A Ca^(2+) cycling defect connects insulin resistance and heart failure

作     者：Qian Shi Duane D.Hall Long-Sheng Song 

作者机构：Division of Cardiovascular MedicineDepartment of Internal MedicineAbboud Cardiovascular Research CenterCarver College of MedicineUniversity of IowaIowa CityIA 52242USA 

出 版 物：《Life Metabolism》 (生命（代谢（英文）)

年 卷 期：2022年第1卷第1期

页      面：2-3页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：metabolism cardiac al. 

摘      要：In a recent study published in Life Metabolism,Quan et *** that intracellular Ca^(2+)dysregulation in cardiomyocyte can be both a cause and an effect of cardiac insulin resistance that ultimately leads to diabetic *** epidemiologic studies across several decades indicate that insulin-resistant states such as diabetes and obesity are risk factors for congestive heart failure independent of common cardiovascular disease factors such as hypertension and coronary artery diseases[1,2].On the other hand,there is evidence that heart failure itself causes the onset and development of insulin resistance[3].Restoring normal cardiac output in advanced heart failure patients with left ventricular assistance devices improves insulin sensitivity and cardiac metabolism[4].