Aggregation-enabled alkene insertion into carbon–halogen bonds

作     者：Meng-Yao Li Xiao-Mei Nong Han Xiao Ao Gu Shuyang Zhai Jiatong Li Ge Zhang Ze-Jian Xue Yingbin Liu Chunsen Li Guo-Qiang Lin Chen-Guo Feng 

作者机构：Shanghai Cancer InstituteDepartment of Biliary-Pancreatic SurgeryRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina The Research Center of Chiral DrugsInnovation Research Institute of Traditional Chinese MedicineShanghai Frontiers Science Center for Traditional Chinese Medicine Chemical BiologyShanghai University of Traditional Chinese MedicineShanghaiChina State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouChina Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghaiChina 

出 版 物：《Aggregate》 (聚集体（英文）)

年 卷 期：2023年第4卷第5期

页      面：128-136页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:91940305,21933009,81874181,22271195,21871284 Natural Science Foundation of Fujian Province,Grant/Award Number:2021J01525 Major Scientific and Technological Special Project for“Significant New Drugs Creation”,Grant/Award Number:2019ZX09301158 The Emerging Frontier Program of Hospital Development Centre,Grant/Award Number:SHDC12018107 Shanghai Science and Technology Development Fund from Central Leading Local Government,Grant/Award Number:YDZX20223100001004 Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine,Grant/Award Number:ZY(2021-2023)−0501 

主　　题：aggregated state chemistry atom-and step-economy difunctionalization of alkenes ionic insertion solvent-free and catalyst-free 

摘      要：Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material *** effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less ***,we report the development of aggregation-enabled alkene insertion into carbon–halogen *** spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated *** catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such *** ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory *** also show that the non-aggregated state may quench the transition state and terminate the insertion process.