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“Wrapping the gastroduodenal artery stump” during pancreatoduodenectomy reduced the stump hemorrhage incidence after operation

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Chinese Journal of Cancer Research 2014年第3期26卷 299-308页

作者： Chang Xu Xinwei Yang Xiangji Luo Feng Shen mengchao wu Weifeng Tan Xiaoqing Jiang Eastern Hepatobiliary Surgery Hospital Second Military Medical University

Objective： After pancreaticoduodenectomy （PD）, the postoperative gastroduodenal artery stump （GDAS） hemorrhage is one of the most serious complications. The purpose of this study is to determine whether wrapping the GDAS during PD could decrease the postoperative GDAS hemorrhage incidence. Methods： A retrospective review involving 280 patients who underwent PD from 2005 to 2012 was performed. Wrapping the GDAS during PD was defined as ＂Wrapping the GDAS using the teres hepatis ligamentum during PD＂. A total of 140 patients accepted the ＂wrapping＂ procedure （wrapping group）. The other 140 patients didn＇t apply the procedure （non-wrapping group）. Age, sex, preoperative data, estimated intraoperative blood loss, postoperative complications, pathologic parameters and hospitalization time were compared between two groups. ResultsI There were no significant differences in patient characteristics between two groups. After wrapping, the incidence of postoperative GDAS bleeding decreased significantly （1/140 vs. 9/140, P=0.01）. The rates of the other complications （such as intra-abdominal infection pancreatic fistula, billiary fistula, gastrointestinal bleeding, et aL） showed no significant differences. Conclusions： Wrapping the GDAS during PD significantly reduced the postoperative GDAS hemorrhage incidence. And the ＂wrapping＂ had no obvious influence on other complications.

关键词： Pancreaticoduodenectom (PD) wrapping the gastroduodenal artery stump (GDAS) GDAShemorrhage

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

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Cellular & Molecular Immunology 2008年第5期5卷 373-378页

作者： Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun mengchao wu Weiping Zhou The 3rd Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Chemokines are involved in human hepatocellular carcinoma （HCC） carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 （CXCR4） and chemokine ligand 12 （CXCL12） in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ±1.13, 2.34 ±1.16 and 1.63 ±1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96± 0.32 and 1.86 ±0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes （CI） of 3.9 ±1.1 and 4.1± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells.

关键词： CXCR4 CXCL12 hepatocellular carcinoma migration metastasis

多维度强化结合阶段性康复训练对骨折患者康复及静脉血栓栓塞症发生的影响

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中国医学创新 2024年第17期21卷 107-112页

作者：温恒萍王梦莹张慧吴梦超叶爽景德镇市第三人民医院骨一科江西景德镇333000

目的:探究多维度强化结合阶段性康复训练对骨折患者康复及静脉血栓栓塞症发生的影响。方法:选取景德镇市第三人民医院于2020年1月—2023年3月收治的下肢骨折患者88例,根据单双数标记法,将单数归为对照组,双数归为观察组,各44例。对照组... 详细信息

目的:探究多维度强化结合阶段性康复训练对骨折患者康复及静脉血栓栓塞症发生的影响。方法:选取景德镇市第三人民医院于2020年1月—2023年3月收治的下肢骨折患者88例,根据单双数标记法,将单数归为对照组,双数归为观察组,各44例。对照组采用常规护理干预,观察组采用多维度强化结合阶段性康复训练,干预周期为6个月。比较两组患者干预疗效(住院时间、下床活动时间、骨折愈合时间)、疼痛程度[视觉模拟评分法(visual analog scale,VAS)评分]、自护能力[自我护理能力量表(exercise of self-care ability,ESCA)]、下肢运动功能恢复情况[简式下肢Fugl-Meyer运动评估表(Fugl-Meyer assessment scale,FMA)和Berg平衡量表(Berg balance scale,BBS)]及静脉血栓栓塞症(VTE)发生率。结果:干预后,两组患者VAS评分均低于干预前,ESCA各维度评分、FMA评分及BBS评分均高于干预前,差异均有统计学意义(P<0.05);观察组住院时间、骨折愈合时间均短于对照组,下床活动时间早于对照组,VAS评分低于对照组,ESCA各维度评分、FMA评分、BBS评分均高于对照组,差异均有统计学意义(P<0.05)。干预6个月,观察组VTE发生率低于对照组(P<0.05)。结论:多维度强化结合阶段性康复训练能显著缩短下肢骨折患者的住院和恢复时间,降低疼痛程度,提高下肢运动功能和自护能力,并有效减少VTE的发生。

关键词：多维度强化护理康复训练阶段性护理静脉血栓栓塞症

Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection

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World Journal of Gastroenterology 2012年第47期18卷 7021-7025页

作者： Liang Huang Jing Li Jian-Jun Yan Cai-Feng Liu mengchao wu Yi-Qun Yan Department of Hepatic SurgeryⅠ Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM:To investigate the risk factors for postoperative liver insufficiency in patients with Child-Pugh class A liver function undergoing liver ***:A total of 427 consecutive patients undergoing partial hepatectomy from October 2007 to April 2011 at a single center(Department of Hepatic SurgeryⅠ,Eastern Hepatobiliary Surgery Hospital,Shanghai,China) were included in the *** the patients had preoperative liver function of Child-Pugh class A and were diagnosed as having primary liver cancer by postoperative *** was performed by the same team and hepatic resection was carried out by a clamp crushing method.A clamp/unclamp time of 15 min/5 min was adopted for hepatic inflow ***' records of demographic variables,intraoperative parameters,pathological findings and laboratory test results were *** liver insufficiency and failure were defined as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,clinically apparent ascites,prolonged coagulopathy requiring frozen fresh plasma,and/or hepatic *** incidence of postoperative liver insufficiency or liver failure was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive ***:Among the 427 patients,there were 362 males and 65 females,with a mean age of 51.1 ± 10.4 *** patients(86.4%) had a background of viral hepatitis and 234(54.8%) patients had liver *** for partial hepatectomy included hepatocellular carcinoma(391 patients),intrahepatic cholangiocarcinoma(31 patients) and a combination of both(5 patients).Hepatic resections of ≤ 3 and ≥ 4 liver segments were performed in 358(83.8%) and 69(16.2%) patients,***(4.0%) patients developed liver insufficiency after hepatectomy,of whom 10 patients manifested as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,6 patients had clinic

关键词： Prealbumin Hepatectomy Liver insufficiency Child-Pugh class A Primary liver cancer

Spontaneous complete necrosis of hepatocellular carcinoma: a case report

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 152-154页

作者： AiJun Li mengchao wu WenMing Cong Feng Shen Bing Yi Eastern Hospital of Hepatobiliary Surgery Second Military Medical University Shanghai 200438 China. liaijun172@***

Spontaneous regression of hepatocellular carci- noma (HCC) is rare. We found spontaneousregression of HCC in a 53-year-old Chinese withliver cirrhosis. A liver mass 3cm in diameter wasrevealed by B-ultrasonography. The resected massshowed histologically complete necrosis. The nec-rotic tissue was filled with large debris from a neo-plastic tissue, regardless of no viable tumor cellswere seen among them. The postoperative coursewas uneventful, and the patient is alive and wellfor 4 years after surgery.

关键词： HCC in on et is as of a case report Spontaneous complete necrosis of hepatocellular carcinoma case

Structural basis of interaction between protein tyrosine phosphatase PCP-2 and β-catenin

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Science China(Life Sciences) 2005年第2期48卷 163-167页

作者： HE Yaqin YAN Hexin DONG Hui ZHANG Peng TANG Liang QIU Xiuhua wu mengchao WANG Hongyang International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

PCP-2 is a member of receptor-like protein tyrosine phosphatase of the MAM do-main *** investigate which part of PCP-2 was involved in its interaction withβ-catenin,we constructed various deletion mutants of *** PCP-2 mutants and wild-type PCP-2 were co-transfected into BHK-21 cells withβ-catenin *** in vivo binding assay revealed that the expression of wild-type PCP-2,PCP-2?C1C2(deleted PCP-2 without both PTP domains)and PCP-2?C2(deleted PCP-2 without the second PTP domain)could be immunoprecipitated by anti-catenin antibody in every co-transfection,but PCP-2 EXT(deleted PCP-2 without the juxtamembrane region and both PTP domains)was missing,which implied that PCP-2 andβ-catenin could associate directly and the juxtamembrane region in PCP-2 was sufficient for the process.

关键词： PCP-2 β-catenin protein tyrosine phosphatase interaction.

Experimental study on enhancement of the metastatic potential of portal vein tumor thrombus-originated hepatocellular carcinoma cells using portal vein serum

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Chinese Journal of Cancer Research 2014年第5期26卷 588-595页

作者： Yufu Tang Hongming Yu Long Zhang Kang Wang Weixing Guo Jie Shi Shupeng Liu mengchao wu Hongyang Wang Shuqun Cheng Eastern Hepatobiliary Surgery Hospital Second Military Medical University Department of Hepatobiliary Surgery General Hospital of Shenyang Military Area Command Changhai Hospital Second Military Medical University International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Institute Second Military Medical University

Objective： Portal vein metastasis of hepatocellular carcinoma（HCC） results in a poor prognosis and seriously affects the survival rate of patients. The mechanism underlying the formation of portal vein tumor thrombus（PVTT） is complex and is not yet fully understood. This study was conducted to investigate the impact of portal vein blood on the proliferation, metastasis, invasion and apoptosis of PVTT cells and to explore its possible mechanisms, which was expected to lay a foundation for ascertaining the mechanism underlying the portal vein metastasis of HCC.Methods： Peripheral blood and portal vein blood were collected from patients with HCC, and the sera from these two sources were used to culture the PVTT-originated HCC cell line CSQT-2. The cells were collected after 24 h, and flow cytometry was performed to detect cell proliferation, cell cycle stages and apoptosis. Transwell migration and invasion assays were applied to detect the metastasis and invasion of the cells in each group. The changes in the expression of MMP-2 and MMP-9 in cells were detected via Western blotting. The contents of IL-12, IFN-γ, IL-1β, IL-2 and TNF-α in the two groups of sera were quantified using corresponding kits. Results： Compared with the group of cells cultured with peripheral serum, the cells cultured with portal vein serum showed significantly lower apoptosis（P〈0.01）, significantly enhanced cell metastasis and invasion（P〈0.01）, whereas cell proliferation and the stages of the cell cycle did not differ significantly（P〉0.05）. A significantly increased expression level of MMP-2 has been observed in tumor cells treated portal vein serum. In addition, compared with peripheral serum, the content of IL-12 was significantly decreased in portal vein serum（P〈0.05）, while the contents of IFN-γ, IL-1β, IL-2, and TNF-α did not differ significantly（P〈0.05）. Conclusions： Portal vein serum from HCC patients could inhibit the apoptosis of PVTT-originated HCC cells and promote cell metasta

关键词： Hepatocellular carcinoma(HCC) portal vein portal vein tumor thrombus(PVTT) metastasis

Surgical excision of giant primary carcinoma in the medial liver lobe

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Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 362-366页

作者： JiaMei Yang Bin Zhu JingJian Sun Yi Wang XiaoPing Yao BoWen wu Han Chen mengchao wu Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China. yangjiamei100@***

OBJECTIVE: To assess the techniques for surgical excision of giant primary carcinoma in the medialliver ***: Operative managements, complications and their causes during and after resection of giantcarcinoma in the medial liver lobe were analyzed retrospectively in 166 cases treated from October 1996through December ***: Of the 166 patients, 123 (74.1%) underwent tumor resection and 43 (25.9%) regularlobectomy, including left trilobectomy (8,4.8%), medial lobectomy (21,12.7%), right anteriorlobectomy (11, 6.6%), and hemihepatectomy (3,1.8%). All patients were subjected to surgery withintermittent interruption of the first porta hepatis under normothermia. The total interruption time was 7-68 minutes and average time was 24.5 minutes. The maximum single interruption time was 41 *** blood loss was 50-4000 ml, averaging 726 ml. The maximum blood transfusion was 5200ml, averaging was 811 ml, and transfusion was not needed in 54 patients. Postoperative complicationsoccurred in 9 patients (5.4%), of whom, 2 (1.2%) died of liver failure and acute respiratory distresssyndrome ***: An adequate reserve of liver function is a prerequisite for a smooth recovery afteroperation. Careful intraoperative management is crucial to decrease postoperative complications.

关键词： giant primary liver cancer operation

Primary hepatic malignant fibrous histiocytoma mimicking cystadenocarcinoma: a case report

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 620-623页

作者： GuangHui Ding mengchao wu JiaHe Yang ShuQun Cheng Nan Li Kai Liu BingHua Dai WenMing Cong Department of Comprehensive Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China. guanghuiding@***

BACKGROUND:Malignant fibrous histiocytoma is the most common sarcoma of soft tissue, which occurs usually in the extremities, but less common in the retroperitoneal space, abdominal cavity or other sites. Primary malignant fibrous histiocytoma of the liver is extremely rare; only 28 cases have been reported to date in the English literature.;METHODS:In this report, a case of primary malignant fibrous histiocytoma of the liver was described in terms of clinical presentations, diagnosis and treatment and outcome.;RESULTS:A 50-year-old man had a large multicystic-mass lesion in the left lobe of the liver, which was inoperable by laparotomy. Pathological examination of biopsy specimen after operation confirmed a malignant fibrous histiocytoma of storiform-pleomorphic type. The tumor developed rapidly, and the patient died of hepatic failure 2 months after the surgery.;CONCLUSIONS:Primary malignant fibrous histiocytoma of the liver is diagnosed in late stage because of its rarity and non-specific presentations. Surgical resection, if feasible, is the first step treatment. The prognosis of primary malignant fibrous histiocytoma of the liver is grim with a median survival of 3 months as reported. Surgeons should be alert to the existence of this type of soft tissue tumor in the liver.

关键词： malignant fibrous histiocytoma liver differential diagnosis multicystic presentation