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Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer:A case report and review of literature

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World Journal of Clinical Cases 2023年第12期11卷 2839-2847页

作者： li-Yong Zhang Shao-Jun Cai Bo-Yan liang Shou-Yi Yan Bo Wang meng-yao li Wen-Xin Zhao Department of Thyroid Surgery General SurgeryMinimal Invasive CenterThe Training Center for Intraoperative Neurophysiologic Monitoring of Thyroid and ParathyroidFujian Medical University Union HospitalFujian Medical UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND Papillary thyroid cancer(PTC)is one of the well-differentiated thyroid tumors.Cutaneous metastasis from differentiated thyroid cancers occurs in<1%of primary thyroid carcinomas but produces the worst survival prognosis.The multi-targeting tyrosine kinase inhibitor anlotinib has been approved to treat refractory advanced non-small-cell lung cancer as well as advanced soft-tissue and clear cell sarcomas in China.CASE SUMMARY In a patient with scalp metastasis caused by PTC,thyroid and skull metastasis tumor sizes were significantly reduced after a trial of neoadjuvant anlotinib therapy for 3 cycles.Anlotinib maintenance medication after thyroidectomy further reduced the metastatic skull tumor size thereby preventing the requirement for craniotomy.CONCLUSION The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future.

关键词： Papillary thyroid cancer Tyrosine kinase inhibitor Neoadjuvant anlotinib therapy literature review Case report

Aggregation-enabled alkene insertion into carbon–halogen bonds

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Aggregate

Aggregate 2023年第5期4卷 128-136页

作者： meng-yao li Xiao-Mei Nong Han Xiao Ao Gu Shuyang Zhai Jiatong li Ge Zhang Ze-Jian Xue Yingbin liu Chunsen li Guo-Qiang lin Chen-Guo Feng Shanghai Cancer Institute Department of Biliary-Pancreatic SurgeryRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai Frontiers Science Center for Traditional Chinese Medicine Chemical BiologyShanghai University of Traditional Chinese MedicineShanghaiChina State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouChina Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghaiChina

Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less explored.Herein,we report the development of aggregation-enabled alkene insertion into carbon–halogen bonds.The spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated state.Additional catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such sequences.The ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory analysis.Results also show that the non-aggregated state may quench the transition state and terminate the insertion process.

关键词： aggregated state chemistry atom-and step-economy difunctionalization of alkenes ionic insertion solvent-free and catalyst-free

The genome sequence of celery(Apium graveolens L.),an important leaf vegetable crop rich in apigenin in the Apiaceae family

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Horticulture Research 2020年第1期7卷 2648-2657页

作者： meng-yao li Kai Feng Xi-lin Hou Qian Jiang Zhi-Sheng Xu Guang-Long Wang Jie-Xia liu Feng Wang Ai-Sheng Xiong State Key Laboratory of Crop Genetics and Germplasm Enhancement Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East ChinaCollege of HorticultureNanjing Agricultural University1 WeigangNanjing 210095China

Celery(Apium graveolens L.)is a vegetable crop in the Apiaceae family that is widely cultivated and consumed because it contains necessary nutrients and multiple biologically active ingredients,such as apigenin and terpenoids.Here,we report the genome sequence of celery based on the use of HiSeq 2000 sequencing technology to obtain 600.8 Gb of data,achieving~189-fold genome coverage,from 68 sequencing libraries with different insert sizes ranging from 180 bp to 10 kb in length.The assembled genome has a total sequence length of 2.21 Gb and consists of 34,277 predicted genes.Repetitive DNA sequences represent 68.88%of the genome sequences,and LTR retrotransposons are the main components of the repetitive sequences.Evolutionary analysis showed that a recent whole-genome duplication event may have occurred in celery,which could have contributed to its large genome size.The genome sequence of celery allowed us to identify agronomically important genes involved in disease resistance,flavonoid biosynthesis,terpenoid metabolism,and other important cellular processes.The comparative analysis of apigenin biosynthesis genes among species might explain the high apigenin content of celery.The whole-genome sequences of celery have been deposited at CeleryDB(http://***/celerydb).The availability of the celery genome data advances our knowledge of the genetic evolution of celery and will contribute to further biological research and breeding in celery as well as other Apiaceae plants.

关键词： metabolism breeding sizes

Identification of SSRs and differentially expressed genes in twocultivars of celery (Apium graveolens L.) by deep transcriptomesequencing

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Horticulture Research 2014年第1期1卷 272-280页

作者： meng-yao li Feng Wang Qian Jiang Jing Ma Ai-Sheng Xiong State Key Laboratory of Crop Genetics and Germplasm Enhancement Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China of Ministry of AgricultureCollege of HorticultureNanjing Agricultural UniversityNanjing 210095China

Celery(Apium graveolens L.)is one of the most important and widely grown vegetables in the Apiaceae family.Due to the lack of comprehensive genomic resources,research on celery has mainly utilized physiological and biochemical approaches,rather than molecular biology,to study this crop.Transcriptome sequencing has become an efficient and economic technology for obtaining information on gene expression that can greatly facilitate molecular and genomic studies of species for which a sequenced genome is not available.In the present study,15893516 and 19818161 high-quality sequences were obtained by RNA-seq from two celery varieties‘Ventura’and‘Jinnan Shiqin’,respectively.The obtained reads were assembled into 39584 and 41740 unigenes with mean lengths of 683 bp and 690 bp,respectively.A total of 1939 simple sequence repeat(SSR)markers were identified in‘Ventura’and 2004 SSRs in‘Jinnan Shiqin’.Di-nucleotide repeats were the most common repeat motif,accounting for 55.49%and 54.84%in‘Ventura’and‘Jinnan Shiqin’,respectively.A comparison of expressed genes between the two libraries,identified 338 differentially expressed genes(DEGs).Three hundred and three of the DEGs were annotated based on a sequence similarity search utilizing eight public databases.Additionally,the expression profile of eight annotated DEGs was characterized in response to abiotic stresses.The collective data generated in the present research represent a valuable resource for further genetic and molecular studies in celery.

关键词： collective utilizing utilized

Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-yao Sheng Zi-Fan meng Qiao li Yong-Sheng Yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:literature search was conducted in PubMed,MEDliNE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

Gut microbiota and female health

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World Journal of Gastroenterology 2024年第12期30卷 1655-1662页

作者： meng-yao Wang li-Xuan Sang Si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Endoscopic CenterEngineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.

关键词： Gut microbiota Female health Estrogen Polycystic ovarian syndrome Endometriosis

Multi-Objective Optimization Based on life Cycle Assessment for Hybrid Solar and Biomass Combined Cooling,Heating and Power System

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Journal of Thermal Science 2024年第3期33卷 931-950页

作者： liU Jiejie li yao meng Xianyang WU Jiangtao Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’an710049China

The complementary of biomass and solar energy in combined cooling,heating and power(CCHP)system provides an efficient solution to address the energy crisis and environmental pollutants.This work aims to propose a multi-objective optimization model based on the life cycle assessment(LCA)method for the optimal design of hybrid solar and biomass system.The life-cycle process of the poly-generation system is divided into six phases to analyze energy consumption and greenhouse gas emissions.The comprehensive performances of the hybrid system are optimized by incorporating the evaluation criteria,including environmental impact in the whole life cycle,renewable energy contribution and economic benefit.The non-dominated sorting genetic algorithmⅡ(NSGA-Ⅱ)with the technique for order preference by similarity to ideal solution(TOPSIS)method is employed to search the Pareto frontier result and thereby achieve optimal performance.The developed optimization methodology is used for a case study in an industrial park.The results indicate that the best performance from the optimized hybrid system is reached with the environmental impact load reduction rate(EILRR)of 46.03%,renewable energy contribution proportion(RECP)of 92.73%and annual total cost saving rate(ATCSR)of35.75%,respectively.By comparing pollutant-eq emissions of different stages,the operation phase emits the largest pollutant followed by the phase of raw material acquisition.Overall,this study reveals that the proposed multi-objective optimization model integrated with LCA method delivers an alternative path for the design and optimization of more sustainable CCHP system.

关键词： combined cooling heating and power system solar-biomass multi-objective optimization life cycle assessment optimal design

Study of loess ecological slope protection optimization measures and prediction of the erosion control effect

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Journal of Geographical Sciences 2024年第6期34卷 1083-1108页

作者： ZHANG Xiaochao li Mingli yao Zhongshao QIN liang meng Minghui State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Sichuan Geological Environment Survey and Research Center Chengdu 610084China Sichuan Huadi Building Engineering Co. Ltd.Chengdu 610084China Sichuan Province Engineering Technology Research Center of Geohazard Prevention Chengdu 610084China

The large-scale management of ditches and implementation of land projects in loess areas have increased the arable land area but have caused considerable engineering issues, resulting in severe soil erosion. In this study, field tests were performed at different time scales, a control group was established, organic material–plant joint restoration technology was proposed as an optimized management measure, and the erosion control mechanism and restoration mode of organic material–plant joint restoration technology were analyzed. Based on the obtained experimental data, a Water Erosion Prediction Project(WEPP)-based hydraulic erosion model was constructed, sensitivity parameters were calibrated, and the soil erosion intensity and corresponding spatial distribution in the watershed of the study area were simulated via the geo-spatial interface for WEPP(GeoWEPP) after organic material–plant joint restoration technology was adopted to predict the effect of optimized management measures. The results showed that among the slopes with different restoration measures, organic material–plant joint restoration technology effectively controlled loess slope erosion, and the average erosion modulus of the organic material–grass and shrub transplantation slope reached only 23.37 t/km2, which is a decrease of 97.68% relative to the traditional grass–shrub protection slope. Moreover, the sand content of the joint restoration slope was reduced by 392.41 g/L relative to the bare slope, reaching only 0.29 g/L, and the runoff yield was reduced by 8.88 L/min. The GeoWEPP modeling results revealed that the total runoff yield and average annual erosion modulus of the watershed were lower after joint restoration than during the prerestoration period. Similarly, the total runoff yield of the watershed was 4.6%, the simulated 10-year average annual total sand production reached 2048.3 t,and the average annual erosion modulus was 582.75 t/km2, which is 52.15% lower than that under untreated conditions. This study provides a new strategy for

关键词： loess excavation slope slope surface erosion prevention and control measures GeoWEPP model erosion prediction

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： meng Yuan yao Tang Tianwen Huang lining Ke En Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation