Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection

作     者：Liang Huang Jing Li Jian-Jun Yan Cai-Feng Liu MengChao Wu Yi-Qun Yan 

作者机构：Department of Hepatic SurgeryⅠEastern Hepatobiliary Surgery HospitalSecond Military Medical University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第47期

页      面：7021-7025页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The Grants of National Science and Technology Major Project,No.2008ZX10002-025 Scientific Research Fund of Shanghai Health Bureau,No.2009Y066 

主　　题：Prealbumin Hepatectomy Liver insufficiency Child-Pugh class A Primary liver cancer 

摘      要：AIM:To investigate the risk factors for postoperative liver insufficiency in patients with Child-Pugh class A liver function undergoing liver ***:A total of 427 consecutive patients undergoing partial hepatectomy from October 2007 to April 2011 at a single center(Department of Hepatic SurgeryⅠ,Eastern Hepatobiliary Surgery Hospital,Shanghai,China) were included in the *** the patients had preoperative liver function of Child-Pugh class A and were diagnosed as having primary liver cancer by postoperative *** was performed by the same team and hepatic resection was carried out by a clamp crushing method.A clamp/unclamp time of 15 min/5 min was adopted for hepatic inflow *** records of demographic variables,intraoperative parameters,pathological findings and laboratory test results were *** liver insufficiency and failure were defined as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,clinically apparent ascites,prolonged coagulopathy requiring frozen fresh plasma,and/or hepatic *** incidence of postoperative liver insufficiency or liver failure was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive ***:Among the 427 patients,there were 362 males and 65 females,with a mean age of 51.1 ± 10.4 *** patients(86.4%) had a background of viral hepatitis and 234(54.8%) patients had liver *** for partial hepatectomy included hepatocellular carcinoma(391 patients),intrahepatic cholangiocarcinoma(31 patients) and a combination of both(5 patients).Hepatic resections of ≤ 3 and ≥ 4 liver segments were performed in 358(83.8%) and 69(16.2%) patients,***(4.0%) patients developed liver insufficiency after hepatectomy,of whom 10 patients manifested as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,6 patients had clinic