Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali
作者机构：Institute of Food Science and TechnologyBangladesh Council of Scientific and Industrial ResearchDhaka 1205Bangladesh School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingJiangsu 211198China Department of Food Technology and Nutritional ScienceMawlana Bhashani Science and Technology UniversitySantoshTangail 1902Bangladesh Center for New Drug Safety Evaluation and ResearchChina Pharmaceutical UniversityJiangsuNanjing 211198China School of PharmacyLanzhou UniversityLanzhou 730000China School of PharmacyChina Pharmaceutical UniversityNanjingJiangsu 211198China
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2020年第10卷第12期
页 面：555-562页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Bioactive phytochemicals Anticancer pathways Malignancy Network pharmacology Nymphaea nouchali
摘 要：Objective:To investigate bioactive phytochemicals and antioxidant activities of Nymphaea nouchali and to explore its anticancer pathways by a network pharmacology ***:Using a spectrophotometer and high-performance liquid chromatography-diode array detector(HPLC-DAD),we quantified bioactive phytochemicals in methanolic extract of Nymphaea nouchali *** extracts were investigated for in vitro antioxidant *** of these bioactive phytochemicals were predicted and anticancer-associated pathways were analyzed by a network pharmacology ***,we identified the predicted genes associated with cancer pathways and the hub genes in the protein-protein interaction network of predicted ***:Quantitative results indicated the total phenolics,total flavonoids,and total proanthocyanidins in the methanolic extract of Nymphaea nouchali ***-DAD analysis showed rutin(39.44 mg),catechin(39.20 mg),myricetin(30.77 mg),ellagic acid(11.05 mg),gallic acid(3.67 mg),vanillic acid(0.75 mg),rosmarinic acid(4.81 mg),p-coumaric acid(3.35 mg),and quercetin(0.90 mg)in 1 g of dry *** extract showed the radical scavenging activities of 2,2-diphenyl-1-picrylhydrazyl,2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)and N,*** using network pharmacology,we predicted 130 target genes associated with cancer *** top hub genes(IL6,AKT1,EGFR,JUN,PTGS2,MAPK3,CASP3,and CXCL8)were also identified,which were associated with cancer pathways and interacted with bioactive phytochemicals of the methanolic extract of Nymphaea nouchali ***:Our study provides insights into the mechanism of anticancer activities of the methanolic extract of Nymphaea nouchali tuber.
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