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Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali

Asian Pacific Journal of Tropical Biomedicine 2020年第12期10卷 555-562页

作者： md.Nazim Uddin md.Abdus Samad md.Abu Zubair md.zahurul haque Kanika Mitra Tanzir Ahmed Khan md.Amir Hossain Ashikujaman Syed Aklima Afroze Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhaka 1205Bangladesh School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology UniversitySantoshTangail 1902Bangladesh Center for New Drug Safety Evaluation and Research China Pharmaceutical UniversityJiangsuNanjing 211198China School of Pharmacy Lanzhou UniversityLanzhou 730000China School of Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China

Objective:To investigate bioactive phytochemicals and antioxidant activities of Nymphaea nouchali and to explore its anticancer pathways by a network pharmacology ***:Using a spectrophotometer and high-performance liquid chromatography-diode array detector(HPLC-DAD),we quantified bioactive phytochemicals in methanolic extract of Nymphaea nouchali *** extracts were investigated for in vitro antioxidant *** of these bioactive phytochemicals were predicted and anticancer-associated pathways were analyzed by a network pharmacology ***,we identified the predicted genes associated with cancer pathways and the hub genes in the protein-protein interaction network of predicted ***:Quantitative results indicated the total phenolics,total flavonoids,and total proanthocyanidins in the methanolic extract of Nymphaea nouchali ***-DAD analysis showed rutin(39.44 mg),catechin(39.20 mg),myricetin(30.77 mg),ellagic acid(11.05 mg),gallic acid(3.67 mg),vanillic acid(0.75 mg),rosmarinic acid(4.81 mg),p-coumaric acid(3.35 mg),and quercetin(0.90 mg)in 1 g of dry *** extract showed the radical scavenging activities of 2,2-diphenyl-1-picrylhydrazyl,2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)and N,*** using network pharmacology,we predicted 130 target genes associated with cancer *** top hub genes(IL6,AKT1,EGFR,JUN,PTGS2,MAPK3,CASP3,and CXCL8)were also identified,which were associated with cancer pathways and interacted with bioactive phytochemicals of the methanolic extract of Nymphaea nouchali ***:Our study provides insights into the mechanism of anticancer activities of the methanolic extract of Nymphaea nouchali tuber.

关键词： Bioactive phytochemicals Anticancer pathways Malignancy Network pharmacology Nymphaea nouchali

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Bibliographic survey and comprehensive review on mechanical and durability properties of microorganism based self-healing concrete

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1445-1465页

作者： md Marghoobul haque Kunal M.SHELOTE Namrata SINGH Supratic GUPTA Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Concrete is the most widely utilized material for construction purposes,second only to water,in the ever-increasing need for construction *** is a brittle material and possesses a high risk of crack formation and consequent ***,which allows chemicals to enter and can cause concrete structures to lose their physico-mechanical and durability *** and rehabilitating concrete structures involves high costs and leads to various repair methods including coating,adhesives,polymers,supplementary cementitious materials(SCMs),and *** of the latest technologies is the use of microorganisms in *** added microorganisms lead to calcite precipitation and thereby heal the cracks *** study presents a comprehensive literature survey on bacteria-included concrete,before which a bibliographic survey is performed using VOSViewer *** addition to regular bacterial concrete,this study focuses on also using SCMs and fibers in bacterial concrete.A detailed literature review with data representation for various mechanical properties including compressive strength(CS),split tensile strength(SS),and flexure strength(FS),along with durability properties including carbonation,water absorption,resistance against chloride ion penetration,gas permeation,and resistance against cyclic freeze-and-thaw is presented.A study on the use of X-ray computed tomography(XCT)in bacterial concrete is highlighted,and the scope for future research,along with identification of the research gap,is presented.

关键词： bacterial concrete bibliographic survey biomineralization carbonation fibers

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Ionotropic receptors mediate olfactory learning and memory in Drosophila

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Insect Science 2024年第4期31卷 1249-1269页

作者： md Zeeshan Ali Anushree Aarif Ahsan Mohammad Shamsul Ola Rizwanul haque Jawaid Ahsan Department of Biotechnology Central University of South BiharGayaBiharIndia Department of Radiation Oncology University of MichiganAnn ArborMichiganUSA Department of Biochemistry College of ScienceKing Saud UniversityRiyadhSaudi Arabia

Phenylacetaldehyde(PAH),an aromatic compound,is present in a diverse range of fruits including overripe bananas and prickly pear cactus,the two major host fruits for Drosophila *** acts as a potent ligand for the ionotropic receptor 84a(IR84a)in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric *** role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional *** ***,two distinct kinds of olfactory receptors,that is,odorant receptors(ORs)and ionotropic receptors(IRs),perceive the odorant *** display unique structural,molecular,and functional characteristics in addition to having different evolutionary ***,olfactory cues detected by the ORs such as ethyl acetate,1-butanol,isoamyl acetate,1-octanol,4-methylcyclohexanol,*** as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit *** underlines the participation of OR-activated olfactory pathways in learning and memory *** study elucidates that likewise ethyl acetate(EA)(an OR-responsive odorant),PAH(an IR-responsive aromatic compound)too can form learning and memory when associated with an appetitive gustatory *** association of PAH with sucrose(PAH/SUC)led to learning and formation of the long-term memory(LTM).Additionally,the Orco^(1),Ir84a^(MI00501),and Ir8a^(1)mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative *** results highlight the involvement of IRs via an IR-activated pathway in facilitating robust olfactory behavior.

关键词： appetitive conditioning Drosophila melanogaster ethyl acetate ionotropic receptors learning and memory phenylacetaldehyde

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An integrated framework for assessing renewable-energy supply chains using multicriteria decision-making:a study on Bangladesh

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Clean Energy 2024年第3期8卷 1-19页

作者： A.M.Almas Shahriyar Azad Zarin Tasnim Oishi md.Ariful haque Pronob Das Sabbir Ahmed Udoy Khaled Mohammad Shifullah Bhuiya Department of Industrial&Production Engineering Rajshahi University of Engineering&TechnologyRajshahi-6204Bangladesh Department of Mechanical Engineering Rajshahi University of Engineering&TechnologyRajshahi-6204Bangladesh

The depletion in non-renewable energy sources and a fast-growing population in Bangladesh are exacerbating the already existing energy scarcity,highlighting the need for an efficient and robust renewable-energy supply *** primary goal of this study is to evaluate the most optimized renewable-energy supply chain based on natural resource availability and government policies of *** the present study,four renewable energy resources,including solar,biomass,wind and hydropower,are studied and nine subcriteria are defined under four primary criteria for each supply *** for Order Preference by Similarity to Ideal Solution(TOPSIS)and VIseKriterijumska Optimizacija I Kompromisno Resenje(VIKOR)are multicriteria decision-making approaches used in this study to compare and choose the best renewable-energy supply *** relative significance of four supply-chain criteria for primary renewable energy in this study,namely energy procurement,production,operations and maintenance costs,and social and environmental impact,is gathered via a *** results of this research,supported by a comprehensive sensitivity analysis,indicate that hydropower is the best renewable-energy supply chain,followed by wind as a compromise solution,biomass and *** study also demonstrates that no energy source can satisfy all supply-chain criteria alone;each resource is better for a specific criterion-solar is better for procurement,hydropower is significant for production and wind is remarkable for operations and social ***,to maximize output,renewable energy sources must be *** Bangladesh’s perspective,for the first time,by using TOPSIS and VIKOR together,this study offers significant insights to establish an efficient and sustainable renewable-energy supply chain for practitioners,academics and policymakers.

关键词： renewable-energy supply chain Bangladesh multicriteria decision-making TOPSIS(Technique for Order Preference by Similarity to Ideal Solution) VIKOR(VIseKriterijumska Optimizacija I Kompromisno Resenje)

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Hybrid Effects on MHD Mixed Convective Boundary Layer Flow through a Sloped Plate in Existence of Nanofluid-Saturated Porous Medium

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Journal of Applied Mathematics and Physics 2024年第9期12卷 3037-3052页

作者： md. Nasir Uddin Abdul Halim Bhuiyan zahurul Islam Tahmina Tahrim Department of Mathematics Bangladesh Army University of Engineering & Technology Natore Bangladesh Department of Mathematics Bangladesh University of Engineering and Technology Dhaka Bangladesh Department of Computer Science and Engineering Jagannath University Dhaka Bangladesh

This study examines the effects of heat, mass, and boundary layer assumptions-based nanoparticle characteristics on the hybrid effects of using MHD in conjunction with mixed convective flow through a sloped vertical pore plate in the existence of medium of porous. Physical characteristics such as thermo-diffusion, injection-suction, and viscous dissipation are taken into consideration, in addition to an equally distributed magnetic force utilized as well in the completely opposite path of the flow. By means of several non-dimensional transformations, the momentum, energy, concentration, and nanoparticle volume fraction equations under investigation are converted in terms of nonlinear boundary layer equations and computationally resolved by utilizing the sixth-order Runge-Kutta strategy in combination together with the iteration of Nachtsheim-Swigert shooting procedure. By contrasting the findings produced for a few particular examples with those found in the published literature, the correctness of the numerical result is verified, and a rather good agreement is found. Utilizing various ranges of pertinent factors, computing findings are determined not only regarding velocity, temperature, and concentration as well as nanoparticle fraction of volume but also concerning with local skin-friction coefficient, local Nusselt and general Sherwood numbers associated with nanoparticle Sherwood number. The findings of the study demonstrate that increasing the fluid suction parameter decreases the velocity and temperature of the flow field in conjunction with concentration and has a variable impact on the nanoparticle fraction of volume, despite an increasing behavior in the local skin friction coefficient and local Nusselt as well as general Sherwood numbers and an increasing behavior in the local nanoparticle Sherwood number. Furthermore, enhancing a Schmidt number leads to a reduction in the local nanoparticle Sherwood number and a rise in the nanoparticle proportion of vo

关键词： Hybrid Effects Mixed Convection MHD Nanofluid Viscous Dissipation

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A Novel LSB Steganography Technique for Enhancing Cloud Security

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Journal of Information Security 2024年第3期15卷 355-377页

作者： Ahsan Ullah md. Inzamul haque md. Mokarom Hossain md. Sadman Ahammad Mst. Nishita Aktar Department of Computer Science and Engineering World University of Bangladesh Dhaka Bangladesh

Steganography is a technique that is frequently used to hide hidden information in multimedia artifacts including music, video, and images. In order to protect data saved in the cloud, this paper presents a steganography method for encrypting sound utilizing LSB-based computation. By using the least significant bit (LSB) of a byte to represent a message and then substituting each LSB bit with a binary message and encrypting a significant quantity of data. The proposed system uses the LSB technique of picture steganography, Multi-Level Encryption Algorithm (MLEA) and Two-Level Encryption Algorithm (TLEA) data encryption to give the highest level of cloud security. Compared to other current schemes, the performance of the suggested method is 1.732125% better on average.

关键词： Steganography LSB Cloud Computing Security Cryptography TLEA MLEA

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Numerical Study and Optimization of CZTS-Based Thin-Film Solar Cell Structure with Different Novel Buffer-Layer Materials Using SCAPS-1D Software

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Energy and Power Engineering 2024年第4期16卷 179-195页

作者： md. Zamil Sultan Arman Shahriar Rony Tota md. Nuralam Howlader Hasibul haque Rodro Mahfuja Jannat Akhy md. Abir Al Rashik Department of Electrical and Electronic Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh

This study explored the performances of CZTS-based thin-film solar cell with three novel buffer layer materials ZnS, CdS, and CdZnS, as well as with variation in thickness of buffer and absorber-layer, doping concentrations of absorber-layer material and operating temperature. Our aims focused to identify the most optimal thin-film solar cell structure that offers high efficiency and lower toxicity which are desirable for sustainable and eco-friendly energy sources globally. SCAPS-1D, widely used software for modeling and simulating solar cells, has been used and solar cell fundamental performance parameters such as open-circuited voltage (), short-circuited current density (), fill-factor() and efficiency() have been optimized in this study. Based on our simulation results, it was found that CZTS solar cell with Cd0.4Zn0.6S as buffer-layer offers the most optimal combination of high efficiency and lower toxicity in comparison to other structure investigated in our study. Although the efficiency of Cd0.4Zn0.6S, ZnS and CdS are comparable, Cd0.4Zn0.6S is preferable to use as buffer-layer for its non-toxic property. In addition, evaluation of performance as a function of buffer-layer thickness for Cd0.4Zn0.6S, ZnS and CdS showed that optimum buffer-layer thickness for Cd0.4Zn0.6S was in the range from 50 to 150nm while ZnS offered only 50 – 75 nm. Furthermore, the temperature dependence performance parameters evaluation revealed that it is better to operate solar cell at temperature 290K for stable operation with optimum performances. This study would provide valuable insights into design and optimization of nanotechnology-based solar energy technology for minimizing global energy crisis and developing eco-friendly energy sources sustainable and simultaneously.

关键词： Thin-Film Solar Cell CZTS Buffer-Layer Renewable Energy Green-House Gases Efficiency

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Acute Lymphoblastic Leukemia Presenting as Systemic Juvenile Idiopathic Arthritis: Experience from Bangladesh

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第1期14卷 1-12页

作者： Manik Kumar Talukder Kamrul Laila md. Arif Hossain md. Shafiqul Islam md. Zahidul Islam Kalyan Benjamin Gomes Mujammel haque md. Mahbubul Islam md. Imnul Islam Department of Paediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Health Services Dhaka Bangladesh NICVD Dhaka Bangladesh

Background: Acute lymphoblastic leukemia (ALL), the most common paediatric malignancy, is a heterogeneous hematologic disease. ALL patients may present with isolated and persistent osteo-articular complaints, lower incidence of hepatomegaly, splenomegaly or lymphadenopathy without clear laboratory features, and misdiagnosed as systemic juvenile idiopathic arthritis (sJIA). Methods: This was a single center cross sectional study over a period of 4 years. Clinic laboratory profiles of 39 ALL children were compared with 39 age and sex-matched sJIA cases. Result: Among 39 ALL patients 89.7% were initially misdiagnosed as sJIA upon clinical presentation. Majority (66.7%) of ALL patients had oligo-articular joint involvement. In sJIA, small joints of the hands were most commonly involved. The total WBC count was significantly higher in ALL patients (p-value 0.0065). CRP and LDH values between the two groups showed significant differences (p-value 0.00006 and 0.00001 respectively). Conclusion: The presentation of leukemia with arthralgia or arthritis makes the diagnosis difficult for the physicians. The diagnosis of sJIA must be made with caution keeping the possibility of haematological malignancy in mind.

关键词： ALL sJIA Arthritis Arthralgia Musculoskeletal

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ZnO Incorporated Acrylamide Grafted Chitosan Based Composite Film for Advanced Wound Healing Applications

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Open Journal of Applied Sciences 2024年第4期14卷 1034-1051页

作者： Khodeja Afrin Kaniz Fatema Fariha Afrose md. Abdus Samad Azad md. Shamim Akter md. Saiful Alam Papia haque Yeasmin Akter Newaz Mohammed Bahadur Department of Applied Chemistry and Chemical Engineering Noakhali Science and Technology University Noakhali Bangladesh Department of Applied Chemistry and Chemical Engineering University of Dhaka Dhaka Bangladesh

This study was carried out to prepare ZnO nanoparticles incorporated acrylamide grafted chitosan composite film for possible biomedical application especially drug loading in wound healing. ZnO nanoparticles were prepared by co-precipitation method from zinc acetate di-hydrate and incorporated in acrylamide grafted chitosan. FT-IR and TGA of the prepared composite film confirmed the successful incorporation of ZnO nanoparticles in the acrylamide-grafted polymer matrix. SEM images showed that the ZnO nanoparticles were homogeneously distributed on the porous matrix of the composite film. Water uptake and buffer uptake analysis revealed that the composite film could hold water and buffer sufficiently, which facilitated the absorption of exudate from the wound site. Amoxicillin was loaded in the prepared composite film and the maximum loading efficiency was found to be 67.33% with drug concentration of 300 ppm. In vitro studies showed greater antimicrobial activity of drug-loaded composite film compared to both pure film and standard antibiotic disc. Finally, the In vivo mouse model showed maximum healing efficiency compared to conventional gauge bandages because the loading of antibiotic in the film produced a synergistic effect and healing time was reduced.

关键词： Chitosan ZnO Nanoparticles Wound Management Acrylamide Grafting Bacterial Resistance Drug Loading

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Frequency of Uveitis among Juvenile Idiopathic Arthritis Patients in a Tertiary Care Hospital of Bangladesh: A Retrospective Study

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 144-156页

作者： md. Asif Ali Mujammel haque Kamrul Laila Mohammad Hafiz Al-Mamun Mohammed Mahbubul Islam Mohammad Imnul Islam Manik Kumar Talukder Pediatric Rheumatology Division Department of Pediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Background: Juvenile idiopathic arthritis (JIA) is the most frequently encountered pediatric rheumatologic disorder with an unknown etiology. At present there is no published data regarding the frequency of uveitis in patients with JIA in Bangladesh. This study aimed to observe the frequency of JIA-associated uveitis (JIAU) and distribution of uveitis among different sub-categories of JIA at the Pediatric Rheumatology division, both outdoor and indoor patients, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU) in Bangladesh. Methods: This was a retrospective study of 1784 JIA patients at the Pediatric Rheumatology division, BSMMU from July 2010 to March 2023. Results: Among the 1784 enrolled JIA patients, we observed that 0.73% of cases had uveitis. Here, 61.5% of JIAU cases were male. Most of the cases (92.3%) had bilateral uveitis and only 7.7% cases had unilateral uveitis. Among JIAU patients, the majority were Oligo JIA (53.8%), followed by ERA 30.8%, Poly JIA RF(−) 7.7% and Systemic JIA 7.7% cases respectively. This study also revealed that 15.4% of JIAU patients had ANA positivity and 23% had HLA B-27 positivity. Here we also found ocular complications associated with uveitis such as band keratopathy (23.1%), posterior synechiae (15.4%) and cataract (15.4%). Conclusions: In this study, we observed only 0.73% of patients of JIA had developed uveitis which is lower than the frequency observed in other European studies. This study also showed various ocular complications amongst JIA-associated uveitis patients which signifies the importance of adherence to periodic ophthalmological follow-up to prevent these ocular complications.

关键词： JIA Uveitis HLA-B27 ANA BSMMU

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