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Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds

science China Chemistry 2010年第5期53卷 1010-1016页

作者： BAsTON David s. KHAN Elaine sORRENTINO Claudio DENIsON michael s. Laboratorium voor Analytische en Milieu Chemie Vrije Universiteit Brussel Pesticide Epidemiology section Pesticide and Environmental Toxicology BranchOffice of Environmental Health Hazard Assessment Human and Ecological Risk Office Brownfields and Environmental Restoration ProgramDepartment of Toxic Substances Control Department of Environmental Toxicology University of California

Reporter genes produce a protein product in transfected cells that can be easily measured in intact or lysed cells and they have been extensively used in numerous basic and applied research *** the past 10 years,reporter gene assays have been widely accepted and used for analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like compounds in various types of matrices,such as biological,environmental,food and feed samples,given that high-resolution instrumental analysis techniques are impractical for large-scale screening *** most sensitive cell-based reporter gene bioassay systems developed are the mechanism-based CALUX(Chemically Activated Luciferase Expression) and CAFLUX(Chemically Activated Fluorescent Expression) bioassays,which utilize recombinant cell lines containing stably transfected dioxin(AhR) responsive firefly luciferase or enhanced green fluorescent protein(EGFP) reporter genes,*** the current CALUX and CAFLUX bioassays are very sensitive,increasing their lower limit of sensitivity,magnitude of response and dynamic range for chemical detection would significantly increase their utility,particularly for those samples that contain low levels of dioxin-like HAHs(i.e.,serum) .In this study,we report that the addition of modulators of cell signaling pathways or modification of cell culture conditions results in significant improvement in the magnitude and overall responsiveness of the existing CALUX and CAFLUX cell bioassays.

关键词： dioxin reporter gene bioassay CALUX CAFLUX

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semiconducting Carbon Nanotube/Fullerene Blended Heterojunctions for Photovoltaic Near-Infrared Photon Harvesting

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Nano Research 2011年第11期4卷 1174-1179页

作者： Dominick J. Bindl Adam s. Brewer michael s. Arnold 1509 University Ave. Materials Science and Engineering Dept. University of Wisconsin-Madison Madison WI 53706 USA

We demonstrate that the near-infrared （NIR） absorptivity of semiconducfing single-walled carbon nanotubes （s-sWCNTs） can be harnessed in blended heterojunctions with the fullerene derivative [6,6]-phenyl-C61-butyric acid methyl ester （PCBM）. Photogenerated charge separation is efficiently driven by the ultrahigh interracial area of the blends and the favorable energy offsets between the two materials. NIR-sensitive photovoltaic and photodetector devices utilizing the stack （indium tin oxide/ca. 10 nm s-sWCNT：PCBM/100 nm CJ10 nm 2,9- dimethyl-4,7-diphenyl-],10-phenanthroline （BCP）/Ag） were fabricated with NIR power conversion efficiencies 〉1.3% and peak, zero bias external quantum efficiency of 18% at λ = 1205 nm.

关键词： Carbon nanotube bulk heterojunction photovoltaic photodetector near-infrared (NIR)

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Factorizations that Involve Ramanujan＇s Function k（q） = r（q）r2（q2）

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Acta Mathematica sinica,English series 2011年第12期27卷 2301-2308页

作者： shaun COOPER michael D. HIRsCHHORN Institute of Information and Mathematical sciences Massey University-Albany Private Bag 102904North Shore Mail Centre Auckland New Zealand school of Mathematics and statistics UNSW Sydney NSW 2（}52 Australia

In the ＂lost notebook＂, Ramanujan recorded infinite product expansions for where r -= r（q） is the Rogers-Ramanujan continued fraction. We shall give analogues of these results that involve Ramanujan＇s function k ... 详细信息

关键词： Infinite product Rogers-Ramanujan continued fraction Jacobi triple product identity

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Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens

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World Journal of Gastroenterology 2018年第48期24卷 5418-5432页

作者： sandra Wagner Christina s Mullins michael Linnebacher section of Molecular Oncology and Immunotherapy General SurgeryUniversity Medical Center

Therapeutic options for the treatment of colorectal cancer(CRC) are diverse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. substantial improvement in treatment outcome could be achieved by development of efficient patient-individual CRC vaccination strategies. This mini-review summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a variety of clinical studies examined the efficacy of different TAA-derived peptide vaccines. Combinations of several TAAs as the next step and the development of personalized TAA-based peptide vaccines are discussed. Improvements of peptidebased vaccines achievable by adjuvants and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusively neoantigens-which revealed promising results; particularly no severe adverse events were reported so far. Critical progress for clinical outcomes can be expected by individualizing neoantigen-based peptide vaccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest developments, truly personalized neoantigen-based peptide vaccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC.

关键词： Cancer vaccines Colorectal neoplasm Immunotherapy Neoplasm antigen tumor-associated antigens tumor-specific antigens Neoantigen(s)

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Empirical analysis for the characterization of geo-mechanical strength and pressure regime:Implications on hydraulic fracturing stimulation

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Petroleum 2019年第3期5卷 260-270页

作者： Dorcas s.Eyinla michael A.Oladunjoye Department of Earth sciences Adekunle Ajasin UniversityNigeria Department of Geology University of IbadanNigeria

Among the several activities involved in oil exploration are the determination of hydrocarbon in-place and mechanical competency of the oil *** pressure regimes of the formation have also become vital properties which must be well known to ensure preliminary awareness of the hydraulic *** study seeks to adopt a prediction strategy of the overall geo-mechanical competency and strength of the formation,using a less stressful computational process and an empirical analysis,developed using three wells from ED BON area in parts of Niger *** constants such as Poisson Ratio,Young's,shear and Bulk moduli which are the parameters for characterizing rock mechanical properties were estimated,as well as the subsurface formation pressures and the associated fracture gradient using P-wave sonic and density *** results from the analysis showed that there is correlation between elastic strength and fracture pressure.

关键词： Elastic strength Hydraulic fracturing Competency Prediction strategy Geomechanical parameters

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C:N:P stoichiometry and nutrient limitation of the soil microbial biomass in a grazed grassland site under experimental P limitation or exces

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Ecological Processes 2012年第1期1卷 66-76页

作者： Bryan s Griffiths Annette spilles michael Bonkowski Teagasc Environment Research CentreJohnstown CastleWexfordCoWexfordIreland Current address:sAC King's BuildingsWest Mains RoadEdinburgh EH93JGUK Mathematisch Naturwissenschaftliche Fakultät der Universität zu Köln Zoologisches Institut Abt.TerrestrischeÖkologieBiowissenschaftliches ZentrumOtto-Fischer-Str.6D-50674KölnGermany

Introduction:The availability of essential nutrients,such as nitrogen(N)and phosphorus(P),can feedback on soil carbon(C)and the soil microbial *** cycles can be supplemented by agricultural fertiliser addition,and we determined whether the stoichiometry and nutrient limitation of the microbial biomass could be affected by an unbalanced nutrient ***:samples were taken from a long-term trial(in effect since 1968)with annual applications of 0,15 and 30 kg P ha^(−1) with constant N and *** and microbial biomass CNP contents were measured and nutrient limitation assessed by substrate-induced *** regression and discriminant analyses were used to identify the variables explaining nutrient ***:soil and biomass CNP increased with increasing P fertiliser,and there was a significant,positive,correlation between microbial biomass P and biomass C,apart from at the highest level of P fertilisation when the microbial biomass was over-saturated with *** molar ratios of C:N:P in the microbial biomass remained constant(homeostatic)despite large changes in the soil nutrient *** growth was generally limited by C and N,except in soil with no added P when C and P were the main limiting nutrients.C,N and P,however,did not explain all the growth limitation on the soils with no added ***:Increased soil C and N were probably due to increased net primary *** results confirm that C:N:P ratios within the microbial biomass were constrained(***)under near optimum soil *** with no added P were characterised by strong microbial P limitation and soils under high P by over-saturation of microorganisms with *** changes in biomass C:P can be indicative of nutrient limitation within a site.

关键词： Carbon Nitrogen Nutrient limitation Phosphorus soil microbial biomass stoichiometry

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s Y Yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNs Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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sEMILINEAR HEMIVARIATIONAL INEQUALITIEs WITH sTRONG REsONANCE AT INFINITY

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Acta Mathematica scientia 2006年第1期26卷 59-73页

作者： michael Filippakis Leszek Gasi■ski Nikolaos s.Papageorgiou Department of Mathematics National Technical University Zografou CampusAthens 15780Greece Institute of Computer science Jagiellonian University ul.Nawojki 1130072 CracowPoland

A semilinear elliptic equation with strong resonance at infinity and with a nonsmooth potential is studied. Using nonsmooth critical point theory and developing some abstract minimax principles which complement and ex... 详细信息

关键词： strong resonance hemivariational inequality Laplacian principal eigenvalue locally Lipschitz function Clarke subdifferential nonsmooth criticalpoint theory

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Flavonoids:New Roles for Old Molecules

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Journal of Integrative Plant Biology 2010年第1期52卷 98-111页

作者： Charles s. Buer Nijat Imin michael A. Djordjevic Genomic Interactions Group ARC Centre of Excellence for Integrative Legume Research Research School of Biology College of Medicine Biology and Environment The Australian National University

Flavonoids are ubiquitous in the plant kingdom and have many diverse functions including defense, UV protection, auxin transport inhibition, allelopathy, and flower coloring. Interestingly, these compounds also have considerable biological activity in plant, animal and bacterial systems - such broad activity is accomplished by few compounds. Yet, for all the research over the last three decades, many of the cellular targets of these secondary metabolites are unknown. The many mutants available in model plant species such as Arabidopsis thaliana and Medicago truncatula are enabling the intricacies of the physiology of these compounds to be deduced. In the present review, we cover recent advances in flavonoid research, discuss deficiencies in our understanding of the physiological processes, and suggest approaches to identify the cellular targets of flavonoids.

关键词： Flavonoids DPBA Figure TTG root

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Consumption of rice and fish in an electronic waste recycling area contributes significantly to total daily intake of mercury

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Journal of Environmental sciences 2015年第12期27卷 83-86页

作者： Hanyong Peng michael s.Reid X.Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of Alberta

Mercury is a global pollutant due to its widespread use,emission,and long-range transport（Blum,2013;Pacyna et al.,2010）.It is considered a priority pollutant due to its neurological toxicity,persistence,and bioaccumulation（Pacyna et al.,2010;sharma et al.,2015）.Mercury pollution can occur when products that contain mercury are improperly disposed of and mercury is released into the air,water,and soil（Zhang and Wong,2007）.An estimated 22%of the annual world usage of mercury is in electrical equipment such as batteries,thermometers,and discharge lamps,and electronic devices such as monitors and

关键词： Mercury Methyl mercury Electronic waste Biomonitoring Dietary intake Human exposure assessment Environmental health

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