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Towards understanding the ecology and mechanisms of biocontrol of Clonostachys rosea IK726

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 397-397页

作者： mette lübeck Inge M B Knudsen Birgit Jensen Mojtaba Mamarabadi Dan Funck Jensen Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. DenmarkDepartment of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark

Clonostachys rosea (syn. Gliocladium roseum) IK726 was originally selected as an effective biocontrol agent (BCA) against cereal seed borne diseases caused by Fusarium culmorum and Bipolaris sorokiniana. We have studied the efficacy of the antagonist against different pathogens in several crops and found that the antagonist also is able to control Alternaria radicina and A. dauci on carrot seeds and different cold-storage fungi in acorns. IK726 is also able to reduce severity of soil borne Pythium spp. in cabbage, carrot and sugar beet. In addition, growth-promoting effects of IK726 have been demonstrated in barley and tomato. In order to develop and improve application methods and control strategies, essential basic studies of ecology and the mechanisms of control of IK726 is needed and has led us to use various molecular tools. The UP-PCR technology is used for strain recognition and we have developed GUS and GFP-transformants that resembles the wildtype strain in ecological fitness parameters. Using either the GUS-transformant or UP-PCR we have found that IK726, when applied with seeds, reproduces and survives several months in the rhizosphere of field grown barley and carrot. The GFP-transformant is used to study the behavior and in situ interactions of the antagonist with pathogens and plants. Using the GFP marker, we have observed conidial germination, colonization and conidiogenesis in natural soil, in vermiculite and on carrot and barley seed and roots and on barley leaves. Moreover in situ interactions with Alternaria on carrot material have been studied. The modes of action of C. rosea are not well understood but enzymatic activity, mycoparasitism, substrate competition, antibiosis and induced resistance are thought to play a role. Barley treated with C. rosea IK726 has an enhanced chitinolytic and glucanolytic activity compared to the activity in non-treated barley in pot experiments with field soil. Identification of chitinases from IK726 and studies of

关键词：生态学机制生物控制 GUS GFP 几丁质酶镰刀霉病害

Towards understanding the ecology and mechanisms of biocontrol of Clonostachys rosea IK726

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浙江大学学报(农业与生命科学版) 2004年第4期 47-47页

作者： mette lübeck,Inge M B Knudsen,Birgit Jensen,Mojtaba Mamarabadi,Dan Funck Jensen Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark Department of Plant Biology Plant Pathology Section The Royal Veterinary and Agricultural University Thorvaldsensvej 40 DK-1871 Frederiksberg C. Denmark

关键词： Gliocladium roseum . biocontrol . GUS . GFP . UP-PCR . chitinase.

Anorexia nervosa:Outpatient treatment and medical management

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World Journal of Psychiatry 2022年第4期12卷 558-579页

作者： Stein Frostad mette Bentz Department of Mental Health Research Division of PsychiatryHaukeland University HospitalBergen 5021Norway Child and Adolescent Mental Health Centre Capital Region of DenmarkUniversity of CopenhagenCopenhagen 2400Denmark

Anorexia nervosa(AN)is a disabling,costly and potentially deadly *** failure and relapse are common after completing treatment,and a substantial proportion of patients develop severe and enduring *** time from AN debut to the treatment initiation is normally unreasonably *** the past 20 years there has been empirical support for the efficacy of several treatments for ***,outpatient treatment with family-based therapy or individual psychotherapy is associated with good outcomes for a substantial proportion of *** intervention improves outcomes and should be a priority for all *** treatment is usually the best format for early intervention,and it has been demonstrated that even patients with severe or extreme AN can be treated as outpatients if they are medically *** care is more disruptive,more costly,and usually has a longer waiting list than does outpatient *** decision as to whether to proceed with outpatient treatment or to transfer the patient for inpatient therapy may be *** core aim of this opinion review is to provide the knowledge base needed for performing safe outpatient treatment of *** scientific essentials for outpatient treatment are described,including how to assess and manage the medical risks of AN and how to decide when transition to inpatient care is *** following aspects are discussed:early intervention,outpatient treatment of AN,including outpatient psychotherapy for severe and extreme AN,how to determine when outpatient treatment is safe,and when transfer to inpatient healthcare is *** treatments,ethical issues and outstanding research questions are also addressed.

关键词： Anorexia nervosa Outpatient treatment Medical management Outpatient psychotherapy Inpatient healthcare

i2dash:Creation of Flexible,Interactive,and Web-based Dashboards for Visualization of Omics Data

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 568-577页

作者： Arsenij Ustjanzew Jens Preussner mette Bentsen Carsten Kuenne Mario looso Max Planck Institute for Heart and lung Research Bioinformatics UnitD-61231 Bad NauheimGermany

Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data.A suitable visualization has to be intuitive and ***-based dashboards have become popular tools for the arrangement,consolidation,and display of such ***,the combination of automated data processing pipelines handling omics data and dynamically generated,interactive dashboards is poorly ***,we present i2dash,an R package intended to encapsulate functionality for the programmatic creation of customized *** supports interactive and responsive(linked)visualizations across a set of predefined graphical layouts.i2dash addresses the needs of data analysts/software developers for a tool that is compatible and attachable to any R-based analysis pipeline,thereby fostering the separation of data visualization on one hand and data analysis tasks on the other *** addition,the generic design of i2dash enables the development of modular extensions for specific *** a proof of principle,we provide an extension of i2dash optimized for single-cell RNA sequencing analysis,supporting the creation of dashboards for the visualization needs of such *** with these features,i2dash is suitable for extensive use in large-scale sequencing/bioinformatics *** this line,we provide i2dash as a containerized solution,enabling a straightforward large-scale deployment and sharing of dashboards using cloud services.i2dash is freely available via the R package archive CRAN(https://***/package=i2dash).

关键词： Data visualization Dashboard Cloud Data analysis Automation

When is parenteral nutrition indicated?

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Journal of Intensive Medicine 2022年第1期2卷 22-28页

作者： mette M.Berger Claude Pichard Adult Intensive Care Lausanne University HospitalLausanne 1011Switzerland Clinical Nutrition Geneva University HospitalGeneva 1203Switzerland

The indications and contraindications of parenteral nutrition(PN)are discussed in view of recent clinical *** decades,PN has been restricted to patients unable to tolerate enteral nutrition(EN)intake owing to the perceived risk of severe *** evolution of the PN substrate composition and delivery of nutrition via all-in-one bags has dramatically improved the application prospects of *** studies show similar compli-cation rates of nutrition therapy administered through enteral and intravenous ***,indications of PN have,based on evidence,extended beyond complete gastrointestinal(GI)failure to include conditions such as insufficient EN generating persistent negative energy balance and insufficient protein intakes,malabsorption,or specific needs that are impossible to cover with EN feeds.

关键词： Parenteral nutrition Nutrition therapy Critical illness Clinical outcome Gastro-intestinal failure Indication Indirect calorimetry

levels of l-carnitine in human seminal plasma are associated with sperm fatty acid composition

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Asian Journal of Andrology 2022年第5期24卷 451-457页

作者： Mario Iliceto mette Haug Stensen Jorunn M Andersen Trine B Haugen Oliwia Witczak Fertilitetssenteret Oslo 0176Norway Department of life Sciences and Health OsloMet-Oslo Metropolitan UniversityOslo 0130Norway

The fatty acid composition of spermatozoa has been shown to be important for their function,and l-carnitine is crucial for fatty acid *** levels in the seminal plasma positively correlate with semen quality,whereas high body mass index(BMI)is associated with both reduced semen quality and altered sperm fatty acid ***,we examined the associations between free seminal l-carnitine levels and sperm fatty acid composition as well as *** samples were collected and analyzed from 128 men with unknown fertility status and with BMI ranging from 19 kg m^(−2) to 63 kg m^(−2).Sperm fatty acid composition was assessed by gas chromatography,while free seminal l-carnitine analysis was performed using high-performance liquid *** linear regression analysis showed a positive correlation of free seminal l-carnitine levels with the amount of sperm palmitic acid(β=0.21;P=0.014),docosahexaenoic acid(DHA;β=0.23;P=0.007),and total n-3 polyunsaturated fatty acids(β=0.23;P=0.008)and a negative correlation of free seminal l-carnitine levels with lignoceric acid(β=−0.29;P=0.001)and total n-6 polyunsaturated fatty acids(β=−0.24;P=0.012)when adjusted for *** was no relationship between free seminal l-carnitine levels and *** free seminal l-carnitine levels are associated with semen quality,the absence of a correlation with BMI suggests that reduced semen quality in obese men is independent of seminal l-carnitine.

关键词： body mass index l-carnitine male fertility semen quality sperm fatty acids spermatozoa

Impact of dietary fat levels and fatty acid composition on milk fat synthesis in sows at peak lactation

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1134-1149页

作者： li Zhe Uffe Krogh Charlotte lauridsen mette Olaf Nielsen Zhengfeng Fang Peter Kappel Theil Key laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationAnimal Nutrition InstituteSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130China Department of Animal and Veterinary Sciences Aarhus UniversityFoulumDk‑8830 TjeleDenmark

Background Dietary fat is important for energy provision and immune function of lactating sows and their ***,knowledge on the impact of fat on mammary transcription of lipogenic genes,de novo fat synthesis,and milk fatty acid(FA)output is sparse in *** study aimed to evaluate impacts of dietary fat levels and FA composition on these traits in *** second-parity sows(Danish landrace×Yorkshire)were assigned to 1 of 5 dietary treatments from d 108 of gestation until weaning(d 28 of lactation):low-fat control diet(3%added animal fat);or 1 of 4 high-fat diets with 8%added fat:coconut oil(CO),fish oil(FO),sunflower oil(SO),or 4%octanoic acid plus 4%FO(OFO).Three approaches were taken to estimate de novo milk fat synthesis from glucose and body *** Daily intake of FA was lowest in low-fat sows within fat levels(Ply milk outputs of fat,FA,energy,and FA-derived carbon reflected to a large extent the intake of *** average,estimates for de novo fat synthesis were 82 or 194 g/d from glucose according to method 1 or 2 and 255 g de novo+mobilized FA/d according to method *** low-fat diet increased mammary FAS expression(Plly upregulated mammary FAS expression compared to the other high-fat *** diets,a daily intake of 440 g digestible FA minimized milk fat originating from glucose and mobilized body *** Sows fed diets with low-fat or octanoic acid,through upregulating FAS expression,increased mammary de novo fat synthesis whereas the milk FA output remained low in sows fed the low-fat diet or high-fat OFO or FO diets,indicating that dietary FA intake,dietary fat level,and body fat mobilization in concert determine de novo fat synthesis,amount and profiles of FA in milk.

关键词： Carbon metabolism De novo fat synthesis Dietary fatty acid Fat balance Mammary gene expression Mammary lipogenesis Milk fat production Piglet growth

为实现联合国17项可持续发展目标的建筑——研究的作用

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世界建筑 2024年第1期 46-53页

作者：梅特·拉姆斯加德·汤姆森马丁·塔姆克叶扬(译) 国际建筑师协会

科学赛道是为国际建筑师协会2023哥本哈根世界建筑师大会奠定知识基础的关键部分。通过6个专题讨论小组,我们探讨了建筑及其实践如何成为实现联合国可持续发展目标的一部分。我们的目标是了解建筑研究和设计整合如何通过批判性思考及其... 详细信息

科学赛道是为国际建筑师协会2023哥本哈根世界建筑师大会奠定知识基础的关键部分。通过6个专题讨论小组,我们探讨了建筑及其实践如何成为实现联合国可持续发展目标的一部分。我们的目标是了解建筑研究和设计整合如何通过批判性思考及其应用来行动,在塑造我们的社会方面发挥独特的作用。本文将介绍科学赛道的目标、关注点和观点,我们讲述了如何通过6个小组的工作,使17项联合国可持续发展目标在建筑实践和研究中变得易于理解和操作;我们如何围绕国际建筑师协会2023哥本哈根议程,在研究和实践中建立起一个广泛的国际社区;我们如何质疑建筑研究的传播模式,以找到新的模式来捕捉和传播建筑知识文化的广度。

关键词：国际建筑师协会可持续发展目标批判性思考世界建筑师大会哥本哈根传播模式设计整合新的模式

Impacts of prenatal nutrition on animal production and performance： a focus on growth and metabolic and endocrine function in sheep

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Journal of Animal Science and Biotechnology 2018年第1期9卷 10-23页

作者： Prabhat Khanal mette Olaf Nielsen Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of Copenhagen Gronnegardsvey 31st floorDK-1870 Frederiksberg CDenmark Department of Nutrition Faculty of MedicineTransgenic Animal and Lipid StorageNorwegian Transgenic Centre(NTS)University of OsloOsloNotway

The concept of foetal programming（FP） originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been evaluated in various animal models to gain further insights into the mechanisms underlying the foetal origins of health and disease in humans. In FP research, the sheep has been quite extensively used as a model for humans. In this paper we will review findings mainly from our Copenhagen sheep model, on the implications of late gestation malnutrition for growth, development, and metabolic and endocrine functions later in life, and discuss how these implications may depend on the diet fed to the animal in early postnatal life. Our results have indicated that negative implications of foetal malnutrition, both as a result of overnutrition and, particularly, late gestation undernutrition, can impair a wide range of endocrine functions regulating growth and presumably also reproductive traits. These implications are not readily observable early in postnatal life, but are increasingly manifested as the animal approaches adulthood. No intervention or cure is known that can reverse this programming in postnatal life. Our findings suggest that close to normal growth and slaughter results can be obtained at least until puberty in animals which have undergone adverse programming in foetal life, but manifestation of programming effects becomes increasingly evident in adult *** to the risk of transfer of the adverse programming effects to future generations, it is therefore recommended that animals that are suspected to have undergone adverse FP are not used for reproduction. Unfortunately, no reliable biomarkers have as yet been identified that allow accurate identification of adversely programmed offspring at birth,except for very low or high birth weights, and, in pigs, characteristic changes in head shape（dolphin head）. Future efforts should be therefo

关键词： Adipose tissue Endocrine function Foetal programming Metabolic function Sheep