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Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 357-381页

作者： Zhi-Ren Chen mei-fang yang Zhi-Yuan Xie Pei-An Wang Liang Zhang Ze-Hua Huang Yao Luo Department of Science and Education Xuzhou Medical UniversityXuzhou Clinical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Neurology Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Neurology Clinical LaboratoryGastrointestinal SurgeryCentral Hospital of XuzhouCentral Hospital of XuzhouXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Central HospitalXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology Xuzhou Centre HospitalXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is prevalent and aggressive,especially when patients have distant lung metastases,which often places patients into advanced *** identifying prognostic variables for lung metastasis in GC patients,it may be po-ssible to construct a good prediction model for both overall survival(OS)and the cumulative incidence prediction(CIP)plot of the *** To investigate the predictors of GC with lung metastasis(GCLM)to produce nomograms for OS and generate CIP by using cancer-specific survival(CSS)*** Data from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance,epidemiology,and end results program *** major observational endpoint was OS;hence,patients were se-parated into training and validation *** analysis determined va-rious *** and multivariate Cox analyses validated the independent predictive *** distinction and calibration were performed with the time-dependent area under the curve(AUC)and calibration *** evaluate the accuracy and clinical usefulness of the nomograms,decision curve analysis(DCA)was *** clinical utility of the novel prognostic model was compared to that of the 7th edition of the American Joint Committee on Cancer(AJCC)staging system by utilizing Net Reclassification Improvement(NRI)and Integrated Discrimination Improvement(IDI).Finally,the OS prognostic model and Cox-AJCC risk stratification model modified for the AJCC system were *** For the purpose of creating the OS nomogram,a CIP plot based on CSS was *** multivariate regression analysis identified eleven significant prognostic factors(P0),time-de-pendent ROC curve(training/v

关键词： Gastric cancer Lung metastasis Nomograms Surveillance Epidemiology Surveillance epidemiology and end results program database Overall survival Prognosis

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HSP25 Affects the Proliferation and Differentiation of Rat Dental Follicle Cells

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International Journal of Oral Science 2009年第2期1卷 72-80页

作者： Yu Du Hai-jing Gu Qi-mei Gong fang yang Jun-qi Ling Department of Conservative Dentistry and Endodontics Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou China

Aim To detect the expression of HSP25 in rat dental follicles both in vivo and vitro, and explore the underlying mechanism of HSP25 on the proliferation and differentiation of rat dental follicle cells （DFCs）. Methodology Immunohistochemistry was performed to detect the expression of HSP25 in mandibles of postnatal rats on days 1, 3, 5, 7, 9 and 11 in vivo. In vitro, the expression of HSP25 in DFCs was detected by an indirect immunofluorescence assay. Thiazolyl blue tetrazolium bromide （MTT） assay, flow cytometry and alkaline phosphatase （ALP） assay were used to identify the time-course effect mediated by different concentrations of recombinant murine HSP25 of 0, 1, 10, 50 and 100 ng/mL on rat DFCs. Results Expression of HSP25 was not detected in dental follicles of the rats until day 5 after birth, but became up-regulated in a time-dependent manner till day 11. HSP25 was detected in the cytoplasm of cultured rat DFCs. No significant difference could be observed in the proliferation of DFCs after stimulation with different concentrations of HSP25 on days 1, 2 and 3 （P〉0.05）. HSP25 at concentrations of 50 ng/mL and 100 ng/mL up-regulated the ALP activity of DFCs on day 9 （P〈0.05）. Conclusion HSP25-immunoreactivity increased chronologically during the development of dental follicles. The protein had no significant effect on cell proliferation but may play a role in cementoblast/osteoblast differentiation of DFCs.

关键词： dental follicle HSP25 cell proliferation cell differentiation alkaline phosphatase (ALP)

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Study on the Relationship Between the Ploidy Level of Microspore-Derived Plants and the Number of Chloroplast in Stomatal Guard Cells in Brassica oleracea

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Agricultural Sciences in China 2009年第8期8卷 939-946页

作者： YUAN Su-xia,LIU Yu-mei,fang Zhi-yuan,yang Li-mei,ZHUANG Mu,ZHANG yang-yong and SUN Pei-tian Institute of Vegetables and Flowers,Chinese Academy of Agricultural Sciences,Beijing 100081,P.R.China Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 P. R. China

The relationship between the ploidy level of microspore-derived plants and chloroplast number in stomatal guard cells was studied in cabbage, broccoli, and Chinese kale. In the experiment, distribution statistics analysis and t-test were used to perform statistical analysis on chloroplast number of different ploidy level in those stomatal guard cells mentioned above, and morphology identifying and chromosome counting were used to test accuracy of counting chloroplast number in stomatal guard cells. The chloroplast average number in stomatal guard cells was very similar among the different leaf positions on the same plant and among significantly among the different ploidy the different locations in the same stoma in the same variety. All the leaf, while the chloroplast number varied distributions of the chloroplast number in different ploidy stoma were normal distribution fitted. A correlation has been established between ploidy and chloroplast number in the stomatal guard cells. In every single stoma of microspore-derived plants, the chloroplast number for a haploid should not be more than 10, diploids 11 to 15, and polyploids more than 15. The accuracy of this method for identification of different ploidy plants was 93.93%. Furthermore, the accuracy of this method was reliable and did not vary with the plants growth conditions. Therefore, the chromosome ploidy of plants derived from microspore culture in cabbage, broccoli, and Chinese kale can be identified by simply counting the chloroplast number in stomatal guard cells.

关键词： Brassica oleracea stomatal guard cells chloroplast number identification of ploidy

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Clinical signif icance of C-reactive protein values in antibiotic treatment for pyogenic liver abscess

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World Journal of Gastroenterology 2010年第38期16卷 4871-4875页

作者： Hai-Nv Gao Wen-Xia Yuan mei-fang yang Hong Zhao Jian-Hua Hu Xuan Zhang Jun Fan Wei-Hang Ma State Key Laboratory of Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

AIM:To investigate the clinical signifi cance of C-reactive protein (CRP) values in determining the endpoint of antibiotic treatment for liver abscess after drainage. METHODS: The endpoints of antibiotic treatment in 46 patients with pyogenic liver abscess after complete percutaneous drainage were assessed by performing a retrospective study. After complete percutaneous drainage, normal CRP values were considered as the endpoint in 18 patients (experimental group), and normal body temperature for at least 2 wk were considered as the endpoints in the other 28 patients (control group). RESULTS:The duration of antibiotic treatment after complete percutaneous drainage was 15.83 ± 6.45 d and 24.25 ± 8.18 d for the experimental and the control groups, respectively (P=0.001), being significantly shorter in the experimental group than in the control group. The recurrence rate was 0% for both ***, we could not obtain the follow-up data about 3 patients in the control group. CONCLUSION: CRP values can be considered as an independent factor to determine the duration of the antibiotic treatment for pyogenic liver abscess after complete percutaneous drainage.

关键词： Liver abscess C-reactive protein Antibiotic treatment Drainage Retrospective studies

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Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： Lan-mei Wang Wei-Wei Zhang Ying-yang Qiu fang Wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

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From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations

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Journal of Bioresources and Bioproducts 2024年第2期9卷 185-196页

作者： Zongpu Xu fang He Jing Yu Zhangze yang Yu Zhu Rong Liao Ruyin Lyu mei yang Liangjun Zhu Mingying yang Institute of Applied Bioresources College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Neurosurgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic *** as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable ***,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering ***,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very ***,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating *** biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(>87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and *** importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.

关键词： Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility

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Indocyanine green clearance in evaluating the recovery of liver reserve function after superselective transarterial chemoembolization

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 656-660页

作者： Xin Chen Hai-Bing Zhang Zhong-Qi Li Xiong-Fei Yu mei-fang yang Hao-Hao Wang Li-Song Teng Department of Oncology First Affiliated Hospital Zhejiang University School of Medicine State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine

Transarterial chemoembolization(TACE)may ravage normal liver tissues apart from the neoplastic nodules which offset the anti-tumor *** study aimed to evaluate the recovery of liver reserve function(LRF)after TACE by indocyanine green(ICG)clearance test and other routine liver function ***-six newly diagnosed HCC patients who had undergone TACE as the initial treatment from January 2011 to January 2012 were enrolled in this *** effects of age,basic ICG clearance rate and interval time between two assessments on the recovery of LRF were *** found that ICG retention rate at the 15 minutes(ICGR15)was significantly increased after TACE(12.3±8.1%vs 16.8±12.1%,P55 years,20.3±12.5%vs 13.7±7.2%,P<0.01).The interval of ICG test also affected the ICGR15 value(≤47days,17.8±11.4%after vs 12.1±7.1%before TACE,P<0.01).Our data suggested that TACE decreased LRF,especially in older *** test was more sensitive to evaluate the recovery of LRF after TACE than the Child-Pugh grade and routine liver function tests.

关键词： hepatocellular carcinoma transarterial chemoembolization liver reserve function indocyanine green clearance

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Structural and magnetic properties of micropolycrystalline cobalt thin films fabricated by direct current magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 384-394页

作者： Kerui Song Zhou Li mei fang Zhu Xiao Qian Lei School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Super-Microstructure and Ultrafast Process School of Physics and electronicsCentral South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metal Materials Science and Engineering Ministry of EducationChangsha 410083China

Pure cobalt(Co)thin films were fabricated by direct current magnetron sputtering,and the effects of sputtering power and pres-sure on the microstructure and electromagnetic properties of the films were *** the sputtering power increases from 15 to 60 W,the Co thin films transition from an amorphous to a polycrystalline state,accompanied by an increase in the intercrystal pore ***,the resistivity decreases from 276 to 99μΩ·cm,coercivity increases from 162 to 293 Oe,and in-plane magnetic aniso-tropy *** the sputtering pressure decreases from 1.6 to 0.2 Pa,grain size significantly increases,resistivity significantly de-creases,and the coercivity significantly increases(from 67 to 280 Oe),which can be attributed to the increase in defect ***-pondingly,a quantitative model for the coercivity of Co thin films was *** polycrystalline films sputtered under pressures of 0.2 and 0.4 Pa exhibit significant in-plane magnetic anisotropy,which is primarily attributable to increased microstress.

关键词： cobalt thin film magnetron sputtering microstructure electromagnetic properties

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O_(2) adsorption on Fe_(3)O_(4) (110) surface and effect of gangue element Al doping: combined study of binding experiment and ab initio molecular dynamics

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Journal of Iron and Steel Research International 2024年第4期31卷 810-827页

作者： Zheng-jian Liu Hui-qing Jiang Yao-zu Wang Jian-liang Zhang Hong-mei Qiao An-yang Zheng fang-yu Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Beijing Shougang Co. Ltd.Qian'an 064404HebeiChina Department of Physics National University of Defense TechnologyChangsha 410128HunanChina

At high temperature,the chemical reaction mechanism at the interface of magnetite and the influence mechanism of gangue element Al on the oxidation performance of magnetite are not *** addition,due to the limitation of existing experimental equipment,it is difficult to clarify the interface reaction mechanism in the oxidation process and the influence mechanism of Al on the surface oxidation reaction of Fe_(3)O_(4) at an atomic scale at high *** surface oxidation reaction mechanism of magnetite and the influence mechanism of Al on the oxidation of magnetite were studied by experiments and AIMD(ab initio molecular dynamics).The experimental results show that the existence of Al_(2)O_(3) will reduce the initial oxidation temperature and comprehensive oxidation performance of *** AIMD results show that aluminum can accelerate the interface reaction rate of Fe_(3)O_(4) in the high-temperature oxidation atmosphere,but the strong Al-O binding ability is not conducive to the transfer of O atoms in the oxidation process.

关键词： Ironmaking Magnetite oxidation Interface reaction Adsorption-Gangue aluminum AIMD

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Prediction and quantification of effective gas source rocks in a lacustrine basin: Western Depression in the Liaohe Subbasin, China

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Petroleum Science 2024年第4期21卷 2218-2239页

作者： Si-Bo yang mei-Jun Li Hong Xiao fang-Zheng Wang Guo-Gang Cai Shuang-Quan Huang State Key Laboratory of Petroleum Resources and Prospecting College of Geosciences China University of Petroleum China University of Petroleum-Beijing at Karamay College of Petroleum Research Institute of Petroleum Exploration and Development Liaohe Oilfield Company PetroChina

Due to limited data on the geochemical properties of natural gas, estimations are needed for the effective gas source rock in evaluating gas potential. However, the pronounced heterogeneity of mudstones in lacustrine successions complicates the prediction of the presence and geochemical characteristics of gas source rocks. In this paper, the Liaohe Subbasin of Northeast China is used as an example to construct a practical methodology for locating effective gas source rocks in typical lacustrine basins. Three types of gas source rocks, microbial, oil-type, and coal-type, were distinguished according to the different genetic types of their natural gas. A practical three-dimensional geological model was developed, refined, and applied to determine the spatial distribution of the mudstones in the Western Depression of the Liaohe Subbasin and to describe the geochemical characteristics(the abundance, type, and maturation levels of the organic matter). Application of the model in the subbasin indicates that the sedimentary facies have led to heterogeneity in the mudstones, particularly with respect to organic matter types. The effective gas source rock model constructed for the Western Depression shows that the upper sequence(SQ2) of the Fourth member(Mbr 4) of the Eocene Shahejie Formation(Fm) and the lower and middle sequences(SQ3 and SQ4) of the Third member(Mbr 3) form the principal gas-generating interval. The total volume of effective gas source rocks is estimated to be 586 km3. The effective microbial, oil-type, and coal-type gas source rocks are primarily found in the shallow western slope, the central sags, and the eastern slope of the Western Depression, respectively. This study provides a practical approach for more accurately identifying the occurrence and geochemical characteristics of effective natural gas source rocks, enabling a precise quantitative estimation of natural gas reserves.

关键词： Effective gas source rock 3D geological modeling Spatial distribution Geochemical characteristics Lacustrine rift basin

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