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The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

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Military Medical Research 2024年第5期11卷 697-716页

作者： Na Li Ling Wang Lei Li meng-zhao yang Qing-Xiang Wang Xi-Wen Bai Feng Gao Yi-Qiang Yuan Zu-Jiang Yu Zhi-Gang Ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Jinan Microecological Biomedicine Shandong Laboratory Jinan250000China Department of Cardiovascular Medicine Henan Provincial Chest HospitalZhengzhou450008China Department of Blood Collection Xuchang Blood CenterXuchang461000HenanChina Nanchang University Queen Marry School Nanchang330036China

Regulation of gut microbiota and its impact on human health is the theme of intensive *** incidence and prevalence of atrial fibrillation(AF)are continuously escalating as the global population ages and chronic disease survival rates increase;however,the mechanisms are not entirely *** is gaining awareness that alterations in the assembly,structure,and dynamics of gut microbiota are intimately engaged in the AF *** to advancements in next-generation sequencing technologies and computational strategies,researchers can explore novel linkages with the genomes,transcriptomes,proteomes,and metabolomes through parallel meta-omics approaches,rendering a panoramic view of the culture-independent microbial *** this review,we summarized the evidence for a bidirectional correlation between AF and the gut ***,we proposed the concept of“gut-immune-heart”axis and addressed the direct and indirect causal roots between the gut microbiome and *** intricate relationship was unveiled to generate innovative microbiota-based preventive and therapeutic interventions,which shed light on a definite direction for future experiments.

关键词： Atrial fibrillation(AF) Gut microbiome Meta-omics Metabolites Immunity

HA/ZnO/SiO2梯度涂层材料的制备及其体外抗菌活性测试

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无机化学学报 2020年第11期36卷 2041-2047页

作者：钟欣黄紫洋赵梦阳福建师范大学化学与材料学院福州350007

采用区带电泳法电泳羟基磷灰石(HA)、壳聚糖(CS)、ZnO和SiO2悬浊液,接着施予反向电场进行电泳沉积从而在钛基材表面获得HA/CS/ZnO/SiO2复合涂层材料,而后经710℃焙烧2 h后得到HA/ZnO/SiO2涂层材料(Z1)。同时也仅用电泳沉积法直接制得HA/... 详细信息

采用区带电泳法电泳羟基磷灰石(HA)、壳聚糖(CS)、ZnO和SiO2悬浊液,接着施予反向电场进行电泳沉积从而在钛基材表面获得HA/CS/ZnO/SiO2复合涂层材料,而后经710℃焙烧2 h后得到HA/ZnO/SiO2涂层材料(Z1)。同时也仅用电泳沉积法直接制得HA/ZnO/SiO2涂层材料(E1)作为对比。X射线能谱分析发现Si和Zn两种元素在Z1的径向上均呈现梯度分布,初步说明Z1具有一定的梯度。结合扫描电子显微镜、粉末X射线衍射、傅里叶红外光谱等手段对2种材料进行表征,发现Z1的各种性能较E1更为优异,主要表现在Z1与钛基材表面的结合强度达31.2 MPa,且在HEPES模拟体液中培养14 d后Z1表面碳磷灰石化程度更加完全。另外,抑菌实验发现Z1粉末对大肠杆菌和金黄色葡萄球菌的抑菌率分别为81.7%和89.4%。

关键词：羟基磷灰石/ZnO/SiO2梯度涂层材料结合强度抑菌性体外生物活性

Expression and clinical significance of MN1 and PTEN gene in patients with acute myeloid leukemia

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The Chinese-German Journal of Clinical Oncology 2011年第4期10卷 232-234页

作者： Xueshen Yan Fanjun meng Hongguo zhao Jie yang Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China

Objective:The aim of our study was to explore the correlations between both the genes,evolution and prognosis of the disease by detecting the expression of MN1(meningioma 1) gene and PTEN(phosphatase and tensin homolog) gene in patients with acute myeloid leukemia(AML).Method:MN1 and PTEN mRNA were detected by reverse transcription-PCR in mononuclear cells of 38 patients with AML and 13 patients with normal bone ***:Positive rates of MN1 and PTEN genes were 76.3% and 60.5% respectively in bone marrow mononuclear *** expression level of MN1 mRNA for the de novo group increased comparing with that for normal control group(P < 0.05),the expression level of PTEN mRNA for de novo group decreased obviously comparing with that for normal control group(P < 0.01),MN1 mRNA level decreased in remission group,while PTEN mRNA level increased comparing with that in de novo group(P < 0.05).MN1 mRNA level increased and PTEN mRNA decreased in relapsed group comparing with that in control group,and their difference was statistical significance(P < 0.05).The two genes' levels had negative correlations in acute myeloid leukemia(r =-0.314,P < 0.05).Conclusion:There is close correlations between expression of MN1 and PTEN genes and the prognosis and occurrence of acute myeloid leukemia,and their expression can be taken as significant indexes to access the de novo,relapse and prognosis of acute myeloid leukemia.

关键词： AML MN1 gene PTEN gene

纤维素酶水解老化纸张中纤维素物质的酶活力分析

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光谱实验室 2010年第1期27卷 107-111页

作者：孟朝阳辽宁警官高等专科学校公安技术系辽宁省高校物证分析重点实验室

应用3,5-二硝基水杨酸测定法,分析了纤维素酶水解老化纸张中纤维素物质的酶活力影响因素,根据酶活力确定了酶解反应条件。pH=4.8,温度为50℃,酶解时间为60min,加酶量为10kU/mL条件下,经纤维素酶水解后测得的还原糖量呈现一定的趋势,可... 详细信息

应用3,5-二硝基水杨酸测定法,分析了纤维素酶水解老化纸张中纤维素物质的酶活力影响因素,根据酶活力确定了酶解反应条件。pH=4.8,温度为50℃,酶解时间为60min,加酶量为10kU/mL条件下,经纤维素酶水解后测得的还原糖量呈现一定的趋势,可以此来初步判定纸张纤维的老化程度。

关键词：纤维素酶活力纤维素纤维老化

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微生物培养法推断纸张的相对生产时间

光谱实验室 2010年第3期27卷 958-960页

作者：孟朝阳辽宁警官高等专科学校公安技术系文照教研室

利用微生物培养法检测两种制浆方式的纸张,观察随着生产时间的不同,纸张上细菌和霉菌数量上的变化,根据其纸张上细菌和霉菌的变化规律,推断纸张的相对生产时间。该方法利用现代生物技术,对文件制成时间的检验提供一种新的思路和方法。

关键词：微生物培养细菌霉菌纸张生产时间

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治安调解的界定及适用范围与条件

中国人民公安大学学报（社会科学版） 2008年第6期24卷 90-96页

作者：孟昭阳中国人民公安大学北京100038

治安调解是指公安机关依法对因民间纠纷引起的打架斗殴或毁损他人财物等情节轻微的违反治安管理行为及其损害后果,在自愿的基础上,采取说服教育的方法,促使当事人互谅互让,通过协商达成协议,解决纠纷、处理治安案件的方式。治安调解是... 详细信息

治安调解是指公安机关依法对因民间纠纷引起的打架斗殴或毁损他人财物等情节轻微的违反治安管理行为及其损害后果,在自愿的基础上,采取说服教育的方法,促使当事人互谅互让,通过协商达成协议,解决纠纷、处理治安案件的方式。治安调解是公安机关以非处罚的方式办理治安案件的职权行为,应准确理解《治安管理处罚法》关于治安调解适用范围和条件的规定,正确把握何为民间纠纷、何为打架斗殴或损毁他人财物、何为情节较轻等问题,做出符合立法原意和能更好地发挥治安调解功能的解释。

关键词：治安调解界定适用范围条件

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警察法的界定及地位

中国人民公安大学学报（社会科学版） 2007年第5期23卷 34-39页

作者：孟昭阳中国人民公安大学北京100038

警察法理论研究特别是基本理论研究滞后,什么是警察法、警察法在我国法律体系中处于何种地位等问题有不同的认识与主张。界定警察法和其部门法地位是研究警察法首先要解决的问题,具有重要的理论和实践价值,警察法是我国社会主义法律体... 详细信息

警察法理论研究特别是基本理论研究滞后,什么是警察法、警察法在我国法律体系中处于何种地位等问题有不同的认识与主张。界定警察法和其部门法地位是研究警察法首先要解决的问题,具有重要的理论和实践价值,警察法是我国社会主义法律体系中的一个独立的法律部门。

关键词：警察法界定地位法律部门

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纸张纤维老化的生物检测方法

大连工业大学学报 2009年第6期28卷 429-432页

作者：孟朝阳赵长新大连工业大学生物与食品工程学院辽宁大连116034 辽宁警官高等专科学校公安技术系辽宁大连116036

探讨了检测纸张纤维老化的纤维素酶酶解生物分析方法。纤维素酶酶解法采用条件实验,分别考察了反应温度、pH值、酶解时间及加酶量对纤维素酶活力的影响趋势,确定了纤维素酶酶解纸张的最佳条件。实验结果表明,在最适pH值为4.8、最适反应... 详细信息

探讨了检测纸张纤维老化的纤维素酶酶解生物分析方法。纤维素酶酶解法采用条件实验,分别考察了反应温度、pH值、酶解时间及加酶量对纤维素酶活力的影响趋势,确定了纤维素酶酶解纸张的最佳条件。实验结果表明,在最适pH值为4.8、最适反应温度50℃、纤维素酶解时间60 min、加酶量为10 kU/mL的条件下,不同老化程度的纸张经纤维素酶分解后,利用3,5-二硝基水杨酸法测得的还原糖量呈现上升的趋势,可以此来初步判定纸张纤维的老化程度,确定纸张的相对形成时间,从而建立了用生物方法检测纸张纤维老化程度的方法。该方法与其他检验方法相比,能够区分出纸张相对形成时间较小的样品,达到鉴别的目的。

关键词：纸张老化纤维素酶生物检测

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li meng-Xiang Wu Hao Kang Xiao-Li zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction