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SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

作     者:Meng-Yu Lai Jie Li Xi-Xi Zhang Wei Wu Zhi-Ping Li Zhi-Xin Sun Meng-Yang Zhao Dong-Ming Yang Dong-Dong Wang Wen Li De-Ming Zhao Xiang-Mei Zhou Li-Feng Yang Meng-Yu Lai;Jie Li;Xi-Xi Zhang;Wei Wu;Zhi-Ping Li;Zhi-Xin Sun;Meng-Yang Zhao;Dong-Ming Yang;Dong-Dong Wang;Wen Li;De-Ming Zhao;Xiang-Mei Zhou;Li-Feng Yang

作者机构:National Animal Transmissible Spongiform Encephalopathy LaboratoryCollege of Veterinary MedicineChina Agricultural UniversityBeijingChina 

出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))

年 卷 期:2022年第17卷第10期

页      面:2293-2299页

核心收录:

学科分类:090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学] 

基  金:supported by the National Natural Science Foundation of China,No.31972641 the National Key Research and Development Program of China,No.2017YFC1200500(both to LFY) 

主  题:axonal degeneration mitochondrial dysfunction NAD+metabolism NADase neurodegenerative disease prion disease SARM1 sterile alpha and TIR motif-containing 1 

摘      要:Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss,axonal degeneration,and mitochondrial *** degeneration is an early hallmark of neurodegeneration and is triggered by *** found that depletion or dysfunctional mutation of SARM1 protected against NAD+loss,axonal degeneration,and mitochondrial functional disorder induced by the neurotoxic peptide ***+supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective ***+supplementation in PrP106-126-incubated N2a cells,SARM1 depletion,and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell *** results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP^(106-126) are partially dependent on SARM1 NADase *** pathway has potential as a therapeutic target in the early stages of prion disease.

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