SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease作者机构:National Animal Transmissible Spongiform Encephalopathy LaboratoryCollege of Veterinary MedicineChina Agricultural UniversityBeijingChina
出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))
年 卷 期:2022年第17卷第10期
页 面:2293-2299页
核心收录:
学科分类:090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
基 金:supported by the National Natural Science Foundation of China,No.31972641 the National Key Research and Development Program of China,No.2017YFC1200500(both to LFY)
主 题:axonal degeneration mitochondrial dysfunction NAD+metabolism NADase neurodegenerative disease prion disease SARM1 sterile alpha and TIR motif-containing 1
摘 要:Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss,axonal degeneration,and mitochondrial *** degeneration is an early hallmark of neurodegeneration and is triggered by *** found that depletion or dysfunctional mutation of SARM1 protected against NAD+loss,axonal degeneration,and mitochondrial functional disorder induced by the neurotoxic peptide ***+supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective ***+supplementation in PrP106-126-incubated N2a cells,SARM1 depletion,and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell *** results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP^(106-126) are partially dependent on SARM1 NADase *** pathway has potential as a therapeutic target in the early stages of prion disease.