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Partial Protection by Lipoic Acid Against Carboplantin-induced Ototoxicity in Rats

Biomedical and Environmental Sciences 2005年第3期18卷 198-206页

作者： KAZIm HUSAIN CRAIG WHITWORTH SATU m. SOmANI leonard P. RYBAK Departments of Surgery Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Surgery Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Pharmacology Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Surgery Southern Illinois University School of Medicine Springfield IL 62794 USA

Objective To investigate the alterations in auditory brainstem evoked responses (ABRs) and the changes of carboplatin-induced ototoxicity in the cochlear oxidant/antioxidant systems and otoprotection by an antioxidant lipoate. methods male wistar rats were divided into four groups and treated as follows: 1) vehicle (saline) control, 2) carboplatin (256 mg/kg, i.p.), 3) lipoate (100 mg/kg, i.p.), 4) lipoate + carboplatin. Post-treatment ABRs were performed after four days and rats were sacrificed with their cochleae harvested and analyzed. Results Carboplatin significantly elevated ABR threshold above the pretreatment thresholds. Lipoate+carboplatin treated rats showed decreased elevation of hearing threshold. Carboplatin significantly depleted cochlear reduced to oxizized glutathione (GSH/GSSG) ratio, whereas lipoate+carboplatin treatment increased GSH/GSSG ratio. Carboplatin significantly decreased cochlear copper zinc-superoxide dismutase (CuZn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST) activities and enzyme protein expressions and a significant increase in mn-SOD activity, protein expression and malondialdehyde (mDA) level. Cochlear antioxidant enzyme activities, enzyme protein expressions and mDA level were partially restored in lipoate+carboplatin treated rats, compared to carboplatin alone. Conclusion Carboplatin-induced ototoxicity is related to impairment of cochlear antioxidant system and otoprotection conferred by lipoate is associated with partial sparing of the cochlear antioxidant defense system.

关键词： Carboplatin Alpha-lipoic acid Ototoxicity Antioxidants Rats

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Ab externo implantation of the microShunt, a poly (styrene-block-isobutylene-blockstyrene) surgical device for the treatment of primary open-angle glaucoma: a review

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Eye and Vision 2019年第1期6卷 303-311页

作者： Omar Sadruddin leonard Pinchuk Raymund Angeles Paul Palmberg Santen Inc EmeryvilleCAUSA. InnFocus Inc. a Santen CompanyMiamiFLUSA Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Trabeculectomy remains the‘gold standard’intraocular pressure(IOP)-lowering procedure for moderate-to-severe glaucoma;however,this approach is associated with the need for substantial post-operative *** glaucoma surgery(mIGS)procedures aim to reduce the need for intra-and post-operative management and provide a less invasive means of lowering ***,mIGS procedures are associated with only modest reductions in IOP and are targeted at patients with mild-to-moderate glaucoma,highlighting an unmet need for a less invasive treatment of advanced and refractory *** PRESERFLO®microShunt(formerly known as InnFocus microShunt)is an 8.5 mm-long(outer diameter 350μm;internal lumen diameter 70μm)glaucoma drainage device made from a highly biocompatible,bioinert material called poly(styrene-block-isobutylene-blockstyrene),or *** lumen size is sufficiently small that at normal aqueous flow hypotony is avoided,but large enough to avoid being blocked by sloughed cells or *** microShunt achieves the desired pressure range in the eye by draining aqueous humor from the anterior chamber to a bleb formed under the conjunctiva and Tenon’s *** device is implanted ab externo with intraoperative mitomycin C via a minimally invasive(relative to incisional surgery)surgical procedure,enabling precise control of placement without the need for gonioscopy,suture tension control,or suture *** implantation procedure can be performed in combination with cataract surgery or as a standalone *** microShunt received ConformitéEuropéenne(CE)marking in 2012 and is intended for the reduction of IOP in eyes of patients with primary open-angle glaucoma in which IOP remains uncontrolled while on maximum tolerated medical therapy and/or in which glaucoma progression warrants *** clinical studies assessing the long-term safety and efficacy of the microShunt have been completed;a Phase 3 multicenter,randomized clinical study comp

关键词： Ab externo Glaucoma micro-invasive glaucoma surgery microShunt mitomycin C SIBS polymer

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magnetically actuated glaucoma drainage devicefor regulating intraocular pressure afterimplantation

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microsystems & Nanoengineering 2023年第4期9卷 91-105页

作者： Inês C.F.Pereira Ralph J.S.van mechelen Hans m.Wyss leonard Pinchuk Henny J.m.Beckers Jaap m.J.den Toonder microsystems Department of Mechanical EngineeringEindhoven University of Technology5600MB EindhovenThe Netherlands Institute for Complex molecular Systems(ICmS) Eindhoven University of Technology5600MB EindhovenThe Netherlands University Eye Clinic maastricht Maastricht University Medical Centre+(MUMC+)6202AZ MaastrichtThe Netherlands InnFocus Inc.a Santen CompanyMiamiFlorida 33186USA Ophthalmic Biophysics Center Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFlorida 33136USA

The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in theeye can reduce IOP and thus stop disease progression. However, most devices currently used in clinical practice arepassive and do not allow for postsurgical IOP control, which may result in serious complications such as hypotony (i.e.,excessively low IOP). To enable noninvasive IOP control, we demonstrate a novel, miniature glaucoma implant that willenable the repeated adjustment of the hydrodynamic resistance after implantation. This is achieved by integrating amagnetic microvalve containing a micropencil-shaped plug that is moved using an external magnet, thereby openingor closing fluidic channels. The microplug is made from biocompatible poly(styrene-block-isobutylene-block-styrene)(SIBS) containing iron microparticles. The complete implant consists of an SIBS drainage tube and a housing elementcontaining the microvalve and fabricated with hot embossing using femtosecond laser-machined glass molds. Usingin vitro and ex vivo microfluidic experiments, we demonstrate that when the microvalve is closed, it can providesufficient hydrodynamic resistance to overcome hypotony. Valve function is repeatable and stable over time. Due to itssmall size, our implant is a promising, safe, easy-to-implant, minimally invasive glaucoma surgery device.

关键词： enable implantation overcome

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A myosin XI Tail Domain Homologous to the Yeast myosin Vacuole-Binding Domain Interacts with Plastids and Stromules in Nicotiana benthamiana

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molecular Plant 2009年第6期2卷 1351-1358页

作者： Amir Sattarzadeh Johanna Krahmer Arnaud D. Germain maureen R. Hanson Department of molecular Biology and Genetics Biotechnology Building Cornell University Ithaca NY 14853 USA

The actin cytoskeleton plays a role in mobility of many different organelles in plant cells, including chloroplasts, mitochondria, Golgi, and peroxisomes. While progress has been made in identifying the myosin motors involved in trafficking of various plant organelles, not all of the cargoes mobilized by different members of the myosin XI family have yet been identified. The involvement of myosins in chloroplast positioning and mitochondrial movement was demonstrated by expression of a virus-induced gene silencing （VIGS） construct in tobacco. When VIGS with two different conserved sequences from a myosin Xl motor was performed in plants with either GFP-labeled plastids or mitochondria, chloroplast positioning in the dark was abnormal, and mitochondrial movement ceased. Because these and prior obser- vations have implicated a role for myosins and the actin cytoskeleton in plastid and stromule movement, we searched for myosin tail domains that could associate with plastids and stromules. While a yellow fluorescent protein （YFP） fusion with the entire tail region of myosin XI-F was usually found only in the cytoplasm, we observed that an Arabidopsis or Nicotiana benthamiana YFP：：myosin XI-F tail domain homologous to the yeast myo2p vacuole-binding domain associated with plastids and stromules after transient expression in N. benthamiana. Taken together, these observations implicate myosin motor proteins in dynamics of plastids and stromules.

关键词： Chloroplast biology cytoskeleton dynamics mitochondria gene silencing fluorescent protein.

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Fhe X and Y chromosome in meiosis： how and why they ceep silent

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Asian Journal of Andrology 2011年第6期13卷 779-780页

作者： Godfried W van der Heijden maureen Eijpe Willy m Baarends Department of Reproduction and Development Erasmus MC-University Medical Center Rotterdam PO Box 2040 3000CA the Netherlands

The XX/XY sex chromosomal system of mammals, including human, challengesthe chromosome pairing mechanism during male meiosis. Pairing and subsequent separation of homologous chromosomes generates haploid cells from diploid cells during the meiotic divisions. One of the basic requirements for recognition between homologous chromosomes is DNA sequence identity.

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Tango Controls and data pipeline for petawatt laser experiments

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High Power Laser Science and Engineering 2023年第4期11卷 2-8页

作者： Nils Weiße leonard Doyle Johannes Gebhard Felix Balling Florian Schweiger Florian Haberstroh Laura D.Geulig Jinpu Lin Faran Irshad Jannik Esslinger Sonja Gerlach max Gilljohann Vignesh Vaidyanathan Dennis Siebert Andreas münzer Gregor Schilling Jörg Schreiber Peter G.Thirolf Stefan Karsch Andreas Döpp Ludwig-maximilians-Universität münchen GarchingGermany

The Centre for Advanced Laser Applications in Garching,Germany,is home to the ATLAS-3000 multi-petawatt laser,dedicated to research on laser particle acceleration and its applications.A control system based on Tango Controls is implemented for both the laser and four experimental *** device server approach features high modularity,which,in addition to the hardware control,enables a quick extension of the system and allows for automated data acquisition of the laser parameters and experimental data for each laser *** this paper we present an overview of our implementation of the control system,as well as our advances in terms of experimental operation,online supervision and data *** also give an outlook on advanced experimental supervision and online data evaluation–where the data can be processed in a pipeline–which is being developed on the basis of this infrastructure.

关键词： data processing high-power laser experiments laser-plasma acceleration online diagnostics

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Impact of ozone assisted ultrasonication pre-treatment on anaerobic digestibility of sewage sludge

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Journal of Environmental Sciences 2015年第7期27卷 29-38页

作者： Xinbo Tian Antoine Prandota Trzcinski Li leonard Lin Wun Jern Ng Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research Institute Nanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University Public Utilities Board Water Reclamation (Plants) Department Nanyang Environment and Water Research Institute Nanyang Technological University

Impact of ultrasonication（ULS） and ultrasonication-ozonation（ULS-Ozone） pre-treatment on the anaerobic digestibility of sewage sludge was investigated with semi-continuous anaerobic reactors at solid retention time（SRT） of 10 and 20 days. The control, ULS and ULS-Ozone reactors produced 256, 309 and 348 m L biogas/g CODfedand the volatile solid（VS） removals were 35.6%, 38.3% and 42.1%, respectively at SRT of 10 days. At SRT of20 days, the biogas yields reached 313, 337 and 393 m L biogas/g CODfedand the VS removal rates were 37.3%, 40.9% and 45.3% in the control, ULS and ULS-Ozone reactors, ***-Ozone pre-treatment increased the residual organic amount in the digested *** soluble residual organics were found to contain macromolecules with molecular weights（mW） larger than 500 k Da and smaller polymeric products with mW around 19.4and 7.7 k Da. These compounds were further characterized to be humic acid-like substances with fluorescent spectroscopy analysis.

关键词： Sewage sludge Ultrasound Ozone Pre-treatment molecular weight Anaerobic digestion

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Pembrolizumab as a novel therapeutic option for patients with refractory thymic epithelial tumor:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1139-1147页

作者： Jonathan Wong-Chong maureen Bernadach Angeline Ginzac Hugo Veyssière Xavier Durando Département d’Oncologie médicale Centre Jean PERRINClermont-Ferrand 63011France UFR médecine UniversitéClermont AuvergneClermont-Ferrand 63011France Division de Recherche Clinique Délégation Recherche Clinique et InnovationCentre Jean PERRINClermont-Ferrand 63011France INSERm U1240 Imagerie Moléculaire et Stratégies ThéranostiquesUniversitéClermont AuvergneClermont-Ferrand 63011France Centre d’Investigation Clinique UMR501Clermont-Ferrand 63011France

BACKGROUND Thymic epithelial carcinomas are rare and have a poor *** of thymic epithelial carcinoma is multimodal and includes surgery,post-operative radiation therapy,adjuvant and neoadjuvant chemotherapy,or exclusive chemotherapy based on disease ***,there is currently no standard treatment regimen for metastatic and recurrent thymic *** SUmmARY A 45-year-old Caucasian male,with no past medical history,presented with hepatalgia and a cervical mass.A computed tomography(CT)scan showed multiple suspect lesions in the lungs,liver,and anterior mediastinum associated with mediastinal and cervical ***-guided percutaneous biopsies of the liver lesions and anterior mediastinal mass were performed,confirming the histopathology of thymic epithelial *** consisted of several chemotherapy regimens and radiation therapy,administered between April 2016 and December *** patient achieved complete metabolic *** positron emission tomography/CT performed in June 2019 showed disease relapse,with reappearance of a large hypermetabolic hepatic mass and involvement of mediastinal and axillary lymph *** pembrolizumab(200 mg,every 3 wk)was administered after two prior systemic *** patient’s response to treatment was last documented on march 5,*** Pembrolizumab was successful in treatment of a patient with programmed deathligand 1-negative metastatic thymic carcinoma,pretreated with chemotherapy.

关键词： Thymic epithelial carcinoma Programmed death-ligand 1 negative Pembrolizumab Immune checkpoint metastasis Case report

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Online Learning: Advantages and Challenges in Implementing an Effective Practicum Experience

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Open Journal of Nursing 2014年第6期4卷 379-384页

作者： maureen m. mitchell Cheryl Delgado School of Nursing Cleveland State University Cleveland USA

Executing an effective clinical practicum experience for distance learners requires systems to be in place to ensure that all students receive a quality clinical experience and meet course and program objectives. Key to achieving these successful outcomes is recognizing and overcoming the challenges involved in designing graduate practica for master of Science in nursing candidates. A systematic approach is presented for consideration.

关键词： Clinical Practica Distance Learning Online mSN Programs

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A Case Study of Ocean-Atmosphere Interactions during the Passage of an Extra-Tropical Cyclone in the Vicinity of Cape Hatteras, North Carolina

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International Journal of Geosciences 2023年第9期14卷 855-876页

作者： Neil Jacobs James Churchill leonard Pietrafesa Shaowu Bao Paul Gayes University Corporation for Atmospheric Research Boulder USA Department of Physical Oceanographym Woods Hole Oceanographic Institution Woods Hole USA School of Coastal & marine Systems Science Burroughs & Chapin Center for Marine & Wetland Studies Coastal Carolina University Conway USA Department of marine Earth Atmospheric Sciences North Carolina State University Raleigh USA

The authors document the interaction of the atmosphere and ocean during the formation and passage of an Extra-Tropical Cyclone, which is a Nor-Easter, winter storm that formed in the southern apex of the middle Atlantic Bight near Cape Hatteras North Carolina, between February 15 and 18, 1996. While Nor-Easters per se, which have formed along the Atlantic Eastern Seaboard of the United States have been studied for decades, the actual atmospheric-oceanic mechanics and thermodynamics in the formation of a Nor-Easter has never been documented. We report on having done so with in-situ observations and data-based calculations and a numerical model. The in-situ observations were made via a Control Volume consisting of an array of Eulerian Oceanic-Atmospheric moorings with current meters, temperature and salinity sensors and meteorological towers. We find that Gulf Stream waters were located surrounding the mooring array, and that with the invasion of cold dry atmospheric air, there was a rapid loss of heat from the ocean to the atmosphere via latent and sensible surface heat flux during the cyclogenesis onset of the storm. A unique feature of this storm was that neither satellite nor buoy data showed significant sea surface cooling in the control volume. The findings indicate that storm winds drove warm saline waters from the Gulf Stream across the continental shelf into the control volume, accounting for a 51 cm rise in water level along the coast. This lateral heat advection provided heat to the control volume of 3.4e+18 Joules. On average, the heat loss at the surface of the control volume, via sensible and latent heat fluxes and radiation, was 0.7e+18 Joules, corresponding to a surface heat flux of -600 Watts per meter2 (W/m2). However, the heat lost by the control volume as latent and sensible heat fluxes was less than the heat it received via lateral heat advection, resulting in the lack of an often-observed sea surface cooling during other winter storms.

关键词： mid-Latitude Cyclone Extra-Tropical Cyclone Cyclogenesis Nor’easter Winter Storms Latent and Sensible Heat Fluxes Salt Flux

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