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Photoactivatable Cell-Surface DNAzyme Sensor for Real-Time Monitoring of the Metal Ion-Induced AβAggregation

CCS Chemistry 2023年第9期5卷 1999-2011页

作者： Lu Liu Mei Zhang Qiming Rong mengyi xiong Huang Su Xuhua Zhao Guoliang Ke Xiao-Bing Zhang Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollaborative Innovation Center for Chemistry and Molecular MedicineHunan UniversityChangsha 410082 Department of Biochemistry and Molecular Biology Shanxi Medical UniversityTaiyuan 030001

Precisely monitoring the distribution and local fluctuation of metal ions,which play vital roles in many physiological and pathological processes,contributes largely to the study of metal ion-induced ***,current reactive fluorescent sensors can hardly realize the monitoring of metal ions in situ due to the premature activation and aimless dispersion of the sensors,which hinder their applications in biological ***,we report a photoactivatable cell-surface DNAzyme sensor to monitor metal ions in the microenvironment of living cells or tissues with high spatial resolution and temporal *** sensor can efficiently anchor to the cell membrane through amphipathic interaction,and the activity of the sensor can be restored after the irradiation by light,which avoids false positive signals from the reaction with metal cofactors during ***,the properties of the sensor were investigated either in buffer or on amodel cell surface,inwhich the sensor responded to Zn2+with superior temporal and spatial resolution under light ***,the sensor was applied tomonitor the dynamic changes ofmetal ions during the formation of Aβaggregates in the cellular microenvironment of brain cells and brain *** strategy provides a potential tool to understand the roles ofmetal ions in the progression of diseases,such as Alzheimer’s disease.

关键词： DNAzyme photoactivatable controllability cell-surface Aβaggregates brain tissues

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Framework nucleic acid-based confined enzyme cascade for efficient synergistic cancer therapy in vivo

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Science China Chemistry 2021年第4期64卷 660-665页

作者： Gezhi Kong Meng Zhang mengyi xiong Mei Chen Chan Yang Yan Zhao Yue Yang Zilong Zhao Zhi-Ling Song Liang Gong Guoliang Ke Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollaborative Innovation Center for Chemistry and Molecular MedicineHunan UniversityChangsha 410082China College of Materials Science and Engineering Hunan UniversityChangsha 410082China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of Education/Shandong Key Laboratory of Biochemical Analysis/College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Sciences and ChemistryHunan University of TechnologyZhuzhou 412007China

Artificial enzyme cascade systems with confinement effect are highly important in synthetic biology and ***,a framework nucleic acid-based confined enzyme cascade(FNA-CEC)for synergistic cancer therapy in vivo was *** FNA-CEC consisted of glucose oxidase and horseradish peroxidase precisely assembled on an addressable DNA tetrahedron scaffold within few *** oxidase(GOx)can trigger efficient glucose depletion for tumor starvation therapy,and increase the local concentration of H_(2)O_(2) in situ for enhanced downstream horseradish peroxidase(HRP)-activated prodrug *** to the spatial-confinement on DNA tetrahedron scaffold,the efficiency of intermediate metabolites transportation between the enzyme cascades was ***,FNA-CEC was applied for efficient synergistic cancer therapy in vitro and in *** a simple and efficient approach,the FNA-CEC is expected to expand the toolbox of technologies in synthetic biology and biomedicine.

关键词： DNA nanotechnology DNA nanostructures drug delivery enzyme cascade cancer therapy

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Construction of Three-in-one Industry and Cultural Inheritance of Musical Instruments of Li People in Hainan from the Perspective of Rural Revitalization

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Asian Agricultural Research 2022年第6期14卷 47-50,54页

作者： Jianjian HE Wenhao JIAN Pingping WENG Jiangtao LIANG mengyi xiong Jiangxi Normal University Nanchang 330224 China

From the perspective of industrial integration,how the musical instruments of Li people in Hainan can solve the current development problems such as lack of endogenous power and market enthusiasm under the strategy of... 详细信息

关键词： Instrumental music culture of Li people Rural revitalization Industrial integration

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Molecular imaging:design mechanism and bioapplications

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Science China Chemistry 2023年第5期66卷 1336-1383页

作者： Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren mengyi xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and Chemomet-ricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education) College of ChemistryFuzhou UniversityFuzhou 350108China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Institute of Molecular Medicine(IMM) State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Chemistry and Chemical Engineering University of JinanJinan 250022China

Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of ***,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission *** this review,we summarize the development of current state-of-the-art molecular imaging *** introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided *** we discuss the perspectives and challenges in this emerging *** expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices.

关键词： molecular imaging imaging probes multimodality biomedical applications diseases diagnosis

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A Dual Yamabe Flow and Related Integral Flows

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 319-348页

作者： Jingang xiong School of Mathematical Sciences Laboratory of Mathematics and Complex SystemsMinistry of EducationBeijing Normal UniversityBeijing 100875China

The author studies a family of nonlinear integral flows that involve Riesz potentials on Riemannian manifolds. In the Hardy-Littlewood-Sobolev (HLS for short)subcritical regime, he presents a precise blow-up profile exhibited by the flows. In the HLS critical regime, by introducing a dual Q curvature he demonstrates the concentrationcompactness phenomenon. If, in addition, the integral kernel matches with the Green’s function of a conformally invariant elliptic operator, this critical flow can be considered as a dual Yamabe flow. Convergence is then established on the unit spheres, which is also valid on certain locally conformally flat manifolds.

关键词： Hardy-Littlewood-Sobolev functional Dual Q curvature Integral flow

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Convex-up Style of Deformation within Grabens in Regions of Incomplete Crossing Conjugate Normal Faults: A Numerical Simulation Investigation and Case Study

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Journal of Earth Science 2024年第3期35卷 839-849页

作者： Zheng Li Kai Wang xiong xiong Bing Zhou School of Geophysics and Geomatics China University of GeosciencesWuhan 430074China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China Department of Earth Sicences Khalifa UniversityAbu DhabiUnited Arab Emirates

Crossing conjugate normal faults(CCNFs)are extensively developed in many hydrocarbon-producing basins,generally existing in the form of incomplete ***,the effect of the non-conjugate zone of the CCNFs on the conjugate relay zone post late tectonic action has not been previously *** use 3D elastic-plastic modeling to investigate the influence of incomplete(i.e.,partially intersecting)CCNFs on the pattern of deformation of strata in the intersection region.A series of model simulations were performed to examine the effects of horizontal tectonic extension,fault size,and fault depth on the deformation of conjugate relay zones of incomplete *** analyses yielded the following results.(1)The model of incomplete conjugation predicts a convex-up style of deformation in the conjugate graben region superimposed on overall subsidence under applied horizontal tectonic extension.(2)The degree of convex-up deformation of the conjugate graben depends on the influence of the non-conjugate zone on the conjugate relay zone,which varies with the amount of horizontal tectonic extension,fault size,and fault burial depth.(3)Our results indicate that incomplete CCNFs can form convex-up deformation,similar to that in the Nanpu Sag area and provide a sound understanding of hydrocarbon migration and accumulation.

关键词： incomplete conjugate normal fault conjugate graben convex-up deformation hydrocarbons Nanpu Sag tectonics.

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Light People:Professor Che Ting Chan,curiosity drives to create the impossibilities

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Light(Science & Applications) 2024年第7期13卷 1229-1233页

作者： Tingting Sun Ying xiong Light Publishing Group Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesNo.3888 Dong Nanhu RoadChangchun 130033China College of Intelligence Science and Technology National University of Defense TechnologyNo.109 Deya RoadChangsha 410073China

Editorial“When something is said to be impossible,there are two points for researchers to initially clarify:whether it really is forbidden by the laws of nature;or whether it is simply that no material that currently exists in nature can do that.”Metamaterials are such magical beings,which have physical properties like invisibility,negative refraction,super-resolution,and perfect absorption that are absent from natural *** has been rated by Science as one of the top ten scientific and technological breakthroughs affecting human beings in the 21st *** this issue of Light People,we spoke with a“magic”creator,Professor Che Ting Chan,the Associate VicePresident(Research&Development)of the Hong Kong University of Science and Technology(HKUST),Member of the Hong Kong Academy of Sciences and Fellow of the American Physical *** has researched a number of theoretical problems in material physics,investigated the theory behind what they seek to achieve,and modulated light(electromagnetism)and acoustic waves through *** the following,let’s take a closer look at Professor Che Ting Chan’s research life,and appreciate his style and the background of his accomplishment.

关键词： breakthrough closer visibility

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Recent Progress in Bionic Hydrogels for Articular Cartilage:Tribological and Mechanical Characteristics

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Journal of Bionic Engineering 2024年第2期21卷 653-673页

作者： Mohammad Javan Almasi Dangsheng xiong School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Cartilage regeneration and repair are considered clinical challenges since cartilage has limited capability for *** tissue-engineered materials have the ability to repair cartilage,they have weak mechanical characteristics and cannot resist long-term *** the other hand,surgery to replace the joint is frequently done to treat significant cartilage deterioration these ***,the materials that are being used for replacement have high friction coefficients,lack shock absorption functions,and lack *** research on natural articular cartilage structure and function may lead to bionic hydrogels,which have suitable physicochemical and biological characteristics(e.g.,tribological and mechanical properties and the ability to support loadbearing capability),but need *** on their tribological and mechanical characteristics,the current review highlights the most recent advancements of bionic hydrogels used for articular cartilage,highlighting both the field's recent progress and its potential for future *** this reason,firstly,some important property improvement methods of bionic hydrogels are discussed and then,the recent findings of various research on the making of those bionic materials are provided and *** seems that by using some modifications such as product design,surface treatments,animal tests,controlling the isoelectric point of hydrogels,and computer simulation,the intended mechanical and tribological characteristics of natural articular cartilage may be attained by the bionic hydrogels.

关键词： Bionic hydrogel Articular cartilage Mechanical property Tribological property Lubrication

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A Generalized Blow up Criteria with One Component of Velocity for 3D Incompressible MHD System

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 253-264页

作者： Bin HAN Xi xiong Department of Mathematics Hangzhou Dianzi UniversityHangzhou 310018China

In this paper,the authors study the global regularity of the 3D magnetohydrodynamics system in terms of one velocity *** particular,they establish a new Prodi-Serrin type regularity criterion in the framework of weak ... 详细信息

关键词： MHD Regularity Blow-up criterion

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Hole mobility enhancement in monolayer WSe2 p-type transistors through molecular doping

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Science China(Information Sciences) 2024年第6期67卷 207-213页

作者： Shiyuan LIU xiong xiong Xin WANG Xinhang SHI Ru HUANG Yanqing WU School of Integrated Circuits and Beijing Advanced Innovation Center for Integrated Circuits Peking University Wuhan National High Magnetic Field Center and School of Integrated Circuits Huazhong University of Science and Technology

Two-dimensional （2D） transition metal dichalcogenide （TMDC） semiconductor materials exhibit extraordinary electrical properties,holding promise for the realization of next-generation complementary metal-oxide-semiconductor （CMOS） devices at ultimate ***,constrained by effective device doping strategies,the hole mobility and device performance of tungsten diselenide （WSe2） p-type transistors,especially monolayer chemical vapor deposition （CVD）-grown WSe2,have not met *** this paper,an effective performance enhancement of monolayer WSe2p-type transistor was achieved through a molecular doping *** monolayer WSe2directly on SiO2back-gated substrates and leveraging energy band alignment design,4-nitrobenzenediazonium tetrafluoroborate （4-NBD） molecular dopant with a concentration of 10 m M was utilized to modulate the Fermi level position of monolayer WSe2for hole *** devices demonstrated a more than 98%increase in hole mobility,reaching up to 97 cm2·V-1·s-1while maintaining the current on/off ratio of *** p-type WSe2transistors with 1μm channel length exhibit a high drive current surpassing 176μA·μm-1,exceeding previous CVD-WSe2devices with similar channel *** straightforward and effective approach to improving the electrical performance of WSe2transistors paves the way for advanced logic technologies based on transition metal dichalcogenide semiconductors.

关键词： CVD-grown WSe2 molecular doping 4-NBD p-type transistors hole mobility

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