Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)

作     者：Andrew H Jheon Michaela Prochazkova Michael Sherman Devanand S Manoli Nirao M Shah Lawrence Carbone Ophir Klein 

作者机构：Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology University of California San Francisco (UCSF) Department of Anthropology and Human Genetics Faculty of Science Charles University in Prague Laboratory Animal Resource Center UCSF Department of Psychiatry UCSF Department of Anatomy UCSF 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2015年第7卷第1期

页      面：23-26页

核心收录：

学科分类：1003[医学-口腔医学] 100301[医学-口腔基础医学] 10[医学] 

基　　金：funded by the National Institutes of Health through grants R00DE022059 to Andrew H Jheon DP2-OD007191 and R01-DE021420 to Ophir Klein National Alliance for Research on Schizophrenia and Depression (NARSAD) grant to Devanand S Manoli DP1MH099900 to Nirao M Shah supported by the Department of Health and Human Services/NIH S10 Shared Instrumentation Grant (S10RR026645) the Departments of Preventive and Restorative Dental Sciences and Orofacial Sciences, School of Dentistry, UCSF 

主　　题：continuously growing teeth molar phenotype mutation stem cell regulation voles 

摘      要：Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles （Microtus ochrogaster）. We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography （microCT） analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.