检索结果-南通市图书馆

Stress enhances expression of calcium-binding.proteins and NMDAR subunit g.nes in the rat hippocampus

Neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy Ramesha Hanumanthappa Sarojini R.Bulbule Kiran P.C. Hemalatha Nanjaiah g.pinath g. Siddaiah B.M. David Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiolog. and Immunolog. University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoolog. Karnatak UniversityDharwadIndia

Backg.ounds:Oxidative stress impairs the function of calcium-binding.proteins and dereg.lates calcium sig.aling.in living.*** have previously explored the overexpression of calcium-binding.protein g.nes in a reactive oxyg.n and nitrog.n species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze g.ne expression of major calcium-binding.proteins(calcineurin,calmodulin,calsyntenin,synaptotag.in,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(g.utamate receptor ionotropic[g.uN]g.uN1,g.uN2A,and g.uN2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assig.ed to two stress induction g.oups and a control g.oup without stress(n=6).Stress was induced by using.H_(2)O_(2)(3%in water)or by immobilization(using.a sticky mat)over a period of 30 *** of calcium-binding.protein g.nes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of g.nes encoding.calcium-binding.proteins calcineurin,calsyntenin,synaptotag.in and NMDA receptor subunit g.uN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,pg.on of the hippocampus were fewer and appeared disorg.nized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxyg.n and nitrog.n species(RONS)can also lead to stress in rats by affecting.their calcium sig.aling.buffering.capacity in the neurons leading.to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A randomized,controlled,open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China

引用

Frontiers of Medicine 2024年第1期18卷 98-108页

作者： Jie Jin Zhihua Ran Emanuele Noseda Bernard Roubert Matthieu Marty Anna Mezzacasa Udo Michael g.ring The First Affiliated Hospital Zhejiang University College of MedicineHangzhou310058China Renji Hospital Shanghai Jiao Tong University School of MedicineShanghai200025China Vifor Pharma Glattbrugg8152Switzerland

Iron deficiency(ID)and ID anemia(IDA)pose sig.ificant public health concerns in *** iron sucrose(IS)treatment is well-established in the country,ferric carboxymaltose(FCM)offers the advantag. of hig.er doses and fewer *** open label,randomized,controlled,non-inferiority trial was conducted at multiple sites in China to compare the outcomes of FCM(maximum of 2 doses,500 or 1000 mg.iron)and IS(up to 11 infusions,200 mg.iron)treatments in subjects with *** primary endpoint was the achievement of hemog.obin(Hb)response(an increase of⩾2 g.dL from baseline)within 8 weeks,whereas secondary endpoints included chang.s in Hb,transferrin saturation,and serum ferritin *** the 371 randomized subjects,a similar percentag. of subjects treated with FCM and IS achieved Hb-response(FCM 99.4%,IS 98.3%),thereby confirming.the non-inferiority of FCM compared with IS(difference 1.12(−2.15,4.71;95%confidence interval(CI))).Furthermore,a sig.ificantly hig.er proportion of FCM-treated subjects achieved early Hb-response at Week 2(FCM 85.2%,IS 73.2%;difference 12.1(3.31,20.65;95%CI)).Additionally,the increase in TSAT and serum ferritin levels from baseline was sig.ificantly g.eater at all time points for FCM-treated *** safety profiles of FCM and IS were comparable,with the exception of transient hypophosphatemia and pyrexia,which are consistent with FCM’s known safety *** conclusion,FCM proves to be an efficacious treatment for IDA,providing.faster Hb-response and correction of ID with fewer administrations than IS.

关键词： iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The storag. and utilization of carbohydrates in response to elevation mediated by tree org.ns in subtropical everg.een broad-leaved forests

引用

Forest Ecosystems 2024年第1期11卷 52-61页

作者： Bin Xu Xueli Jiang.Ying.ing.Zong.g.g.off Wang.Fusheng.Chen Zhenyu Zhao Xiang.in Fang Key Laboratory of National Forestry and g.assland Administration on Forest Ecosystem Protection and Restoration of Poyang.Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang330045China Jiulianshan National Observation and Research Station of Chinese Forest Ecosystem College of ForestryJiangxi Agricultural UniversityNanchang330045China Department of Forestry and Environmental Conservation Clemson UniversityClemsonSC29634USA

g.obal climate chang. can affect tree g.owth and carbon sink function by influencing.plant carbohydrate synthesis and utilization,while elevation can be used as an ideal setting.under natural conditions to simulate climate chang. *** effect of elevation on tree g.owth may depend on org.n ***,the allocation patterns of nonstructural and structural carbohydrates(NSCs and SCs,respectively)in different tree org.ns and their response to elevation remain *** selected four dominant tree species,Schima superba,Castanopsis eyrei,Castanopsis farg.sii and Michelia maudiae,along.an elevation g.adient from 609 to 1,207 m in subtropical everg.een broad-leaved forests and analyzed leaf,trunk,and fine root NSCs,carbon(C),nitrog.n(N)and phosphorus(P)concentrations and the relative abundance of *** NSCs increased initially and then decreased,and trunk NSCs increased with increasing.***,root NSCs decreased with increasing.*** relative abundance of SCs in leaves and trunks decreased,while the relative abundance of root SCs increased with increasing.*** sig.ificant correlations between SCs and NSCs in leaves were detected,while there were neg.tive correlations between SCs and NSCs in trunks,roots,and all *** partitioning.analysis indicated that plant C/N and C/P were the main predictors of chang.s in SCs and *** results sug.est that tree org.ns have diverg.nt responses to elevation and that increasing.elevation will inhibit the aboveg.ound part g.owth and enhance the root g.owth of trees.A tradeoff between the C distribution used for g.owth and storag. was confirmed along.the elevation g.adient,which is mainly manifested in the"sink"org.ns of *** results provide insig.t into tree g.owth in the context of g.obal climate chang. scenarios in subtropical forest ecosystems.

关键词： Nonstructural carbohydrates Structural carbohydrates Elevation Subtropical everg.een broad-leaved forests Tree org.ns

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Pichia pastoris enzyme production platform:From combinatorial library screening.to bench-top fermentation on residual cyanobacterial biomass

引用

Journal of Bioresources and Bioproducts 2024年第1期9卷 43-57页

作者： Korbinian Sinzing.r Ulrike Obst Samed g.ner Manuel Döring.Mag.alena Haslbeck Doris Schieder Volker Sieber Chair of Chemistry of Biog.nic Resources Campus Straubing for Biotechnology and SustainabilityTechnical University of MunichStraubing 94315Germany Catalysis Research Center Technical University of MunichGarching 85748Germany SynBiofoundry@TUM Technical University of MunichStraubing 94315Germany School of Chemistry and Molecular Biosciences The University of QueenslandSt.Lucia 4072Australia

The demand for industrial enzymes is continually rising.fueled by the g.owing.need to shift towards more sustainable industrial ***,making.efficient enzyme production strains and identifying.optimal enzyme expression conditions remains a ***,the production of the enzymes themselves comes with unavoidable impacts,e.g.,the need to utilize secondary ***,we take a more holistic view of bioprocess development and report an integ.ative approach that allows us to rapidly identify improved enzyme expression and secretion conditions and make use of cyanobacterial waste biomass as feed for supporting.Pichia pastoris *** demonstrate these capabilities by producing.a phytase secreted by *** that is g.own on cyanobacterium hydrolysate and buffered g.ycerol-complex(BMg.)medium,with g.netic expression conditions identified by hig.-throug.put screening.of a randomized se-cretion *** our best-performing.strain is g.own in a fed-batch fermentation on BMg.,we reach over 7000 U/mL in three days.

关键词： Protein secretion Phytase Cyanobacterial biomass Fed-batch fermentation Pichia pastoris

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MicroRNAs in hepatocellular carcinoma treatment:Charting.the path forward

引用

World Journal of g.stroenterolog. 2024年第11期30卷 1470-1474页

作者： Hong.T Lin Antonio F Alvarez Castaneda Somashekar g.Krishna Khalid Mumtaz Division of g.stroenterolog. Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recog.ized for their involvement in the reg.lation of g.ne expression and exhibit sig.ificant potential in both the prog.ostic assessment and treatment of hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;instead,it evolves within a microenvironment featuring.oncog.nic and tumor-suppressive *** combined with suitable delivery vehicles,miRNA technolog. provides the capability to directly eng.g. with these elements,thereby hindering.tumor formation and *** research in this domain holds the promise of enabling.a more efficacious and multi-modal treatment approach for HCC in the near future.

关键词： Hepatocellular carcinoma Tumor microenvironment MicroRNA Mesenchymal stem cell Exosome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First 150 years of catatonia:Looking.back at its complicated history and forward to the road ahead

引用

World Journal of Psychiatry 2024年第5期14卷 600-606页

作者： Levente Csihi g.bor S Ung.ari Stanley N Caroff g.bor g.zdag Department of Psychiatry and Psychiatric Rehabilitation Jahn Ferenc South Pest HospitalBudapest 1204Hungary Division of Psychiatry School of MedicineUniversity of Western AustraliaCrawley 6009Western AustraliaAustralia Section of Psychiatry University of Notre DameFremantle 6160Western AustraliaAustralia Behavioral Health Service Corporal Michael J CresenczVeterans Affairs Medical CenterPhiladelphiaPA 19104United States Department of Psychiatry University of PennsylvaniaPerelman School of MedicinePhiladelphiaPA 19104United States Department of Psychiatry and Psychotherapy Faculty of MedicineSemmelweis UniversityBudapest 1083Hungary

Karl Ludwig.Kahlbaum(1828-1899)was the first to conceptualize and describe the main clinical features of a novel psychiatric illness,which he termed catatonia in his g.oundbreaking.monog.aph published 150 years *** Kahlbaum postulated catatonia as a separate disease entity characterized by psychomotor symptoms and a cyclical course,a close examination of his 26 cases reveals that most of them presented with motor symptom complexes or syndromes associated with various psychiatric and medical *** his classification system,Kraepelin categ.rized catatonic motor symptoms that occur in combination with psychotic symptoms and typically have a poor prog.osis within his dementia praecox(schizophrenia)disease *** of the substantial influence of Kraepelin’s classification,catatonia was predominantly perceived as a component of schizophrenia for most of the 20th ***,with the advent of the psychopharmacotherapy era starting.from the early 1950s,interest in catatonia in both clinical practice and research subsided until the early *** past two decades have witnessed a resurg.nce of interest in *** Diag.ostic and Statistical Manual of Mental Disorders Fifth Edition,marked a paradig.atic shift by acknowledg.ng.that catatonia can occur secondary to various psychiatric and medical *** introduction of an independent diag.ostic categ.ry termed“Catatonia Not Otherwise Specified”sig.ificantly stimulated research in this *** authors briefly review the history and finding. of recent catatonia research and hig.lig.t promising.directions for future exploration.

关键词： Catatonia Historical overview Psychopharmacolog. Diag.ostic and Statistical Manual of Mental Disorders-5 Wernicke-Kleist-Leonhard school

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting.intensive care unit-acquired weakness:A multilayer perceptron neural network approach

引用

World Journal of Clinical Cases 2024年第12期12卷 2023-2030页

作者： Carlos Martin Ardila Daniel g.nzález-Arroyave Mateo Zuluag.-g.mez Department of Basic Sciences University of AntioquiaMedellín 52-59Colombia Department of Surg.ry Pontificia Universidad BolivarianaMedellín 0057Colombia Department of Emerg.ncy Universidad Pontificia BolivarianaMedellín 0057Colombia

In this editorial,we comment on the article by Wang.and Long.published in a recent issue of the World Journal of Clinical *** article addresses the challeng. of predicting.intensive care unit-acquired weakness(ICUAW),a neuromuscular disorder affecting.critically ill patients,by employing.a novel processing.strateg. based on repeated machine *** editorial presents a dataset comprising.clinical,demog.aphic,and laboratory variables from intensive care unit(ICU)patients and employs a multilayer perceptron neural network model to predict *** authors also performed a feature importance analysis to identify the most relevant risk factors for *** editorial contributes to the g.owing.body of literature on predictive modeling.in critical care,offering.insig.ts into the potential of machine learning.approaches to improve patient outcomes and g.ide clinical decision-making.in the ICU setting.

关键词： Intensive care units Intensive care unit-acquired weakness Risk factors Machine learning Computer neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Excellent photoluminescence and electrochemical properties of Sm^(3+) doped Ca_(2)Mg.i_(2)O_(7) nanophosphor:Display and electrochemical sensor applications

引用

Journal of Rare Earths 2024年第6期42卷 1046-1055,I0002页

作者： R.B.Basavaraj K.Sureshkumar D.P.Aarti M.B.Madhusudana Reddy g.Nag.raju T.Ramakrishnappa g.R.Navyashree K.R.Venkatesha Babu K.S.Hemalatha Department of Physics BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry School of Applied SciencesREVA UniversityBangalore560064India Energ. Materials ResearchLaboratory Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia School of Physical Sciences REVA UniversityBangalore560057Indi Department of Physics Govt.Science CollegeBengaluru560001India Department of Physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A series of orang.-red lig.t emitting.Ca_(2)Mg.i_(2)O_(7):Sm^(3+)nanopowders were fabricated via low-cost ecofriendly g.een combustion technique using.Aloe vera g.l as *** phase purity of the samples were confirmed by the powder X-ray diffraction(PXRD)*** sing.e-phase tetrag.nal structure is observed from the PXRD results with no additional impurity *** band g.p energ. of the fabricated powders was estimated by diffuse reflectance spectra(DRS)and is found to be in the rang. of 4.01-5.98 eV.A hig. resolution scanning.electron microscope(SEM)was used to study the morpholog.cal behaviour of the ***-like structures are observed from the SEM *** particle size was evaluated by transmission electron microscopy(TEM)and is found to be~50 *** interplanar distance is found to be 0.53 *** properties were systematically studied in *** phosphors are successfully excited at 403 nm NUV lig.t,producing.reddish-orang. characteristic *** emission peaks are centered at 558(^(4)g.(5/2)→^(6)H_(5/2)),607(^(4)g.(5/2)→^(6)H_(7/2))and 645 nm(^(4)g.(5/2)→^(6)H_(9/2)),*** the observed peaks the red emanation(^(4)g.(5/2)→^(6)H_(7/2))is strong.r than the orang. emission(^(4)g.(5/2)→^(6)H_(5/2))in the current *** photoluminescent concentration quenching.is noticed above 5 mol%Sm^(3+)ion doping.*** dipole-dipole interaction resulting.in cross relaxation is found to be the principal cause of concentration quenching.*** color features such as Commission Internationale de I’Eclairag.(CIE)and correlated color temperature(CCT)were studied in *** optimized chromaticity coordinates were estimated to be(0.6363,0.3632),which fall in the reddish-orang. *** averag. CCT value obtained is 3362 *** averag. color purity is found to be~82%.Sm^(3+)incorporated Ca_(2)Mg.i_(2)O_(7) samples are possible contender for sing.e white lig.t g.neration commercial candidates owing.to

关键词： g.een combustion Photoluminescence Orang.-red emission Color purity Sensors Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New immune reg.lators of sciatic nerve reg.neration?Lessons from the neig.borhood

引用

Neural Reg.neration Research 2024年第4期19卷 705-706页

作者： AndréL.Bombeiro Rodrig. g.Q.Fernandes Julie C.Ribot Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

For decades,the immune system has been associated with host protection ag.inst infectious pathog.ns or tumors,while also contributing.to ***,this paradig. is now chang.ng.with recent studies hig.lig.ting.novel roles for immune mediators in the maintenance of steady-state tissue *** this perspective,we review some of the latest finding. featuring.immune modulators of the nervous system pathophysiolog.,with a special focus on interleukin(IL)-17.

关键词： homeostasis neig.borhood finding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mycorrhizal fung. mitig.te nitrog.n losses of an experimental g.assland by facilitating.plant uptake and soil microbial immobilization

引用

Pedosphere 2024年第2期34卷 399-410页

作者： Yang.ang.JIA Marcel g.A.VAN DER HEIJDEN Alain Y.VALZANO-HELD Markus JOCHER Florian WALDER Postdoctoral Mobile Station of Ecolog. College of Ecology and EnvironmentXinjiang UniversityÜrümqi 830046China Research g.oup Plant-Soil Interactions AgroscopeZürich 8046Switzerland Research g.oup Climate and Ag.iculture AgroscopeZürich 8046Switzerland Department of Plant and Microbial Biolog. University of ZürichZürich 8008Switzerland Research g.oup Soil Quality and Soil Use AgroscopeZürich 8046Switzerland

Nitrog.n(N)is one of the most limited nutrients of terrestrial ecosystems,whose losses are prevented in tig.tly coupled cycles in finely tuned *** chang.-induced N enrichment throug. atmospheric deposition and application of vast amounts of fertilizer are now challeng.ng.the terrestrial N *** mycorrhizal fung.(AMF)are known drivers of plant-soil nutrient fluxes,but a comprehensive assessment of AMF involvement in N cycling.under g.obal chang. is still ***,we simulated N enrichment by fertilization(low/hig.)in experimental g.assland microcosms under g.eenhouse conditions in the presence or absence of AMF and continuously monitored different N pathways over nine *** found that hig. N enrichment by fertilization decreased the relative abundance of leg.mes and the plant species dominating.the plant community chang.d from g.asses to forbs in the presence of AMF,based on aboveg.ound *** presence of AMF always maintained plant N:phosphorus(P)ratios between 14 and 16,no matter how the soil N availability *** in plant N:P ratios due to the increased plant N and P uptake mig.t thus be a primary pathway of AMF altering.plant community ***,we constructed a comprehensive picture of AMF’s role in N cycling.hig.lig.ting.that AMF reduced N losses primarily by mitig.ting.N leaching.while N_(2)O emissions played a marg.nal *** mycorrhizal fung. reduced N_(2)O emissions directly throug. the promotion of N_(2)O-consuming.*** underlying.mechanism for reducing.N leaching.is mainly the AMF-mediated improved nutrient uptake and AMF-associated microbial *** results indicate that synerg.es between AMF and other soil microorg.nisms cannot be ig.ored in N cycling.and that the integ.al role of AMF in N cycling.terrestrial ecosystems can buffer the upcoming.g.obal chang.s.

关键词： N cycling N enrichment N uptake N:P ratio plant community structure symbiotic soil fung.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：