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Ultra-high suppression microwave photonic bandstop filters

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Chinese Science Bulletin 2014年第22期59卷 2684-2692页

作者： David Marpaung Blair Morrison mattia Pagani Ravi Pant Benjamin J.Eggleton Centre for Ultrahigh Bandwidth Devices for Optical Systems (CUDOS) the Institute of Photonics and Optical Sciences (IPOS) School of Physics University of Sydney Sydney NSW 2006 Australia

A bandstop radio frequency(RF)filter can enhance the capabilities of RF communication systems by removing unwanted signal components such as distortion,or *** modern cognitive radio systems,frequency agile filters are desired to block interferers with dynamically changing frequencies and *** filters should be tunable over a broad frequency range,and they should be capable of suppressing very strong signals with a high *** simultaneously meet these requirements with traditional RF filters are highly *** photonic(MWP),a technology that primary deals with the generation,distribution,and processing of high speed RF signals using photonic techniques and components,is promising for creating frequency agile RF ***,traditional MWP filters are lacking the high resolution and peak suppression exhibited by state-ofthe-art RF electrical *** recently introduced a new class of MWP notch filter which is free from this *** scheme allowed the creation of anomalously high suppression MWP notch filter from virtually any kind of optical resonance,irrespective of its type(gain or absorption),or its *** enabled,for the first time,simultaneous optimization of the MWP filter resolution,peak attenuation,and frequency tuning *** this paper,we present the analysis of notch filter response creation using the novel sideband processing *** thenshow the applicability of this technique to a wide range of optical *** compare simulated and experimental results of the notch filter response created using three types of optical filter commonly used in MWP signal processing,namely stimulated Brillouin scattering(SBS),an integrated optical ring resonator(ORR),and a phase-shifted fiber Bragg-grating(FBG).

关键词： RF滤波器微波光子陷波滤波器光学滤波器受激布里渊散射 RF信号光子技术频率捷变

Antegrade scrotal sclerotherapy of internal spermatic veins for varicocele treatment： technique, complications, and results

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Asian Journal of Andrology 2016年第2期18卷 292-295,J0007,J0008页

作者： Alessandro Crestani Gianluca Giannarini mattia Calandriello Marta Rossanese Mariangela Mancini Giacomo Novara Vincenzo Ficarra Academic Medical Centre Hospital Santa Maria della Misericordia Udine Italy Department of Oncologic Surgical and Gastrointestinal Sciences Urologic Unit PadovaItaly Department of Experimental and Clinic Medical Sciences Urology Unit University of Udine Udine Italy.

Varicocele repair is mainly indicated in young adult patients with clinical palpable varicocele and abnormal semen parameters. Varicocele treatment is associated with a significant improvement in sperm concentration, motility, morphology, and pregnancy rate. Antegrade scrotal sclerotherapy （ASS） represented one of the main alternatives to the traditional inguinal or suprainguinal surgical ligation. This article reviews the use of ASS for varicocele treatment. We provide a brief overview of the history of the procedure and present our methods used in ASS. In addition, we review complication and success of ASS, including our own retrospective data of treating 674 patients over the last 17 years. Herein, we analyzed step by step the ASS technique and described our results with an original modified technique with a long follow-up. Between December 1997 and December 2014, we performed 674 ASS. Mean operative time was 14 min （range 9 to 50 min）. No significant intraoperative complications were reported. Within 90 days from the procedure, postoperative complications were recorded in overall 49 （7.2%） patients. No major complications were recorded. A persistent/recurrent varicocele was detected in 40 （5.9%） cases. In 32/40 （80%） cases, patients showed preoperative grade III varicoceles. In patients with a low sperm number before surgery, sperm count improved from 13 x 106 to 21 x 106 m1-1 （P〈 0.001）. The median value of the percentage of progressive motile forms at 1 h improved from 25% to 45% （P 〈 0.001）. Percentage of normal forms increased from 17% before surgery to 35% 1 year after the procedure （P 〈 0.001）. In the subgroup of the 168 infertile patients, 52 （31%） fathered offspring at a 12-month-minimum follow-up. Therefore, ASS is an effective minimal invasive treatment for varicocele with low recurrence/persistence rate.

关键词： antegrade scrotal sclerotherapy male infertility outcomes varicocele

Dendritic cell subsets in cancer immunity and tumor antigen sensing

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Cellular & Molecular Immunology 2023年第5期20卷 432-447页

作者： Annalisa Del Prete Valentina Salvil Alessandra Soriani mattia Laffranchi Francesca Sozio Daniela Bosisio Silvano Sozzani Department of Molecular and Translational Medicine University of BresciaBresciaItaly Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti Department of Molecular Medicine Sapienza University of RomeRomeItaly

Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune *** to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell *** an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely *** this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq *** therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.

关键词： Dendritic cell subsets Tumor microenvironment Migration Innate immune sensing Immune cell death Tumor-derived extracellularvesicles

Current trends on the use of deep learning methods for image analysis in energy applications

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Energy and AI 2024年第1期15卷 342-355页

作者： mattia Casini Paolo De Angelis Eliodoro Chiavazzo Luca Bergamasco Department of Energy Politecnico di TorinoCorso Duca degli Abruzzi 24Turin10129Italy

Deep learning methods for image analysis are attracting increasing interest for application in a wide range of different research *** we aim to systematically analyze and discuss the most relevant examples for the energy *** this,we perform a comprehensive literature screening on applications of deep learning methods for image analysis,classify the results in application macro-areas,and discuss the emerging trends on the available energy-related *** results of the analysis show that,while the exploitation of these methods for energy applications still appears to be at an early stage,the interest during the last years,in terms of number of published works,has considerably *** provide a systematic overview on the available energy-related examples,we present a schematic correlation chart mapping algorithms,tasks,and *** reported analysis is intended to provide an up-to-date overview on the current application trends and potential developments for energy applications in the next future.

关键词： Deep learning Image analysis Convolutional neural networks Energy applications

Publishing NextGEOSS data on the GEOSS Platform

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Big Earth Data 2023年第2期7卷 413-427页

作者： Roberto Roncella Enrico Boldrini mattia Santoro Paolo Mazzetti João Andrade Nuno Catarino Stefano Nativi National Research Council of Italy Institute of Atmospheric Pollution ResearchDivision of FlorenceFlorenceItaly Deimos Engenharia Avenida Columbano BordaloPinheiroLisbonPortugal

This paper is the second of a series that describes some of the main dataset resources presently shared through the GEOSS Platform. The GEOSS Platform was created as the technological tool to implement interoperability among the Global Earth Observation System of Systems (GEOSS);it is a brokering infrastructure that presently brokers more than 190 autonomous data catalogs and information systems. This paper is focused on the analysis of the NextGEOSS datasets describing the data publishing process from NextGEOSS to the GEOSS platform. In particular, both the administrative registration and the technical registration were taken into consideration. One of the most important data shared by the GEOSS Platform are the NextGEOSS datasets: the present study provides some insights in terms of GEOSS user searches for NextGEOSS data.

关键词： Earth observation GEOSS data interoperability data sharing data brokering services

A DNA origami plasmonic sensor with environment-independent read-out

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Nano Research 2019年第11期12卷 2900-2907页

作者： Valentina Masciotti Luca Piantanida Denys Naumenko Heinz Amenitsch mattia Fanetti Matjaz Valant Dongsheng Lei Gang Ren Marco Lazzarino CNR-IOM AREA Science ParkBasovizza TriesteI-34149Italy PhD Course in Nanotechnology University of TriesteTriesteI-34127Italy Institute for Physics of Semiconductors National Academy of Sciences of UkraineKyiv03028Ukraine Institute of Inorganic Chemistry Graz University of TechnologyGrazA-8010Austria Materials Research Laboratory University of Nova GoricaNova GoricaSI-5000Slovenia Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610054China The Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA School of Physical Science and Technology Electron Microscopy Center of LZULanzhou UniversityLanzhou730000China Micron School of Materials Science&Engineering Boise State UniversityBoiseID 83725USA

DNA origami is a promising technology for its reproducibility,flexibility,scalability and *** the several potential applications,DNA origami has been proposed as a tool for drug delivery and as a contrast agent,since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal,***,its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place,such as pressure,viscosity and any other unspecific interaction other than the desired target *** we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration,which is transduced in a change of its plasmonic properties,upon interaction with a specific DNA *** investigated its response when analyzed in three different media:aqueous solution,solid support and viscous *** show that,once a conformational variation is produced,it remains unaffected by the subsequent physical interactions with the environment.

关键词： DNA origami plasmonic sensor molecular detection gold nanoparticle

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone Margaard Offersen Anders Brunse mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all P<0.05).CcFT also showed a lower ETEC prevalence on d 27(P<0.05).CMT showed a higher alpha diversity and a difference in beta diversity compared to CON(P<0.05).Growth and other paraclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

Micro RNAs as lung cancer biomarkers

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World Journal of Clinical Oncology 2014年第4期5卷 604-620页

作者： Valerio Del Vescovo Margherita Grasso mattia Barbareschi Michela A Denti Laboratory of RNA Biology and Biotechnology Centre for Integrative Biology University of Trento Unit of Surgical Pathology Laboratory of Molecular Pathology Trentino Biobank S.Chiara Hospital

Lung cancer is the leading cause of cancer mortality worldwide. Its high mortality is due to the poor prognosis of the disease caused by a late disease presentation, tumor heterogeneities within histological subtypes, and the relatively limited understanding of tumor biology. Importantly, lung cancer histological subgroups respond differently to some chemotherapeutic substances and side effects of some therapies appear to vary between subgroups. Biomarkers able to stratify for the subtype of lung cancer, prognosticate the course of disease, or predict the response to treatment are in high demand. In the last decade, microR NAs(miR NAs), measured in resected tumor samples or in fine needle aspirate samples have emerged as biomarkers for tumor diagnosis, prognosis and prediction of response to treatment, due to the ease of their detection and in their extreme specificity. Moreover, miR NAs present in sputum, in plasma, in serum or in whole blood have increasingly been explored in the last five years as less invasive biomarkers for the early detection of cancers. In this review we cover the increasing amounts of datathat have accumulated in the last ten years on the use of miR NAs as lung cancer biomarkers.

关键词： Lung cancer Non-small cell lung carcinomas MicroRNAs Biomarkers

Non-anatomical liver resection for hepatocellular carcinoma:the SegSubTe classification to overcome the problem of heterogeneity

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 265-271页

作者： mattia Garancini Alessandro Fogliati Mauro Alessandro Scotti Cristina Ciulli Francesca Carissimi Antonio Rovere Luca Gianotti Fabrizio Romano Unit of Hepatobiliopancreatic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Background:The superiority of anatomical resection(AR)***-anatomical resection(NAR)in the surgical management of hepatocellular carcinoma(HCC)is *** are well-defined procedures,whereas the lack of NAR standardization results in heterogeneous *** study aimed to introduce the SegSubTe classification for NAR detailing the appropriateness of the level of surgical section of the Glissonean pedicles feeding the ***:A single-center retrospective analysis of pre-and postoperative imaging of consecutive patients treated with NAR for single HCC between 2012 and 2020 was *** quality of surgery was assessed classifying the type of vascular supply and the level of surgical section(segmental,subsegmental or terminal next to the tumor)of vascular pedicles feeding the HCCs;then,the population was divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,and the tumor recurrence and survival were ***:Ninety-seven patients who underwent NAR were included;76%were SegSubTe-IN and 24%were *** disease recurrence,local recurrence and cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)and 16%vs.39%(P=0.020),***-OUT odds ratio for local recurrence was 4.1 at univariate regression ***-,three-,and five-year disease-free survival rates in the SegSubTe-IN ***-OUT groups were 81%,58%and 35%vs.46%,21%and 11%,respectively(P<0.001).Conclusions:The SegSubTe classification is a useful tool to stratify and standardize NAR for HCC,aiming at improving long-term oncological outcomes and reducing the heterogeneity of quality of NAR for HCC.

关键词： Hepatocellular carcinoma Intraoperative ultrasound Liver surgery Computed tomography Surgical procedure