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Formation and evolution of layered structure in dissimilar welded joints between ferritic-martensitic steel and 316L stainless steel with fillers

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Journal of Materials Science & Technology 2019年第11期35卷 2665-2681页

作者： Guoliang Liu Shanwu Yang Jianwen Ding Wentuo Han Lujun Zhou mengqi zhang Shanshan Zhou RDKMisra Farong Wan Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing AijieMo Robotic System Co.LTD Beijing 102202China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biological EngineeringUniversity of Texas El PasoTX 79968USA

Dissimilar high-energy beam(HEB)welding is necessary in many industrial *** composition of heat-affected zone(HAZ)and weld metal(WM)lead to variation in mechanical properties within the dissimilar joint,which determines the performance of the welded *** the present study,appropriate filler material was used during electron beam welding(EBW)to obtain a reliable dissimilar joint between reduced-activation ferritic-martensitic(RAFM)steel and 316L austenitic stainless *** was observed that the layered structure occurred in the weld metal with 310S filler(310S-WM),which had the inferior resistance to thermal disturbance,leading to severe hardening of 310S-WM after one-step tempering *** further ameliorate the joint inhomogeneity,two-step heat treatment processes were imposed to the joints and optimized.δ-ferrite in the layered structure transformed intoγ-phase in the first-step normalizing and remained stable during *** the second-step of tempering,tempered martensite was obtained in the HAZ of the RAFM steel,while the microstructure of 310S-WM was not ***,the optimized properties for HAZ and 310S-WM in dissimilar welded joint was both obtained by a two-step heat *** creep failure position of two dissimilar joints both occurred in CLAM-BM.

关键词： Dissimilar welding with fillers Electron beam welding Layered structure Post weld heat treatment Microstructural evolution

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Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen mengqi Hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

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Identification and Expression of PPAR in Sinonovacula constricta and Their Potential Regulatory Effects on Δ6 Fad Transcription

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Journal of Ocean University of China 2021年第6期20卷 1557-1566页

作者： RAN Zhaoshou KONG Fei LIAO Kai XU Jilin LIU Xingwang SHI Peng zhang mengqi WU Kaibin YAN Xiaojun Key Laboratory of Applied Marine Biotechnology Ningbo UniversityMinistry of Education of ChinaNingbo 315211China Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture Ningbo UniversityNingbo 315211China Fujian Baozhi Aquatic Science and Technology Co. Ltd.Zhangzhou 363503China National and Local Joint Engineering Laboratory of Marine Biotechnology and Engineering Ningbo 315211China Key Laboratory of Marine Biological Engineering Ningbo 315211China Evergreen Feed Co. Ltd.Ningbo 315211China

Peroxisome proliferator activated receptors(PPAR)are kinds of key transcriptional factors in regulating LC-PUFA *** now,little is known about PPAR in marine molluscs as well as in other *** constricta is the first marine mollusc that is proved to possess the complete LC-PUFA biosynthetic pathway,and it can be a perfect representative to clarify this *** this study,the molecular properties of *** PPAR were characterized,and corresponding potential regulatory roles in ***Δ6 fatty acyl desaturase(Fad)transcription were estimated by dual luciferase *** showed that two PPAR homologs(PPAR_a and_b)were identified in *** both contain typical features of vertebrate PPAR,suggesting highly conserved functional regions in *** phylogenetic comparison,they are clearly different with vertebrate PPAR and can be divided into two distinctive ***,they show a high expression level in gill,labial palps,mantle and *** down-regulated expressions in trochophore larva and veliger larva might be attributed to ***,the transcriptional activity of ***Δ6 Fad promoter was significantly activated by both PPAR_a and_b,indicating that *** PPAR might play a role in the regulation of LC-PUFA *** our knowledge,this is the first systematic analysis of PPAR in a marine *** results will provide a valuable reference for further researches on the function of marine molluscan PPAR and their underlying mechanisms in regulating LC-PUFA biosynthesis.

关键词： Sinonovacula constricta peroxisome proliferator activated receptors Δ6 fatty acyl desaturase long chain-polyunsaturated fatty acids

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带放热效应的标量场驱动对流

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Acta Mechanica Sinica 2022年第10期38卷 56-65页

作者：杜宇航张蒙齐杨延涛 State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of Engineeringand Beijing Innovation Center for Engineering Science and Advanced TechnologyPeking UniversityBeijing100871China Department of Mechanical Engineering National University of SingaporeSingapore117575Singapore

本文研究了带放热效应的浓度场所引起的浮力对流现象,与之前带放热效应的双扩散对流问题(IHDDC)不同,本研究中流体密度只依赖于温度场,而浓度场只充当内热源,即带放热效应的瑞利-伯纳德对流(IHRBC).线性稳定性分析揭示出最不稳定模态总... 详细信息

本文研究了带放热效应的浓度场所引起的浮力对流现象,与之前带放热效应的双扩散对流问题(IHDDC)不同,本研究中流体密度只依赖于温度场,而浓度场只充当内热源,即带放热效应的瑞利-伯纳德对流(IHRBC).线性稳定性分析揭示出最不稳定模态总是静态模态(相速度为零).临界瑞利数(衡量不稳定驱动力的大小)随着施密特数(粘性与浓度扩散系数的比值)的增大而减小,随普朗特数(粘性与热扩散系数的比值)的增大而增大.同时针对充分发展的流动开展非线性三维直接数值模拟研究.结果表明适用于IHDDC的理论模型也可以用来描述IHRBC的传输特性.浓度场流动结构出现垂向的非对称性,从顶部下降的羽状结构尺度要小于从底部上升的结构尺度.

关键词：线性稳定性分析双扩散对流热扩散系数普朗特数浮力对流直接数值模拟标量场浓度场

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A novel FZD6 mutation revealed the cause of cleft lip and/or palate in a Chinese family

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Genes & Diseases 2020年第3期7卷 440-447页

作者： Jieni zhang Huaxiang Zhao Wenbin Huang Fengqi Song Wenjie Zhong mengqi zhang Yunfan zhang Zhibo Zhou Jiuxiang Lin Feng Chen Department of Orthodontics Peking University School and Hospital of StomatologyBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Department of Orthodontics College of StomatologyXi’an Jiaotong UniversityXi’anShaanxiChina Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijingChina

Cleft lip and/or palate(CL/P)is a most common craniofacial birth defect which has multifactorial *** our study,we aimed to discover the underlying etiological gene variation in a Chinese family diagnosed as non-syndromic CL/P(NSCL/P).The blood sample of the proband and her parents were detected by whole exome *** Mendelian inheritance pattern,allele frequency,variation location,function analysis and literature search were applied to filtrate and screen the ***,the candidates were confirmed by Sanger *** meanwhile explored the conservative analysis and protein homology *** a result,a start-lost mutation c.1A>GAtg/Gtg in the Frizzled-6(FZD6)gene predicting ***1 was *** variation has not been reported before and was predicted to be *** alteration caused missing of two starting amino acids that are evolutionarily conserved for FZD6 ***,the specific structure of the mutant protein obviously changed according to the results of the homologous *** conclusion,the results suggest c.1A>GAtg/Gtg in the FZD6(NM_001164616)might be the genetic etiology for non-syndromic CL/P in this ***,this finding provided new etiologic information,supplementing the evidence that FZD6 is a strong potential gene for CL/P.

关键词： Cleft lip and/or palate Frizzled-6 Hereditary pedigree Variant Whole-exome sequencing

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Cultivating the uncultured:Harnessing the“sandwich agar plate”approach to isolate heme-dependent bacteria from marine sediment

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mLife 2024年第1期3卷 143-155页

作者： Jing zhang Qi-Yun Liang Da-Shuai Mu Fengbai Lian Ya Gong mengqi Ye Guan-Jun Chen Yuqi Ye Zong-Jun Du State Key Laboratory of Microbial Techlogy Insttute of Micrbial TchnoogyShandong UniversityQingdaoChina Marine College Shandong UniverstyWeihaiChina Shandong University-Weihai Research Institute of Industrial Technology WeihaiChina

In the classical microbial isolation technique,the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for *** this study,we designed a simple coculture technique named the“sandwich agar plate method,”which maintains microbial interactions throughout the isolation and pure culture *** total yield of uncultured species in sandwich agar plates based on eight helper strains was almost 10-fold that of the control *** uncultured species displayed commensal *** study found that heme was the growth-promoting factor of some marine commensal *** genomic analysis revealed that heme auxotrophies were common in various biotopes and prevalent in many uncultured microbial ***,our study supported that the survival strategies of heme auxotrophy in different habitats varied *** findings highlight that cocultivation based on the“sandwich agar plate method”could be developed and used to isolate more uncultured bacteria.

关键词： cultivation growth factors heme sandwich agar plate uncultured bacteria

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可见光介导喹喔啉-2(1H)-酮C3-H缩醛化反应

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有机化学 2022年第12期42卷 4315-4322页

作者：张孟琪南光明赵晓辉魏伟伊犁师范大学化学与环境科学学院、新疆普通高等学校天然产物化学与应用重点实验室新疆伊宁835000 中国科学院西北高原生物研究所、中国科学院藏药研究重点实验室西宁810008 曲阜师范大学化学与化工学院山东曲阜273165

报道了一种可见光介导1,2,3,5-四(咔唑-9-基)-4,6-二氰基苯(4Cz IPN)催化喹喔啉-2(1H)-酮与乙缩醛酸的C3-H脱羧乙缩醛反应合成3-乙缩醛基喹喔啉-2(1H)-酮的方法.该反应采用空气为氧化剂,在室温下实现了一系列3-乙缩醛基喹喔啉-2(1H)-酮... 详细信息

报道了一种可见光介导1,2,3,5-四(咔唑-9-基)-4,6-二氰基苯(4Cz IPN)催化喹喔啉-2(1H)-酮与乙缩醛酸的C3-H脱羧乙缩醛反应合成3-乙缩醛基喹喔啉-2(1H)-酮的方法.该反应采用空气为氧化剂,在室温下实现了一系列3-乙缩醛基喹喔啉-2(1H)-酮的绿色构建,反应具有能源清洁、条件温和、非金属参与和氧化剂绿色等优点.自由基捕捉实验和荧光猝灭实验表明,该反应涉及光诱导自由基反应历程.

关键词：可见光喹喔啉-2(1H)-酮脱羧缩醛化自由基反应

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The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan Wang mengqi Qu Yuhai Bi William J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping zhang George F.Gao International Joint Research Center of National Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu Laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

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Short-term environmental enrichment exposure induces proliferation and maturation of doublecortin-positive cells in the prefrontal cortex

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Neural Regeneration Research 2014年第3期9卷 318-328页

作者： Chunling Fan mengqi zhang Lei Shang Ngobe Akume Cynthia Zhi Li Zhenyu Yang Dan Chen Jufang Huang Kun Xiong Department of Anatomy and Neurobiology Central South University School of Basic Medical Sciences Grade 2006 Eight-year Medicine Doctor Program Central South University Xiangya School of Medicine Grade 2011 Six-year Medicine Program of International Student Central South University Xiangya School of Medicine Grade 2008 Eight-year Medicine Doctor Program Central South University Xiangya School of Medicine

Previous studies have demonstrated that doublecortin-positive immature neurons exist pre- dominantly in the superficial layer of the cerebral cortex of adult mammals such as guinea pigs, and these neurons exhibit very weak properties of self-proliferation during adulthood under physiological conditions. To verify whether environmental enrichment has an impact on the proliferation and maturation of these immature neurons in the prefrontal cortex of adult guinea pigs, healthy adult guinea pigs were subjected to short-term environmental enrichment. Animals were allowed to play with various cognitive and physical stimulating objects over a period of 2 weeks, twice per day, for 60 minutes each. Immunofluorescence staining results indicated that the number of doublecortin-positive cells in layer II of the prefrontal cortex was significantly increased after short-term environmental enrichment exposure. In addition, these doublecortin-positive cells co-expressed 5-bromo-2-deoxyuridine （a marker of cell prolifera- tion）, c-Fos （a marker of cell viability） and NeuN （a marker of mature neurons）. Experimental findings showed that short-term environmental enrichment can induce proliferation, activation and maturation of doublecortin-positive cells in layer II of the prefrontal cortex of adult guinea pigs.

关键词： nerve regeneration neurogenesis prefrontal cortex neocortex guinea pig doublecortinprotein cell proliferation neurons 5-bromodeoxyuridine NSFC grant neural regeneration

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艾滋病病人腹部外科围术期护理质量评价体系的构建

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循证护理 2024年第1期10卷 84-89页

作者：赵静张志云文静张艳华王颖张梦琪闫芳然首都医科大学附属北京地坛医院国家传染病医学中心北京100015

目的:构建艾滋病病人腹部外科围术期护理质量评价体系。方法:通过文献学习、经验总结和半结构式访谈,拟定初稿,采用德尔菲法对18名专家进行两轮函询。结果:两轮专家函询问卷有效回收率均为100%,专家权威系数为0.858和0.823,Kendall′s ... 详细信息

目的:构建艾滋病病人腹部外科围术期护理质量评价体系。方法:通过文献学习、经验总结和半结构式访谈,拟定初稿,采用德尔菲法对18名专家进行两轮函询。结果:两轮专家函询问卷有效回收率均为100%,专家权威系数为0.858和0.823,Kendall′s W值为0.195和0.194(P<0.001),建立3个一级指标、13个二级指标、78个三级指标构成的艾滋病病人腹部外科围术期护理质量评价体系。结论:构建的艾滋病病人腹部外科围术期护理质量评价体系符合临床要求,具有可行性。

关键词：艾滋病腹部外科手术围术期护理质量评价德尔菲法

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