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Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer

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World Journal of Gastroenterology 2020年第6期26卷 598-613页

作者： Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande duane T Smoot Hassan Ashktorab Sanjay Gupta Epigenetics and Chromatin Biology Group Gupta LaboratoryCancer Research InstituteAdvanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Homi Bhabha National Institute Training School ComplexAnushakti NagarMumbaiMaharashtra 400085India Department of Developmental Biology School of MedicineWashington University in St.LouisSaint LouisMO 63130United States Animal House Facility Cancer Research InstituteAdvanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Biorepository Lab Advanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Gastrointestinal and Hepato-Pancreato-Biliary Service Department of Surgical OncologyTata Memorial HospitalParelMumbai 400012India Department of Medicine Meharry Medical CenterNashvilleTN 37208United States Department of Medicine and Cancer Center College of MedicineHoward UniversityWashington DCWA 20060United States

BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic ***,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective *** study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug *** The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and *** potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell *** In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric *** data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle ***-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell *** Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient ***,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis.

关键词： Chemotherapy Combinatorial index Gastric cancer Histone acetylation Histone deacetylase inhibitor Patient stratification

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Phosphorus availability in two soils amended with poultry litter

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Journal of Environmental Sciences 1996年第4期8卷 483-490页

作者： Han Xingguo (Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China)duane C.Wolf (Department of Agronomy,University of Arkansas,Fayetteville, AR 72701,USA) Institute of Botany Chinese Academy of Sciences Beijing 100093 China Department of Agronomy University of Arkansas Fayetteville AR 72701 United States

Understanding P transformation in soils amended with poultry litter is important if water quality is to be *** objectives were to determine the influence of method of litter application and temperature on P availability. Poultry litter containing 20. 8g P/kg (dry weight) was either surface-applied or incorporated into Captina (fine-silty, siliceous, mesic Typic Fragiudult) and Nixa (loamy-skeletal,siliceous,Glossic Fragiudult) silt loams at rates of 0 or 10g/kg and incubated at 20℃ or 35℃ at a water potential of -40 kpa. Water soluble and available P (0.03 mol/L NH4F+0. 025mol/L HCl extraction) were determined during a 60d laboratory study. Results indicated that water soluble and available P levels in the soils initially decreased, then rapidly increased,and approached a steady state phase after approximately 20d. After 60d, water soluble P levels were significantly higher when litter was surface applied than when litter was incor porated. When the incubation was terminated, the net increase in available P in both soils was>100 mg P/*** efficient recycling of P and protection of water quality, application method and temperature should be considered when amending soils with poultry litter,

关键词： nutrient cycling phosphorus availability poultry litter water quality.

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Factors Affecting Energy Efficiency Investments—A Case Study of Bhutan

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Journal of Electrical Engineering 2019年第2期7卷 54-60页

作者： Roshan Chhetri Young-Ho LEE duane Robinson Sumitra Pokhrel Department of Electrical Engineering College of Science and TechnologyRoyal University of BhutanPhuentsholingP.O.Box 450Bhutan Division of Mechanical Engineering Korea Maritime and Ocean UniversityBusan 606 791South Korea Sustainable Building Research Centre University of Wollongong NSW 2522Australia Phuentsholing Higher Secondary School PhuentsholingBhutan

Energy efficiency is providing the same services consuming less *** energy means less energy bill and less greenhouse *** presents a unique scenario in promoting the use of energy efficiency equipment and *** enjoys availability of adequate low cost hydropower energy resource that is green and clean and enjoys cheap electrical *** aggravate the situation,the domestic tariffs are subsidized and even free up to 100 units in rural parts of the *** tariffs are determined independently according to entirely different *** for cooking,Bhutan imports LPG(Liquefied Petroleum Gas)from *** increasing threats of climate change,it is reported water flow in rivers is *** energy security and related socio environmental issues,prospects of energy supply constraints and increasing demand of quality power in the country,there is a need to take appropriate policy measures which would lead to the development of indigenous,local and dispersed clean energy sources in the *** a customer is asked to retrofit the house with energy efficiency,the owner questions oneself if the available investment resources are being directed to an effective *** criteria are available but all can not to be considered to come to a final *** paper presents an overview of many factors which affect energy efficiency investment in building in Bhutan.

关键词： Energy efficiency policies retrofits incentives

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3ds max 4创意工作室

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丛书名： “图形图像百宝箱”丛书

2002年

作者：（美）duane Loose 毕建明杜昱等译

作者从一位工业设计师、艺术指导、动画师、设计导师的角度出发，向3ds max 4初、中级用户介绍了数字作品创作的原理和过程，以及该软件的基本工具和使用技巧。

ISBN: (数字)750537401X

ISBN: (纸本)750537401X

关键词：三维计算机图形学动画

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Mathematical reasoning for elementary teachers / Calvin Long, duane DeTemple. 2nd ed.

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2000年

作者： Calvin Long duane DeTemple.

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Organizational Paradigms:An Examination of Open,Natural and Rational Systems for Crisis Response

Organizational Paradigms:An Examination of Open,Natural and ...

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第三届风险分析与危机反应国际学术研讨会

作者： duane ‘Mike’ Smith,D.M. Principal Sextant Strategic Consulting LLC

Three predominant paradigms describe the organizational structure of most organizations;rational, natural and open. This paper examines each of these paradigms, exploring their main characteristics and most recognized forms of application. The review further provides an overview of how these systems compare and contrast to each other, with examples of organizations that utilize these different organizational systems. In this ever increasingly complex world of crisis response, it is reasonable to expect that complex organizations will need to be created. The paper seeks to provide an insight into the complexity of identifying one system as being the singular answer to what can be defined as the best organization to respond to crisis events.

关键词： crisis, organizational change, crisis response, organizational structure crisis management change management, organizational effectiveness

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Multifunctional facets of retrovirus integrase

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World Journal of Biological Chemistry 2015年第3期6卷 83-94页

作者： duane P Grandgenett Krishan K Pandey Sibes Bera Hideki Aihara Institute for Molecular Virology Saint Louis University Health Sciences Center Department of Biochemistry Molecular Biology and Biophysics University of Minnesota

The retrovirus integrase(IN) is responsible for integration of the reverse transcribed linear c DNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends. IN utilizes the 3' OH ends to catalyze the concerted integration of the two ends into opposite strands of the cellular DNA producing 4 to 6 bp staggered insertions, depending on the retrovirus species. The staggered ends are repaired by host cell machinery that results in a permanent copy of the viral DNA in the cellular genome. Besides integration, IN performs other functions in the replication cycle of several studied retroviruses. The proper organization of IN within the viral internal core is essential for the correct maturation of the virus. IN plays a major role in reverse transcription by interacting directly with the reverse transcriptase and by binding to the viral capsid protein and a cellular protein. Recruitment of several other host proteins into the viral particle are also promoted by IN. IN assists with the nuclear transport of the preintegration complex across the nuclear membrane. With several retroviruses, IN specifically interacts with different host protein factors that guide the preintegration complex to preferentially integrate the viral genome into specific regions of the host chromosomal target. Human gene therapy using retrovirus vectors is directly affected by the interactions of IN with these host factors. Inhibitors directed against the human immunodeficiency virus(HIV) IN bind within the active site of IN containing viral DNA ends thus preventing integration and subsequent HIV/AIDS.

关键词： Retrovirus integrase Integration Host factors Atomic structure Human immunodeficiency virus integrase inhibitors

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A Ca^(2+) cycling defect connects insulin resistance and heart failure

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Life Metabolism 2022年第1期1卷 2-3页

作者： Qian Shi duane D.Hall Long-Sheng Song Division of Cardiovascular Medicine Department of Internal MedicineAbboud Cardiovascular Research CenterCarver College of MedicineUniversity of IowaIowa CityIA 52242USA

In a recent study published in Life Metabolism,Quan et *** that intracellular Ca^(2+)dysregulation in cardiomyocyte can be both a cause and an effect of cardiac insulin resistance that ultimately leads to diabetic *** epidemiologic studies across several decades indicate that insulin-resistant states such as diabetes and obesity are risk factors for congestive heart failure independent of common cardiovascular disease factors such as hypertension and coronary artery diseases[1,2].On the other hand,there is evidence that heart failure itself causes the onset and development of insulin resistance[3].Restoring normal cardiac output in advanced heart failure patients with left ventricular assistance devices improves insulin sensitivity and cardiac metabolism[4].

关键词： metabolism cardiac al.

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减少N型(100)硅片表面堆垛层错的工艺分析

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微电子学 1987年第5期 69-73+68页

作者： P.W.koob 宋湘云孟山多电子材料公司

用化学腐蚀法、光学显微技术、透射电子显微技术(TEM)和能量分散X线(EDX)分析方法,研究了在1100℃水汽氧化后在N型(100)硅片上发现的表面堆垛层错。认为氧化时在反应炉中存在的金属杂质(特别是Cu和Ni)是产生这些堆垛层错的主要来源。结... 详细信息

用化学腐蚀法、光学显微技术、透射电子显微技术(TEM)和能量分散X线(EDX)分析方法,研究了在1100℃水汽氧化后在N型(100)硅片上发现的表面堆垛层错。认为氧化时在反应炉中存在的金属杂质(特别是Cu和Ni)是产生这些堆垛层错的主要来源。结果表明,在N型(100)硅片上有金属杂质时,通常形成堆垛层错而不形成S-坑的原因是这种硅片表面更容易被金属污染。观察结果表明,对金属敏感性的增强(和其它类型和晶向的硅片相比)可能是:(i)本征吸除得到更少的体缺陷和(ii)表面定向特性所致。反应炉的清洗和背面吸除处理能够减少N型(100)硅表面的堆垛层错密度。

关键词：硅片层错密度金属杂质本征吸除堆垛层错层错面缺陷 TEM 反应炉反应设备

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Prebles' artforms : 9th ed.

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2009年

作者： Frank Patrick Preble duane.

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