Faculty of Medicine University Hospital Bratislava Ruzinov

AIM To analyze 1-year liver injury burden in inflammatory bowel disease(IBD) patients. METHODS During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase(AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase(GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal(ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > *** injury was reported when AT elevations were found on > 1 measurement. Risk factors for the patterns of liver injury were identified among demographic parameters, disease phenotype and IBD treatment in univariate and multivariate analysis. Finally, implications for the change in IBD management were evaluated in cases with persisting hepatocellular or cholestatic *** Two hundred and fifty-one patients were included having 917 ALT and 895 ALP and GGT measurements. Over one year, grade 1 injury was found in 66(26.3%), grade 2 in 5(2%) and hepatocellular injury in 16 patients(6.4%). Persisting hepatocellular injury was found in 4 cases. Cholestasis appeared in 11 cases(4.4%) and persisted throughout the entire study period in 1 case. In multivariate analysis, hepatocellular injury was associated with BMI(OR = 1.13, 1.02-1.26), liver steatosis(OR = 10.61, 2.22-50.7), IBD duration(1.07, 1.00-1.15) and solo infliximab(OR = 4.57, 1.33-15.7). Cholestatic liver injury was associated with prior intestinal resection(OR = 32.7, 3.18-335), higher CRP(OR = 1.04, 1.00-1.08) and solo azathioprine(OR = 10.27, 1.46-72.3). In one case with transient hepatocellular injury azathioprine dose was decreased. In 4 cases with persisting hepatocellular injury, fatty liver or alcohol were most likely causes

关键词：导致药的肝损害冒险因素煽动性的肠疾病 Infliximab Adalimumab Azathioprine

Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)

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International Journal of Oral Science 2015年第1期7卷 23-26页

作者： Andrew H Jheon michaela Prochazkova Michael Sherman Devanand S Manoli Nirao M Shah Lawrence Carbone Ophir Klein Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology University of California San Francisco (UCSF) Department of Anthropology and Human Genetics Faculty of Science Charles University in Prague Laboratory Animal Resource Center UCSF Department of Psychiatry UCSF Department of Anatomy UCSF

Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles （Microtus ochrogaster）. We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography （microCT） analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.

关键词： continuously growing teeth molar phenotype mutation stem cell regulation voles