检索结果-南通市图书馆

Neuroscience & Medicine 2010年第1期1卷 1-13页

作者： Angel Alvarez Monowar Hossain Elise Dantuma Stephanie merchant Kiminobu Sugaya 不详

Although stem cell therapies have been proposed as a candidate for treating neurological diseases, the best stem cell source and their therapeutic efficacy remain uncertain. Embryonic stem cells (ESCs) can efficiently generate multiple cell types, but pose ethical and clinical challenges, while the more accessible adult stem cells have a limited develop-mental potential. Following included-expression of Nanog, an ESC gene, adult human mesenchymal stem cells (HMSCs) are able to develop into cells exhibiting neural cell-like characteristics based on morphology, cell markers, and gene expressions. After expansion, Nanog overexpressed HMSCs differentiated into cells immunopositive for betaIII-tubulin and glial fibrillary acidic protein, lineage markers for neurons and astrocytes, respectively, under the influence of con-ditional media from differentiated human neural stem cells. This result indicates that the Nanog expression increased the ability of HMSCs to become a neural cell lineage. We further demonstrated that Nanog-overexpressed HMSCs were able to survive, migrate, and undergo neural cell-like differentiation after transplantation in vivo. This data offers an exciting prospect that peripheral adult stem cells can be modified and used to treat neurological diseases.

关键词： Stem Cells Dedifferentiation Transplantation Nanog

The Influence of Gratering, Fermentation and Variety on the Physio-Chemical Quality of Cassava Starch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2024年第10期15卷 1004-1015页

作者： Sallu Karteh Georgiana Allie Joseph Sherman Kamara Amis Cecelia merchant Nah Department of Agricultural and Bio-Systems Engineering Njala University Freetown Sierra Leone Central Agricultural Research Institute (CARI) Monrovia Liberia

The study was conducted to determine the influence of gratering and fermentation parameters on the physicochemical quality of starch obtained from two cassava varieties in Sierra Leone (i.e., SLICASS 11 and SLICASS 6). Fresh cassava roots harvested from the Department of Agricultural Engineering were peeled, washed and grated before fermentation and starch extraction. Fermentation was carried out under separate aerobic and anaerobic conditions for a period of Seven days. Physicochemical analyses were conducted at the Postharvest Food and Bioprocess Engineering Laboratory of the Department of Agricultural and Bio-System Engineering, Njala University to determine the solubility, water absorption capacity and swelling power of starch extracts obtained from various experimental treatments. Fermentation method and duration had significant effects on the solubility, water absorption capacity (WAC) and swelling power (SP) of starch extracts. Maximum solubility and WAC were recorded on the fifth day, for both cassava varieties tested, with apparent significant difference resulting from the two gratering bands (i.e., with 1.5-inch nail hole and 4-inch nail hole sizes, respectively). While swelling power increased consistently with temperature for starch obtained from SLICASS-11 variety, an irregular pattern was observed for SLICASS-6 variety. A multiple correlation analysis proposes a significant and weak correlation between temperature, WAC (+0.150) and swelling power (+0.048). Also multiple correlation analyses suggest a significant correlation between fermentation period, the functional properties of starch extracts obtained from both fermentation methods and cassava varieties (i.e., solubility (−0.226), water absorption capacity (+0.301) and swelling power (+0.329)).

关键词： Fermentation Gratering Band Cassava Variety Solubility Swelling Power and Water Absorption Capacity

A pilot study of radiologic measures of abdominal adiposity:weighty contributors to early pancreatic carcinogenesis worth evaluating?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2017年第1期14卷 66-73页

作者： Jennifer B.Permuth Jung W.Choi Dung-Tsa Chen Kun Jiang Gina DeNicola Jian-Nong Li Domenico Coppola Barbara A.Centeno Anthony Magliocco Yoganand Balagurunathan Nipun merchant Jose G.Trevino Daniel Jeong Departments of Cancer Epidemiology Gastrointestinal Oncology Diagnostic Imaging and Interventional Radiology Biostatistics and Bioinformatics Anatomic Pathology Cancer Imaging and Metabolism Moffitt Cancer Center and Research InstituteTamPa 33612FLUSA Department of Surgery Sylvester Comprehensive Cancer Center at the University of Miami Miller School of MedicineMiami 33136FLUSA Department of Surgery Division of General SurgeryUniversity of Florida Health Sciences CenterGainesville 32611FLUSA

Objective:Intra-abdominal fat is a risk factor for pancreatic cancer(PC),but little is known about its contribution to PC precursors known as intraductal papillary mucinous neoplasms(IPMNs).Our goal was to evaluate quantitative radiologic measures of abdominal/visceral obesity as possible diagnostic markers of IPMN severity/***:In a cohort of 34 surgically-resected,pathologically-confirmed IPMNs(17 benign;17 malignant) with preoperative abdominal computed tomography(CT) images,we calculated body mass index(BMI) and four radiologic measures of obesity:total abdominal fat(TAF) area,visceral fat area(VFA),subcutaneous fat area(SFA),and visceral to subcutaneous fat ratio(V/S).Measures were compared between groups using Wilcoxon two-sample exact tests and other ***:Mean BMI for individuals with malignant IPMNs(28.9 kg/m^2) was higher than mean BMI for those with benign IPMNs(25.8 kg/m^2)(P=0.045).Mean VFA was higher for patients with malignant IPMNs(199.3 cm^2) compared to benign IPMNs(120.4cm^2),P=0.092.V/S was significantly higher(P=0.013) for patients with malignant versus benign IPMNs(1.25 vs.0.69 cm^2),especially among *** accuracy,sensitivity,specificity,and positive and negative predictive value of V/S in predicting malignant IPMN pathology were 74%,71%,76%,75%,and 72%,***:Preliminary findings suggest measures of visceral fat from routine medical images may help predict IPMN pathology,acting as potential noninvasive diagnostic adjuncts for management and targets for intervention that may be more biologically-relevant than *** investigation of gender-specific associations in larger,prospective IPMN cohorts is warranted to validate and expand upon these observations.

关键词： Abdominal obesity pre-malignant lesions pancreatic cancer computed tomography

维普期刊数据库

高电压负输出充电泵可产生低噪声的正和负电源设计要点507

在线全文

学校读者我要写书评

暂无评论

电子设计技术 2012年第11期 49-50页

作者： Marty merchant

引言诸如运算放大器、驱动器或传感器等电子组件的运作通常需要双极性电源,但是在负载点却很少有一个可用的双极性电源。LTC3260是一款具有两个低噪声LDO稳压器的负输出充电泵(无电感器)DC/DC转换器,可利用单个宽输入(4.5V至32V)电源产... 详细信息

引言诸如运算放大器、驱动器或传感器等电子组件的运作通常需要双极性电源,但是在负载点却很少有一个可用的双极性电源。LTC3260是一款具有两个低噪声LDO稳压器的负输出充电泵(无电感器)DC/DC转换器,可利用单个宽输入(4.5V至32V)电源产生正和负电源。该器件能够在高效率的突发模式(Burst Mode)操作与低噪声的恒定频率模式之间切换,从而使其同时受到便携式应用和噪声敏感型应用所欢

关键词：充电泵恒定频率正和负电源低噪声

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

别把员工当螺丝钉

现代企业文化(上旬) 2013年第10期 68-69页

作者： Nilofer merchant

每天我去参加会议,总有人在言谈中有意无意流露出"员工就是螺丝钉"的想法。在几次CEO圆桌会议上,我听到有的同行这样说:"我打算招3个业务员,使人均创造的年收入达到34.5万美元。"我曾写过一本书,建议公司关注"人"的因素,以此弥合执行差... 详细信息

每天我去参加会议,总有人在言谈中有意无意流露出"员工就是螺丝钉"的想法。在几次CEO圆桌会议上,我听到有的同行这样说:"我打算招3个业务员,使人均创造的年收入达到34.5万美元。"我曾写过一本书,建议公司关注"人"的因素,以此弥合执行差距。该书出版后,几家大型公司的CEO(友好地)把我拉到一旁,说我此举过于冒失,会让人以为我脑子出毛病了。尽管《哈佛商业评论》等媒体就"软性"因素的重要性刊登过无数的学术论文和最佳实践,但大多数公司仍将员工视为生产线上的投入要素。曾经有领导人问我,这种"员工参与"是否可以在核心业务完成之后再添加进去,就像在纸杯蛋糕上加糖霜一样。

关键词：螺丝钉纸杯蛋糕

Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2024年第2期13卷 325-328页

作者： Mary P.Martos Haleh Amirian Erin M.Dickey Edmond W.Box Nipun B.merchant Peter J.Hosein Caitlin A.Hester Jashodeep Datta Department of Surgery University of Miami Miller School of MedicineMiamiFLUSA Sylvester Comprehensive Cancer Center MiamiFLUSA Department of Medicine University of Miami Miller School of MedicineMiamiFLUSA

Pancreatic ductal adenocarcinoma(PDAC)is a devastating malignancy,owing in part to the fact that most patients present with advanced disease with only 20%eligible for surgical ***,the dismal oncologic outcomes achieved with surgery alone,coupled with the almost ubiquitous distant recurrence in operable PDAC patients,have mandated a multimodal approach for this *** advent of effective combination chemotherapy regimens delivered increasingly in the perioperative setting,safety and technical mastery of pancreatectomy,and growing appreciation of the molecular underpinnings in PDAC have resulted in gradual but consistent improvements in disease-specific survival and overall survival(OS)in patients with localized PDAC(1).

关键词： Pancreatic adenocarcinoma pancreatic cancer prognostic model preoperative factors patient stratification

通用型工业电源可采用高电压输入并产生从8个1A到2个4A的输出-设计要点520

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电子产品世界 2013年第12期 46-47页

作者： Martin merchant

引言当今的工业电子系统包含了许多与消费电子产品相同的组件,如微控制器、FPGA、片上系统ASIC及其他电子器件,因而在众多不同的负载电流条件下需要多个低电压轨。另外,工业应用还需要一个按钮接口、一个始终保持接通的电源以用于实时... 详细信息

引言当今的工业电子系统包含了许多与消费电子产品相同的组件,如微控制器、FPGA、片上系统ASIC及其他电子器件,因而在众多不同的负载电流条件下需要多个低电压轨。另外,工业应用还需要一个按钮接口、一个始终保持接通的电源以用于实时时钟（RTC）或存储器、以及从一个高电压电源获得输入功率的能力。其他所需的特性可能包括一个看门狗定时器（WDT）、一个总停或复位按钮、软件可调的电压电平、以及低输入/输出电压和高芯片温度的错误报告功能。LTC;3375是一款高度可配置的多输出降压型电源转换器,其拥有工业电子设备通常所需的特性,并可灵活地配置最大电流范围为1A至4A的各种输出。

关键词：按钮配置电子轻子电源电压

Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2010年第5期1卷 154-165页

作者： Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L merchant Departments of Internal Medicine-Gastroenterology University of Michigan Department of Molecular and Cellular Physiology University of Cincinnati Department of Surgery Austin and Repatriation Medical CenterUniversity of Melbourne Departments of Internal Medicine and Molecular and Integrative Physiology University of Michigan

AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in ***:Helicobacter felis(***)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 *** treatment,mice were analyzed for morphological changes and gastric acid *** RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of *** ***, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented ***-induced inflammation and *** to the uninfected controls,infected mice also had significantly decreased gastric *** eradication of *** with THIO treatment,gastric acidity was *** to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during *** elevated gastric acid levels, after eradication of *** with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was *** revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during *** infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R *** stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin.

关键词： Gastrin Somatostatin Histamine Parietal cell Helicobacter felis Nα-methylhistamine Rα-methylhistamine Thioperamide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

战胜备用电源的认证前测试挑战

今日电子 2017年第1期 70-71页

作者： Varun merchant 泰克公司

注意到蠕变备用电源的问题后,全球各地监管机构已开始公开发布标准,对家用电器的备用电源限制提出了明确规定全球各地监管机构已注意到壁插座式电子产品的蠕变备用电源存在问题。国际电工委员会（IEC）等委员会已采取积极措施发布标准,... 详细信息

注意到蠕变备用电源的问题后,全球各地监管机构已开始公开发布标准,对家用电器的备用电源限制提出了明确规定全球各地监管机构已注意到壁插座式电子产品的蠕变备用电源存在问题。国际电工委员会（IEC）等委员会已采取积极措施发布标准,如IEC62301,用以规定家用电器的备用电源界限。类似的标准或其衍生标准已在全球多个地区得以实施。

关键词：备用电源国际电工委员会测试认证监管机构家用电器电子产品标准

维普期刊数据库

Mediation effect of type-2 diabetes in the association between dietary inflammatory potential and pancreatic cancer risk: a pooled analysis of the PLCO Cancer Screening Trial and NIH-AARP Diet and Health Study

在线全文

学校读者我要写书评

暂无评论

Mediation effect of type-2 diabetes in the association betwe...