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Drug clinical trials on high-grade gliomas: challenges and hopes

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Cancer Biology & Medicine 2023年第12期20卷 947-954页

作者： mengqian huang Shenglan Li Parker Li Zhuang Kang Botao Zhang Wenbin Li Cancer Center Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Clinical Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

Gliomas are the most common group of malignant central nervous system tumors across all ages and have high *** to histopathologic criteria and molecular pathology,gliomas are classified as grades 1–***-grade gliomas(HGG),including the most aggressive subtype,glioblastoma(GBM),belong to grade 3 or *** a standard therapy comprising surgical resection,chemotherapy,and radiation is available,almost all patients with HGG experience recurrence within several months and a dismal prognosis1.

关键词： glioma chemotherapy pathology

浅谈隐喻认知理论指导下英语专业高级英语教学现状与基础改革

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英语教师 2023年第11期23卷 12-14,18页

作者：黄梦倩四川外国语大学成都学院四川成都611844

高级英语是英语专业大三年级开设的课程,教学目标在于通过阅读和分析内容广泛的材料,扩大学生的知识面,培养他们对名篇的分析和理解能力与独立思考能力,增强其对文化差异的敏感性,巩固和提高其英语语言技能。分析民办院校英语专业高级... 详细信息

高级英语是英语专业大三年级开设的课程,教学目标在于通过阅读和分析内容广泛的材料,扩大学生的知识面,培养他们对名篇的分析和理解能力与独立思考能力,增强其对文化差异的敏感性,巩固和提高其英语语言技能。分析民办院校英语专业高级英语教学现状。从词汇、语法、阅读三个方面阐述在隐喻认知理论指导下高级英语课程的基础改革方向。

关键词：英语专业高级英语隐喻认知理论

CRISPR/Cas12a Technology Combined with RT-ERA for Rapid and Portable SARS-CoV-2 Detection

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Virologica Sinica 2021年第5期36卷 1083-1087页

作者： Sihua Liu mengqian huang Yanan Xu Jun Kang Sheng Ye Si Liu Zhiyun Wang Hongyun Liu Jibin Yu Kongxin Hu Tao Wang School of Life Sciences Tianjin UniversityTianjin 300072China School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China GenDx Biotech Co.Ltd Suzhou 215000China Institute of Health Quarantine Chinese Academy of Inspection and QuarantineBeijing 100123China Institute of Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures Tianjin 300072China

Dear Editor,The outbreak and rapid spread of the new coronavirus,severe acute respiratory syndrome coronavirus 2(SARSCo V-2),have resulted in more than 120 million confirmed infections and 2 million deaths worldwide as of *** statistical data were from WHO COVID-19Explorer(https://***/covid/).The virus is also responsible for billions of US dollars in economic losses and has attracted great concern about public health safety ***.

关键词： acute respiratory dollar

A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： Kevin huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or H_(2)S),SiO_(2),and P_(2)(or PH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

Distributed Nash Equilibrium Seeking on Compact Action Sets over Jointly Strongly Connected Switching Networks

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Journal of Systems Science & Complexity 2024年第1期37卷 63-81页

作者： HE Xiongnan huang Jie Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China.

This paper studies the distributed Nash equilibrium seeking(DNES)problem for games whose action sets are compact and whose network graph is switching satisfying the jointly strongly connected *** keep the actions of all players in their action sets all the time,one has to resort to the projected gradient-based *** the assumption that the unique Nash equilibrium is the unique equilibrium of the pseudogradient system,an algorithm is proposed that is able to exponentially find the Nash ***,the authors also consider the distributed Nash equilibrium seeking problem for games whose actions are governed by high-order integrator dynamics and belong to some compact *** examples are used to illustrate the proposed approach.

关键词： Compact action sets jointly strongly connected switching graphs Nash equilibrium seeking projected gradient-based algorithm.

Design and pricing of maintenance service contract based on Nash non-cooperative game approach

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Journal of Systems Engineering and Electronics 2024年第1期35卷 118-129页

作者： SU Chun huang Kui School of Mechanical Engineering Southeast UniversityNanjing 211189China

Nowadays manufacturers are facing fierce *** from the products,providing customers with multiple maintenance options in the service contract becomes more popular,since it can help to improve customer satisfaction,and ultimately promote sales and maximize profit for the *** considering the combinations of corrective maintenance and preventive maintenance,totally three types of maintenance service contracts are ***,attractive incentive and penalty mechanisms are adopted in the *** this basis,Nash non-cooperative game is applied to analyze the revenue for both the manufacturer and customers,and so as to optimize the pricing mechanism of maintenance service contract and achieve a win-win *** experiments are *** results show that by taking into account the incentive and penalty mechanisms,the revenue can be improved for both the customers and ***,with the increase of repair rate and improvement factor in the preventive maintenance,the revenue will increase gradually for both the parties.

关键词： maintenance service contract Nash game incentive and penalty mechanism corrective maintenance preventive maintenance

Quantitative phase imaging based on holography:trends and new perspectives

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Light(Science & Applications) 2024年第7期13卷 1235-1277页

作者： Zhengzhong huang Liangcai Cao Department of Precision Instrument Tsinghua UniversityBeijing 100084China

In 1948,Dennis Gabor proposed the concept of holography,providing a pioneering solution to a quantitative description of the optical *** 75 years of development,holographic imaging has become a powerful tool for optical wavefront measurement and quantitative phase *** emergence of this technology has given fresh energy to physics,biology,and materials *** holography(DH)possesses the quantitative advantages of wide-field,non-contact,precise,and dynamic measurement capability for *** has unique capabilities for the propagation of optical fields by measuring light scattering with phase *** offers quantitative visualization of the refractive index and thickness distribution of weak absorption samples,which plays a vital role in the pathophysiology of various diseases and the characterization of various *** provides a possibility to bridge the gap between the imaging and scattering *** propagation of wavefront is described by the complex *** complex-value in the complex-domain is reconstructed from the intensityvalue measurement by camera in the ***,we regard the process of holographic recording and reconstruction as a transformation between complex-domain and real-domain,and discuss the mathematics and physical principles of *** review the DH in underlying principles,technical approaches,and the breadth of *** conclude with emerging challenges and opportunities based on combining holographic imaging with other methodologies that expand the scope and utility of holographic imaging even *** multidisciplinary nature brings technology and application experts together in label-free cell biology,analytical chemistry,clinical sciences,wavefront sensing,and semiconductor production.

关键词： holographic phase precise

Identification of Linear Systems Using Binary Sensors with Random Thresholds

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Journal of Systems Science & Complexity 2024年第3期37卷 907-923页

作者： huang Zhiyong SONG Qijiang School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematics Sino-French InstituteRenmin University of ChinaBeijing 100872China

In this paper,the problem of identifying autoregressive-moving-average systems under random threshold binary-valued output measurements is *** the help of stochastic approximation algorithms with expanding truncations,the authors give the recursive estimates for the parameters of both the linear system and the binary *** reasonable conditions,all constructed estimates are proved to be convergent to the true values with probability one,and the convergence rates are also established.A simulation example is provided to justify the theoretical results.

关键词： α-mixing binary sensor quantized system stochastic approximation stochastic thresh-old strongly consistent system identification

Microstructure and Internal Friction Behavior of Laser 3D Printed Fe-Based Amorphous Composites

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 196-204页

作者： Shuilong huang Qingjun Chen Li Ji Kan Wang Guosheng huang School of Material Science and Engineering Nanchang Hangkong UniversityNanchang330063China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research Institute(LSMRI)Qingdao266237China

Laser 3D printing,also known as laser additive manufacturing(LAM),is favored for its ability to form bulk metallic glass(BMG)and its composite materials(BMGcs)with freeform *** this work,two different kinds of Fe_(41)Co_(7)Cr_(15)Mo_(14)C_(15)B_(6)Y_(2)amorphous coatings(A and B)were prepared by using LAM technology under air-and water-cooled conditions,respectively;meanwhile,to reduce the cracks generated due to the residual thermal stresses,coating C obtained by air-sweep annealing of B with a low energy-density *** morphology and amorphous content and microstructure of the coatings were investigated,the results show many cracks in coating B deposited under water-cooled conditions,and its microstructure shows an amorphous-crystal-nanocrystalline mixed *** was suppressed in coating C,obtained by air-sweep annealing based on coating B,but the amorphous content was reduced from 32.6 to 13.4%.And the hardness and corrosion resistance of the coating will increase with the increase in the amorphous ***,the internal friction behavior of a BMGcs was prepared on the basis of the process of sample C is compared with that of as-cast amorphous *** results show that the low temperature internal friction behavior of BMGcs is affected by the defects produced during printing,and the high temperature internal friction behavior is affected by the precipitated hard phase.

关键词： Laser 3D printing Amorphous coating Microstructure Corrosion resistance Internal friction behavior